Antibody data
- Antibody Data
- Antigen structure
- References [94]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 15822-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15822-1-AP, RRID:AB_1851537
- Product name
- PKM2-specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PKM2-specific antibody (Cat. #15822-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Downregulation of HSPA12A underlies myotoxicity of local anesthetic agent bupivacaine through inhibiting PGC1α-mediated mitochondrial integrity.
Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial-Mesenchymal Transition.
Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis.
EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Plasma‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.
Glucose consumption of vascular cell types in culture; toward optimization of experimental conditions.
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy.
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism.
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo.
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
Differential localization patterns of pyruvate kinase isoforms in murine naïve, formative, and primed pluripotent states.
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.
PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition.
A glycolysis-based 4-mRNA signature correlates with the prognosis and cell cycle process in patients with bladder cancer.
Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells.
Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer.
Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism.
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes.
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes.
AT1-receptor autoantibody exposure in utero contributes to cardiac dysfunction and increased glycolysis in fetal mice.
Cadmium inhibits apoptosis of human esophageal epithelial cells by upregulating CDK6.
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer.
Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis.
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-β1-induced EMT.
Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation.
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling.
1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (-)-5-Hydroxy-equol against Hepatocellular Carcinoma Cells in Vitro.
Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer.
MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Multiomics Integration Reveals the Landscape of Prometastasis Metabolism in Hepatocellular Carcinoma.
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells.
Deciphering the protein-protein interaction network regulating hepatocellular carcinoma metastasis.
Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells.
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma.
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.
Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species.
L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.
Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.
A small subunit processome protein promotes cancer by altering translation.
Estradiol-17β upregulates pyruvate kinase M2 expression to coactivate estrogen receptor-α and to integrate metabolic reprogramming with the mitogenic response in endometrial cells.
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome?
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Mao Q, Yu W, Liu S, Cao X, Dai Y, Zhang X, Min X, Liu L, Ding Z
Toxicology and applied pharmacology 2022 Jan 1;434:115798
Toxicology and applied pharmacology 2022 Jan 1;434:115798
Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial-Mesenchymal Transition.
Zou J, Huang R, Chen Y, Huang X, Li H, Liang P, Chen S
Frontiers in cell and developmental biology 2021;9:641432
Frontiers in cell and developmental biology 2021;9:641432
Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis.
Lu X, Qiao S, Peng C, Yan W, Xu Z, Qu J, Hou Y, Zhao S, Chen P, Wang T
Frontiers in nutrition 2021;8:706382
Frontiers in nutrition 2021;8:706382
EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.
Ni S, Yang B, Xia L, Zhang H
Mediators of inflammation 2021;2021:5591582
Mediators of inflammation 2021;2021:5591582
Trametinib Inhibits the Growth and Aerobic Glycolysis of Glioma Cells by Targeting the PKM2/c-Myc Axis.
Gao M, Yang J, Gong H, Lin Y, Liu J
Frontiers in pharmacology 2021;12:760055
Frontiers in pharmacology 2021;12:760055
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
Chen W, Zhang J, Zhong W, Liu Y, Lu Y, Zeng Z, Huang H, Wan X, Meng X, Zou F, Cai S, Dong H
Frontiers in pharmacology 2021;12:744826
Frontiers in pharmacology 2021;12:744826
Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy.
Qian L, Li Y, Cao Y, Meng G, Peng J, Li H, Wang Y, Xu T, Zhang L, Sun B, Li B, Yu D
Frontiers in oncology 2021;11:689068
Frontiers in oncology 2021;11:689068
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
MiR-489-3p Reduced Pancreatic Cancer Proliferation and Metastasis By Targeting PKM2 and LDHA Involving Glycolysis.
Zhang D, He Z, Shen Y, Wang J, Liu T, Jiang J
Frontiers in oncology 2021;11:651535
Frontiers in oncology 2021;11:651535
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
Li X, Zhang Y, Wang X, Lin F, Cheng X, Wang Z, Wang X
Cell biology and toxicology 2021 Sep 12;
Cell biology and toxicology 2021 Sep 12;
A requirement for autophagy in HMGA2-induced metabolic reprogramming to support Cd-induced migration.
Hasenbilige, Mei J, Dlamini MB, Gao Z, Jiang L, Li Q, Geng C, Shi X, Liu Y, Kong Y, Cao J
Toxicology 2021 Oct;462:152928
Toxicology 2021 Oct;462:152928
Plasma‑derived exosomal pyruvate kinase isoenzyme type M2 accelerates the proliferation and motility of oesophageal squamous cell carcinoma cells.
Yang L, Zheng S, Liu Q, Liu T, Zhang Q, Han X, Tuerxun A, Lu X
Oncology reports 2021 Oct;46(4)
Oncology reports 2021 Oct;46(4)
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
Li M, Chen X, Wang X, Wei X, Wang D, Liu X, Xu L, Batu W, Li Y, Guo B, Zhang L
Biochemical pharmacology 2021 Oct;192:114741
Biochemical pharmacology 2021 Oct;192:114741
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway.
Lu L, Wang H, Liu X, Tan L, Qiao X, Ni J, Sun Y, Liang J, Hou Y, Dou H
Journal of neuroinflammation 2021 Oct 13;18(1):229
Journal of neuroinflammation 2021 Oct 13;18(1):229
Glucose consumption of vascular cell types in culture; toward optimization of experimental conditions.
Torimoto K, Okuno K, Kuroda R, Shanas N, Cicalese SM, Eguchi K, Elliott KJ, Kawai T, Corbett CB, Peluzzo AM, St Paul AK, Autieri MV, Scalia R, Rizzo V, Hashimoto T, Eguchi S
American journal of physiology. Cell physiology 2021 Nov 24;
American journal of physiology. Cell physiology 2021 Nov 24;
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Huang L, He C, Zheng S, Wu C, Ren M, Shan Y
Molecular nutrition & food research 2021 Nov 17;:e2100738
Molecular nutrition & food research 2021 Nov 17;:e2100738
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.
Wu H, Cui M, Li C, Li H, Dai Y, Cui K, Li Z
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
Journal of agricultural and food chemistry 2021 Mar 17;69(10):3060-3068
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy.
Yang J, Ma S, Xu R, Wei Y, Zhang J, Zuo T, Wang Z, Deng H, Yang N, Shen Q
Journal of controlled release : official journal of the Controlled Release Society 2021 Jun 10;334:21-33
Journal of controlled release : official journal of the Controlled Release Society 2021 Jun 10;334:21-33
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Pei L, Le Y, Chen H, Feng J, Liu Z, Zhu J, Wang C, Chen L, Dou X, Lu D
Fitoterapia 2021 Jul;152:104922
Fitoterapia 2021 Jul;152:104922
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism.
Han J, Zhao Z, Zhang N, Yang Y, Ma L, Feng L, Zhang X, Zuo J, Fan Z, Wang Y, Song Y, Wang G
Aging 2021 Jan 20;13(4):5034-5054
Aging 2021 Jan 20;13(4):5034-5054
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Sun T, Liu Z, Bi F, Yang Q
Molecular oncology 2021 Dec;15(12):3639-3658
Molecular oncology 2021 Dec;15(12):3639-3658
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Liu X, Wang C, Li S, Qu L, Yin F, Lu D, Luo H, Chen X, Luo Z, Cui N, Wang X, Kong L
Journal of medicinal chemistry 2021 Dec 9;64(23):17304-17325
Journal of medicinal chemistry 2021 Dec 9;64(23):17304-17325
Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo.
Lin J, Wu S, Shen Q, Liu J, Huang S, Peng G, Qiao Y
Cell proliferation 2021 Aug;54(8):e13096
Cell proliferation 2021 Aug;54(8):e13096
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
Xu Z, Hu H, Fang D, Wang J, Zhao K
The international journal of biochemistry & cell biology 2021 Aug;137:106023
The international journal of biochemistry & cell biology 2021 Aug;137:106023
Differential localization patterns of pyruvate kinase isoforms in murine naïve, formative, and primed pluripotent states.
Dierolf JG, Watson AJ, Betts DH
Experimental cell research 2021 Aug 15;405(2):112714
Experimental cell research 2021 Aug 15;405(2):112714
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis.
Xu L, Yang TY, Zhou YW, Wu MF, Shen J, Cheng JL, Liu QX, Cao SY, Wang JQ, Zhang L
Acta pharmacologica Sinica 2021 Apr 13;
Acta pharmacologica Sinica 2021 Apr 13;
PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition.
Xiao H, Zhang L, Chen Y, Zhou C, Wang X, Wang D, Liu Z
Analytical cellular pathology (Amsterdam) 2020;2020:8396023
Analytical cellular pathology (Amsterdam) 2020;2020:8396023
A glycolysis-based 4-mRNA signature correlates with the prognosis and cell cycle process in patients with bladder cancer.
Zhang C, Gou X, He W, Yang H, Yin H
Cancer cell international 2020;20:177
Cancer cell international 2020;20:177
Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells.
Yuan Q, Yu H, Chen J, Song X, Sun L
OncoTargets and therapy 2020;13:1637-1647
OncoTargets and therapy 2020;13:1637-1647
Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells.
Zeng Z, Lan J, Lei S, Yang Y, He Z, Xue Y, Chen T
OncoTargets and therapy 2020;13:11697-11709
OncoTargets and therapy 2020;13:11697-11709
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
Chen, Wang Y, Lu R, Jiang X, Chen X, Meng N, Chen M, Xie S, Yan GR
Theranostics 2020;10(19):8558-8572
Theranostics 2020;10(19):8558-8572
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Hua Q, Mi B, Xu F, Wen J, Zhao L, Liu J, Huang G
Theranostics 2020;10(11):4762-4778
Theranostics 2020;10(11):4762-4778
Long Noncoding RNA MIR210HG Promotes the Warburg Effect and Tumor Growth by Enhancing HIF-1α Translation in Triple-Negative Breast Cancer.
Du Y, Wei N, Ma R, Jiang SH, Song D
Frontiers in oncology 2020;10:580176
Frontiers in oncology 2020;10:580176
Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism.
Zhang Z, Su H, Ahmed RZ, Zheng Y, Jin X
Environmental pollution (Barking, Essex : 1987) 2020 Sep;264:114659
Environmental pollution (Barking, Essex : 1987) 2020 Sep;264:114659
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Zhang X, Liu T, Zheng S, Liu Q, Shen T, Han X, Zhang Q, Yang L, Lu X
Oncology reports 2020 Oct;44(4):1355-1364
Oncology reports 2020 Oct;44(4):1355-1364
ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells.
Gao Z, Dlamini MB, Ge H, Jiang L, Geng C, Li Q, Shi X, Liu Y, Cao J
Toxicology letters 2020 Oct 1;331:178-187
Toxicology letters 2020 Oct 1;331:178-187
Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes.
Wei X, Jin XH, Meng XW, Hua J, Ji FH, Wang LN, Yang JP
Annals of translational medicine 2020 Nov;8(21):1456
Annals of translational medicine 2020 Nov;8(21):1456
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
Liu R, Deng X, Peng Y, Feng W, Xiong R, Zou Y, Lei X, Zheng X, Xie Z, Tang G
Bioorganic chemistry 2020 Mar;96:103652
Bioorganic chemistry 2020 Mar;96:103652
Novel mitochondrion-targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1-mediating mitophagy in HCC.
Li M, Shao J, Guo Z, Jin C, Wang L, Wang F, Jia Y, Zhu Z, Zhang Z, Zhang F, Zheng S, Wang X
Journal of cellular and molecular medicine 2020 Mar;24(5):3091-3107
Journal of cellular and molecular medicine 2020 Mar;24(5):3091-3107
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R, Zhang N
Nature communications 2020 Jun 22;11(1):3162
Nature communications 2020 Jun 22;11(1):3162
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes.
Jiang Y, Gu Y, Xu H, Tian X, Zhang X, Xu X, Yan W, Zhang X
BMC molecular and cell biology 2020 Jun 19;21(1):44
BMC molecular and cell biology 2020 Jun 19;21(1):44
AT1-receptor autoantibody exposure in utero contributes to cardiac dysfunction and increased glycolysis in fetal mice.
Bai L, Wang M, Zhang S, Yue M, Guo Y, Wang P, Liu H
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1373-1381
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1373-1381
Cadmium inhibits apoptosis of human esophageal epithelial cells by upregulating CDK6.
Yang J, Guo T, Liang X, Zhai Y, Cheng Y, Sun H, Cui Y, Cheng X
Ecotoxicology and environmental safety 2020 Dec 1;205:111146
Ecotoxicology and environmental safety 2020 Dec 1;205:111146
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Deng X, Zhao J, Qu L, Duan Z, Fu R, Zhu C, Fan D
Biochemical pharmacology 2020 Aug;178:114038
Biochemical pharmacology 2020 Aug;178:114038
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
TBC1D8 Amplification Drives Tumorigenesis through Metabolism Reprogramming in Ovarian Cancer.
Chen M, Sheng XJ, Qin YY, Zhu S, Wu QX, Jia L, Meng N, He YT, Yan GR
Theranostics 2019;9(3):676-690
Theranostics 2019;9(3):676-690
Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis.
Ye M, Pang N, Wan T, Huang Y, Wei T, Jiang X, Zhou Y, Huang Y, Yang H, Zhang Z, Yang L
Journal of Cancer 2019;10(3):757-764
Journal of Cancer 2019;10(3):757-764
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Chu X, Xiang M, Feng L, Liu H, Zhou C
Journal of thoracic disease 2019 Sep;11(9):3941-3950
Journal of thoracic disease 2019 Sep;11(9):3941-3950
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S
Cell death & disease 2019 May 28;10(6):404
Cell death & disease 2019 May 28;10(6):404
PKM2-regulated STAT3 promotes esophageal squamous cell carcinoma progression via TGF-β1-induced EMT.
Ma R, Liu Q, Zheng S, Liu T, Tan D, Lu X
Journal of cellular biochemistry 2019 Feb 12;
Journal of cellular biochemistry 2019 Feb 12;
Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells.
Wang F, Jia Y, Li M, Wang L, Shao J, Guo Q, Tan S, Ding H, Chen A, Zhang F, Zheng S
Cell communication and signaling : CCS 2019 Feb 11;17(1):11
Cell communication and signaling : CCS 2019 Feb 11;17(1):11
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Chai XX, Le YF, Wang JC, Mei CX, Feng JF, Zhao H, Wang C, Lu DZ
Journal of food science 2019 Dec;84(12):3825-3832
Journal of food science 2019 Dec;84(12):3825-3832
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Gassaway BM, Cardone RL, Padyana AK, Petersen MC, Judd ET, Hayes S, Tong S, Barber KW, Apostolidi M, Abulizi A, Sheetz JB, Kshitiz, Aerni HR, Gross S, Kung C, Samuel VT, Shulman GI, Kibbey RG, Rinehart J
Cell reports 2019 Dec 10;29(11):3394-3404.e9
Cell reports 2019 Dec 10;29(11):3394-3404.e9
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Liu B, Jin J, Zhang Z, Zuo L, Jiang M, Xie C
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer.
Liu BW, Wang TJ, Li LL, Zhang L, Liu YX, Feng JY, Wu Y, Xu FF, Zhang QS, Bao MZ, Zhang WY, Ye LH
Acta pharmacologica Sinica 2019 Apr;40(4):530-538
Acta pharmacologica Sinica 2019 Apr;40(4):530-538
Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities.
Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL
Frontiers in cardiovascular medicine 2018;5:195
Frontiers in cardiovascular medicine 2018;5:195
Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21.
Yan B, Cheng L, Jiang Z, Chen K, Zhou C, Sun L, Cao J, Qian W, Li J, Shan T, Lei J, Ma Q, Ma J
Oxidative medicine and cellular longevity 2018;2018:1346958
Oxidative medicine and cellular longevity 2018;2018:1346958
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
Fan L, Huang C, Li J, Gao T, Lin Z, Yao T
International journal of molecular medicine 2018 Oct;42(4):2247-2259
International journal of molecular medicine 2018 Oct;42(4):2247-2259
Dauricine upregulates the chemosensitivity of hepatocellular carcinoma cells: Role of repressing glycolysis via miR-199a:HK2/PKM2 modulation.
Li W, Qiu Y, Hao J, Zhao C, Deng X, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Nov;121:156-165
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Nov;121:156-165
Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation.
Yang P, Ding GB, Liu W, Fu R, Sajid A, Li Z
Food & function 2018 Nov 14;9(11):5547-5559
Food & function 2018 Nov 14;9(11):5547-5559
Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling.
Xing YX, Li MH, Tao L, Ruan LY, Hong W, Chen C, Zhao WL, Xu H, Chen JF, Wang JS
Journal of proteome research 2018 May 4;17(5):1943-1952
Journal of proteome research 2018 May 4;17(5):1943-1952
1H Nuclear Magnetic Resonance Based Metabolomics Approach Reveals the Metabolic Mechanism of (-)-5-Hydroxy-equol against Hepatocellular Carcinoma Cells in Vitro.
Gao L, Wang KX, Zhang NN, Li JQ, Qin XM, Wang XL
Journal of proteome research 2018 May 4;17(5):1833-1843
Journal of proteome research 2018 May 4;17(5):1833-1843
Correlation of Pyruvate Kinase M2 Expression with Clinicopathological Data in Ovarian Cancer.
Kobierzycki C, Piotrowska A, Latkowski K, Zabel M, Nowak-Markwitz E, Spaczynski M, Kedzia W, Pula B, Podhorska-Okolow M, Dziegiel P
Anticancer research 2018 Jan;38(1):295-300
Anticancer research 2018 Jan;38(1):295-300
MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma.
Chen J, Yu Y, Chen X, He Y, Hu Q, Li H, Han Q, Ren F, Li J, Li C, Bao J, Ren Z, Duan Z, Cui G, Sun R
Cell proliferation 2018 Dec;51(6):e12510
Cell proliferation 2018 Dec;51(6):e12510
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
Wu H, He L, Shi J, Hou X, Zhang H, Zhang X, An Q, Fan F
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation.
Meng Q, Xu J, Liang C, Liu J, Hua J, Zhang Y, Ni Q, Shi S, Yu X
Cell death & disease 2018 Dec 11;9(12):1187
Cell death & disease 2018 Dec 11;9(12):1187
Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.
Wu L, Cao KX, Ni ZH, Li WD, Chen ZP, Cheng HB, Liu X
Journal of ethnopharmacology 2018 Aug 10;222:71-78
Journal of ethnopharmacology 2018 Aug 10;222:71-78
Multiomics Integration Reveals the Landscape of Prometastasis Metabolism in Hepatocellular Carcinoma.
Li Y, Zhuang H, Zhang X, Li Y, Liu Y, Yi X, Qin G, Wei W, Chen R
Molecular & cellular proteomics : MCP 2018 Apr;17(4):607-618
Molecular & cellular proteomics : MCP 2018 Apr;17(4):607-618
EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
Jing C, Qu X, Li Z, Wu C, Zhao M, Wang Y, Sun S, Zhang S, Chen J, Qiao Y, Hu X, Yao X, Jin R, Wang X, Zhang L, Zhou X
American journal of cancer research 2017;7(12):2491-2502
American journal of cancer research 2017;7(12):2491-2502
Dahuang Zhechong Pill Combined with Doxorubicin Induces Cell Death through Regulating Energy Metabolism in Human Hepatocellular Carcinoma Cells.
Wu L, Zhao J, Cai H, Wang J, Chen Z, Li W, Liu X
Evidence-based complementary and alternative medicine : eCAM 2017;2017:6279576
Evidence-based complementary and alternative medicine : eCAM 2017;2017:6279576
Deciphering the protein-protein interaction network regulating hepatocellular carcinoma metastasis.
Qin G, Dang M, Gao H, Wang H, Luo F, Chen R
Biochimica et biophysica acta. Proteins and proteomics 2017 Sep;1865(9):1114-1122
Biochimica et biophysica acta. Proteins and proteomics 2017 Sep;1865(9):1114-1122
Pyruvate kinase M1 interacts with A-Raf and inhibits endoplasmic reticulum stress-induced apoptosis by activating MEK1/ERK pathway in mouse insulinoma cells.
Horiuchi Y, Nakatsu D, Kano F, Murata M
Cellular signalling 2017 Oct;38:212-222
Cellular signalling 2017 Oct;38:212-222
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.
Huang JZ, Chen M, Chen, Gao XC, Zhu S, Huang H, Hu M, Zhu H, Yan GR
Molecular cell 2017 Oct 5;68(1):171-184.e6
Molecular cell 2017 Oct 5;68(1):171-184.e6
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Lian X, Zhao J, Wu X, Zhang Y, Li Q, Lin S, Bai XY, Chen X
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma.
Huang P, Zhao X, Xiao W, Dong Y, Hu G
Oncotarget 2017 Jun 13;8(24):39618-39626
Oncotarget 2017 Jun 13;8(24):39618-39626
MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion.
Wu H, Li Z, Wang Y, Yang P, Li Z, Li H, Wu C
American journal of cancer research 2016;6(10):2221-2234
American journal of cancer research 2016;6(10):2221-2234
Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer.
Lu W, Cao Y, Zhang Y, Li S, Gao J, Wang XA, Mu J, Hu YP, Jiang L, Dong P, Gong W, Liu Y
Scientific reports 2016 Jun 10;6:26351
Scientific reports 2016 Jun 10;6:26351
Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming.
Konno M, Koseki J, Kawamoto K, Nishida N, Matsui H, Dewi DL, Ozaki M, Noguchi Y, Mimori K, Gotoh N, Tanuma N, Shima H, Doki Y, Mori M, Ishii H
PloS one 2015;10(7):e0132789
PloS one 2015;10(7):e0132789
Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species.
Cautain B, de Pedro N, Schulz C, Pascual J, Sousa Tda S, Martin J, Pérez-Victoria I, Asensio F, González I, Bills GF, Reyes F, Genilloud O, Vicente F
PloS one 2015;10(5):e0125221
PloS one 2015;10(5):e0125221
L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.
Nakatsu D, Horiuchi Y, Kano F, Noguchi Y, Sugawara T, Takamoto I, Kubota N, Kadowaki T, Murata M
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 10;112(10):E1067-76
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 10;112(10):E1067-76
Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.
Konno M, Ishii H, Koseki J, Tanuma N, Nishida N, Kawamoto K, Nishimura T, Nakata A, Matsui H, Noguchi K, Ozaki M, Noguchi Y, Shima H, Gotoh N, Nagano H, Doki Y, Mori M
Regenerative therapy 2015 Jun;1:63-71
Regenerative therapy 2015 Jun;1:63-71
A small subunit processome protein promotes cancer by altering translation.
Yang HW, Kim TM, Song SS, Menon L, Jiang X, Huang W, Black PM, Park PJ, Carroll RS, Johnson MD
Oncogene 2015 Aug 20;34(34):4471-81
Oncogene 2015 Aug 20;34(34):4471-81
Estradiol-17β upregulates pyruvate kinase M2 expression to coactivate estrogen receptor-α and to integrate metabolic reprogramming with the mitogenic response in endometrial cells.
Salama SA, Mohammad MA, Diaz-Arrastia CR, Kamel MW, Kilic GS, Ndofor BT, Abdel-Baki MS, Theiler SK
The Journal of clinical endocrinology and metabolism 2014 Oct;99(10):3790-9
The Journal of clinical endocrinology and metabolism 2014 Oct;99(10):3790-9
The lack of evidence for correlation of pyruvate kinase M2 expression with tumor grade in non-small cell lung cancer.
Kobierzycki C, Pula B, Werynska B, Piotrowska A, Muszczynska-Bernhard B, Dziegiel P, Rakus D
Anticancer research 2014 Jul;34(7):3811-7
Anticancer research 2014 Jul;34(7):3811-7
Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome?
Martinez-Outschoorn UE, Whitaker-Menezes D, Valsecchi M, Martinez-Cantarin MP, Dulau-Florea A, Gong J, Howell A, Flomenberg N, Pestell RG, Wagner J, Arana-Yi C, Sharma M, Sotgia F, Lisanti MP
Seminars in oncology 2013 Aug;40(4):403-18
Seminars in oncology 2013 Aug;40(4):403-18
A study of PKM2, PFK-1, and ANT1 expressions in cervical biopsy tissues in China.
Yuan Y, Guo-Qing P, Yan T, Hong-Lin Y, Gong-Hua H, Cai-Gao Z
Medical oncology (Northwood, London, England) 2012 Dec;29(4):2904-10
Medical oncology (Northwood, London, England) 2012 Dec;29(4):2904-10
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP
Cancer biology & therapy 2011 Dec 15;12(12):1101-13
Cancer biology & therapy 2011 Dec 15;12(12):1101-13
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.
Bonuccelli G, Whitaker-Menezes D, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Witkiewicz AK, Vander Heiden MG, Migneco G, Chiavarina B, Frank PG, Capozza F, Flomenberg N, Martinez-Outschoorn UE, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2010 May 15;9(10):1960-71
Cell cycle (Georgetown, Tex.) 2010 May 15;9(10):1960-71
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
Migneco G, Whitaker-Menezes D, Chiavarina B, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Flomenberg N, Tsirigos A, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2010 Jun 15;9(12):2412-22
Cell cycle (Georgetown, Tex.) 2010 Jun 15;9(12):2412-22
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.
Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes D, Daumer KM, Lin Z, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Knudsen ES, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2010 Aug 15;9(16):3256-76
Cell cycle (Georgetown, Tex.) 2010 Aug 15;9(16):3256-76
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC
Nature 2008 Mar 13;452(7184):230-3
Nature 2008 Mar 13;452(7184):230-3
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 15822-1-AP(PK-M2-specific antibody) at dilution of 1:1500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of MCF-7 cells, using PKM2 antibody 19060-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-PK-M2-specific (IP:15822-1-AP, 4ug; Detection:15822-1-AP 1:300) with MCF-7 cells lysate 3250ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 15822-1-AP(PK-M2-specific antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 15822-1-AP(PK-M2-specific antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue