60268-1-Ig

antibody from Proteintech Group

Targeting: PKM OIP3, PK3, PKM2, THBP1

Provider product page for 60268-1-Ig

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Immunohistochemistry

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Antibody data

Antibody Data
Antigen structure
References [112]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 60268-1-Ig - Provider product page
Provider: Proteintech Group
Product name: PKM2-specific antibody
Antibody type: Monoclonal
Description: KD/KO validated PKM2-specific antibody (Cat. #60268-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1C11C7
Vial size: 20ul, 150ul

PKM protein structure - 60268-1-Ig shown in red.

Submitted references Gomphus floccosus (Schw.) Sing. extract attenuates alcoholic liver disease by suppressing macrophage glycolysis and M1 polarization.

Ruan T, Li X, Li M, Wang S, Shen L, Liu C, Peng Y, Tao Y
Frontiers in immunology 2026;17:1772592

Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.

Qiao X, Xue D, Hu Z, Wang H, Mu L
Toxicology and applied pharmacology 2026 May;510:117775

Glycolytic reprogramming mediated by the ADAM12/IGF1 axis promotes ossification of the posterior longitudinal ligament.

Zhao Q, Wu H, Xie D, Shi M, Niu B, Yang L
Cell death discovery 2026 Mar 25;12(1)

Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages.

Huang J, Wang Y, Li F, Zhang N, Tian G, Guo D, Guo Y, Liu Z, Wu Y, Li X, Xu F, Qin Z, Jia R, Dong L, Gao S, Yu J, Lou J, Ying S, Scharf DH, Li W, Chen Z
Cell reports 2026 Mar 24;45(3):117106

HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis.

Li Y, Wang Q, Liao Z, Wu J, Yu S, Yan H, Xie Z
Stem cell research & therapy 2026 Mar 16;17(1)

Bie-Jia-Jian Pill: Inhibiting tumor glycolysis and promoting CD8(+) cell-mediated anti-tumor immunity by targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in hepatocellular carcinoma.

Liu Y, Yang X, Qin M, Chen W, Liu C, Jiang W, Wang Y, Tan S, Sun H, Chen J, Sun H, He S
Journal of ethnopharmacology 2026 Jun 28;365:121554

Shikonin improves intestinal barrier function through modulation of GPX4 expression in intestinal epithelial cells.

Yang F, Liang P, Guo H, Yan W, Wang G, Tang X, Liang Z
International journal of immunopathology and pharmacology 2026 Jan-Dec;40:3946320261427239

TWEAK exacerbates allergic conjunctivitis via PKM2-dependent NF-κB activation and macrophage M1 polarization.

Yang Y, Zhang Y, Fu J, Yin X
Cellular signalling 2026 Feb;138:112264

RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma.

Jiang Y, Zhou K, Wei X, Feng J, Zhou B, Liu C, Sun J, Zhu H, Liu Z, Yuan N, Li Y, Meng X, Cao J, Jiao Y, Cheng S
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):1201-1214

Deubiquitinase UCH-L1 confers paclitaxel resistance via stabilizing PKM2 to promote glycolysis in triple-negative breast cancer.

Chen X, Zhou X, Meng Y, Zhou Y, Zhang W, Yin L, Shen Y, Zhong J, Zhang T, Zu X
Cell death & disease 2026 Feb 25;17(1)

ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells.

Wang H, Luo K, Li S, Jin D, Ou L, Liu C, Wu Q
Journal of bioenergetics and biomembranes 2026 Feb 15;58(1)

SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity.

Che J, Qiu Z, Hou H, Li Y, He L, Sun J, Zhang S, Li M, Pan S, Zhang W, Niu Y
Journal of tissue engineering and regenerative medicine 2025;2025:6659059

GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.

Kuang X, Niu Z, Liu W, Huang Z, Li S, Zhang Y, Wang L, Cai X, Wang F, Zhang P
Frontiers in immunology 2025;16:1712741

Inhibition of colorectal cancer cell growth by downregulation of M2-PK and reduction of aerobic glycolysis by clove active ingredients.

Liu L, Xing G, Guo X, Chen H, Li J, Wang J, Li Y, Liang G, Liu M
Frontiers in pharmacology 2025;16:1552486

UCHL3 augments cuproptosis via PKM2 deubiquitination in hepatocellular carcinoma.

Yao L, Ye S, Xu D
Free radical biology & medicine 2025 Sep;237:65-75

Novel Isolongifolenone-Based Caprolactam Derivatives as Potential Anticancer Agents via the p53/mTOR/Autophagy Pathway.

Wang Y, Hu M, Han J, Zhao Y, Xiong B, Li P, Wang S
Molecules (Basel, Switzerland) 2025 Oct 8;30(19)

PM(2.5) enhances DRP1-mediated mitochondrial fission to induce ferroptosis and exacerbate asthma through the AHR-HSP90-PKM2 pathway.

Qiao S, Li F, Huang J, Wu X, Cao X, Zhang X, Wei Z
Toxicology and applied pharmacology 2025 Oct 4;505:117590

Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression.

Zhao K, Zhang F, Qin Q, Zhang D, Yang F, Huang Y, Deng R, Jing H, Xiao W, Miao H, Shi R
Molecular biomedicine 2025 Oct 11;6(1):79

Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation.

Wang ZC, Li C, Zhang Z, Lu S, Liu YM, Qi P, Chen X, Wang YB, Feng WJ, Pan CL, Wang QX, Ji ZL, Yu Y, Piao MH, Chi GF, Ge PF
Acta pharmacologica Sinica 2025 Nov;46(11):3071-3086

YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.

Zheng QS, Xiong YQ, Xu JC, Qian JF, Luo W, Wang QY, Zhao YN, Luo Y, Cui YQ, Fang Y, Guo XC, Chen DD, Wang Y, Liang G
Acta pharmacologica Sinica 2025 Nov;46(11):2938-2950

Mogroside V restores glycolytic function via LDHA promoter demethylation independent of alternative splicing in PCOS granulosa cells.

Li S, Wu J, Lu R, Zhou B, Dai H, Zhang Z, Yang X, Liang X
The Journal of steroid biochemistry and molecular biology 2025 Nov;254:106839

Inflammation and Mitochondrial Dysfunction in Cirrhotic Cardiomyopathy: Therapeutic Implications.

Ding Y, Huang C, Yang G, Liu E, Wang Z, Su Y, Ge C
Journal of clinical and translational hepatology 2025 Nov 28;13(11):905-917

Astragalin rescues Cadmium-induced cognitive decline by revering glial metabolic reprogramming and neuroinflammation via the mTOR/HIF-1α axis.

Huang Q, Wang J, Cao MM, Ma HY, Qin XY, Hu Y, Lan R
Neuroscience 2025 Nov 19;588:31-39

PKM2 Drives Lactate-mediated Fibrosis in Liver Transplantation.

Liu JY, Liao W, Chen ZY, Liu T, Wang R, Gong JP, Xu XS, Wu H
Transplantation 2025 Nov 1;109(11):e631-e646

Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.

Cao MM, Guo Z, Wang J, Ma HY, Qin XY, Hu Y, Lan R
Free radical biology & medicine 2025 May;232:340-352

Lactate-associated gene MCU promotes the proliferation, migration, and invasion of pancreatic ductal adenocarcinoma.

Chen Y, Zhang F, Dai S, Zhao J, Cai W, Zhang K, Liao X, Chen L
BMC cancer 2025 May 21;25(1):913

Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway.

Wang Z, Huang Y, Zhang Y, Zhu H, Amin MR, Chen R, Gu L, Xiong X
CNS neuroscience & therapeutics 2025 Mar;31(3):e70314

Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.

Cheng C, Zhang S, Chen C, Gong Y, Ding K, Li G, Jiang W, Zhang Z, He B, Hu Z, Li Y, Yao L
Scientific reports 2025 Mar 9;15(1):8141

TEPP-46 inhibits glycolysis to promote M2 polarization of microglia after ischemic stroke.

Xia X, Chen W, Zhou T, Zhou F, Lu C, Yan Z, Zhao Q, Su Q
International immunopharmacology 2025 Mar 6;149:114148

o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy.

Zhao Q, Cai D, Xu H, Gao Y, Zhang R, Zhou X, Chen X, Chen S, Wu J, Peng W, Yuan S, Li D, Li G, Nan A
Molecular cancer 2025 Mar 17;24(1):82

High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy-lysosomal pathway in endometrial cancer.

Mao X, Huang L, Liu X, Lin X, Wu Q, Wang X, Ren Y, Ma J, Zhang M, Lin Y, Ralser DJ, Mustea A, Chen G, Sun P
Cell death & disease 2025 Mar 17;16(1):182

NONO interacts with nuclear PKM2 and directs histone H3 phosphorylation to promote triple-negative breast cancer metastasis.

Li Q, Ci H, Zhao P, Yang D, Zou Y, Chen P, Wu D, Shangguan W, Li W, Meng X, Xing M, Chen Y, Zhang M, Chen B, Kong L, Zen K, Huang DCS, Jiang ZW, Zhao Q
Journal of experimental & clinical cancer research : CR 2025 Mar 10;44(1):90

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model.

Ding X, Chen C, Zhao H, Dai B, Ye L, Song T, Huang S, Wang J, You T
Neural regeneration research 2025 Mar 1;20(3):858-872

PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer.

Wu X, Wang B, Hou Y, Fang Y, Jiang Y, Song Y, Liu Y, Jin C
Biomolecules 2025 Mar 1;15(3)

ENTR1 affects the progression of colon cancer by regulating energy metabolism under the influence of glycolysis.

Ma A, Zhai C, He Q, Wang W, Ren H, Mao K, Lan W, Lan J
BMC cancer 2025 Jun 3;25(1):992

Leucine-Rich Repeat Containing 15 Promotes the Inflammatory Response in Rheumatoid Arthritis by Regulating NF-κB Pathway.

Xin M, Xia G, Guan X, Xi G, Fu M
Immunity, inflammation and disease 2025 Jul;13(7):e70220

FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.

Wu HY, Han L, Ran T, Sun Y, Zhang QX, Huang T, Zou GL, Zhang Y, Zhou YM, Lin GY, Chen SJ, Wang JL, Pan C, Lu F, Pu HF, Zhao XK
World journal of gastroenterology 2025 Jul 28;31(28):107361

PSD3, regulated by PKM2, endows growth and metastasis advantages in esophageal squamous cell carcinoma by modulating EMT progression.

Zhang Q, Liu Q, Zheng S, Liu T, Yang L, Tan Y, Lu X
Scientific reports 2025 Jul 2;15(1):23212

THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation.

Guo Z, Zhong S, Bai J, Lang X, Cao M, Hu Y, Qin X, Sun Y
Scientific reports 2025 Jul 1;15(1):21721

A Novel, Long-Acting, Small Molecule PKM2 Activator and Its Potential Broad Application Against Photoreceptor Degeneration.

Pan WW, Weh KM, Chaudhury S, Fernando R, Hager H, Wen B, Chinnaswamy K, Stuckey JA, Rech JC, Besirli CG, Weh E, Wubben TJ
Translational vision science & technology 2025 Jul 1;14(7):26

Modified Zuojin pill alleviates gastric precancerous lesions by inhibiting glycolysis through the HIF-1α pathway.

Liu S, Ji H, Zhang T, Huang J, Yin X, Zhang J, Wang P, Wang F, Tang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156255

PKM2-mediated collagen XVII expression is critical for wound repair.

Liu Y, Ho C, Wen D, Sun J, Liu Y, Li Q, Zhang Y, Gao Y
JCI insight 2025 Jan 21;10(4)

Integrative pharmacological analysis of modified Zuojin formula: Inhibiting the HIF-1α-mediated glycolytic pathway in chronic atrophic gastritis.

Liu S, Zhang T, Fang L, Hu L, Yin X, Tang X
Journal of ethnopharmacology 2025 Jan 13;339:119136

Pyruvate kinase M2 modulates mitochondrial dynamics and EMT in alveolar epithelial cells during sepsis-associated pulmonary fibrosis.

Feng J, Huang X, Peng Y, Yang W, Yang X, Tang R, Xu Q, Gao Y, He Z, Xing S, Mei S
Journal of translational medicine 2025 Feb 19;23(1):205

A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.

Zhao Y, Yu H, Li J, Qian J, Li M, Zhang X, Wang M, Wang Y, Dong Y, You Y, Zhou Q, Gao D, Zhao Y, Liu B, Chen R, Ren Z, Wang Z, Zhang K, Cui J
Nature communications 2025 Feb 18;16(1):1736

Discovery of liquiritigenin derivatives as PKM2 allosteric inhibitors via targeting the polyarginine pocket.

Wang X, Qiu J, Xie J, Huang R, Chen Y, Fang Y, Tang Y, Wu S, Zhou X, Chang Z, Wang X, Liu Y, Jin S
Bioorganic chemistry 2025 Dec;167:109212

Reactivating T cell immunity in Wnt-hyperactivated non-small cell lung cancer through a supramolecular droplet of carnosic acid and peptide.

Liu N, Tu Y, Wang H, Zheng X, Ji F, Geng M, Wei X, Xin J, He W, Zhao Q, Liu T
Journal of pharmaceutical analysis 2025 Dec;15(12):101309

SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.

Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489

RASGEF1C affects aerobic glycolysis and facilitates lung cancer progression through the PLK1 signaling pathway.

Wu H, Zheng K, Han F
Expert review of anticancer therapy 2025 Aug;25(8):961-971

Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity.

Dai B, Fan Z, Chen R, Weng X, Fang R
Neuromolecular medicine 2025 Aug 6;27(1):57

The glycolytic enzyme PKM2 regulates inflammatory osteoclastogenesis by modulating STAT3 phosphorylation.

Li M, Li F, Zhu C, Zhang C, Le Y, Li Z, Wan Q
The Journal of biological chemistry 2025 Apr;301(4):108389

Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation.

Yang L, Hu C, Chen X, Sun M, Zhang J, Feng Z, Cui T, Zhu R, Zhang X, Xiao Y, Gong Y, Yang Y, Zhang Q, Zhang Y, Yan Y
Journal of neuroinflammation 2025 Apr 30;22(1):126

HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia.

Xu R, Huang Y, Xie W, Luo D, Mei J, Liu X, Liu F, Luo F
Molecular medicine (Cambridge, Mass.) 2025 Apr 18;31(1):142

Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.

Zhao Y, Han S, Zeng Z, Zheng H, Li Y, Wang F, Huang Y, Zhao Y, Zhuo W, Lv G, Wang H, Zhao G, Zhao E, Hu Y, Hu P, Zhao G
Theranostics 2024;14(18):7088-7110

Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis.

Yang L, Hu C, Chen X, Zhang J, Feng Z, Xiao Y, He W, Cui T, Zhang X, Yang Y, Zhang Y, Yan Y
eLife 2024 Sep 12;13

SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.

Pan S, Yuan T, Xia Y, Yu W, Li H, Rao T, Ye Z, Li L, Zhou X, Cheng F
Biomedicines 2024 Oct 8;12(10)

GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage.

Lu S, Li R, Deng Y, Bai J, Ji B, Chu Y, Xu Y, Qu H, Guo X, Li P, Meng M
Respiratory research 2024 May 9;25(1):201

Fasting-induced RNF152 resensitizes gallbladder cancer cells to gemcitabine by inhibiting mTORC1-mediated glycolysis.

Tao Y, Gong Z, Shen S, Ding Y, Zan R, Zheng B, Sun W, Ma C, Shu M, Lu X, Liu H, Ni X, Liu H, Suo T
iScience 2024 May 17;27(5):109659

Exploration of Nitrotyrosine-Containing Proteins and Peptides by Antibody-Based Enrichment Strategies.

Bhat FA, Mangalaparthi KK, Ding H, Jain A, Hsu JS, Peterson JA, Zenka RM, Mun DG, Kandasamy RK, Pandey A
Molecular & cellular proteomics : MCP 2024 Mar;23(3):100733

Augmentation of scleral glycolysis promotes myopia through histone lactylation.

Lin X, Lei Y, Pan M, Hu C, Xie B, Wu W, Su J, Li Y, Tan Y, Wei X, Xue Z, Xu R, Di M, Deng H, Liu S, Yang X, Qu J, Chen W, Zhou X, Zhao F
Cell metabolism 2024 Mar 5;36(3):511-525.e7

MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration.

Chen J, Duan S, Wang Y, Ling Y, Hou X, Zhang S, Liu X, Long X, Lan J, Zhou M, Xu H, Zheng H, Zhou J
Nature communications 2024 Jun 11;15(1):4969

Dual-Targeted Novel Temozolomide Nanocapsules Encapsulating siPKM2 Inhibit Aerobic Glycolysis to Sensitize Glioblastoma to Chemotherapy.

Zhang Y, Ma H, Li L, Sun C, Yu C, Wang L, Xu D, Song X, Yu R
Advanced materials (Deerfield Beach, Fla.) 2024 Jul;36(29):e2400502

Oridonin attenuates liver ischemia-reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis.

Wu XY, Zhao MJ, Liao W, Liu T, Liu JY, Gong JH, Lai X, Xu XS
Cellular immunology 2024 Jul-Aug;401-402:104838

Targeting PKM2 improves the gemcitabine sensitivity of intrahepatic cholangiocarcinoma cells via inhibiting β-catenin signaling pathway.

Yu W, Zeng F, Xiao Y, Chen L, Qu H, Hong J, Qu C, Cheng G
Chemico-biological interactions 2024 Jan 5;387:110816

TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.

Chen Y, Han Z, Zhang L, Gao C, Wei J, Yang X, Han Y, Li Y, Zhang C, Wei Y, Dong J, Xun W, Sun W, Zhang T, Zhang H, Chen J, Yuan P
Journal of translational medicine 2024 Jan 4;22(1):21

Candida albicans Infection Disrupts the Metabolism of Vaginal Epithelial Cells and Inhibits Cellular Glycolysis.

Zhao Y, Wang P, Sun X, Zhao M, Chen Y, Gao X
Microorganisms 2024 Jan 30;12(2)

Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis.

Li S, Xue X, Zhang H, Jiang L, Zhang Y, Zhu X, Wang Y
Chemico-biological interactions 2024 Feb 25;390:110868

Protein 4.1R regulates M1 macrophages polarization via glycolysis, alleviating sepsis-induced liver injury in mice.

Sang SY, Wang YJ, Liang T, Liu Y, Liu JJ, Li H, Liu X, Kang QZ, Wang T
International immunopharmacology 2024 Feb 15;128:111546

Treponema Pallidum protein Tp47 triggers macrophage inflammatory senescence via PKM2-mediated metabolic reprogramming.

Xie JW, Guo YF, Fan SH, Zheng Y, Zhang HL, Zhang Y, Zhang Y, Lin LR
International journal of biological macromolecules 2024 Dec;283(Pt 4):137991

TRIB3 promotes the growth of oral squamous cell carcinoma by regulating JNK/JUN-mediated aerobic glycolysis.

Meng Z, Wang Y, Wang X, Han X
Archives of oral biology 2024 Aug;164:105977

Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma.

Li G, Wang D, Zhai Y, Pan C, Zhang J, Wang C, Huang R, Yu M, Li Y, Liu X, Liu Y, Wu F, Zhao Z, Hu H, Shi Z, Kahlert UD, Jiang T, Zhang W
Cell metabolism 2024 Aug 6;36(8):1696-1710.e10

The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis.

Zhao J, Feng Y, Liu X, Li H, Guo H, Ke J, Long X
Journal of cellular and molecular medicine 2024 Apr;28(7):e18172

Identification of PKM2 as a pyroptosis-related key gene aggravates senile osteoporosis via the NLRP3/Caspase-1/GSDMD signaling pathway.

Li Z, Wang B, Wang R, Zhang Z, Xiong J, Wang X, Ma Y, Han L
The international journal of biochemistry & cell biology 2024 Apr;169:106537

Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.

Zhang Y, Lu YB, Zhu WJ, Gong XX, Qian R, Lu YJ, Li Y, Yao WF, Bao BH, Zhang Y, Zhang L, Cheng FF
Journal of ethnopharmacology 2024 Apr 24;324:117737

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.

Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8

LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement.

Zhang C, Wang H, Liu Q, Dai S, Tian G, Wei X, Li X, Zhao L, Shan B
Journal of experimental & clinical cancer research : CR 2023 Sep 23;42(1):246

Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury.

Xie W, He Q, Zhang Y, Xu X, Wen P, Cao H, Zhou Y, Luo J, Yang J, Jiang L
Cell death & disease 2023 Oct 10;14(10):663

Nuclear translocation of PKM2 mediates keratinocyte metabolic reprogramming in psoriasis.

Yang L, Zhang J, Hu C, Chen X, Yang Y, Tang H, Ding X, Yan Y
Experimental dermatology 2023 Nov;32(11):1960-1970

The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.

Galiger C, Zohora FT, Dorneburg C, Tews D, Debatin KM, Beltinger C
BMC cancer 2023 Nov 25;23(1):1148

Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis.

Wubben TJ, Chaudhury S, Watch BT, Stuckey JA, Weh E, Fernando R, Goswami M, Pawar M, Rech JC, Besirli CG
Pharmaceuticals (Basel, Switzerland) 2023 May 6;16(5)

Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism.

Shi WP, Lin WJ, Ge WY, Chen LL, Zhang TD, Guo WH, Liu JL, Yin DC
Food & function 2023 May 22;14(10):4621-4631

Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.

Cao L, Wang R, Liu G, Zhang Y, Thorne RF, Zhang XD, Li J, Xia Y, Guo L, Shao F, Gu H, Wu M
EMBO reports 2023 Mar 6;24(3):e55683

Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS.

Wu X, Liu L, Zheng Q, Ye H, Yang H, Hao H, Li P
Acta pharmaceutica Sinica. B 2023 Jan;13(1):113-127

Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.

Lai X, Liang Y, Jin J, Zhang H, Wu Z, Li G, Wang J, Zhang Z, Chen H, Zeng F, Deng F
Experimental cell research 2023 Jan 1;422(1):113427

Exosomal lncRNA HOTAIR induces PDL1(+) B cells to impede anti-tumor immunity in colorectal cancer.

Xie Z, Xia J, Jiao M, Zhao P, Wang Z, Lin S, Xing Y, Li Y, Lu Z, Zhong Z, Miao C, Zhou P, Qian J, Wang L, Zhang D, Gu J, Chu Y, Liu R
Biochemical and biophysical research communications 2023 Feb 12;644:112-121

Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis.

Dai ZQ, Gao F, Zhang ZJ, Lu MJ, Luo YJ, Zhang T, Shang BX, Gu YH, Zeng Q, Gao S, Guo ZQ, Xu B, Lei HM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154912

Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis.

Zhu J, Chen H, Le Y, Guo J, Liu Z, Dou X, Lu D
Frontiers in pharmacology 2022;13:1009229

The MBNL1/circNTRK2/PAX5 pathway regulates aerobic glycolysis in glioblastoma cells by encoding a novel protein NTRK2-243aa.

Zhao Y, Song J, Dong W, Liu X, Yang C, Wang D, Xue Y, Ruan X, Liu L, Wang P, Zhang M, Liu Y
Cell death & disease 2022 Sep 5;13(9):767

Aurora A-mediated pyruvate kinase M2 phosphorylation promotes biosynthesis with glycolytic metabolites and tumor cell cycle progression.

Jiang Y, Wang T, Sheng D, Han C, Xu T, Zhang P, You W, Fan W, Zhang Z, Jin T, Duan X, Yuan X, Liu X, Zhang K, Ruan K, Shi J, Guo J, Cheng A, Yang Z
The Journal of biological chemistry 2022 Nov;298(11):102561

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690

Pyruvate Kinase M2 Protects Heart from Pressure Overload-Induced Heart Failure by Phosphorylating RAC1.

Ni L, Lin B, Hu L, Zhang R, Fu F, Shen M, Yang J, Shi D
Journal of the American Heart Association 2022 Jun 7;11(11):e024854

Development of a one-plasmid system to replace the endogenous protein with point mutation for post-translational modification studies.

Ishrat I, Cheng A, Yu F, Guo J, Zhang P, Zhang K, Yang Z
Molecular biology reports 2022 Jan;49(1):1-7

The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.

Zhu Y, Jin L, Shi R, Li J, Wang Y, Zhang L, Liang CZ, Narayana VK, De Souza DP, Thorne RF, Zhang LR, Zhang XD, Wu M
Molecular cell 2022 Feb 3;82(3):542-554.e6

Tetrahydroxy Stilbene Glucoside Alleviates Ischemic Stroke by Regulating Conformation-Dependent Intracellular Distribution of PKM2 for M2 Macrophage Polarization.

Li M, Lu W, Meng Y, Zhang W, Wang F, Sun L, Xu Y
Journal of agricultural and food chemistry 2022 Dec 14;70(49):15449-15463

Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer.

Yan SH, Hu LM, Hao XH, Liu J, Tan XY, Geng ZR, Ma J, Wang ZL
iScience 2022 Aug 19;25(8):104773

Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.

Yang K, Wu K, Feng J, Yutian L, Zhu X, Xu D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581

Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.

Qian L, Ren S, Xu Z, Zheng Y, Wu L, Yang Y, Wang Y, Li J, Yan S, Fang Z
Frontiers in pharmacology 2021;12:667433

Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2.

Wu X, Liu L, Zheng Q, Hao H, Ye H, Li P, Yang H
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3553-3566

Rapamycin facilitates differentiation of regulatory T cells via enhancement of oxidative phosphorylation.

Chen X, Li S, Long D, Shan J, Li Y
Cellular immunology 2021 Jul;365:104378

Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.

Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796

Rab25 acts as an oncogene and participates in the regulation of aerobic glycolysis via PKM2 in gastric adenocarcinoma.

Zheng T, Huang L, Chen N, Xue H, Ni P, Huang G
Translational cancer research 2021 Feb;10(2):790-805

Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.

Li M, Lu H, Wang X, Duan C, Zhu X, Zhang Y, Ge X, Ji F, Wang X, Su J, Zhang D
Molecular immunology 2021 Dec;140:250-266

Endoplasmic reticulum stress promotes sorafenib resistance via miR-188-5p/hnRNPA2B1-mediated upregulation of PKM2 in hepatocellular carcinoma.

Zhou B, Lu D, Wang A, Cui J, Zhang L, Li J, Fan L, Wei W, Liu J, Sun G
Molecular therapy. Nucleic acids 2021 Dec 3;26:1051-1065

Dihydroartemisinin Inhibits the Proliferation of Leukemia Cells K562 by Suppressing PKM2 and GLUT1 Mediated Aerobic Glycolysis.

Gao P, Shen S, Li X, Liu D, Meng Y, Liu Y, Zhu Y, Zhang J, Luo P, Gu L
Drug design, development and therapy 2020;14:2091-2100

Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.

Zhang Q, Guo D, Wang Y, Wang X, Wang Q, Wu Y, Li C, Wang W, Wang Y
Frontiers in pharmacology 2020;11:458

SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect.

Zhang B, Chen H, Ouyang J, Xie Y, Chen L, Tan Q, Du X, Su N, Ni Z, Chen L
Autophagy 2020 Jul;16(7):1262-1278

Dietary fish oil supplement induces age-specific contractile and proteomic responses in muscles of male rats.

Russ DW, Dimova K, Morris E, Pacheco M, Garvey SM, Scordilis SP
Lipids in health and disease 2020 Jul 9;19(1):165

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.

Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, Yu Q, Kong R, Li S, Zhang J, Ji J, Wu J, Mo W, Xu X, Guo C
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24

Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion.

Tian L, Xiong PY, Alizadeh E, Lima PDA, Potus F, Mewburn J, Martin A, Chen KH, Archer SL
Acta physiologica (Oxford, England) 2020 Aug;229(4):e13483

Regulation of the pyruvate metabolism node by monogene and polygene engineering of HEK-293 cells.

Xie L, Miao J, Li X, Yi X, Chu J
RSC advances 2019 Oct 31;9(61):35760-35770

PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.

Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, Chen J, Mao Y, Wang F, Dai W, Xu L, Wu J, Guo C
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204

miR-122 inhibits cancer cell malignancy by targeting PKM2 in gallbladder carcinoma.

Lu W, Zhang Y, Zhou L, Wang X, Mu J, Jiang L, Hu Y, Dong P, Liu Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Dec;37:15615–15625

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Western blot analysis of PK-M2-specific in various tissues and cell lines using Proteintech antibody 60268-1-Ig at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PK-M2-specific antibody from Proteintech is a mouse monoclonal antibody to a peptide of human PK-M2-specific. This antibody recognizes human,mouse, rat antigen. The PK-M2-specific antibody has been validated for the following applications: ELISA, IHC, IF, WB analysis.
Appendix: 60268-1-Ig.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 60268-1-Ig(PK-M2-specific antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 60268-1-Ig(PK-M2-specific antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue