ABIN1355885

antibody from antibodies-online

Targeting: PKM OIP3, PK3, PKM2, THBP1

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN1355885

Provider

antibodies-online

Product name

anti-PKM2 (AA 405-409) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around AA 405-409 (T-S-D-P-T) derived from Human PKM2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Reactivity

Human

Host

Rabbit

Epitope

AA 405-409

Vial size

100 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

PKM2 regulates chromosome segregation and mitosis progression of tumor cells.

Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z
Molecular cell 2014 Jan 9;53(1):75-87

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z
Nature cell biology 2012 Dec;14(12):1295-304

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PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z
Cell 2012 Aug 17;150(4):685-96

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC
Nature 2008 Mar 13;452(7184):230-3

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Dombrauckas JD, Santarsiero BD, Mesecar AD
Biochemistry 2005 Jul 12;44(27):9417-29

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Pyruvate kinase type M2 and its role in tumor growth and spreading.

Mazurek S, Boschek CB, Hugo F, Eigenbrodt E
Seminars in cancer biology 2005 Aug;15(4):300-8