Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN2841593 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-PKM1 (AA 383-417), (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 383-417, C-Term
- Antibody clone number
- RB18404
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer.
Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.
Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency.
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Nov 15;21(22):5110-20
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Nov 15;21(22):5110-20
Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition.
Hamabe A, Konno M, Tanuma N, Shima H, Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, Yamamoto H, Doki Y, Mori M, Ishii H
Proceedings of the National Academy of Sciences of the United States of America 2014 Oct 28;111(43):15526-31
Proceedings of the National Academy of Sciences of the United States of America 2014 Oct 28;111(43):15526-31
Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency.
Xie Y, Zhou S, Jiang Z, Dai J, Puscheck EE, Lee I, Parker G, Hüttemann M, Rappolee DA
Stem cell research 2014 Nov;13(3 Pt A):478-91
Stem cell research 2014 Nov;13(3 Pt A):478-91
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.
Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB
Proceedings of the National Academy of Sciences of the United States of America 2012 May 1;109(18):6904-9
Proceedings of the National Academy of Sciences of the United States of America 2012 May 1;109(18):6904-9
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.
Wittwer JA, Robbins D, Wang F, Codarin S, Shen X, Kevil CG, Huang TT, Van Remmen H, Richardson A, Zhao Y
Cancer prevention research (Philadelphia, Pa.) 2011 Sep;4(9):1476-84
Cancer prevention research (Philadelphia, Pa.) 2011 Sep;4(9):1476-84
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 8;108(10):4129-34
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 8;108(10):4129-34
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC