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antibody from Proteintech Group
Targeting: KEAP1
INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [609]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 10503-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10503-2-AP, RRID:AB_2132625
- Product name
- KEAP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KEAP1 antibody (Cat. #10503-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dual-Stimuli-Responsive Gut Microbiota-Targeting Nitidine Chloride-CS/PT-NPs Improved Metabolic Status in NAFLD.
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
A novel UVA-associated circUBE2I mediates ferroptosis in HaCaT cells.
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Oxidised rice bran oil induced oxidative stress and apoptosis in IPEC-J2 cells via the Nrf2 signalling pathway.
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Homocysteine-potentiated Kelch-like ECH-associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β-catenin.
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis.
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy.
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.
Structure characterization of polysaccharides from Cistanche deserticola and their neuroprotective effects against oxidative stress in slow transit constipation mice.
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
Mechanism of Porphyra Yezoensis Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition.
A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver.
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway.
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Photothermal and ferroptosis synergistic therapy for liver cancer using iron-doped polydopamine nanozymes.
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice.
Physiological and molecular predictors of cycling sprint performance.
Chronic restraint stress induces abnormal behaviors in pain sensitivity and cognitive function in mice: the role of Keap1/Nrf2 pathway.
Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway.
Improvement of sea buckthorn (Hippophae rhamnoides L.) flavonoids on the antioxidant and immune performance of Yellow River carp (Cyprinus carpio L.) fed high-carbohydrate diet.
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway.
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Quercetin stimulates trophoblast fusion via the mitochondrial function.
Prothymosin α accelerates dengue virus-induced thrombocytopenia.
Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets.
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Wnt5a/Ror2 promotes Nrf2-mediated tissue protective function of astrocytes after brain injury.
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.
Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
Melatonin protects photoreceptor cells against ferroptosis in dry AMD disorder by inhibiting GSK-3B/Fyn-dependent Nrf2 nuclear translocation.
Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination.
4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis.
Rapid Discovery of Aβ(42) Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.
Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways.
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
Synergistic suppression of ovarian cancer by combining NRF2 and GPX4 inhibitors: in vitro and in vivo evidence.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Breast cancer cells have an increased ferroptosis risk induced by system x(c)(-) blockade after deliberately downregulating CYTL1 to mediate malignancy.
SN-38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2-related factor 2 and enhances drug sensitivity of colorectal cancer cells.
Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy-induced bone loss.
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Multienzyme Active Manganese Oxide Alleviates Acute Liver Injury by Mimicking Redox Regulatory System and Inhibiting Ferroptosis.
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Molecular mechanisms of the chemical constituents from anti-inflammatory and antioxidant active fractions of Ganoderma neo-japonicum Imazeki.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation.
miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1.
Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury.
Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium.
Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia.
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
DUOX2-Induced Oxidative Stress Inhibits Intestinal Angiogenesis through MMP3 in a Low-Birth-Weight Piglet Model.
Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish.
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Paraquat-induced ferroptosis suppression via NRF2 expression regulation.
Determinants of the maximal functional reserve during repeated supramaximal exercise by humans: The roles of Nrf2/Keap1, antioxidant proteins, muscle phenotype and oxygenation.
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
SUMOylation of the ubiquitin ligase component KEAP1 at K39 upregulates NRF2 and its target function in lung cancer cell proliferation.
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
Effects of dietary resveratrol supplementation in cattle on the anti-oxidative capacity and meat quality of beef steaks under high‑oxygen packaging.
Immunohistochemical expression of NRF2 is correlated with the magnitude of inflammation and fibrosis in chronic liver disease.
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway.
LRRK2 Attenuates Antioxidant Response in Familial Parkinson's Disease Derived Neural Stem Cells.
2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis.
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment.
Curdione inhibits ferroptosis in isoprenaline-induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway.
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
Delineating involvement of MAPK/NF-κB pathway during mitigation of permethrin-induced oxidative damage in fish gills by melatonin.
Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress.
High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi.
The master antioxidant defense is activated during EBV latent infection.
Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells.
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway.
The protective effects of uric acid against myocardial ischemia via the Nrf2 pathway.
The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury.
Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Nrf2 and NF-қB interplay in tamoxifen-induced hepatic toxicity: A promising therapeutic approach of sildenafil and low-dose γ radiation.
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice.
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis.
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis.
Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region?
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.
Meloxicam inhibited oxidative stress and inflammatory response of LPS-stimulated bovine endometrial epithelial cells through Nrf2 and NF-κB pathways.
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.
Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis.
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier.
A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle.
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.
EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis.
NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors.
Astragaloside IV attenuates podocyte apoptosis through ameliorating mitochondrial dysfunction by up-regulated Nrf2-ARE/TFAM signaling in diabetic kidney disease.
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Nuclear Factor Erythroid 2-Related Factor 2/Kelch-Like ECH-Associated Protein 1 as a Predictor of Prognosis and Radiotherapy Resistance in Patients With Locally Advanced Rectal Cancer: A Prospective Analysis.
Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis.
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex.
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal.
Pine pollen extract alleviates ethanol-induced oxidative stress and apoptosis in HepG2 cells via MAPK signaling.
Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes.
Bifidobacterium animalis A12 and Lactobacillus salivarius M18-6 Alleviate Alcohol Injury by keap1-Nrf2 Pathway and Thioredoxin System.
Hydrogen sulfide protects retinal pigment epithelium cells against ferroptosis through the AMPK- and p62-dependent non-canonical NRF2-KEAP1 pathway.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities.
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis.
Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells.
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.
Piperlongumine conjugates induce targeted protein degradation.
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
Cytotoxicity and cell injuries of flavored electronic cigarette aerosol and mainstream cigarette smoke: A comprehensive in vitro evaluation.
17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation.
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis.
Novel Antioxidant Peptides Derived from Feather Keratin Alleviate H(2)O(2)-Induced Oxidative Damage in HepG2 Cells via Keap1/Nrf2 Pathway.
Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2.
Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia.
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.
FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner.
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways.
Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling.
Molecular mechanism of kidney damage caused by abamectin in carp: Oxidative stress, inflammation, mitochondrial damage, and apoptosis.
TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
GSK-3β-dependent Nrf2 antioxidant response modulates ferroptosis of lens epithelial cells in age-related cataract.
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Synthesis of Lathyrol PROTACs and Evaluation of Their Anti-Inflammatory Activities.
MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer.
Involvements of Nrf2 and oxidative stress in the ozone-elicited exacerbation in an allergic rhinitis model.
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Tannic acid attenuates intestinal oxidative damage by improving antioxidant capacity and intestinal barrier in weaned piglets and IPEC-J2 cells.
Carbon Monoxide-Releasing Molecule-3 Suppresses the Malignant Biological Behavior of Tongue Squamous Cell Carcinoma via Regulating Keap1/Nrf2/HO-1 Signaling Pathway.
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury.
Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos.
Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester.
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
The Protective Effect of Ursolic Acid on Unilateral Ureteral Obstruction in Rats by Activating the Nrf2/HO-1 Antioxidant Signaling Pathway.
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress.
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H(2)O(2) Through Activation of Nrf2 Pathway.
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Berberine prevents lethal EV71 neurological infection in newborn mice.
Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection.
Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.
Acadesine alleviates acute pancreatitis-related lung injury by mediating the barrier protective function of pulmonary microvascular endothelial cells.
Immature rat testis sustained long-term development using an integrative model.
Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion.
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis.
Oxidative stress in the RVLM mediates sympathetic hyperactivity induced by circadian disruption.
Salecan ameliorates liver injury by regulating gut microbiota and its metabolites.
FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling.
Caspase-8 mutants activate Nrf2 via phosphorylating SQSTM1 to protect against oxidative stress in esophageal squamous cell carcinoma.
Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation.
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.
The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma.
Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells.
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects.
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5).
Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.
Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.
Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice.
Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Sulforaphane Acts Through NFE2L2 to Prevent Hypoxia-Induced Apoptosis in Porcine Granulosa Cells via Activating Antioxidant Defenses and Mitophagy.
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.
Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model.
Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine.
An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.
Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction.
GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling.
Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury.
Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition.
USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity.
Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1.
Ellagic Acid Alleviates Oxidative Stress by Mediating Nrf2 Signaling Pathways and Protects against Paraquat-Induced Intestinal Injury in Piglets.
Ellagic acid ameliorates paraquat-induced liver injury associated with improved gut microbial profile.
MiR-125b attenuates retinal pigment epithelium oxidative damage via targeting Nrf2/HIF-1α signal pathway.
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Proteome analysis of NRF2 inhibition in melanoma reveals CD44 up-regulation and increased apoptosis resistance upon vemurafenib treatment.
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.
Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction.
SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease.
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Hatched Eggshell Membrane Can Be a Novel Source of Antioxidant Hydrolysates to Protect against H(2)O(2)-Induced Oxidative Stress in Human Chondrocytes.
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats.
Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice.
Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH.
PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway.
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Sulforaphane improves cognitive dysfunction after surgery and anesthesia in mice: The role of Keap1-Nrf2 signaling.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway.
A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells.
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.
Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM(2.5).
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets.
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Salmonella Effector SpvB Inhibits NF-κB Activity via KEAP1-Mediated Downregulation of IKKβ.
Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription.
NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Chemical Constituents from the Rhizome of Ligusticum chuanxiong Hort. and Their Nrf2 Inducing Activity.
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway.
NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells.
Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.
Coordinate regulation of the senescent state by selective autophagy.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Sinomenine protects bone from destruction to ameliorate arthritis via activating p62(Thr269/Ser272)-Keap1-Nrf2 feedback loop.
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.
Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis.
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.
The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro.
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
The piperine derivative HJ105 inhibits Aβ(1-42)-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin.
Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells.
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome.
H(2)S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.
Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice.
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Proanthocyanidins regulate the Nrf2/ARE signaling pathway and protect neurons from cypermethrin-induced oxidative stress and apoptosis.
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Physical plasma-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death.
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351.
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis.
Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.
C2C12 Mouse Myoblasts Damage Induced by Oxidative Stress Is Alleviated by the Antioxidant Capacity of the Active Substance Phloretin.
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
LncRNA MALAT1 Regulates miR-144-3p to Facilitate Epithelial-Mesenchymal Transition of Lens Epithelial Cells via the ROS/NRF2/Notch1/Snail Pathway.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways.
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
p62 Suppressed VK3-induced Oxidative Damage Through Keap1/Nrf2 Pathway In Human Ovarian Cancer Cells.
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Polarization of Low-Grade Inflammatory Monocytes Through TRAM-Mediated Up-Regulation of Keap1 by Super-Low Dose Endotoxin.
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
NRF2-Driven KEAP1 Transcription in Human Lung Cancer.
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D(3) Plus Nicotine.
Normobaric hyperoxia plays a protective role against renal ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway.
Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound: Effect of organobismuth(III) compound on NRF2 signaling.
Niacin Alleviates Dairy Cow Mastitis by Regulating the GPR109A/AMPK/NRF2 Signaling Pathway.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy.
Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma.
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells.
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway.
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma.
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways.
Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
CCl(4)-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation.
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation.
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
The Nrf2 pathway is required for intracellular replication of Toxoplasma gondii in activated macrophages.
The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis.
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression.
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.
Neuroprotective Effect of Dioscin on the Aging Brain.
Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities.
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.
(-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress.
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.
A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.
TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.
Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.
Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats.
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Nrf2 protects stellate cells from Smad-dependent cell activation.
A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.
Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.
The PKCδ-Nrf2-ARE signalling pathway may be involved in oxidative stress in arsenic-induced liver damage in rats.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.
Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.
Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy.
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.
Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer.
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells.
Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant.
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.
p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.
CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells.
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.
A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1.
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.
Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.
Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses.
The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells.
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.
Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.
RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.
CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells.
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.
Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.
Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.
p62 Deficiency Enhances α-Synuclein Pathology in Mice.
p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2.
Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.
Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.
PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.
The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells.
Potent effects of dioscin against obesity in mice.
Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.
Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages.
Potent effects of dioscin against liver fibrosis.
SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.
Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.
MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).
The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.
Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts.
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.
Association of p62/SQSTM1 excess and oral carcinogenesis.
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.
Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.
Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.
Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue.
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma.
[Keap1 expression for predicting the chemoresistance and prognosis of advanced non-small cell lung cancer].
Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.
Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.
Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.
Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.
Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2.
Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Autophagy-deficient mice develop multiple liver tumors.
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis.
Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.
Lu J, Zeng Y, Zhong H, Guo W, Zhang Y, Mai W, Qin Y, Su X, Zhang B, Wu W, Zhu Y, Huang Q, Ye Y
International journal of nanomedicine 2024;19:2409-2428
International journal of nanomedicine 2024;19:2409-2428
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Dong J, Liu M, Bian Y, Zhang W, Yuan C, Wang D, Zhou Z, Li Y, Shi Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Zhou J, Zhou J, Liu R, Liu Y, Meng J, Wen Q, Luo Y, Liu S, Li H, Ba L, Du J
Frontiers in immunology 2024;15:1380846
Frontiers in immunology 2024;15:1380846
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway.
Sun X, Dong M, Li J, Sun Y, Gao Y, Wang Y, Du L, Liu Y, Ji K, He N, Wang J, Zhang M, Song H, Xu C, Liu Q
Theranostics 2024;14(2):681-698
Theranostics 2024;14(2):681-698
A novel UVA-associated circUBE2I mediates ferroptosis in HaCaT cells.
Yi P, Huang Y, Zhao X, Qin Z, Zhu D, Liu L, Zheng Y, Feng J, Long M
Photochemistry and photobiology 2024 Sep-Oct;100(5):1365-1377
Photochemistry and photobiology 2024 Sep-Oct;100(5):1365-1377
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Feng J, Ji K, Pan Y, Huang P, He T, Xing Y
Molecular neurobiology 2024 Oct;61(10):8454-8466
Molecular neurobiology 2024 Oct;61(10):8454-8466
Oxidised rice bran oil induced oxidative stress and apoptosis in IPEC-J2 cells via the Nrf2 signalling pathway.
Wang R, Wang C, Chen P, Qi H, Zhang J
Journal of animal physiology and animal nutrition 2024 Nov;108(6):1844-1855
Journal of animal physiology and animal nutrition 2024 Nov;108(6):1844-1855
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Wang G, Zhu ZM, Wang K
Drug development research 2024 May;85(3):e22200
Drug development research 2024 May;85(3):e22200
Homocysteine-potentiated Kelch-like ECH-associated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of β-catenin.
Zhang Y, Xie JZ, Jiang YL, Yang SJ, Wei H, Yang Y, Wang JZ
The European journal of neuroscience 2024 May;59(10):2732-2747
The European journal of neuroscience 2024 May;59(10):2732-2747
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis.
Liu Z, Wang K, Jiang C, Chen Y, Liu F, Xie M, Yim WY, Yao D, Qian X, Chen S, Shi J, Xu K, Wang Y, Dong N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(20):e2307319
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(20):e2307319
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy.
Takahashi K, Kurokawa K, Hong L, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M
Experimental neurology 2024 Mar;373:114671
Experimental neurology 2024 Mar;373:114671
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.
Jiang Z, Yang H, Ni W, Gao X, Pei X, Jiang H, Su J, Weng R, Fei Y, Gao Y, Gu Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14646
CNS neuroscience & therapeutics 2024 Mar;30(3):e14646
Structure characterization of polysaccharides from Cistanche deserticola and their neuroprotective effects against oxidative stress in slow transit constipation mice.
Jiang HY, Ma RA, Ji FL, Liu Y, Wang B, Fu SQ, Ma LS, Wang S, Liu CX, Guo Z, Li R, Wang YC, Sun W, Dong L, Dong CX, Sun DQ
International journal of biological macromolecules 2024 Mar;260(Pt 2):129527
International journal of biological macromolecules 2024 Mar;260(Pt 2):129527
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
β-Sitosterol targets ASS1 for Nrf2 ubiquitin-dependent degradation, inducing ROS-mediated apoptosis via the PTEN/PI3K/AKT signaling pathway in ovarian cancer.
Wang H, Liu J, Zhang Z, Peng J, Wang Z, Yang L, Wang X, Hu S, Hong L
Free radical biology & medicine 2024 Mar;214:137-157
Free radical biology & medicine 2024 Mar;214:137-157
LuQi formula attenuates Cardiomyocyte ferroptosis via activating Nrf2/GPX4 signaling axis in heart failure.
Cheng P, Wang X, Liu Q, Yang T, Dai E, Sha W, Qu H, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155357
Mechanism of Porphyra Yezoensis Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition.
Deng JW, Li CY, Huang YP, Liu WF, Zhang Q, Long J, Wu WQ, Huang LH, Zeng GH, Sun XY
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6372-6388
Journal of agricultural and food chemistry 2024 Mar 27;72(12):6372-6388
A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver.
Materozzi M, Resnati M, Facchi C, Trudu M, Orfanelli U, Perini T, Gennari L, Milan E, Cenci S
Scientific reports 2024 Mar 27;14(1):7290
Scientific reports 2024 Mar 27;14(1):7290
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.
Chen X, Zhou Q, Chen H, Bai J, An R, Zhang K, Zhang X, An H, Zhang J, Wang Y, Li M
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q
Cell death & disease 2024 Mar 23;15(3):233
Cell death & disease 2024 Mar 23;15(3):233
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Xin X, Liu J, Liu X, Xin Y, Hou Y, Xiang X, Deng Y, Yang B, Yu W
ACS nano 2024 Mar 19;18(11):8307-8324
ACS nano 2024 Mar 19;18(11):8307-8324
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
Wang W, Zhou C, Ma Z, Zeng L, Wang H, Cheng X, Zhang C, Xue Y, Yuan Y, Li J, Hu L, Huang J, Luo T, Zheng L
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway.
Qian Z, Zhang Q, Li P, Li Y, Zhang Y, Li R, Zhao T, Xia M, Chen Y, Hong X
Molecular neurobiology 2024 Jun;61(6):3490-3502
Molecular neurobiology 2024 Jun;61(6):3490-3502
A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM.
Liu C, Sun Y, Li D, Wang F, Wang H, An S, Sun S
Materials today. Bio 2024 Jun;26:101034
Materials today. Bio 2024 Jun;26:101034
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
Fu S, Li Y, Shen L, Chen Y, Lu J, Ran Y, Zhao Y, Tang H, Tan L, Lin Q, Hao Y
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.
Duan WL, Ma YP, Wang XJ, Ma CS, Han B, Sheng ZM, Dong H, Zhang LY, Li PA, Zhang BG, He MT
European journal of pharmacology 2024 Jun 5;972:176553
European journal of pharmacology 2024 Jun 5;972:176553
Photothermal and ferroptosis synergistic therapy for liver cancer using iron-doped polydopamine nanozymes.
Li Y, Qian L, Yang Z, Li S, Wu A, Wang X
Colloids and surfaces. B, Biointerfaces 2024 Jul;239:113911
Colloids and surfaces. B, Biointerfaces 2024 Jul;239:113911
The effect and mechanism of combined exposure of MC-LR and NaNO(2) on liver lipid metabolism.
Yang J, Zhang Z, Du X, Wang Y, Meng R, Ge K, Wu C, Liang X, Zhang H, Guo H
Environmental research 2024 Jul 1;252(Pt 4):119113
Environmental research 2024 Jul 1;252(Pt 4):119113
Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice.
Fan S, Lin L, Li P, Tian H, Shen J, Zhou L, Zhao Q, Zhang J, Qin Y, Tang C
Toxicology 2024 Jan;501:153689
Toxicology 2024 Jan;501:153689
Physiological and molecular predictors of cycling sprint performance.
Galvan-Alvarez V, Gallego-Selles A, Martinez-Canton M, Perez-Suarez I, Garcia-Gonzalez E, Martin-Rincon M, Calbet JAL
Scandinavian journal of medicine & science in sports 2024 Jan;34(1):e14545
Scandinavian journal of medicine & science in sports 2024 Jan;34(1):e14545
Chronic restraint stress induces abnormal behaviors in pain sensitivity and cognitive function in mice: the role of Keap1/Nrf2 pathway.
Yang N, Wang Y, Luo X, Zhan G
Stress (Amsterdam, Netherlands) 2024 Jan;27(1):2316050
Stress (Amsterdam, Netherlands) 2024 Jan;27(1):2316050
Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway.
Zhao L, Tao X, Wang Q, Yu X, Dong D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116067
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:116067
Improvement of sea buckthorn (Hippophae rhamnoides L.) flavonoids on the antioxidant and immune performance of Yellow River carp (Cyprinus carpio L.) fed high-carbohydrate diet.
Yan X, Pang P, Qin C, Mi J, Yang L, Yang B, Nie G
Fish & shellfish immunology 2024 Jan;144:109289
Fish & shellfish immunology 2024 Jan;144:109289
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z
International immunopharmacology 2024 Jan 5;126:111183
International immunopharmacology 2024 Jan 5;126:111183
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Wang R, Zeng J, Chen L, Sun L, Wang Y, Xu J, He X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Qi XY, Peng GC, Han QT, Yan J, Chen LZ, Wang T, Xu LT, Liu MJ, Xu ZP, Wang XN, Shen T
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway.
Ba L, E M, Wang R, Wu N, Wang R, Liu R, Feng X, Qi H, Sun H, Qiao G
Heliyon 2024 Jan 30;10(2):e24010
Heliyon 2024 Jan 30;10(2):e24010
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Wu W, Li G, Dong S, Huihan Chu C, Ma S, Zhang Z, Yuan S, Wu J, Guo Z, Shen Y, Wang J, Tang C
International immunopharmacology 2024 Jan 25;127:111423
International immunopharmacology 2024 Jan 25;127:111423
Quercetin stimulates trophoblast fusion via the mitochondrial function.
Yoshida K, Kusama K, Shinohara G, Sato S, Yoshie M, Tamura K
Scientific reports 2024 Jan 2;14(1):287
Scientific reports 2024 Jan 2;14(1):287
Prothymosin α accelerates dengue virus-induced thrombocytopenia.
Yang ML, Lin CL, Chen YC, Lu IA, Su BH, Chen YH, Liu KT, Wu CL, Shiau AL
iScience 2024 Jan 19;27(1):108422
iScience 2024 Jan 19;27(1):108422
Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets.
Cui C, Wei Y, Wang Y, Ma W, Zheng X, Wang J, Ma Z, Wu C, Chu L, Zhang S, Guan W, Chen F
Journal of animal science and biotechnology 2024 Jan 19;15(1):4
Journal of animal science and biotechnology 2024 Jan 19;15(1):4
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Wu DZ, Zhu GZ, Zhao K, Gao JW, Cai GX, Li HZ, Huang YS, Tu C, Zhuang JS, Huang ZW, Zhong ZM
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Wnt5a/Ror2 promotes Nrf2-mediated tissue protective function of astrocytes after brain injury.
Endo M, Tanaka Y, Fukuoka M, Suzuki H, Minami Y
Glia 2024 Feb;72(2):411-432
Glia 2024 Feb;72(2):411-432
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.
Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Acta pharmacologica Sinica 2024 Feb;45(2):391-404
Epigallocatechin-3-gallate promotes wound healing response in diabetic mice by activating keratinocytes and promoting re-epithelialization.
Ning Y, Yuan Z, Wang Q, He J, Zhu W, Ren DN, Wo D
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027
Phytotherapy research : PTR 2024 Feb;38(2):1013-1027
Isoquercitrin attenuates the osteoclast-mediated bone loss in rheumatoid arthritis via the Nrf2/ROS/NF-κB pathway.
Liu Y, Li TQ, Bai J, Liu WL, Wang ZR, Feng C, Pu LL, Wang XX, Liu H
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166977
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166977
Melatonin protects photoreceptor cells against ferroptosis in dry AMD disorder by inhibiting GSK-3B/Fyn-dependent Nrf2 nuclear translocation.
Zhi X, Lu H, Ma D, Liu J, Luo L, Wang L, Qin Y
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166969
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166969
Vialinin A alleviates oxidative stress and neuronal injuries after ischaemic stroke by accelerating Keap1 degradation through inhibiting USP4-mediated deubiquitination.
Mao M, Xia Q, Zhan G, Bing H, Zhang C, Wang J, Tian W, Lian H, Li X, Chu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155304
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155304
4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis.
Dan Z, Shi X, Shu C, Zhu R, Wang Y, Zhu H
Cellular signalling 2024 Feb;114:111001
Cellular signalling 2024 Feb;114:111001
Rapid Discovery of Aβ(42) Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.
Li QM, Han HH, Zang DD, Zha XQ, Zhou A, Zhang FY, Luo JP
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4127-4141
Journal of agricultural and food chemistry 2024 Feb 28;72(8):4127-4141
Chemical Characterization of Honeysuckle Polyphenols and Their Alleviating Function on Ultraviolet B-Damaged HaCaT Cells by Modulating the Nrf2/NF-κB Signaling Pathways.
Zheng SL, Wang YM, Chi CF, Wang B
Antioxidants (Basel, Switzerland) 2024 Feb 28;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 28;13(3)
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
Li J, Shi D, Li S, Shi X, Liu Y, Zhang Y, Wang G, Zhang C, Xia T, Piao HL, Liu HX
Cell death & disease 2024 Feb 27;15(2):175
Cell death & disease 2024 Feb 27;15(2):175
Synergistic suppression of ovarian cancer by combining NRF2 and GPX4 inhibitors: in vitro and in vivo evidence.
Li N, Jiang X, Zhang Q, Huang Y, Wei J, Zhang H, Luo H
Journal of ovarian research 2024 Feb 23;17(1):49
Journal of ovarian research 2024 Feb 23;17(1):49
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, Liu H, Ruan Z, Hou L, Guo Z, Wang G, Xu F, Guo F
Free radical biology & medicine 2024 Feb 20;212:336-348
Free radical biology & medicine 2024 Feb 20;212:336-348
Ivacaftor attenuates gentamicin-induced ototoxicity through the CFTR-Nrf2-HO1/NQO1 pathway.
Hu R, Wu F, Zheng YQ
Redox report : communications in free radical research 2024 Dec;29(1):2332038
Redox report : communications in free radical research 2024 Dec;29(1):2332038
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2024 Aug;23(8):e14202
Aging cell 2024 Aug;23(8):e14202
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Dong Y, Kang H, Peng R, Liu Z, Liao F, Hu SA, Ding W, Wang P, Yang P, Zhu M, Wang S, Wu M, Ye D, Gan X, Li F, Song K
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Breast cancer cells have an increased ferroptosis risk induced by system x(c)(-) blockade after deliberately downregulating CYTL1 to mediate malignancy.
Xue W, Yu Y, Yao Y, Zhou L, Huang Y, Wang Y, Chen Z, Wang L, Li X, Wang X, Du R, Shen Y, Xu Q
Redox biology 2024 Apr;70:103034
Redox biology 2024 Apr;70:103034
SN-38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2-related factor 2 and enhances drug sensitivity of colorectal cancer cells.
Wang J, Xu J, Yang S, He L, Xu W, Liu Y, Cao B, Yu S
Molecular carcinogenesis 2024 Apr;63(4):742-756
Molecular carcinogenesis 2024 Apr;63(4):742-756
Cichoric acid targets RANKL to inhibit osteoclastogenesis and prevent ovariectomy-induced bone loss.
Xian Y, Gao Y, Su Y, Su Y, Lian H, Feng X, Liu Z, Zhao J, Xu J, Liu Q, Song F
Phytotherapy research : PTR 2024 Apr;38(4):1971-1989
Phytotherapy research : PTR 2024 Apr;38(4):1971-1989
Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta.
Li Q, Kang J, Liu N, Huang J, Zhang X, Pang K, Zhang S, Wang M, Zhao Y, Dong S, Li H, Zhao D, Lu F, Zhang W
Free radical biology & medicine 2024 Apr;216:118-138
Free radical biology & medicine 2024 Apr;216:118-138
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Xu Y, Sun D, Xiong L, Zhang Z, Li Y, Liu K, Li H, Chen L
Bioorganic chemistry 2024 Apr;145:107190
Bioorganic chemistry 2024 Apr;145:107190
ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.
Qian Z, Xia M, Zhao T, Li Y, Li G, Zhang Y, Li H, Yang L
Clinical and translational medicine 2024 Apr;14(4):e1661
Clinical and translational medicine 2024 Apr;14(4):e1661
Multienzyme Active Manganese Oxide Alleviates Acute Liver Injury by Mimicking Redox Regulatory System and Inhibiting Ferroptosis.
Wu A, Li M, Chen Y, Zhang W, Li H, Chen J, Gu K, Wang X
Advanced healthcare materials 2024 Apr;13(11):e2302556
Advanced healthcare materials 2024 Apr;13(11):e2302556
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
Huang Q, Liu J, Peng C, Han X, Tan Z
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Zeng Q, Wen BB, Liu X, Luo YY, Hu ZG, Huang L, Zhang XH, Huang XT, Zhou TT, Sang XX, Luo YY, Xiong DY, Luo ZQ, Liu W, Tang SY
Chinese medicine 2024 Apr 8;19(1):60
Chinese medicine 2024 Apr 8;19(1):60
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Zeng Z, Fu Y, Li M, Shi Y, Ding Q, Chen S
Journal of ethnopharmacology 2024 Apr 6;323:117674
Journal of ethnopharmacology 2024 Apr 6;323:117674
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Molecular mechanisms of the chemical constituents from anti-inflammatory and antioxidant active fractions of Ganoderma neo-japonicum Imazeki.
Zhang RR, Zhang J, Guo X, Chen YY, Sun JY, Miao JL, Carpena M, Prieto MA, Li NY, Zhou QX, Liu C
Current research in food science 2023;6:100441
Current research in food science 2023;6:100441
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
Li Q, Li Z, Liu C, Xu M, Li T, Wang Y, Feng J, Yin X, Du X, Lu C
The American journal of Chinese medicine 2023;51(4):929-951
The American journal of Chinese medicine 2023;51(4):929-951
JFD, a Novel Natural Inhibitor of Keap1 Alkylation, Suppresses Intracellular Mycobacterium Tuberculosis Growth through Keap1/Nrf2/SOD2-Mediated ROS Accumulation.
Wan H, Cai Y, Xiao L, Ling Y, Ge L, Mo S, Xie Q, Peng S, Zhou B, Zeng X, Chen X
Oxidative medicine and cellular longevity 2023;2023:6726654
Oxidative medicine and cellular longevity 2023;2023:6726654
miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1.
Geng W, Yan S, Li X, Liu Q, Zhang X, Gu X, Tian X, Jiang Y
Analytical cellular pathology (Amsterdam) 2023;2023:1293200
Analytical cellular pathology (Amsterdam) 2023;2023:1293200
Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury.
Zhang J, Luan ZL, Huo XK, Zhang M, Morisseau C, Sun CP, Hammock BD, Ma XC
International journal of biological sciences 2023;19(1):294-310
International journal of biological sciences 2023;19(1):294-310
Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium.
Hirose W, Horiuchi M, Li D, Motoike IN, Zhang L, Nishi H, Taniyama Y, Kamei T, Suzuki M, Kinoshita K, Katsuoka F, Taguchi K, Yamamoto M
Cellular and molecular gastroenterology and hepatology 2023;15(1):153-178
Cellular and molecular gastroenterology and hepatology 2023;15(1):153-178
Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia.
Yamada M, Warabi E, Oishi H, Lira VA, Okutsu M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23156
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23156
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Li J, Zhang J, Xue Q, Liu B, Qin R, Li Y, Qiu Y, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2023 Sep;22(9):e13912
Aging cell 2023 Sep;22(9):e13912
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Xiang X, Chen J, Jiang T, Yan C, Kang Y, Zhang M, Xiang K, Guo J, Jiang G, Wang C, XiangXu, Yang X, Chen Z
Drug delivery and translational research 2023 Sep;13(9):2286-2296
Drug delivery and translational research 2023 Sep;13(9):2286-2296
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Tong G, Chen Y, Chen X, Fan J, Zhu K, Hu Z, Li S, Zhu J, Feng J, Wu Z, Hu Z, Zhou B, Jin L, Chen H, Shen J, Cong W, Li X
Nature communications 2023 Sep 30;14(1):6107
Nature communications 2023 Sep 30;14(1):6107
Krüppel-like Factor 15 Suppresses Ferroptosis by Activating an NRF2/GPX4 Signal to Protect against Folic Acid-Induced Acute Kidney Injury.
Yang X, Dong S, Fan Y, Xia Y, Yang F, Chen Z, Chen D, Zhang M, Liang D, Zeng C
International journal of molecular sciences 2023 Sep 26;24(19)
International journal of molecular sciences 2023 Sep 26;24(19)
DUOX2-Induced Oxidative Stress Inhibits Intestinal Angiogenesis through MMP3 in a Low-Birth-Weight Piglet Model.
Zou D, Yang Y, Ji F, Lv R, Xu T, Hu C
Antioxidants (Basel, Switzerland) 2023 Sep 25;12(10)
Antioxidants (Basel, Switzerland) 2023 Sep 25;12(10)
Cadmium exposure promotes ferroptosis by upregulating Heat Shock Protein 70 in vascular endothelial damage of zebrafish.
Zhang T, Yan W, Liu C, Duan W, Duan Y, Li Y, Yu Q, Sun Y, Tian J, Zhou J, Xia Z, Wang G, Xu S
Ecotoxicology and environmental safety 2023 Sep 15;263:115241
Ecotoxicology and environmental safety 2023 Sep 15;263:115241
MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating lipopolysaccharide-induced inflammation and oxidative stress in bovine mammary epithelial cells and murine mammary glands.
Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu G, Han B
Veterinary research 2023 Sep 14;54(1):78
Veterinary research 2023 Sep 14;54(1):78
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
Paraquat-induced ferroptosis suppression via NRF2 expression regulation.
Cai Q, Shen Q, Zhu W, Zhang S, Ke J, Lu Z
Toxicology in vitro : an international journal published in association with BIBRA 2023 Oct;92:105655
Toxicology in vitro : an international journal published in association with BIBRA 2023 Oct;92:105655
Determinants of the maximal functional reserve during repeated supramaximal exercise by humans: The roles of Nrf2/Keap1, antioxidant proteins, muscle phenotype and oxygenation.
Galvan-Alvarez V, Martin-Rincon M, Gallego-Selles A, Martínez Canton M, HamedChaman N, Gelabert-Rebato M, Perez-Valera M, García-Gonzalez E, Santana A, Holmberg HC, Boushel R, Hallén J, Calbet JAL
Redox biology 2023 Oct;66:102859
Redox biology 2023 Oct;66:102859
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Liang C, Zhang HY, Wang YQ, Yang LA, Du YS, Luo Y, Zhang TC, Xu Y
Current medical science 2023 Oct;43(5):1023-1032
Current medical science 2023 Oct;43(5):1023-1032
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
Liu L, Zhang Y, Wang L, Liu Y, Chen H, Hu Q, Xie C, Meng X, Shen X
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
SUMOylation of the ubiquitin ligase component KEAP1 at K39 upregulates NRF2 and its target function in lung cancer cell proliferation.
Yang H, Du Y, Fei X, Huang S, Yimiti M, Yang X, Ma J, Li S, Tuoheniyazi H, Zhao Y, Gu Z, Xu D
The Journal of biological chemistry 2023 Oct;299(10):105215
The Journal of biological chemistry 2023 Oct;299(10):105215
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
Tian J, Zhang S, Li L, Lin X, Li Y, Zhao K, Zheng F, Chen Y, Yang Y, Wu T, Pang J
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
Effects of dietary resveratrol supplementation in cattle on the anti-oxidative capacity and meat quality of beef steaks under high‑oxygen packaging.
Cui Y, Qi J, Li J, Zhang Y, Yang X, Xin L, Niu L, Xu B, Qian Z, Zhu L, Liang R
Meat science 2023 Oct;204:109238
Meat science 2023 Oct;204:109238
Immunohistochemical expression of NRF2 is correlated with the magnitude of inflammation and fibrosis in chronic liver disease.
To K, Okada K, Watahiki T, Suzuki H, Tsuchiya K, Tokushige K, Yamamoto M, Ariizumi SI, Shoda J
Cancer medicine 2023 Oct;12(19):19423-19437
Cancer medicine 2023 Oct;12(19):19423-19437
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Zhou W, He H, Wei Q, Che L, Zhao X, Liu W, Yan Y, Hu L, Du Y, Yin Z, Shuai Y, Yang L, Feng R
Food science & nutrition 2023 Oct;11(10):6604-6615
Food science & nutrition 2023 Oct;11(10):6604-6615
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway.
Wang R, Dong S, Xia R, Sun M, Sun Y, Ren H, Zhang Y, Xia Z, Yao S, Wang T
European journal of pharmacology 2023 Oct 5;956:175985
European journal of pharmacology 2023 Oct 5;956:175985
LRRK2 Attenuates Antioxidant Response in Familial Parkinson's Disease Derived Neural Stem Cells.
Kim J, Daadi EW, Daadi ES, Oh T, Deleidi M, Daadi MM
Cells 2023 Oct 31;12(21)
Cells 2023 Oct 31;12(21)
2, 2-dimethylthiazolidine hydrochloride protects against experimental contrast-induced acute kidney injury via inhibition of tubular ferroptosis.
Dai B, Su Q, Liu X, Mi X, Dou L, Zhou D, Su Y, Shen T, Zhang Y, Xu W, Tan X, Wang D
Biochemical and biophysical research communications 2023 Oct 30;679:15-22
Biochemical and biophysical research communications 2023 Oct 30;679:15-22
Exogenous H(2)S initiating Nrf2/GPx4/GSH pathway through promoting Syvn1-Keap1 interaction in diabetic hearts.
Wang M, Tang J, Zhang S, Pang K, Zhao Y, Liu N, Huang J, Kang J, Dong S, Li H, Tian Z, Duan B, Lu F, Zhang W
Cell death discovery 2023 Oct 24;9(1):394
Cell death discovery 2023 Oct 24;9(1):394
Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment.
Cheng Z, Xue C, Liu M, Cheng Z, Tian G, Li M, Xue R, Yao X, Zhang Y, Luo Z
Acta biomaterialia 2023 Oct 1;169:289-305
Acta biomaterialia 2023 Oct 1;169:289-305
Curdione inhibits ferroptosis in isoprenaline-induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway.
Wang H, Xie B, Shi S, Zhang R, Liang Q, Liu Z, Cheng Y
Phytotherapy research : PTR 2023 Nov;37(11):5328-5340
Phytotherapy research : PTR 2023 Nov;37(11):5328-5340
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
Shen X, Chen H, Zhang H, Luo L, Wen T, Liu L, Hu Q, Wang L
International immunopharmacology 2023 Nov;124(Pt B):110965
International immunopharmacology 2023 Nov;124(Pt B):110965
Delineating involvement of MAPK/NF-κB pathway during mitigation of permethrin-induced oxidative damage in fish gills by melatonin.
Moniruzzaman M, Kumar S, Mukherjee M, Chakraborty SB
Environmental toxicology and pharmacology 2023 Nov;104:104312
Environmental toxicology and pharmacology 2023 Nov;104:104312
Vasculoprotective Potential of Baicalein in Angiotensin II-Infused Abdominal Aortic Aneurysms through Inhibiting Inflammation and Oxidative Stress.
Sulistyowati E, Huang SE, Cheng TL, Chao YY, Li CY, Chang CW, Lin MX, Lin MC, Yeh JL
International journal of molecular sciences 2023 Nov 6;24(21)
International journal of molecular sciences 2023 Nov 6;24(21)
High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi.
Zhang A, Li H, Song Q, Cui Y, Zhang Y, Wang X, Li Z, Hou Y
Lipids in health and disease 2023 Nov 6;22(1):189
Lipids in health and disease 2023 Nov 6;22(1):189
The master antioxidant defense is activated during EBV latent infection.
Wang L, Howell MEA, Hensley CR, Ning K, Moorman JP, Yao ZQ, Ning S
Journal of virology 2023 Nov 30;97(11):e0095323
Journal of virology 2023 Nov 30;97(11):e0095323
Lactoferrin Alleviates Ethanol-Induced Injury via Promoting Nrf2 Nuclear Translocation in BRL-3A Rat Liver Cells.
Li D, Ding L, Yan Y, Xing Y, Xu J, Qin L
International journal of molecular sciences 2023 Nov 28;24(23)
International journal of molecular sciences 2023 Nov 28;24(23)
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway.
Wang Q, Liu T, Koci M, Wang Y, Fu Y, Ma M, Ma Q, Zhao L
Antioxidants (Basel, Switzerland) 2023 Nov 22;12(12)
Antioxidants (Basel, Switzerland) 2023 Nov 22;12(12)
The protective effects of uric acid against myocardial ischemia via the Nrf2 pathway.
Ma P, Zhao M, Li Y, Zhang G, Ma Y, Shi Y, Su P, Chen R, Tang ZG, Zhang Y, Liu B, Zhang Q, Liu X, Li F
European journal of pharmacology 2023 Nov 15;959:176062
European journal of pharmacology 2023 Nov 15;959:176062
The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury.
Tang M, Su Q, Duan Y, Fu Y, Liang M, Pan Y, Yuan J, Wang M, Pang X, Ma J, Laher I, Li S
Scientific reports 2023 Nov 13;13(1):19781
Scientific reports 2023 Nov 13;13(1):19781
Effect of arsenic and copper in kidney of mice: Crosstalk between Nrf2/ Keap1 pathway in apoptosis and pyroptosis.
Li Y, Zhong G, He T, Quan J, Liu S, Liu Z, Tang Z, Yu W
Ecotoxicology and environmental safety 2023 Nov 1;266:115542
Ecotoxicology and environmental safety 2023 Nov 1;266:115542
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Li X, Tao H, Zhou J, Zhang L, Shi Y, Zhang C, Sun W, Chu M, Chen K, Gu C, Yang X, Geng D, Hao Y
Free radical biology & medicine 2023 Nov 1;208:13-25
Free radical biology & medicine 2023 Nov 1;208:13-25
Photobiomodulation augments the effects of mitochondrial transplantation in the treatment of spinal cord injury in rats by facilitating mitochondrial transfer to neurons via Connexin 36.
Zhu Z, Li X, Wang X, Zuo X, Ma Y, Gao X, Liang Z, Zhang Z, Song Z, Ding T, Ju C, Li P, Li K, Zhang J, Quan H, Wang Z, Hu X
Bioengineering & translational medicine 2023 May;8(3):e10473
Bioengineering & translational medicine 2023 May;8(3):e10473
Nrf2 and NF-қB interplay in tamoxifen-induced hepatic toxicity: A promising therapeutic approach of sildenafil and low-dose γ radiation.
Karam HM, Galal SM, Lotfy DM
Environmental toxicology 2023 May;38(5):990-996
Environmental toxicology 2023 May;38(5):990-996
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Xi Y, Chi Z, Tao X, Zhai X, Zhao Z, Ren J, Yang S, Dong D
Environmental toxicology 2023 May;38(5):1153-1161
Environmental toxicology 2023 May;38(5):1153-1161
Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice.
Liu Y, Mi Y, Wang Y, Meng Q, Xu L, Liu Y, Zhou D, Wang Y, Liang D, Li W, Li N, Hou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154729
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Wang X, Zhou T, Yang X, Cao X, Jin G, Zhang P, Guo J, Rong K, Li B, Hu Y, Liu K, Ma P, Qin A, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Shang Z, Fan M, Zhang J, Wang Z, Jiang S, Li W
International journal of molecular sciences 2023 May 4;24(9)
International journal of molecular sciences 2023 May 4;24(9)
Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis.
Fan P, Meng H, Hao W, Zheng Y, Li H, Zhang Z, Du L, Guo X, Wang D, Wang Y, Wu H
Food & function 2023 May 22;14(10):4905-4920
Food & function 2023 May 22;14(10):4905-4920
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, Jiang C, Wang X, Jiang X
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
PM(2.5) caused ferroptosis in spermatocyte via overloading iron and disrupting redox homeostasis.
Wang J, Zhang Z, Shi F, Li Y, Tang Y, Liu C, Wang Y, Chen J, Jiang X, Yang H, Sun L, Chen Q, Ao L, Han F, Liu J, Cao J
The Science of the total environment 2023 May 10;872:162089
The Science of the total environment 2023 May 10;872:162089
Is Nrf2 Behind Endogenous Neuroprotection of the Hippocampal CA2-4,DG Region?
Lewczuk A, Zablocka B, Beresewicz-Haller M
Molecular neurobiology 2023 Mar;60(3):1645-1658
Molecular neurobiology 2023 Mar;60(3):1645-1658
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Wang YX, Dai W, Li YZ, Wu ZY, Kan YQ, Zeng HC, He QZ
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.
Qi Z, Tong Y, Luo H, Chen M, Zhou N, Chen L
Bioorganic chemistry 2023 Mar;132:106350
Bioorganic chemistry 2023 Mar;132:106350
Meloxicam inhibited oxidative stress and inflammatory response of LPS-stimulated bovine endometrial epithelial cells through Nrf2 and NF-κB pathways.
Cui L, Guo J, Wang Z, Zhang J, Li W, Dong J, Liu K, Guo L, Li J, Wang H, Li J
International immunopharmacology 2023 Mar;116:109822
International immunopharmacology 2023 Mar;116:109822
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
Yang C, Lu T, Liu M, Yuan X, Li D, Zhang J, Zhou L, Xu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury.
Zhang J, Zhang M, Huo XK, Ning J, Yu ZL, Morisseau C, Sun CP, Hammock BD, Ma XC
ACS central science 2023 Mar 22;9(3):440-456
ACS central science 2023 Mar 22;9(3):440-456
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Yang X, Dong S, Li C, Li M, Xing C, He J, Peng C, Shao H, Jia Q
Toxicology letters 2023 Mar 1;376:39-50
Toxicology letters 2023 Mar 1;376:39-50
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Ma Y, Zhang X, Han X, Hao Z, Ji R, Li J, Guo W, Zhang Y, Guan F, Ma S
Molecular carcinogenesis 2023 Jun;62(6):866-881
Molecular carcinogenesis 2023 Jun;62(6):866-881
Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Li ZB, Jiang L, Ni JD, Xu YH, Liu F, Liu WM, Wang SG, Liu ZQ, Wang CY
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
Acta pharmacologica Sinica 2023 Jun;44(6):1191-1205
TRIM25 promotes temozolomide resistance in glioma by regulating oxidative stress and ferroptotic cell death via the ubiquitination of keap1.
Wei J, Wang L, Zhang Y, Sun T, Zhang C, Hu Z, Zhou L, Liu X, Wan J, Ma L
Oncogene 2023 Jun;42(26):2103-2112
Oncogene 2023 Jun;42(26):2103-2112
Impact of Nrf2 overexpression on cholangiocarcinoma treatment and clinical prognosis.
Lee H, Min SK, Cho MS, Lee HK
Korean journal of clinical oncology 2023 Jun;19(1):18-26
Korean journal of clinical oncology 2023 Jun;19(1):18-26
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Wang Z, Li R, Hou N, Zhang J, Wang T, Fan P, Ji C, Zhang B, Liu L, Wang Y, Kong J, Yao Q, Duan J, Zhao G, Ling R, Zhang J
Journal for immunotherapy of cancer 2023 Jun;11(6)
Journal for immunotherapy of cancer 2023 Jun;11(6)
Formononetin alleviates acute pancreatitis by reducing oxidative stress and modulating intestinal barrier.
Yang J, Sha X, Wu D, Wu B, Pan X, Pan LL, Gu Y, Dong X
Chinese medicine 2023 Jun 27;18(1):78
Chinese medicine 2023 Jun 27;18(1):78
A Mango Leaf Extract (Zynamite(®)) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle.
Martinez-Canton M, Galvan-Alvarez V, Garcia-Gonzalez E, Gallego-Selles A, Gelabert-Rebato M, Garcia-Perez G, Santana A, Lopez-Rios L, Vega-Morales T, Martin-Rincon M, Calbet JAL
Nutrients 2023 Jun 23;15(13)
Nutrients 2023 Jun 23;15(13)
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway.
Dong L, Xu M, Li Y, Xu W, Wu C, Zheng H, Xiao Z, Sun G, Ding L, Li X, Li W, Zhou L, Xia Q
Cell death & disease 2023 Jun 14;14(6):361
Cell death & disease 2023 Jun 14;14(6):361
EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis.
Zhang CY, Zhong WJ, Liu YB, Duan JX, Jiang N, Yang HH, Ma SC, Jin L, Hong JR, Zhou Y, Guan CX
Redox biology 2023 Jul;63:102765
Redox biology 2023 Jul;63:102765
NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors.
Zhong Z, Zhang C, Ni S, Ma M, Zhang X, Sang W, Lv T, Qian Z, Yi C, Yu B
Redox biology 2023 Jul;63:102711
Redox biology 2023 Jul;63:102711
Astragaloside IV attenuates podocyte apoptosis through ameliorating mitochondrial dysfunction by up-regulated Nrf2-ARE/TFAM signaling in diabetic kidney disease.
Shen Q, Fang J, Guo H, Su X, Zhu B, Yao X, Wang Y, Cao A, Wang H, Wang L
Free radical biology & medicine 2023 Jul;203:45-57
Free radical biology & medicine 2023 Jul;203:45-57
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Li X, Yu X, He S, Li J
International immunopharmacology 2023 Jul;120:110404
International immunopharmacology 2023 Jul;120:110404
Nuclear Factor Erythroid 2-Related Factor 2/Kelch-Like ECH-Associated Protein 1 as a Predictor of Prognosis and Radiotherapy Resistance in Patients With Locally Advanced Rectal Cancer: A Prospective Analysis.
Park JM, Kim S, Bae SU, Byun SJ, Seo I, Lee HW
Journal of Korean medical science 2023 Jul 3;38(26):e200
Journal of Korean medical science 2023 Jul 3;38(26):e200
Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis.
Wen RJ, Dong X, Zhuang HW, Pang FX, Ding SC, Li N, Mai YX, Zhou ST, Wang JY, Zhang JF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154881
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154881
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
Ikeda R, Noshiro D, Morishita H, Takada S, Kageyama S, Fujioka Y, Funakoshi T, Komatsu-Hirota S, Arai R, Ryzhii E, Abe M, Koga T, Motohashi H, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura Y, Noda NN, Komatsu M
The EMBO journal 2023 Jul 17;42(14):e113349
The EMBO journal 2023 Jul 17;42(14):e113349
Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro.
Zhu Y, Han Y, Wang W, Liang G, Qi J
Journal of ethnopharmacology 2023 Jul 15;311:116286
Journal of ethnopharmacology 2023 Jul 15;311:116286
Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex.
Kurusu R, Fujimoto Y, Morishita H, Noshiro D, Takada S, Yamano K, Tanaka H, Arai R, Kageyama S, Funakoshi T, Komatsu-Hirota S, Taka H, Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, Komatsu M
Developmental cell 2023 Jul 10;58(13):1189-1205.e11
Developmental cell 2023 Jul 10;58(13):1189-1205.e11
Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway.
Xiao S, Zhou Y, Gao H, Yang D
Molecular medicine reports 2023 Jan;27(1)
Molecular medicine reports 2023 Jan;27(1)
Induction of ferroptosis by HO-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal.
Chen C, Yang K, He D, Yang B, Tao L, Chen J, Wu Y
Free radical biology & medicine 2023 Jan;194:245-254
Free radical biology & medicine 2023 Jan;194:245-254
Pine pollen extract alleviates ethanol-induced oxidative stress and apoptosis in HepG2 cells via MAPK signaling.
Ma D, Wang Z, He Z, Wang Z, Chen Q, Qin F, Zeng M, Chen J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113550
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113550
Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes.
Tsui KH, Li CJ
Aging 2023 Jan 9;15(1):246-260
Aging 2023 Jan 9;15(1):246-260
Bifidobacterium animalis A12 and Lactobacillus salivarius M18-6 Alleviate Alcohol Injury by keap1-Nrf2 Pathway and Thioredoxin System.
Zhang Y, Ma J, Jing N, Zhang H, Xie Y, Liu H, Shan X, Ren J, Jin J
Foods (Basel, Switzerland) 2023 Jan 17;12(3)
Foods (Basel, Switzerland) 2023 Jan 17;12(3)
Hydrogen sulfide protects retinal pigment epithelium cells against ferroptosis through the AMPK- and p62-dependent non-canonical NRF2-KEAP1 pathway.
Yu M, Wang W, Dang J, Liu B, Xu J, Li J, Liu Y, He L, Ying Y, Cai J, Cheng G, Liu K
Experimental cell research 2023 Jan 1;422(1):113436
Experimental cell research 2023 Jan 1;422(1):113436
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Yang J, Han F, Wu G, Dong Y, Su H, Xu J, Li J
Digestive diseases and sciences 2023 Feb;68(2):478-486
Digestive diseases and sciences 2023 Feb;68(2):478-486
Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities.
Gao C, Zhu M, Xu W, Wang Y, Xiong L, Sun D, Sun M, Lin Y, Li H, Chen L
Bioorganic chemistry 2023 Feb;131:106281
Bioorganic chemistry 2023 Feb;131:106281
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Zhu D, Kong M, Chen C, Luo J, Kong L
International immunopharmacology 2023 Feb;115:109689
International immunopharmacology 2023 Feb;115:109689
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Li M, Peng Y, Chen W, Gao Y, Yang M, Li J, He J
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Zhang M, Zhang J, Zhu QM, Zhao WY, Lv X, Yi J, Huo XK, Wang MJ, Sun CP
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
The Journal of pharmacy and pharmacology 2023 Feb 8;75(2):287-299
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis.
Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X, Lin SH, Xu Y, Qiu Y
mBio 2023 Feb 28;14(1):e0237022
mBio 2023 Feb 28;14(1):e0237022
Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells.
Fernández-Acosta R, Hassannia B, Caroen J, Wiernicki B, Alvarez-Alminaque D, Verstraeten B, Van der Eycken J, Vandenabeele P, Vanden Berghe T, Pardo-Andreu GL
Cells 2023 Feb 24;12(5)
Cells 2023 Feb 24;12(5)
Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy.
Xia Q, Li Y, Xu W, Wu C, Zheng H, Liu L, Dong L
Cell & bioscience 2023 Feb 21;13(1):37
Cell & bioscience 2023 Feb 21;13(1):37
Piperlongumine conjugates induce targeted protein degradation.
Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, Zhou S, Hua N, Mackintosh SG, Zhang X, Basso KB, Kamat M, Yang Q, Licht JD, Zheng G, Zhou D, Lv D
Cell chemical biology 2023 Feb 16;30(2):203-213.e17
Cell chemical biology 2023 Feb 16;30(2):203-213.e17
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Yang CS, Guo XS, Yue YY, Wang Y, Jin XL
International journal of molecular sciences 2023 Feb 14;24(4)
International journal of molecular sciences 2023 Feb 14;24(4)
Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
Fei Q, Liu J, Qiao L, Zhang M, Xia H, Lu D, Wu D, Wang J, Li R, Li J, Yang F, Liu D, Xie B, Hui W, Qian B
Biochemical and biophysical research communications 2023 Feb 12;644:140-148
Biochemical and biophysical research communications 2023 Feb 12;644:140-148
Cytotoxicity and cell injuries of flavored electronic cigarette aerosol and mainstream cigarette smoke: A comprehensive in vitro evaluation.
Wang L, Wang Y, Yang X, Duan K, Jiang X, Chen J, Liu P, Li M
Toxicology letters 2023 Feb 1;374:96-110
Toxicology letters 2023 Feb 1;374:96-110
17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation.
Yang R, Li J, Zhang J, Xue Q, Qin R, Wang R, Goltzman D, Miao D
Free radical biology & medicine 2023 Feb 1;195:231-244
Free radical biology & medicine 2023 Feb 1;195:231-244
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.
Ding J, Lu B, Liu L, Zhong Z, Wang N, Li B, Sheng W, He Q
Pharmaceutical biology 2023 Dec;61(1):213-227
Pharmaceutical biology 2023 Dec;61(1):213-227
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Huang J, Zhu Y, Li S, Jiang H, Chen N, Xiao H, Liu J, Liang D, Zheng Q, Tang J, Meng X
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis.
Ji ZH, Xie WY, Zhao PS, Wu HY, Ren WZ, Hu JP, Gao W, Yuan B
Nutrients 2023 Dec 9;15(24)
Nutrients 2023 Dec 9;15(24)
Novel Antioxidant Peptides Derived from Feather Keratin Alleviate H(2)O(2)-Induced Oxidative Damage in HepG2 Cells via Keap1/Nrf2 Pathway.
Pei XD, He YN, Wu QL, Zhang YM, Li F, Jiao DQ, Liu XL, Wang CH
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20062-20072
Journal of agricultural and food chemistry 2023 Dec 20;71(50):20062-20072
Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2.
LaPak KM, Saeidi S, Bok I, Wamsley NT, Plutzer IB, Bhatt DP, Luo J, Ashrafi G, Ben Major M
Science signaling 2023 Dec 12;16(815):eadi9018
Science signaling 2023 Dec 12;16(815):eadi9018
Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia.
Joma N, Zhang I, Righetto GL, McKay L, Gran ER, Kakkar A, Maysinger D
Cells 2023 Dec 12;12(24)
Cells 2023 Dec 12;12(24)
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats.
He JY, Li DD, Wen Q, Qin TY, Long H, Zhang SB, Zhang F
CNS neuroscience & therapeutics 2023 Aug;29(8):2281-2291
CNS neuroscience & therapeutics 2023 Aug;29(8):2281-2291
FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner.
Kim JW, Kim MJ, Han TH, Lee JY, Kim S, Kim H, Oh KJ, Kim WK, Han BS, Bae KH, Ban HS, Bae SH, Lee SC, Lee H, Lee EW
Cell death & disease 2023 Aug 26;14(8):567
Cell death & disease 2023 Aug 26;14(8):567
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways.
Shi M, Zhang J, Li M, Zhao Y, Guo Y, Xu J, Liu R, Li Z, Ren D, Liu P
Journal of medicinal chemistry 2023 Aug 24;66(16):11324-11334
Journal of medicinal chemistry 2023 Aug 24;66(16):11324-11334
Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling.
Lai X, Wu A, Bing Y, Liu Y, Luo J, Yan H, Zheng P, Yu J, Chen D
Free radical biology & medicine 2023 Aug 20;205:202-213
Free radical biology & medicine 2023 Aug 20;205:202-213
Molecular mechanism of kidney damage caused by abamectin in carp: Oxidative stress, inflammation, mitochondrial damage, and apoptosis.
Wu X, Ma Y, Li X, He N, Zhang T, Liu F, Feng H, Dong J
Toxicology 2023 Aug 1;494:153599
Toxicology 2023 Aug 1;494:153599
TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling.
Xu T, Yang Y, Chen Z, Wang J, Wang X, Zheng Y, Wang C, Wang Y, Zhu Z, Ding X, Zhou J, Li G, Zhang H, Zhang W, Wu Y, Song X
Journal of experimental & clinical cancer research : CR 2023 Aug 1;42(1):190
Journal of experimental & clinical cancer research : CR 2023 Aug 1;42(1):190
GSK-3β-dependent Nrf2 antioxidant response modulates ferroptosis of lens epithelial cells in age-related cataract.
Ma DY, Liu JX, Wang LD, Zhi XY, Luo L, Zhao JY, Qin Y
Free radical biology & medicine 2023 Aug 1;204:161-176
Free radical biology & medicine 2023 Aug 1;204:161-176
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Wang Y, Tang B, Li H, Zheng J, Zhang C, Yang Z, Tan X, Luo P, Ma L, Wang Y, Long L, Chen Z, Xiao Z, Ma L, Zhou J, Wang Y, Shi C
EBioMedicine 2023 Apr;90:104480
EBioMedicine 2023 Apr;90:104480
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Synthesis of Lathyrol PROTACs and Evaluation of Their Anti-Inflammatory Activities.
Wang W, Liu Y, Xiong L, Sun D, Wang H, Song Z, Li Y, Li H, Chen L
Journal of natural products 2023 Apr 28;86(4):767-781
Journal of natural products 2023 Apr 28;86(4):767-781
MTX-211 Inhibits GSH Synthesis through Keap1/NRF2/GCLM Axis and Exerts Antitumor Effects in Bladder Cancer.
Hu B, Chen R, Jiang M, Xiong S, Xie A, Liu X, Fu B
International journal of molecular sciences 2023 Apr 20;24(8)
International journal of molecular sciences 2023 Apr 20;24(8)
Involvements of Nrf2 and oxidative stress in the ozone-elicited exacerbation in an allergic rhinitis model.
Sun N, Huang Y, Zhang X, Niu Y, Duan Y, Kan H, Zhang R
Ecotoxicology and environmental safety 2023 Apr 15;255:114822
Ecotoxicology and environmental safety 2023 Apr 15;255:114822
Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress.
Zou P, Zhang X, Zhang R, Chai X, Zhao Y, Li E, Zhang Q, Yan R, Yang J, Liao B
Frontiers in molecular biosciences 2022;9:853654
Frontiers in molecular biosciences 2022;9:853654
Tannic acid attenuates intestinal oxidative damage by improving antioxidant capacity and intestinal barrier in weaned piglets and IPEC-J2 cells.
Wang M, Huang H, Wang L, Yin L, Yang H, Chen C, Zheng Q, He S
Frontiers in nutrition 2022;9:1012207
Frontiers in nutrition 2022;9:1012207
Carbon Monoxide-Releasing Molecule-3 Suppresses the Malignant Biological Behavior of Tongue Squamous Cell Carcinoma via Regulating Keap1/Nrf2/HO-1 Signaling Pathway.
Dai Y, Chen H, Pan Y, Song H
BioMed research international 2022;2022:9418332
BioMed research international 2022;2022:9418332
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury.
Li X, Chen J, Yuan S, Zhuang X, Qiao T
Oxidative medicine and cellular longevity 2022;2022:8973509
Oxidative medicine and cellular longevity 2022;2022:8973509
Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos.
Yan CY, Sun J, Yu GY, Liu JH, Huang RP, Han SC, Zhang QY, Li XM, Yan JG, Kurihara H, Li WX, Li YF, He RR
Oxidative medicine and cellular longevity 2022;2022:4932304
Oxidative medicine and cellular longevity 2022;2022:4932304
Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester.
Guan D, Zhou W, Wei H, Wang T, Zheng K, Yang C, Feng R, Xu R, Fu Y, Li C, Li Y, Li C
Oxidative medicine and cellular longevity 2022;2022:3920664
Oxidative medicine and cellular longevity 2022;2022:3920664
HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation.
Han S, Lin F, Qi Y, Liu C, Zhou L, Xia Y, Chen K, Xing J, Liu Z, Yu W, Zhang Y, Zhou X, Rao T, Cheng F
Oxidative medicine and cellular longevity 2022;2022:3846217
Oxidative medicine and cellular longevity 2022;2022:3846217
The Protective Effect of Ursolic Acid on Unilateral Ureteral Obstruction in Rats by Activating the Nrf2/HO-1 Antioxidant Signaling Pathway.
Pei J, Wu M, Cai S, Peng J, Zhan X, Wang D, Wang W, An N
Computational intelligence and neuroscience 2022;2022:3690524
Computational intelligence and neuroscience 2022;2022:3690524
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Chen P, Yang J, Wu N, Han B, Kastelic JP, Gao J
Oxidative medicine and cellular longevity 2022;2022:2549772
Oxidative medicine and cellular longevity 2022;2022:2549772
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Xiao S, Zhou Y, Wang Q, Yang D
Drug design, development and therapy 2022;16:4411-4428
Drug design, development and therapy 2022;16:4411-4428
Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress.
Jia Z, Wang P, Xu Y, Feng G, Wang Q, He X, Song Y, Liu P, Chen J
Frontiers in pharmacology 2022;13:986510
Frontiers in pharmacology 2022;13:986510
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Wang J, Wang K, Ding L, Zhao P, Zhang C, Wang H, Yang Z, Liu Z
Frontiers in pharmacology 2022;13:969892
Frontiers in pharmacology 2022;13:969892
(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H(2)O(2) Through Activation of Nrf2 Pathway.
Qi S, Zhang X, Fu Z, Pi A, Shi F, Fan Y, Zhang J, Xiao T, Shang D, Lin M, Gao N, Chang J, Gao Y
Frontiers in pharmacology 2022;13:943111
Frontiers in pharmacology 2022;13:943111
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Yang T, Lin X, Li H, Zhou X, Fan F, Yang J, Luo Y, Liu X
Frontiers in pharmacology 2022;13:927871
Frontiers in pharmacology 2022;13:927871
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Berberine prevents lethal EV71 neurological infection in newborn mice.
Cui G, Wang H, Yang C, Zhou X, Wang J, Wang T, Ma T
Frontiers in pharmacology 2022;13:1027566
Frontiers in pharmacology 2022;13:1027566
Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection.
Xi J, Zhang Z, Wang Z, Wu Q, He Y, Xu Y, Ding Z, Zhao H, Da H, Zhang F, Zhao H, Fang J
Free radical biology & medicine 2022 Sep;190:202-215
Free radical biology & medicine 2022 Sep;190:202-215
Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment.
Burns VE, Kerppola TK
Immunology 2022 Sep;167(1):105-121
Immunology 2022 Sep;167(1):105-121
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
Wang ZC, Niu KM, Wu YJ, Du KR, Qi LW, Zhou YB, Sun HJ
Cell death & disease 2022 Sep 26;13(9):824
Cell death & disease 2022 Sep 26;13(9):824
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
Wang K, Tang Y, Wu X, Liang H, Chen D, Yu B, He J, Mao X, Huang Z, Yan H, Wu A, Luo Y, Zheng P, Yu J, Wang H, Luo J
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Chen TY, Zheng SK
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling.
Zhang Y, Yang S, Qiu Z, Huang L, Huang L, Liang Y, Liu X, Wang M, Zhou B
Free radical biology & medicine 2022 Oct;191:66-81
Free radical biology & medicine 2022 Oct;191:66-81
Acadesine alleviates acute pancreatitis-related lung injury by mediating the barrier protective function of pulmonary microvascular endothelial cells.
Zhu X, Duan F, Zhang Y, Wang X, Wang Y, Chen J, Zhang L, Wu M, Pan Z, Chen B
International immunopharmacology 2022 Oct;111:109165
International immunopharmacology 2022 Oct;111:109165
Immature rat testis sustained long-term development using an integrative model.
Ma Y, Chen J, Li H, Xu F, Chong T, Wang Z, Zhang L
Biological research 2022 Oct 4;55(1):30
Biological research 2022 Oct 4;55(1):30
Potential contribution of early endothelial progenitor cell (eEPC)-to-macrophage switching in the development of pulmonary plexogenic lesion.
Shao FJ, Guo XL, Xu JX, Liu R, Li DY, Li QH, Zhou T, Fang C, Tan X
Respiratory research 2022 Oct 23;23(1):290
Respiratory research 2022 Oct 23;23(1):290
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Zhou W, Wu WH, Si ZL, Liu HL, Wang H, Jiang H, Liu YF, Alolga RN, Chen C, Liu SJ, Bian XY, Shan JJ, Li J, Tan NH, Zhang ZH
Nature communications 2022 Oct 14;13(1):6081
Nature communications 2022 Oct 14;13(1):6081
Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue.
Li Y, Hao D, Wei D, Xiao Y, Liu L, Li X, Wang L, Gan Y, Yan W, Ke B, Jiang X
Molecules (Basel, Switzerland) 2022 Oct 10;27(19)
Molecules (Basel, Switzerland) 2022 Oct 10;27(19)
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Wang T, Liu J, Huang X, Zhang C, Shangguan M, Chen J, Wu S, Chen M, Yang Z, Zhao S
Oncology reports 2022 Nov;48(5)
Oncology reports 2022 Nov;48(5)
Xiaojianzhong decoction attenuates gastric mucosal injury by activating the p62/Keap1/Nrf2 signaling pathway to inhibit ferroptosis.
Chen J, Zhang J, Chen T, Bao S, Li J, Wei H, Hu X, Liang Y, Liu F, Yan S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113631
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113631
Oxidative stress in the RVLM mediates sympathetic hyperactivity induced by circadian disruption.
Duan W, Ye P, Leng YQ, Liu DH, Sun JC, Tan X, Wang WZ
Neuroscience letters 2022 Nov 20;791:136917
Neuroscience letters 2022 Nov 20;791:136917
Salecan ameliorates liver injury by regulating gut microbiota and its metabolites.
Li P, Liu Y, Zhao J, Pan W, He Y, Fu S, Liu Y, Xu YJ
Food & function 2022 Nov 14;13(22):11744-11757
Food & function 2022 Nov 14;13(22):11744-11757
FOXO4 mediates resistance to oxidative stress in lens epithelial cells by modulating the TRIM25/Nrf2 signaling.
Yang X, Zhang F, Liu X, Meng J, Du S, Shao J, Liu J, Fang M
Experimental cell research 2022 Nov 1;420(1):113340
Experimental cell research 2022 Nov 1;420(1):113340
Caspase-8 mutants activate Nrf2 via phosphorylating SQSTM1 to protect against oxidative stress in esophageal squamous cell carcinoma.
Li L, Feng R, Li Y, Yu X, Liu Y, Zhao Y, Liu Z
Free radical biology & medicine 2022 Nov 1;192:51-62
Free radical biology & medicine 2022 Nov 1;192:51-62
Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation.
Wang YF, Chang YY, Zhang XM, Gao MT, Zhang QL, Li X, Zhang L, Yao WF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154020
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154020
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Li J, Li Y, Lin S, Zhao W, Chen Y, Jin H
Journal of food science 2022 May;87(5):2185-2196
Journal of food science 2022 May;87(5):2185-2196
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Zhao R, Wang L, Wang T, Xian P, Wang H, Long Q
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2.
Sun X, Dong M, Gao Y, Wang Y, Du L, Liu Y, Wang Q, Ji K, He N, Wang J, Zhang M, Gu Y, Song H, Zhai H, Feng L, Xu C, Liu Q
Biochemical pharmacology 2022 May;199:114981
Biochemical pharmacology 2022 May;199:114981
The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway.
Xu J, Wu H, Sun J, Gong Z, Lu X, Yang E, Chen Z, Huang S, Nong X, Zhang D
Head & face medicine 2022 May 6;18(1):15
Head & face medicine 2022 May 6;18(1):15
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H
Cell 2022 May 26;185(11):1974-1985.e12
Cell 2022 May 26;185(11):1974-1985.e12
Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma.
Fahrmann JF, Tanaka I, Irajizad E, Mao X, Dennison JB, Murage E, Casabar J, Mayo J, Peng Q, Celiktas M, Vykoukal JV, Park S, Taguchi A, Delgado O, Tripathi SC, Katayama H, Soto LMS, Rodriguez-Canales J, Behrens C, Wistuba I, Hanash S, Ostrin EJ
Cancers 2022 May 21;14(10)
Cancers 2022 May 21;14(10)
Protective effect of resveratrol against hydrogen peroxide-induced oxidative stress in bovine skeletal muscle cells.
Zhang X, Liu X, Wan F, You W, Tan X, Sheng Q, Li C, Hu Z, Liu G, Zhao H
Meat science 2022 Mar;185:108724
Meat science 2022 Mar;185:108724
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
Ding XQ, Jian TY, Gai YN, Niu GT, Liu Y, Meng XH, Li J, Lyu H, Ren BR, Chen J
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2923-2935
A Novel Pyrazolo[3,4-d]pyrimidine Induces Heme Oxygenase-1 and Exerts Anti-Inflammatory and Neuroprotective Effects.
Lee JA, Kwon YW, Kim HR, Shin N, Son HJ, Cheong CS, Kim DJ, Hwang O
Molecules and cells 2022 Mar 31;45(3):134-147
Molecules and cells 2022 Mar 31;45(3):134-147
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
Fu F, Lai Q, Hu J, Zhang L, Zhu X, Kou J, Yu B, Li F
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.
Kunder R, Velyunskiy M, Dunne SF, Cho BK, Kanojia D, Begg L, Orriols AM, Fleming-Trujillo E, Vadlamani P, Vialichka A, Bolin R, Perrino JN, Roth D, Clutter MR, Zielinski-Mozny NA, Goo YA, Cristofanilli M, Mendillo ML, Vassilopoulos A, Horiuchi D
Cell chemical biology 2022 Mar 17;29(3):358-372.e5
Cell chemical biology 2022 Mar 17;29(3):358-372.e5
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Xu F, Zhang J, Zhou X, Hao H
Experimental cell research 2022 Mar 1;412(1):113025
Experimental cell research 2022 Mar 1;412(1):113025
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.
Zhu L, He S, Huang L, Ren D, Nie T, Tao K, Xia L, Lu F, Mao Z, Yang Q
Aging cell 2022 Jun;21(6):e13616
Aging cell 2022 Jun;21(6):e13616
m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Liang D, Lin WJ, Ren M, Qiu J, Yang C, Wang X, Li N, Zeng T, Sun K, You L, Yan L, Wang W
Autophagy 2022 Jun;18(6):1318-1337
Autophagy 2022 Jun;18(6):1318-1337
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Li S, Ma Y, Ye S, Su Y, Hu D, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells.
Han X, Liu P, Zheng B, Zhang M, Zhang Y, Xue Y, Liu C, Chu X, Wang X, Sun S, Chu L
The Journal of nutritional biochemistry 2022 Jun;104:108975
The Journal of nutritional biochemistry 2022 Jun;104:108975
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H
Stem cell research & therapy 2022 Jun 7;13(1):241
Stem cell research & therapy 2022 Jun 7;13(1):241
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Zhou X, Wang S, Zhou R, Zhang T, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhou X, Song N
Toxicology 2022 Jun 15;475:153227
Toxicology 2022 Jun 15;475:153227
Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5).
Shi F, Zhang Z, Cui H, Wang J, Wang Y, Tang Y, Yang W, Zou P, Ling X, Han F, Liu J, Chen Q, Liu C, Cao J, Ao L
Ecotoxicology and environmental safety 2022 Jun 15;238:113569
Ecotoxicology and environmental safety 2022 Jun 15;238:113569
Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.
Li N, Du H, Mao L, Xu G, Zhang M, Fan Y, Dong X, Zheng L, Wang B, Qin X, Jiang X, Chen C, Zou Z, Zhang J
Journal of nanobiotechnology 2022 Jun 11;20(1):270
Journal of nanobiotechnology 2022 Jun 11;20(1):270
Antioxidant potential of Pediococcus pentosaceus strains from the sow milk bacterial collection in weaned piglets.
Wang L, Liu Q, Chen Y, Zheng X, Wang C, Qi Y, Dong Y, Xiao Y, Chen C, Chen T, Huang Q, Zhai Z, Long C, Yang H, Li J, Wang L, Zhang G, Liao P, Liu YX, Huang P, Huang J, Wang Q, Chu H, Yin J, Yin Y
Microbiome 2022 Jun 1;10(1):83
Microbiome 2022 Jun 1;10(1):83
Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice.
Li A, Li XM, Song CG, Xiao X, Yao WM, Tian HS
Amino acids 2022 Jul;54(7):1069-1081
Amino acids 2022 Jul;54(7):1069-1081
Clusterin protects against Cr(VI)-induced oxidative stress-associated hepatotoxicity by mediating the Akt-Keap1-Nrf2 signaling pathway.
Ma Y, Li S, Tang S, Ye S, Liang N, Liang Y, Xiao F
Environmental science and pollution research international 2022 Jul;29(34):52289-52301
Environmental science and pollution research international 2022 Jul;29(34):52289-52301
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
Sulforaphane Acts Through NFE2L2 to Prevent Hypoxia-Induced Apoptosis in Porcine Granulosa Cells via Activating Antioxidant Defenses and Mitophagy.
Zhang X, Chen Y, Li H, Chen B, Liu Z, Wu G, Li C, Li R, Cao Y, Zhou J, Shen M, Liu H, Tao J
Journal of agricultural and food chemistry 2022 Jul 6;70(26):8097-8110
Journal of agricultural and food chemistry 2022 Jul 6;70(26):8097-8110
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
Zhang QY, Han SC, Huang RP, Jiang MY, Yan CY, Li XY, Zhan YJ, Li XM, Li YF, Kurihara H, Tan RR, Li WX, He RR
Food & function 2022 Jul 4;13(13):6962-6974
Food & function 2022 Jul 4;13(13):6962-6974
Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.
Li DM, Wu YX, Hu ZQ, Wang TC, Zhang LL, Zhou Y, Tong X, Xu JY, Qin LQ
Antioxidants (Basel, Switzerland) 2022 Jul 31;11(8)
Antioxidants (Basel, Switzerland) 2022 Jul 31;11(8)
Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model.
Joelsson JP, Asbjarnarson A, Sigurdsson S, Kricker J, Valdimarsdottir B, Thorarinsdottir H, Starradottir E, Gudjonsson T, Ingthorsson S, Karason S
Laboratory animal research 2022 Jul 22;38(1):23
Laboratory animal research 2022 Jul 22;38(1):23
Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine.
Li F, Zhou J, Zhu X, Lu R, Ye Y, Wang S, Xing G, Shen H
Toxicology letters 2022 Jul 15;365:61-73
Toxicology letters 2022 Jul 15;365:61-73
An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.
Zhao X, Sun J, Dong J, Guo C, Cai W, Han J, Shen H, Lv S, Zhang R
Acta biomaterialia 2022 Jul 15;147:327-341
Acta biomaterialia 2022 Jul 15;147:327-341
Upregulation of Nox4 induces a pro-survival Nrf2 response in cancer-associated fibroblasts that promotes tumorigenesis and metastasis, in part via Birc5 induction.
Mir S, Ormsbee Golden BD, Griess BJ, Vengoji R, Tom E, Kosmacek EA, Oberley-Deegan RE, Talmon GA, Band V, Teoh-Fitzgerald ML
Breast cancer research : BCR 2022 Jul 14;24(1):48
Breast cancer research : BCR 2022 Jul 14;24(1):48
GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling.
Chen T, Jinlin D, Wang F, Yuan Z, Xue J, Lu T, Huang W, Liu Y, Zhang Y
Cancer letters 2022 Jul 10;538:215692
Cancer letters 2022 Jul 10;538:215692
Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury.
Luo C, Ding W, Yang C, Zhang W, Liu X, Deng H
Journal of proteome research 2022 Jul 1;21(7):1759-1770
Journal of proteome research 2022 Jul 1;21(7):1759-1770
Role of Nox4 in High Calcium-Induced Renal Oxidative Stress Damage and Crystal Deposition.
Xun Y, Zhou P, Yang Y, Li C, Zhang J, Hu H, Qin B, Zhang Z, Wang Q, Lu Y, Wang S
Antioxidants & redox signaling 2022 Jan;36(1-3):15-38
Antioxidants & redox signaling 2022 Jan;36(1-3):15-38
USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity.
Sango J, Kakihana T, Takahashi M, Katsuragi Y, Anisimov S, Komatsu M, Fujii M
The Journal of biological chemistry 2022 Jan;298(1):101448
The Journal of biological chemistry 2022 Jan;298(1):101448
Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.
Yang R, Zhang J, Li J, Qin R, Chen J, Wang R, Goltzman D, Miao D
Free radical biology & medicine 2022 Jan;178:246-261
Free radical biology & medicine 2022 Jan;178:246-261
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth-retarded finishing pigs.
Zhang J, Yan E, Zhang L, Wang T, Wang C
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13741
Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats.
Sargin P, Roethle MF, Jia S, Pant T, Ciecko AE, Atkinson SN, Salzman NH, Teng RJ, Chen YG, Cabrera SM, Hessner MJ
Gut microbes 2022 Jan-Dec;14(1):2136467
Gut microbes 2022 Jan-Dec;14(1):2136467
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB.
Xu LT, Wang T, Fang KL, Zhao Y, Wang XN, Ren DM, Shen T
Journal of ethnopharmacology 2022 Jan 30;283:114694
Journal of ethnopharmacology 2022 Jan 30;283:114694
Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1.
Ngo V, Karunatilleke NC, Brickenden A, Choy WY, Duennwald ML
Antioxidants (Basel, Switzerland) 2022 Jan 27;11(2)
Antioxidants (Basel, Switzerland) 2022 Jan 27;11(2)
Ellagic Acid Alleviates Oxidative Stress by Mediating Nrf2 Signaling Pathways and Protects against Paraquat-Induced Intestinal Injury in Piglets.
Xiao Y, Huang R, Wang N, Deng Y, Tan B, Yin Y, Qi M, Wang J
Antioxidants (Basel, Switzerland) 2022 Jan 27;11(2)
Antioxidants (Basel, Switzerland) 2022 Jan 27;11(2)
Ellagic acid ameliorates paraquat-induced liver injury associated with improved gut microbial profile.
Qi M, Wang N, Xiao Y, Deng Y, Zha A, Tan B, Wang J, Yin Y, Liao P
Environmental pollution (Barking, Essex : 1987) 2022 Jan 15;293:118572
Environmental pollution (Barking, Essex : 1987) 2022 Jan 15;293:118572
MiR-125b attenuates retinal pigment epithelium oxidative damage via targeting Nrf2/HIF-1α signal pathway.
Liu JX, Ma DY, Zhi XY, Wang MW, Zhao JY, Qin Y
Experimental cell research 2022 Jan 1;410(1):112955
Experimental cell research 2022 Jan 1;410(1):112955
A detrimental role of NLRP6 in host iron metabolism during Salmonella infection.
Deng Q, Yang S, Sun L, Huang K, Dong K, Zhu Y, Cao Y, Li Y, Wu S, Huang R
Redox biology 2022 Feb;49:102217
Redox biology 2022 Feb;49:102217
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liu YP, Yuan XY, Li XY, Wang Y, Sun ZB, Deng WH, Lei YD, Huang L, Jiang TY, Zhang ZH
Journal of applied toxicology : JAT 2022 Feb;42(2):230-243
Journal of applied toxicology : JAT 2022 Feb;42(2):230-243
Proteome analysis of NRF2 inhibition in melanoma reveals CD44 up-regulation and increased apoptosis resistance upon vemurafenib treatment.
Weitzenböck HP, Gschwendtner A, Wiesner C, Depke M, Schmidt F, Trautinger F, Hengstschläger M, Hundsberger H, Mikula M
Cancer medicine 2022 Feb;11(4):956-967
Cancer medicine 2022 Feb;11(4):956-967
Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways.
Zhong CC, Zhao T, Hogstrand C, Chen F, Song CC, Luo Z
The Journal of nutritional biochemistry 2022 Feb;100:108883
The Journal of nutritional biochemistry 2022 Feb;100:108883
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, Xu Z, Zhang S, Liu B, Chen Q
Cell & bioscience 2022 Feb 25;12(1):20
Cell & bioscience 2022 Feb 25;12(1):20
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Liu H, Zhao D, Li H, Zhang W, Lin Q, Wang X, Zheng S, Zhang L, Li L, Hu S, Hu Y
Cell death & disease 2022 Feb 21;13(2):166
Cell death & disease 2022 Feb 21;13(2):166
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Zhang L, Zhu XZ, Badamjav R, Zhang JZ, Kou JP, Yu BY, Li F
European journal of pharmacology 2022 Feb 15;917:174748
European journal of pharmacology 2022 Feb 15;917:174748
Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.
Chen GH, Song CC, Zhao T, Hogstrand C, Wei XL, Lv WH, Song YF, Luo Z
Environmental science & technology 2022 Feb 15;56(4):2407-2420
Environmental science & technology 2022 Feb 15;56(4):2407-2420
Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
Wang W, Xiong L, Li Y, Song Z, Sun D, Li H, Chen L
Bioorganic & medicinal chemistry 2022 Feb 15;56:116627
Bioorganic & medicinal chemistry 2022 Feb 15;56:116627
Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction.
Mundal SB, Rakner JJ, Silva GB, Gierman LM, Austdal M, Basnet P, Elschot M, Bakke SS, Ostrop J, Thomsen LCV, Moses EK, Acharya G, Bjørge L, Iversen AC
International journal of molecular sciences 2022 Feb 10;23(4)
International journal of molecular sciences 2022 Feb 10;23(4)
SRT1720 as an SIRT1 activator for alleviating paraquat-induced models of Parkinson's disease.
Chao CC, Huang CL, Cheng JJ, Chiou CT, Lee IJ, Yang YC, Hsu TH, Yei CE, Lin PY, Chen JJ, Huang NK
Redox biology 2022 Dec;58:102534
Redox biology 2022 Dec;58:102534
Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.
Zhang J, Zhang M, Zhang WH, Zhu QM, Huo XK, Sun CP, Ma XC, Xiao HT
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154380
Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.
Zhang J, Zhang M, Zhang WH, Zhu QM, Ning J, Huo XK, Xiao HT, Sun CP
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Dec;107:154377
Hatched Eggshell Membrane Can Be a Novel Source of Antioxidant Hydrolysates to Protect against H(2)O(2)-Induced Oxidative Stress in Human Chondrocytes.
Zhu L, Ma M, Ahn DU, Guyonnet V, Wang L, Zheng Y, He Q, Xiong H, Huang X
Antioxidants (Basel, Switzerland) 2022 Dec 9;11(12)
Antioxidants (Basel, Switzerland) 2022 Dec 9;11(12)
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
Shi K, Xiao Y, Dong Y, Wang D, Xie Y, Tu J, Xu K, Zhou Z, Cao G, Liu Y
International journal of molecular sciences 2022 Dec 17;23(24)
International journal of molecular sciences 2022 Dec 17;23(24)
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Ye H, Ma Z, Liu L, Zhang T, Han Q, Xiang Z, Xia Y, Ke Y, Guan X, Shi Q, Ataullakhanov FI, Panteleev M
ChemMedChem 2022 Dec 16;17(24):e202200317
ChemMedChem 2022 Dec 16;17(24):e202200317
The Integrated Analysis of Transcriptomics and Metabolomics Unveils the Therapeutical Effect of Asiatic Acid on Alcoholic Hepatitis in Rats.
Chen S, Huang Y, Su H, Zhu W, Wei Y, Long Y, Shi Y, Wei J
Inflammation 2022 Aug;45(4):1780-1799
Inflammation 2022 Aug;45(4):1780-1799
Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice.
Li H, Cao T, Ding W, Liang L, Fan GC, Qu L, Peng T
Journal of cardiovascular translational research 2022 Aug;15(4):805-815
Journal of cardiovascular translational research 2022 Aug;15(4):805-815
Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH.
Yang C, Wang T, Zhao Y, Meng X, Ding W, Wang Q, Liu C, Deng H
Free radical biology & medicine 2022 Aug 1;188:14-23
Free radical biology & medicine 2022 Aug 1;188:14-23
PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway.
Lee DH, Park JS, Lee YS, Bae SH
Redox biology 2022 Apr;50:102235
Redox biology 2022 Apr;50:102235
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Wu XY, Wang T, Hu HX, Zhang K, Zhao Y, Zhao BB, Lou HX, Wang XN, Shen T
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Phytotherapy research : PTR 2022 Apr;36(4):1692-1707
Sulforaphane improves cognitive dysfunction after surgery and anesthesia in mice: The role of Keap1-Nrf2 signaling.
Hua D, Luo A, Wu Z, Huang C, Li S, Xu X, Xu J, Yang C, Wang D, Liu C
Brain research bulletin 2022 Apr;181:1-11
Brain research bulletin 2022 Apr;181:1-11
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Hesperidin protects against cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2 pathway.
Jia Y, Guo H, Cheng X, Zhang Y, Si M, Shi J, Ma D
Food & function 2022 Apr 4;13(7):4205-4215
Food & function 2022 Apr 4;13(7):4205-4215
A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90.
Ngo V, Brickenden A, Liu H, Yeung C, Choy WY, Duennwald ML
Disease models & mechanisms 2022 Apr 1;15(4)
Disease models & mechanisms 2022 Apr 1;15(4)
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Peptides Isolated from Yak Milk Residue Exert Antioxidant Effects through Nrf2 Signal Pathway.
Yang F, He X, Chen T, Liu J, Luo Z, Sun S, Qin D, Huang W, Tang Y, Liu C, Luo F
Oxidative medicine and cellular longevity 2021;2021:9426314
Oxidative medicine and cellular longevity 2021;2021:9426314
Microglia-Derived Exosomes Improve Spinal Cord Functional Recovery after Injury via Inhibiting Oxidative Stress and Promoting the Survival and Function of Endothelia Cells.
Peng W, Wan L, Luo Z, Xie Y, Liu Y, Huang T, Lu H, Hu J
Oxidative medicine and cellular longevity 2021;2021:1695087
Oxidative medicine and cellular longevity 2021;2021:1695087
Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.
Pang Z, Jiang Z, Zhu R, Song C, Tang H, Cao L, Guo C
Drug design, development and therapy 2021;15:3735-3747
Drug design, development and therapy 2021;15:3735-3747
Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice.
Chen D, Gao ZQ, Wang YY, Wan BB, Liu G, Chen JL, Wu YX, Zhou Q, Jiang SY, Yu RQ, Pang QF
Journal of inflammation research 2021;14:803-816
Journal of inflammation research 2021;14:803-816
Analysis by Metabolomics and Transcriptomics for the Energy Metabolism Disorder and the Aryl Hydrocarbon Receptor Activation in Male Reproduction of Mice and GC-2spd Cells Exposed to PM(2.5).
Shi F, Zhang Z, Wang J, Wang Y, Deng J, Zeng Y, Zou P, Ling X, Han F, Liu J, Ao L, Cao J
Frontiers in endocrinology 2021;12:807374
Frontiers in endocrinology 2021;12:807374
Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice.
Jia Y, Li J, Liu P, Si M, Jin Y, Wang H, Ma D, Chu L
Frontiers in pharmacology 2021;12:758670
Frontiers in pharmacology 2021;12:758670
Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets.
Wang M, Huang H, Wang L, Yang H, He S, Liu F, Tu Q, He S
Frontiers in microbiology 2021;12:706758
Frontiers in microbiology 2021;12:706758
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, Wang Y, Du Z, Peng K, Liu H, Zhang Q, Tang F, Wang P, Gao S, Wang Y, Ding WX, Guo G, Wang F, Zong WX
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.
Cheng Y, Cheng L, Gao X, Chen S, Wu P, Wang C, Liu Z
Theranostics 2021;11(2):861-877
Theranostics 2021;11(2):861-877
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Salmonella Effector SpvB Inhibits NF-κB Activity via KEAP1-Mediated Downregulation of IKKβ.
Yang S, Deng Q, Sun L, Zhu Y, Dong K, Wu S, Huang R, Li Y
Frontiers in cellular and infection microbiology 2021;11:641412
Frontiers in cellular and infection microbiology 2021;11:641412
Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.
Jiang W, Wan L, Chen P, Lu W
Saudi journal of biological sciences 2021 Sep;28(9):4987-4993
Saudi journal of biological sciences 2021 Sep;28(9):4987-4993
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Li R, Qi Y, Yuan Q, Xu L, Gao M, Xu Y, Han X, Yin L, Liu C
European journal of pharmacology 2021 Sep 15;907:174277
European journal of pharmacology 2021 Sep 15;907:174277
Aged Ripe Pu-erh Tea Reduced Oxidative Stress-Mediated Inflammation in Dextran Sulfate Sodium-Induced Colitis Mice by Regulating Intestinal Microbes.
Hu S, Li S, Liu Y, Sun K, Luo L, Zeng L
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10592-10605
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription.
Burns VE, Kerppola TK
Journal of immunology (Baltimore, Md. : 1950) 2021 Sep 1;207(5):1437-1447
Journal of immunology (Baltimore, Md. : 1950) 2021 Sep 1;207(5):1437-1447
NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
Joshi CS, Mora A, Felder PA, Mysorekar IU
Cell reports 2021 Oct 19;37(3):109856
Cell reports 2021 Oct 19;37(3):109856
(-)-Epicatechin ameliorates cigarette smoke-induced lung inflammation via inhibiting ROS/NLRP3 inflammasome pathway in rats with COPD.
Tian X, Xue Y, Xie G, Zhou Y, Xiao H, Ding F, Zhang M
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Toxicology and applied pharmacology 2021 Oct 15;429:115674
Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway.
Ma Y, Li S, Ye S, Tang S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Ecotoxicology and environmental safety 2021 Oct 15;223:112614
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z, Wang W
Cell death & disease 2021 Oct 11;12(10):928
Cell death & disease 2021 Oct 11;12(10):928
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Nicotinamide improves NAD(+) levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Tripartite motif-containing protein 16 protects against myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis.
Cui Q, Yan L
Cell and tissue research 2021 Nov;386(2):349-363
Cell and tissue research 2021 Nov;386(2):349-363
Chemical Constituents from the Rhizome of Ligusticum chuanxiong Hort. and Their Nrf2 Inducing Activity.
Zhang K, Fang KL, Wang T, Xu LT, Zhao Y, Wang XN, Xiang L, Shen T
Chemistry & biodiversity 2021 Nov;18(11):e2100302
Chemistry & biodiversity 2021 Nov;18(11):e2100302
Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response.
Wang L, Wang X, Kong L, Wang S, Huang K, Wu J, Wang C, Sun H, Liu K, Meng Q
International immunopharmacology 2021 Nov;100:108159
International immunopharmacology 2021 Nov;100:108159
Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway.
Lin CY, Chang CB, Wu RC, Chao A, Lee YS, Tsai CN, Chen CH, Yen CF, Tsai CL
Antioxidants (Basel, Switzerland) 2021 Nov 26;10(12)
Antioxidants (Basel, Switzerland) 2021 Nov 26;10(12)
NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells.
Zhang H, Ge F, Shui X, Xiang Y, Wang X, Liao C, Wang J
Cell stress & chaperones 2021 May;26(3):495-504
Cell stress & chaperones 2021 May;26(3):495-504
Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities.
Hori Y, Tsutsumi R, Nasu K, Boateng A, Ashikari Y, Sugiura M, Nakajima M, Kurauchi Y, Hisatsune A, Katsuki H, Seki T
Cells 2021 May 3;10(5)
Cells 2021 May 3;10(5)
Coordinate regulation of the senescent state by selective autophagy.
Lee Y, Kim J, Kim MS, Kwon Y, Shin S, Yi H, Kim H, Chang MJ, Chang CB, Kang SB, Kim VN, Kim JH, Kim JS, Elledge SJ, Kang C
Developmental cell 2021 May 17;56(10):1512-1525.e7
Developmental cell 2021 May 17;56(10):1512-1525.e7
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
Sinomenine protects bone from destruction to ameliorate arthritis via activating p62(Thr269/Ser272)-Keap1-Nrf2 feedback loop.
Liao K, Su X, Lei K, Liu Z, Lu L, Wu Q, Pan H, Huang Q, Zhao Y, Wang M, Cai J, Liu L, Li T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111195
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Mar;135:111195
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Lei F, Wang W, Fu Y, Wang J, Zheng Y
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Wang W, Zhai D, Bai Y, Xue K, Deng L, Ma L, Du T, Ye Z, Qu D, Xiang A, Chen G, Zhao Y, Wang L, Lu Z
Cell death discovery 2021 Mar 23;7(1):58
Cell death discovery 2021 Mar 23;7(1):58
STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.
Sitthideatphaiboon P, Galan-Cobo A, Negrao MV, Qu X, Poteete A, Zhang F, Liu DD, Lewis WE, Kemp HN, Lewis J, Rinsurongkawong W, Giri U, Lee JJ, Zhang J, Roth JA, Swisher S, Heymach JV
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Mar 15;27(6):1720-1733
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Mar 15;27(6):1720-1733
Correlation of hepatitis C virus-mediated endoplasmic reticulum stress with autophagic flux impairment and hepatocarcinogenesis.
Honma Y, Miyagawa K, Hara Y, Hayashi T, Kusanaga M, Ogino N, Minami S, Oe S, Ikeda M, Hino K, Harada M
Medical molecular morphology 2021 Jun;54(2):108-121
Medical molecular morphology 2021 Jun;54(2):108-121
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Peng J, Jiang Z, Wu G, Cai Z, Du Q, Tao L, Zhang Y, Chen Y, Shen X
Journal of drug targeting 2021 Jun;29(5):520-530
Journal of drug targeting 2021 Jun;29(5):520-530
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury.
Liu M, Zheng B, Liu P, Zhang J, Chu X, Dong C, Shi J, Liang Y, Chu L, Liu Y, Han X
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro.
Wang M, Ke Y, Li Y, Shan Z, Mi W, Cao Y, Feng W, Zheng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111305
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111305
Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.
Zhang M, Zhang T, Song C, Qu J, Gu Y, Liu S, Li H, Xiao W, Kong L, Sun Y, Lv W
Journal of ethnopharmacology 2021 Jun 28;274:114064
Journal of ethnopharmacology 2021 Jun 28;274:114064
Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.
Chen Y, Zhang H, Chen Y, Jia P, Ji S, Zhang Y, Wang T
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
Journal of animal science and biotechnology 2021 Jun 10;12(1):70
The piperine derivative HJ105 inhibits Aβ(1-42)-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.
Yang X, Zhi J, Leng H, Chen Y, Gao H, Ma J, Ji J, Hu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jul;87:153571
Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin.
Hou K, Shen J, Yan J, Zhai C, Zhang J, Pan JA, Zhang Y, Jiang Y, Wang Y, Lin RZ, Cong H, Gao S, Zong WX
EBioMedicine 2021 Jul;69:103456
EBioMedicine 2021 Jul;69:103456
Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells.
Sriramajayam K, Peng D, Lu H, Zhou S, Bhat N, McDonald OG, Que J, Zaika A, El-Rifai W
Redox biology 2021 Jul;43:101970
Redox biology 2021 Jul;43:101970
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
Ji JZ, Li YF, Jiang LP, Tai T, Ge PX, Mi QY, Zhu T, Xie HG
Biochemical pharmacology 2021 Jan;183:114313
Biochemical pharmacology 2021 Jan;183:114313
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H
Pharmacological research 2021 Jan;163:105333
Pharmacological research 2021 Jan;163:105333
Obacunone Attenuates Liver Fibrosis with Enhancing Anti-Oxidant Effects of GPx-4 and Inhibition of EMT.
Bai Y, Wang W, Wang L, Ma L, Zhai D, Wang F, Shi R, Liu C, Xu Q, Chen G, Lu Z
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
Molecules (Basel, Switzerland) 2021 Jan 9;26(2)
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Tan CT, Chang HC, Zhou Q, Yu C, Fu NY, Sabapathy K, Yu VC
EMBO reports 2021 Jan 7;22(1):e50854
EMBO reports 2021 Jan 7;22(1):e50854
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M
Nature communications 2021 Jan 4;12(1):16
Nature communications 2021 Jan 4;12(1):16
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H, Xu C
Food & function 2021 Jan 21;12(2):696-705
Food & function 2021 Jan 21;12(2):696-705
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.
Li S, Wang X, Xiao Y, Wang Y, Wan Y, Li X, Li Q, Tang X, Cai D, Ran B, Wu C
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
Ecotoxicology and environmental safety 2021 Jan 15;208:111426
SQSTM1/ p62 oligomerization contributes to Aβ-induced inhibition of Nrf2 signaling.
Guo C, Zhang Y, Nie Q, Cao D, Wang X, Wan X, Liu M, Cui J, Sun J, Bai Y, Li L
Neurobiology of aging 2021 Feb;98:10-20
Neurobiology of aging 2021 Feb;98:10-20
Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome.
Rahim I, Sayed RK, Fernández-Ortiz M, Aranda-Martínez P, Guerra-Librero A, Fernández-Martínez J, Rusanova I, Escames G, Djerdjouri B, Acuña-Castroviejo D
Naunyn-Schmiedeberg's archives of pharmacology 2021 Feb;394(2):261-277
Naunyn-Schmiedeberg's archives of pharmacology 2021 Feb;394(2):261-277
H(2)S probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434.
Li N, Wang J, Zang X, Wang Z, Zhang T, Zhao B, Miao J, Lin Z
Apoptosis : an international journal on programmed cell death 2021 Feb;26(1-2):111-131
Apoptosis : an international journal on programmed cell death 2021 Feb;26(1-2):111-131
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.
Zhang MH, Li J, Zhu XY, Zhang YQ, Ye ST, Leng YR, Yang T, Zhang H, Kong LY
Free radical biology & medicine 2021 Feb 20;164:1-12
Free radical biology & medicine 2021 Feb 20;164:1-12
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Lu Q, Gu W, Luo C, Wang L, Hua W, Sun Y, Tang L
Journal of ethnopharmacology 2021 Feb 10;266:113454
Journal of ethnopharmacology 2021 Feb 10;266:113454
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity.
Faruk MO, Ichimura Y, Kageyama S, Komatsu-Hirota S, El-Gowily AH, Sou YS, Koike M, Noda NN, Komatsu M
The Journal of biological chemistry 2021 Dec;297(6):101405
The Journal of biological chemistry 2021 Dec;297(6):101405
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways.
Deng J, Huang M, Wu H
Bioengineered 2021 Dec;12(1):7975-7984
Bioengineered 2021 Dec;12(1):7975-7984
Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
Ying YT, Yang J, Tan X, Liu R, Zhuang Y, Xu JX, Ren WJ
Cells 2021 Dec 6;10(12)
Cells 2021 Dec 6;10(12)
RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.
Feng X, Jiang T, Yang C, Pang S, Ding Z, Hu H, Wang H, Dong L, Yang N
Cell death & disease 2021 Dec 17;13(1):6
Cell death & disease 2021 Dec 17;13(1):6
Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice.
Li D, Hu Z, He Q, Guo Y, Chong Y, Xu J, Qin L
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14856-14867
Journal of agricultural and food chemistry 2021 Dec 15;69(49):14856-14867
Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination.
Wang Y, Jin R, Chen J, Cao J, Xiao J, Li X, Sun C
Food chemistry 2021 Dec 15;365:130470
Food chemistry 2021 Dec 15;365:130470
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Cao L, Zhao J, Ma L, Chen J, Xu J, Rahman SU, Feng S, Li Y, Wu J, Wang X
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Proanthocyanidins regulate the Nrf2/ARE signaling pathway and protect neurons from cypermethrin-induced oxidative stress and apoptosis.
Zhou L, Chang J, Zhao W, Gao Y
Pesticide biochemistry and physiology 2021 Aug;177:104898
Pesticide biochemistry and physiology 2021 Aug;177:104898
Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death.
Zhang L, Zou L, Jiang X, Cheng S, Zhang J, Qin X, Qin Z, Chen C, Zou Z
Nanotoxicology 2021 Aug;15(6):779-797
Nanotoxicology 2021 Aug;15(6):779-797
LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.
Nieto-Torres JL, Shanahan SL, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras-Bueno S, Verhelle A, Encalada SE, Hansen M
Current biology : CB 2021 Aug 9;31(15):3440-3449.e7
Current biology : CB 2021 Aug 9;31(15):3440-3449.e7
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Zhao Y, Lu J, Mao A, Zhang R, Guan S
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Ge PX, Jiang LP, Tai T, Zhu T, Ji JZ, Li YF, Mi QY, Xie HG
Life sciences 2021 Aug 15;279:119268
Life sciences 2021 Aug 15;279:119268
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378
Free radical biology & medicine 2021 Aug 1;171:365-378
Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.
Liu K, Yang W, Hu M, Xie W, Huang J, Cui M, He X, Nie X
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Journal of cellular and molecular medicine 2021 Apr;25(8):3976-3990
Physical plasma-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death.
Kumar N, Perez-Novo C, Shaw P, Logie E, Privat-Maldonado A, Dewilde S, Smits E, Berghe WV, Bogaerts A
Free radical biology & medicine 2021 Apr;166:187-200
Free radical biology & medicine 2021 Apr;166:187-200
Regulatory effects of flavonoids luteolin on BDE-209-induced intestinal epithelial barrier damage in Caco-2 cell monolayer model.
Yuan J, Che S, Ruan Z, Song L, Tang R, Zhang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Apr;150:112098
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Journal of dairy science 2021 Apr;104(4):4516-4528
Journal of dairy science 2021 Apr;104(4):4516-4528
Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351.
Park JY, Sohn HY, Koh YH, Jo C
Scientific reports 2021 Apr 19;11(1):8430
Scientific reports 2021 Apr 19;11(1):8430
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways.
Yuan J, Che S, Zhang L, Ruan Z
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Journal of agricultural and food chemistry 2021 Apr 14;69(14):4101-4110
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis.
Feng L, Chen M, Li Y, Li M, Hu S, Zhou B, Zhu L, Yu L, Zhou Q, Tan L, An H, Wang X, Jin H
Cell death & disease 2021 Apr 14;12(4):405
Cell death & disease 2021 Apr 14;12(4):405
Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.
Chen YS, Chang HS, Hsiao HH, Chen YF, Kuo YP, Yen FL, Yen CH
Antioxidants (Basel, Switzerland) 2021 Apr 1;10(4)
Antioxidants (Basel, Switzerland) 2021 Apr 1;10(4)
C2C12 Mouse Myoblasts Damage Induced by Oxidative Stress Is Alleviated by the Antioxidant Capacity of the Active Substance Phloretin.
Li J, Yang Q, Han L, Pan C, Lei C, Chen H, Lan X
Frontiers in cell and developmental biology 2020;8:541260
Frontiers in cell and developmental biology 2020;8:541260
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142
The American journal of Chinese medicine 2020;48(1):127-142
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
Zhu Q, Zeng J, Li J, Chen X, Miao J, Jin Q, Chen H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
LncRNA MALAT1 Regulates miR-144-3p to Facilitate Epithelial-Mesenchymal Transition of Lens Epithelial Cells via the ROS/NRF2/Notch1/Snail Pathway.
Ye W, Ma J, Wang F, Wu T, He M, Li J, Pei R, Zhang L, Wang Y, Zhou J
Oxidative medicine and cellular longevity 2020;2020:8184314
Oxidative medicine and cellular longevity 2020;2020:8184314
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways.
Seo HY, Lee SH, Lee JH, Hwang JS, Kim MK, Jang BK
PloS one 2020;15(10):e0240478
PloS one 2020;15(10):e0240478
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Wei X, Wang H, Sun X, Huang X, Xu W, Liang Y, Liu L, Mo S, Lin X, Lin J
American journal of translational research 2020;12(5):2169-2180
American journal of translational research 2020;12(5):2169-2180
p62 Suppressed VK3-induced Oxidative Damage Through Keap1/Nrf2 Pathway In Human Ovarian Cancer Cells.
Xia MH, Yan XY, Zhou L, Xu L, Zhang LC, Yi HW, Su J
Journal of Cancer 2020;11(6):1299-1307
Journal of Cancer 2020;11(6):1299-1307
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Frontiers in pharmacology 2020;11:601716
Frontiers in pharmacology 2020;11:601716
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Li C, Zhang S, Li L, Hu Q, Ji S
Frontiers in pharmacology 2020;11:594496
Frontiers in pharmacology 2020;11:594496
Polarization of Low-Grade Inflammatory Monocytes Through TRAM-Mediated Up-Regulation of Keap1 by Super-Low Dose Endotoxin.
Rahtes A, Li L
Frontiers in immunology 2020;11:1478
Frontiers in immunology 2020;11:1478
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M, Liu F
Molecular medicine reports 2020 Sep;22(3):2545-2550
Molecular medicine reports 2020 Sep;22(3):2545-2550
(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis.
Wang M, Liu CY, Wang T, Yu HM, Ouyang SH, Wu YP, Gong HB, Ma XH, Jiao GL, Fu LL, Wu QS, Kurihara H, Li YF, Shen T, He RR
Cell death & disease 2020 Sep 19;11(9):781
Cell death & disease 2020 Sep 19;11(9):781
NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest.
Sun X, Wang Y, Ji K, Liu Y, Kong Y, Nie S, Li N, Hao J, Xie Y, Xu C, Du L, Liu Q
Nucleic acids research 2020 Sep 18;48(16):9109-9123
Nucleic acids research 2020 Sep 18;48(16):9109-9123
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.
Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Long Q
Biomaterials 2020 Oct;257:120264
Biomaterials 2020 Oct;257:120264
NRF2-Driven KEAP1 Transcription in Human Lung Cancer.
Tian Y, Liu Q, Yu S, Chu Q, Chen Y, Wu K, Wang L
Molecular cancer research : MCR 2020 Oct;18(10):1465-1476
Molecular cancer research : MCR 2020 Oct;18(10):1465-1476
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D(3) Plus Nicotine.
Liou SF, Nguyen TTN, Hsu JH, Sulistyowati E, Huang SE, Wu BN, Lin MC, Yeh JL
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Normobaric hyperoxia plays a protective role against renal ischemia-reperfusion injury by activating the Nrf2/HO-1 signaling pathway.
Pei J, Cai S, Song S, Xu Y, Feng M, Luo G, Wang Y, Sun F, Shi H, Xu S
Biochemical and biophysical research communications 2020 Oct 29;532(1):151-158
Biochemical and biophysical research communications 2020 Oct 29;532(1):151-158
Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.
Qin X, Hua J, Lin SJ, Zheng HT, Wang JJ, Li W, Ke JJ, Cai HB
Biochemical and biophysical research communications 2020 Oct 20;531(3):431-437
Biochemical and biophysical research communications 2020 Oct 20;531(3):431-437
Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress.
Yu Z, Yang L, Deng S, Liang M
European journal of pharmacology 2020 Oct 15;885:173399
European journal of pharmacology 2020 Oct 15;885:173399
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, Li L, Zhao Y
Brain research 2020 Oct 15;1745:146948
Brain research 2020 Oct 15;1745:146948
Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells.
Sun Y, He L, Wang T, Hua W, Qin H, Wang J, Wang L, Gu W, Li T, Li N, Liu X, Chen F, Tang L
Molecular neurobiology 2020 Nov;57(11):4628-4641
Molecular neurobiology 2020 Nov;57(11):4628-4641
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
Li M, Liu P, Xue Y, Liang Y, Shi J, Han X, Zhang J, Chu X, Chu L
Oncology reports 2020 Nov;44(5):2306-2316
Oncology reports 2020 Nov;44(5):2306-2316
SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity.
Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH, Bae SH
Autophagy 2020 Nov;16(11):1949-1973
Autophagy 2020 Nov;16(11):1949-1973
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Cell death & disease 2020 Nov 17;11(11):991
Cell death & disease 2020 Nov 17;11(11):991
The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina.
Toulis V, García-Monclús S, de la Peña-Ramírez C, Arenas-Galnares R, Abril JF, Todi SV, Khan N, Garanto A, Costa MDC, Marfany G
Cell reports 2020 Nov 10;33(6):108360
Cell reports 2020 Nov 10;33(6):108360
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.
Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, Peng J, Jiang DS, Mu X, Wang C, Peng T, Guan JL, Wang Y, Jegga A, Huang K, Fan GC
Redox biology 2020 May;32:101453
Redox biology 2020 May;32:101453
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo GM, Tan H, Manfredi G, Zhao Y, Peng J, Hu B, Chen S, Yue Z
Autophagy 2020 May;16(5):917-931
Autophagy 2020 May;16(5):917-931
Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound: Effect of organobismuth(III) compound on NRF2 signaling.
Iuchi K, Tasaki Y, Shirai S, Hisatomi H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109928
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109928
Niacin Alleviates Dairy Cow Mastitis by Regulating the GPR109A/AMPK/NRF2 Signaling Pathway.
Guo W, Liu J, Li W, Ma H, Gong Q, Kan X, Cao Y, Wang J, Fu S
International journal of molecular sciences 2020 May 8;21(9)
International journal of molecular sciences 2020 May 8;21(9)
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy.
Lin DS, Ho CS, Huang YW, Wu TY, Lee TH, Huang ZD, Wang TJ, Yang SJ, Chiang MF
Cells 2020 May 1;9(5)
Cells 2020 May 1;9(5)
Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.
Kim S, Indu Viswanath AN, Park JH, Lee HE, Park AY, Choi JW, Kim HJ, Londhe AM, Jang BK, Lee J, Hwang H, Lim SM, Pae AN, Park KD
Neuropharmacology 2020 May 1;167:107989
Neuropharmacology 2020 May 1;167:107989
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Cell proliferation 2020 Mar;53(3):e12779
Cell proliferation 2020 Mar;53(3):e12779
NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.
Sánchez-Martín P, Sou YS, Kageyama S, Koike M, Waguri S, Komatsu M
EMBO reports 2020 Mar 4;21(3):e48902
EMBO reports 2020 Mar 4;21(3):e48902
Dietary Supplemented Curcumin Improves Meat Quality and Antioxidant Status of Intrauterine Growth Retardation Growing Pigs via Nrf2 Signal Pathway.
Zhang L, Zhang J, Yan E, He J, Zhong X, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Animals : an open access journal from MDPI 2020 Mar 24;10(3)
Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes.
Wang S, Cheng H, Wang L, Zhao R, Guan D
International journal of molecular sciences 2020 Mar 16;21(6)
International journal of molecular sciences 2020 Mar 16;21(6)
HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.
Yang X, Ji J, Liu C, Zhou M, Li H, Ye S, Hu Q
International immunopharmacology 2020 Jun;83:106383
International immunopharmacology 2020 Jun;83:106383
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation.
Fan Y, Xing Y, Xiong L, Wang J
Chemico-biological interactions 2020 Jun 1;324:109086
Chemico-biological interactions 2020 Jun 1;324:109086
The Clinicopathological and Prognostic Significance of Nrf2 and Keap1 Expression in Hepatocellular Carcinoma.
Lee K, Kim S, Lee Y, Lee H, Lee Y, Park H, Nahm JH, Ahn S, Yu SJ, Lee K, Kim H
Cancers 2020 Jul 31;12(8)
Cancers 2020 Jul 31;12(8)
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Lu Y, Sun Y, Liu Z, Lu Y, Zhu X, Lan B, Mi Z, Dang L, Li N, Zhan W, Tan L, Pi J, Xiong H, Zhang L, Chen Y
Science translational medicine 2020 Jul 29;12(554)
Science translational medicine 2020 Jul 29;12(554)
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Park JS, Lee DH, Lee YS, Oh E, Bae KH, Oh KJ, Kim H, Bae SH
Autophagy 2020 Jan;16(1):86-105
Autophagy 2020 Jan;16(1):86-105
Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells.
Li GH, Li AL, Chen XM, Zhang LY, Wang T, Wang XN, Shen T
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109669
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, Chen Y, Wei Y, He X, Zhao J, Han H, Sun M, Xiao K
Cell death & disease 2020 Jan 2;11(1):6
Cell death & disease 2020 Jan 2;11(1):6
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway.
Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, Lin L, Wan X, Yang X, Chen L
Nature communications 2020 Jan 17;11(1):348
Nature communications 2020 Jan 17;11(1):348
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Xu A, Yang Y, Shao Y, Wu M, Sun Y
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Cell communication and signaling : CCS 2020 Jan 15;18(1):9
Evaluation and Exploration of Potentially Bioactive Peptides in Casein Hydrolysates against Liver Oxidative Damage in STZ/HFD-Induced Diabetic Rats.
Wang C, Zheng L, Su G, Zeng XA, Sun B, Zhao M
Journal of agricultural and food chemistry 2020 Feb 26;68(8):2393-2405
Journal of agricultural and food chemistry 2020 Feb 26;68(8):2393-2405
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress.
Zhang Y, Wang H, Zhang L, Yuan Y, Yu D
International journal of biological macromolecules 2020 Feb 15;145:944-949
International journal of biological macromolecules 2020 Feb 15;145:944-949
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
Nordgren KKS, Wallace KB
Cardiovascular toxicology 2020 Dec;20(6):557-570
Cardiovascular toxicology 2020 Dec;20(6):557-570
Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.
Song S, Nguyen V, Schrank T, Mulvaney K, Walter V, Wei D, Orvis T, Desai N, Zhang J, Hayes DN, Zheng Y, Major MB, Weissman BE
Molecular cancer research : MCR 2020 Dec;18(12):1777-1788
Molecular cancer research : MCR 2020 Dec;18(12):1777-1788
Resveratrol improves meat quality, muscular antioxidant capacity, lipid metabolism and fiber type composition of intrauterine growth retarded pigs.
Cheng K, Yu C, Li Z, Li S, Yan E, Song Z, Zhang H, Zhang L, Wang T
Meat science 2020 Dec;170:108237
Meat science 2020 Dec;170:108237
Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions.
Lu MC, Shao HL, Liu T, You QD, Jiang ZY
European journal of medicinal chemistry 2020 Dec 1;207:112734
European journal of medicinal chemistry 2020 Dec 1;207:112734
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, Wang J, Sun L
IUBMB life 2020 Aug;72(8):1659-1679
IUBMB life 2020 Aug;72(8):1659-1679
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Du J, Zhu M, Li H, Liang G, Li Y, Feng S
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma.
Lippmann J, Petri K, Fulda S, Liese J
Translational oncology 2020 Aug;13(8):100785
Translational oncology 2020 Aug;13(8):100785
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Xie D, Jiang L, Lin Y, Liu Z
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, Leng X
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
Hayashi M, Guida E, Inokawa Y, Goldberg R, Reis LO, Ooki A, Pilli M, Sadhukhan P, Woo J, Choi W, Izumchenko E, Gonzalez LM, Marchionni L, Zhavoronkov A, Brait M, Bivalacqua T, Baras A, Netto GJ, Koch W, Singh A, Hoque MO
Science signaling 2020 Aug 18;13(645)
Science signaling 2020 Aug 18;13(645)
Dandelion Extract Alleviated Lipopolysaccharide-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Sun Y, Wu Y, Wang Z, Chen J, Yang Y, Dong G
Toxins 2020 Aug 1;12(8)
Toxins 2020 Aug 1;12(8)
S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways.
Mo M, Li S, Dong Z, Li C, Sun Y, Li A, Zhao Z
International immunopharmacology 2020 Apr;81:106273
International immunopharmacology 2020 Apr;81:106273
Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses.
Jiang Z, Fu L, Xu Y, Hu X, Yang H, Zhang Y, Luo H, Gan S, Tao L, Liang G, Shen X
Scientific reports 2020 Apr 14;10(1):6427
Scientific reports 2020 Apr 14;10(1):6427
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
Xian P, Hei Y, Wang R, Wang T, Yang J, Li J, Di Z, Liu Z, Baskys A, Liu W, Wu S, Long Q
Theranostics 2019;9(20):5956-5975
Theranostics 2019;9(20):5956-5975
CCl(4)-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Peng C, Zhou ZM, Li J, Luo Y, Zhou YS, Ke XH, Huang KE
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation.
Liu S, Xu S, Wei R, Cui Z, Wu X, Wei R, Xie L, Zhou Y, Li W, Chen W
BioMed research international 2019;2019:5198138
BioMed research international 2019;2019:5198138
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, Ma H, Liang X, Liu X, Yang J, Wei J
Oxidative medicine and cellular longevity 2019;2019:2654910
Oxidative medicine and cellular longevity 2019;2019:2654910
Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies.
Haytural H, Lundgren JL, Köse TB, Jordà-Siquier T, Kalcheva M, Seed Ahmed M, Winblad B, Sundström E, Barthet G, Tjernberg LO, Frykman S
Frontiers in aging neuroscience 2019;11:273
Frontiers in aging neuroscience 2019;11:273
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis.
Li AL, Shen T, Wang T, Zhou MX, Wang B, Song JT, Zhang PL, Wang XL, Ren DM, Lou HX, Wang XN
Free radical biology & medicine 2019 Sep;141:21-33
Free radical biology & medicine 2019 Sep;141:21-33
Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells.
Wu XY, Chen XM, Zhou MX, Hu HX, Zhang JZ, Wang XN, Ren DM, Lou HX, Shen T
Chemico-biological interactions 2019 Sep 1;310:108741
Chemico-biological interactions 2019 Sep 1;310:108741
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.
Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, Yang Z, Zhou J, Gao J, Zhou H, Xu S, Ji H, Shi P, Wu DD, Yang C, Chen Y
Nature communications 2019 Oct 25;10(1):4892
Nature communications 2019 Oct 25;10(1):4892
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation.
Bao F, Tao L, Zhang H
Cellular and molecular neurobiology 2019 Nov;39(8):1177-1186
Cellular and molecular neurobiology 2019 Nov;39(8):1177-1186
MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway.
Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, Ma C, Yang J
Atherosclerosis 2019 Nov;290:9-18
Atherosclerosis 2019 Nov;290:9-18
S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2.
Tocmo R, Parkin K
Free radical biology & medicine 2019 Nov 1;143:164-175
Free radical biology & medicine 2019 Nov 1;143:164-175
The Nrf2 pathway is required for intracellular replication of Toxoplasma gondii in activated macrophages.
Pang Y, Zhang Z, Chen Y, Cao S, Yang X, Jia H
Parasite immunology 2019 May;41(5):e12621
Parasite immunology 2019 May;41(5):e12621
The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis.
Zhou XL, Zhu CY, Wu ZG, Guo X, Zou W
Oncogene 2019 May;38(21):4028-4046
Oncogene 2019 May;38(21):4028-4046
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK
Cell 2019 May 30;177(6):1507-1521.e16
Cell 2019 May 30;177(6):1507-1521.e16
HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression.
Hu T, Schreiter FC, Bagchi RA, Tatman PD, Hannink M, McKinsey TA
The Journal of biological chemistry 2019 May 24;294(21):8640-8652
The Journal of biological chemistry 2019 May 24;294(21):8640-8652
Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.
Sparaneo A, Fabrizio FP, la Torre A, Graziano P, Di Maio M, Fontana A, Bisceglia M, Rossi A, Pizzolitto S, De Maglio G, Tancredi A, Grimaldi F, Balsamo T, Centra F, Manzorra MC, Trombetta D, Pantalone A, Bonfitto A, Maiello E, Fazio VM, Muscarella LA
International journal of molecular sciences 2019 May 23;20(10)
International journal of molecular sciences 2019 May 23;20(10)
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, Sun T, Peng X, Zhuang C, Yu J
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells.
Yang WJ, He JX, Zhou MX, Huang M, Wang SQ, Wang XN, Lou HX, Ren DM, Shen T
Free radical research 2019 Mar;53(3):348-358
Free radical research 2019 Mar;53(3):348-358
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells.
Zuo R, Wang Y, Li J, Wu J, Wang W, Li B, Sun C, Wang Z, Shi C, Zhou Y, Liu M, Zhang C
Stem cells (Dayton, Ohio) 2019 Jun;37(6):828-840
Stem cells (Dayton, Ohio) 2019 Jun;37(6):828-840
Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity.
Park JS, Lee YS, Lee DH, Bae SH
Free radical biology & medicine 2019 Jun;137:143-157
Free radical biology & medicine 2019 Jun;137:143-157
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, Ke P, Zhuang J, Huang X
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Yamada M, Iwata M, Warabi E, Oishi H, Lira VA, Okutsu M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8022-8032
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8022-8032
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity.
Lu MC, Zhang X, Wu F, Tan SJ, Zhao J, You QD, Jiang ZY
Journal of medicinal chemistry 2019 Jul 25;62(14):6796-6813
Journal of medicinal chemistry 2019 Jul 25;62(14):6796-6813
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.
Lignitto L, LeBoeuf SE, Homer H, Jiang S, Askenazi M, Karakousi TR, Pass HI, Bhutkar AJ, Tsirigos A, Ueberheide B, Sayin VI, Papagiannakopoulos T, Pagano M
Cell 2019 Jul 11;178(2):316-329.e18
Cell 2019 Jul 11;178(2):316-329.e18
Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.
Beneduce E, Matte A, De Falco L, Mbiandjeu S, Chiabrando D, Tolosano E, Federti E, Petrillo S, Mohandas N, Siciliano A, Babu W, Menon V, Ghaffari S, Iolascon A, De Franceschi L
American journal of hematology 2019 Jan;94(1):10-20
American journal of hematology 2019 Jan;94(1):10-20
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Karras P, Riveiro-Falkenbach E, Cañón E, Tejedo C, Calvo TG, Martínez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gómez-López G, Ximenez-Embun P, Muñoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodríguez-Peralto JL, Soengas MS
Cancer cell 2019 Jan 14;35(1):46-63.e10
Cancer cell 2019 Jan 14;35(1):46-63.e10
Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities.
Qiao YN, Sun Y, Shen T, Zhang JZ, Zhou JC, Li Y, Chen W, Ren ZJ, Li YL, Wang X, Lou HX
Phytochemistry 2019 Feb;158:77-85
Phytochemistry 2019 Feb;158:77-85
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Shah SZA, Fang N
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.
Wang P, Geng J, Gao J, Zhao H, Li J, Shi Y, Yang B, Xiao C, Linghu Y, Sun X, Chen X, Hong L, Qin F, Li X, Yu JS, You H, Yuan Z, Zhou D, Johnson RL, Chen L
Nature communications 2019 Feb 14;10(1):755
Nature communications 2019 Feb 14;10(1):755
(-)-Epicatechin mitigates radiation-induced intestinal injury and promotes intestinal regeneration via suppressing oxidative stress.
Li Y, Ma S, Zhang Y, Yao M, Zhu X, Guan F
Free radical research 2019 Aug;53(8):851-864
Free radical research 2019 Aug;53(8):851-864
Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells.
Betharia S, Rondόn-Ortiz AN, Brown DA
Neurochemical research 2019 Aug;44(8):1878-1892
Neurochemical research 2019 Aug;44(8):1878-1892
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.
Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, Zaika A, El-Rifai W
Cancer letters 2019 Aug 28;458:46-55
Cancer letters 2019 Aug 28;458:46-55
A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.
Hirose H, Hideshima T, Katoh T, Suga H
Chembiochem : a European journal of chemical biology 2019 Aug 16;20(16):2089-2100
Chembiochem : a European journal of chemical biology 2019 Aug 16;20(16):2089-2100
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats.
Kukoyi AT, Fan X, Staitieh BS, Hybertson BM, Gao B, McCord JM, Guidot DM
American journal of physiology. Cell physiology 2019 Aug 1;317(2):C390-C397
American journal of physiology. Cell physiology 2019 Aug 1;317(2):C390-C397
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner.
Zhang B, Wang G, He J, Yang Q, Li D, Li J, Zhang F
Journal of neuroinflammation 2019 Apr 22;16(1):92
Journal of neuroinflammation 2019 Apr 22;16(1):92
TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.
Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y
Acta biochimica et biophysica Sinica 2019 Apr 1;51(4):375-385
Acta biochimica et biophysica Sinica 2019 Apr 1;51(4):375-385
Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.
Liu J, Li W, Limbu MH, Li Y, Wang Z, Cheng Z, Zhang X, Chen P
Frontiers in pharmacology 2018;9:555
Frontiers in pharmacology 2018;9:555
Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats.
Cai SA, Hou N, Zhao GJ, Liu XW, He YY, Liu HL, Hua YQ, Li LR, Huang Y, Ou CW, Luo CF, Chen MS
Frontiers in pharmacology 2018;9:540
Frontiers in pharmacology 2018;9:540
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Li YR, Li GH, Sun L, Li L, Liu Y, Kong DG, Wang SQ, Ren DM, Wang XN, Lou HX, Shen T
Oxidative medicine and cellular longevity 2018;2018:7616852
Oxidative medicine and cellular longevity 2018;2018:7616852
Nrf2 protects stellate cells from Smad-dependent cell activation.
Prestigiacomo V, Suter-Dick L
PloS one 2018;13(7):e0201044
PloS one 2018;13(7):e0201044
A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.
Adams O, Janser FA, Dislich B, Berezowska S, Humbert M, Seiler CA, Kroell D, Slotta-Huspenina J, Feith M, Ott K, Tschan MP, Langer R
PloS one 2018;13(6):e0197610
PloS one 2018;13(6):e0197610
Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.
Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H
PloS one 2018;13(11):e0203978
PloS one 2018;13(11):e0203978
The PKCδ-Nrf2-ARE signalling pathway may be involved in oxidative stress in arsenic-induced liver damage in rats.
Hu Y, Yu C, Yao M, Wang L, Liang B, Zhang B, Huang X, Zhang A
Environmental toxicology and pharmacology 2018 Sep;62:79-87
Environmental toxicology and pharmacology 2018 Sep;62:79-87
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Yang B, Cheng H, Wang L, Fu J, Zhang G, Guan D, Qi R, Gao X, Zhao R
Toxicology and applied pharmacology 2018 Sep 15;355:189-197
Toxicology and applied pharmacology 2018 Sep 15;355:189-197
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.
Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, Kato T, Araki Y, Huganir RL, Dawson TM, Yanagawa T, Okamoto K, Iijima M, Sesaki H
Cell metabolism 2018 Oct 2;28(4):588-604.e5
Cell metabolism 2018 Oct 2;28(4):588-604.e5
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Li YR, Li GH, Zhou MX, Xiang L, Ren DM, Lou HX, Wang XN, Shen T
Bioorganic & medicinal chemistry 2018 Oct 1;26(18):5140-5150
Bioorganic & medicinal chemistry 2018 Oct 1;26(18):5140-5150
Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.
Eckhardt M, Zhang W, Gross AM, Von Dollen J, Johnson JR, Franks-Skiba KE, Swaney DL, Johnson TL, Jang GM, Shah PS, Brand TM, Archambault J, Kreisberg JF, Grandis JR, Ideker T, Krogan NJ
Cancer discovery 2018 Nov;8(11):1474-1489
Cancer discovery 2018 Nov;8(11):1474-1489
Serum‑free‑medium‑type mesenchymal stem cell culture supernatant exerts a protective effect on A549 lung epithelial cells in acute lung injury induced by H2O2.
Wu J, Shang AQ, Chen C, Wang WW, Xiong CQ, Guo NZ
Oncology reports 2018 Nov;40(5):3033-3039
Oncology reports 2018 Nov;40(5):3033-3039
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2.
Cloer EW, Siesser PF, Cousins EM, Goldfarb D, Mowrey DD, Harrison JS, Weir SJ, Dokholyan NV, Major MB
Molecular and cellular biology 2018 Nov 15;38(22)
Molecular and cellular biology 2018 Nov 15;38(22)
Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S
Cell reports 2018 Nov 13;25(7):1708-1717.e5
Cell reports 2018 Nov 13;25(7):1708-1717.e5
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y, Liu Y
Nature 2018 May;557(7706):585-589
Nature 2018 May;557(7706):585-589
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.
Bi W, He CN, Li XX, Zhou LY, Liu RJ, Zhang S, Li GQ, Chen ZC, Zhang PF
Food & function 2018 May 23;9(5):2809-2819
Food & function 2018 May 23;9(5):2809-2819
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells.
Zhou MM, Zhang WY, Li RJ, Guo C, Wei SS, Tian XM, Luo J, Kong LY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Mar 15;42:152-163
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Mar 15;42:152-163
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy.
Zhang J, Jiao Q, Kong L, Yu J, Fang A, Li M, Yu J
Thoracic cancer 2018 Jun;9(6):726-735
Thoracic cancer 2018 Jun;9(6):726-735
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J
Redox biology 2018 Jun;16:189-198
Redox biology 2018 Jun;16:189-198
Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.
Endo H, Owada S, Inagaki Y, Shida Y, Tatemichi M
Scientific reports 2018 Jul 4;8(1):10122
Scientific reports 2018 Jul 4;8(1):10122
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Lin EY, Bayarsengee U, Wang CC, Chiang YH, Cheng CW
Environmental toxicology 2018 Jan;33(1):72-82
Environmental toxicology 2018 Jan;33(1):72-82
Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.
An H, Harper JW
Nature cell biology 2018 Feb;20(2):135-143
Nature cell biology 2018 Feb;20(2):135-143
Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.
Shen Z, Wang Y, Su Z, Kou R, Xie K, Song F
Chemico-biological interactions 2018 Feb 25;282:22-28
Chemico-biological interactions 2018 Feb 25;282:22-28
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.
Lu M, Liu T, Jiao Q, Ji J, Tao M, Liu Y, You Q, Jiang Z
European journal of medicinal chemistry 2018 Feb 25;146:251-259
European journal of medicinal chemistry 2018 Feb 25;146:251-259
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.
Zhao D, Badur MG, Luebeck J, Magaña JH, Birmingham A, Sasik R, Ahn CS, Ideker T, Metallo CM, Mali P
Molecular cell 2018 Feb 15;69(4):699-708.e7
Molecular cell 2018 Feb 15;69(4):699-708.e7
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
Gong W, Chen Z, Zou Y, Zhang L, Huang J, Liu P, Huang H
Free radical biology & medicine 2018 Feb 1;115:338-350
Free radical biology & medicine 2018 Feb 1;115:338-350
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Li Y, Fu S, Li E, Sun X, Xu H, Meng Y, Wang X, Chen Y, Xie C, Geng S, Wu J, Zhong C, Xu P
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Phytotherapy research : PTR 2018 Dec;32(12):2480-2486
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Shin D, Kim EH, Lee J, Roh JL
Free radical biology & medicine 2018 Dec;129:454-462
Free radical biology & medicine 2018 Dec;129:454-462
dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer.
Hu Q, Qin Y, Xiang J, Liu W, Xu W, Sun Q, Ji S, Liu J, Zhang Z, Ni Q, Xu J, Yu X, Zhang B
Cell proliferation 2018 Aug;51(4):e12456
Cell proliferation 2018 Aug;51(4):e12456
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
Li ST, Dai Q, Zhang SX, Liu YJ, Yu QQ, Tan F, Lu SH, Wang Q, Chen JW, Huang HQ, Liu PQ, Li M
Acta pharmacologica Sinica 2018 Aug;39(8):1294-1304
Acta pharmacologica Sinica 2018 Aug;39(8):1294-1304
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.
Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Vanden Berghe W, Vandenabeele P, Vanden Berghe T
The Journal of clinical investigation 2018 Aug 1;128(8):3341-3355
The Journal of clinical investigation 2018 Aug 1;128(8):3341-3355
Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells.
Zhou MX, Li GH, Sun B, Xu YW, Li AL, Li YR, Ren DM, Wang XN, Wen XS, Lou HX, Shen T
Redox biology 2018 Apr;14:154-163
Redox biology 2018 Apr;14:154-163
Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant.
Kageyama S, Saito T, Obata M, Koide RH, Ichimura Y, Komatsu M
Molecular and cellular biology 2018 Apr 1;38(7)
Molecular and cellular biology 2018 Apr 1;38(7)
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.
Liu J, Li Y, Liu L, Wang Z, Shi C, Cheng Z, Zhang X, Ding F, Chen PS
Frontiers in physiology 2017;8:291
Frontiers in physiology 2017;8:291
p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.
Arai A, Chano T, Ikebuchi K, Hama Y, Ochi Y, Tameno H, Shimada T
American journal of cancer research 2017;7(4):881-891
American journal of cancer research 2017;7(4):881-891
CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells.
Wang Q, Ma J, Lu Y, Zhang S, Huang J, Chen J, Bei JX, Yang K, Wu G, Huang K, Chen J, Xu S
Oncogene 2017 Sep 14;36(37):5321-5330
Oncogene 2017 Sep 14;36(37):5321-5330
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.
Mildenberger J, Johansson I, Sergin I, Kjøbli E, Damås JK, Razani B, Flo TH, Bjørkøy G
Autophagy 2017 Oct 3;13(10):1664-1678
Autophagy 2017 Oct 3;13(10):1664-1678
A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM
Journal of cell science 2017 Oct 15;130(20):3467-3480
Journal of cell science 2017 Oct 15;130(20):3467-3480
miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1.
Akdemir B, Nakajima Y, Inazawa J, Inoue J
Molecular cancer research : MCR 2017 Nov;15(11):1570-1578
Molecular cancer research : MCR 2017 Nov;15(11):1570-1578
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
Huang R, Li X, Yu Y, Ma L, Liu S, Zong X, Zheng Q
Oncotarget 2017 Nov 7;8(55):94080-94090
Oncotarget 2017 Nov 7;8(55):94080-94090
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Ge W, Zhao K, Wang X, Li H, Yu M, He M, Xue X, Zhu Y, Zhang C, Cheng Y, Jiang S, Hu Y
Cancer cell 2017 Nov 13;32(5):561-573.e6
Cancer cell 2017 Nov 13;32(5):561-573.e6
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.
Gong W, Li J, Chen Z, Huang J, Chen Q, Cai W, Liu P, Huang H
Free radical biology & medicine 2017 May;106:393-405
Free radical biology & medicine 2017 May;106:393-405
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.
Ugun-Klusek A, Tatham MH, Elkharaz J, Constantin-Teodosiu D, Lawler K, Mohamed H, Paine SM, Anderson G, John Mayer R, Lowe J, Ellen Billett E, Bedford L
Cell death & disease 2017 Jan 5;8(1):e2531
Cell death & disease 2017 Jan 5;8(1):e2531
Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma.
Fabrizio FP, Costantini M, Copetti M, la Torre A, Sparaneo A, Fontana A, Poeta L, Gallucci M, Sentinelli S, Graziano P, Parente P, Pompeo V, De Salvo L, Simone G, Papalia R, Picardo F, Balsamo T, Flammia GP, Trombetta D, Pantalone A, Kok K, Paranita F, Muscarella LA, Fazio VM
Oncotarget 2017 Feb 14;8(7):11187-11198
Oncotarget 2017 Feb 14;8(7):11187-11198
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.
Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, Janne PA, Shaw AT, McDonald Iii RE, Engelman JA, Stegmeier F, Schlabach MR, Hahn WC
eLife 2017 Feb 1;6
eLife 2017 Feb 1;6
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.
Anzovino A, Chiang S, Brown BE, Hawkins CL, Richardson DR, Huang ML
The American journal of pathology 2017 Dec;187(12):2858-2875
The American journal of pathology 2017 Dec;187(12):2858-2875
Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses.
Hos NJ, Ganesan R, Gutiérrez S, Hos D, Klimek J, Abdullah Z, Krönke M, Robinson N
The Journal of cell biology 2017 Dec 4;216(12):4107-4121
The Journal of cell biology 2017 Dec 4;216(12):4107-4121
The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells.
Huang K, Gao X, Wei W
Experimental cell research 2017 Dec 1;361(1):63-72
Experimental cell research 2017 Dec 1;361(1):63-72
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Yang D, Xiao CX, Su ZH, Huang MW, Qin M, Wu WJ, Jia WW, Zhu YZ, Hu JF, Liu XH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, Zhang L, Dong S, Yang F, Zhong X, Xu C, Lu F, Zhang W
Cell death & disease 2017 Aug 10;8(8):e2992
Cell death & disease 2017 Aug 10;8(8):e2992
The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.
Xiao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, Wang J, Qin Y, Liu Y, Tang C, He L, Greka A, Zhou Z, Liu F, Dong Z, Sun L
Redox biology 2017 Apr;11:297-311
Redox biology 2017 Apr;11:297-311
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.
O'Mealey GB, Berry WL, Plafker SM
Redox biology 2017 Apr;11:103-110
Redox biology 2017 Apr;11:103-110
Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.
Park S, Han S, Choi I, Kim B, Park SP, Joe EH, Suh YH
PloS one 2016;11(9):e0163029
PloS one 2016;11(9):e0163029
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.
Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, Chen Y
Journal of hematology & oncology 2016 Sep 6;9(1):83
Journal of hematology & oncology 2016 Sep 6;9(1):83
RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.
Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D
Oncogene 2016 Sep 22;35(38):5000-9
Oncogene 2016 Sep 22;35(38):5000-9
CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells.
Gong W, Chen C, Xiong F, Yang Z, Wang Y, Huang J, Liu P, Huang H
Biochemical pharmacology 2016 Sep 15;116:140-52
Biochemical pharmacology 2016 Sep 15;116:140-52
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Lee DH, Han DH, Nam KT, Park JS, Kim SH, Lee M, Kim G, Min BS, Cha BS, Lee YS, Sung SH, Jeong H, Ji HW, Lee MJ, Lee JS, Lee HY, Chun Y, Kim J, Komatsu M, Lee YH, Bae SH
Free radical biology & medicine 2016 Oct;99:520-532
Free radical biology & medicine 2016 Oct;99:520-532
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.
Duleh S, Wang X, Komirenko A, Margeta M
Acta neuropathologica communications 2016 Oct 31;4(1):115
Acta neuropathologica communications 2016 Oct 31;4(1):115
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.
Mulvaney KM, Matson JP, Siesser PF, Tamir TY, Goldfarb D, Jacobs TM, Cloer EW, Harrison JS, Vaziri C, Cook JG, Major MB
The Journal of biological chemistry 2016 Nov 4;291(45):23719-23733
The Journal of biological chemistry 2016 Nov 4;291(45):23719-23733
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M
Nature communications 2016 Jun 27;7:12030
Nature communications 2016 Jun 27;7:12030
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, Peng J
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.
Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, Razani B
Science signaling 2016 Jan 5;9(409):ra2
Science signaling 2016 Jan 5;9(409):ra2
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Park JS, Oh SY, Lee DH, Lee YS, Sung SH, Ji HW, Lee MJ, Lee YH, Rhee SG, Bae SH
Free radical research 2016 Dec;50(12):1408-1421
Free radical research 2016 Dec;50(12):1408-1421
NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.
Nlandu-Khodo S, Dissard R, Hasler U, Schäfer M, Pircher H, Jansen-Durr P, Krause KH, Martin PY, de Seigneux S
Scientific reports 2016 Dec 7;6:38598
Scientific reports 2016 Dec 7;6:38598
Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.
Wang S, Chen Y, Kou R, Wang Y, Zeng T, Xie K, Song F
Toxicology 2016 Aug 10;368-369:19-27
Toxicology 2016 Aug 10;368-369:19-27
Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.
Probst BL, McCauley L, Trevino I, Wigley WC, Ferguson DA
PloS one 2015;10(8):e0135257
PloS one 2015;10(8):e0135257
p62 Deficiency Enhances α-Synuclein Pathology in Mice.
Tanji K, Odagiri S, Miki Y, Maruyama A, Nikaido Y, Mimura J, Mori F, Warabi E, Yanagawa T, Ueno S, Itoh K, Wakabayashi K
Brain pathology (Zurich, Switzerland) 2015 Sep;25(5):552-64
Brain pathology (Zurich, Switzerland) 2015 Sep;25(5):552-64
p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2.
Park JS, Kang DH, Bae SH
Biochemical and biophysical research communications 2015 Sep 4;464(4):1139-1144
Biochemical and biophysical research communications 2015 Sep 4;464(4):1139-1144
Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.
Park JS, Kang DH, Lee DH, Bae SH
Biochemical and biophysical research communications 2015 Sep 25;465(3):542-7
Biochemical and biophysical research communications 2015 Sep 25;465(3):542-7
Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.
Park JS, Kang DH, Lee DH, Bae SH
Biochemical and biophysical research communications 2015 Oct 9;466(1):131-7
Biochemical and biophysical research communications 2015 Oct 9;466(1):131-7
PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.
Park JS, Kang DH, Lee DH, Bae SH
Biochemical and biophysical research communications 2015 Oct 23;466(3):499-504
Biochemical and biophysical research communications 2015 Oct 23;466(3):499-504
The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.
Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M
Science signaling 2015 Nov 24;8(404):ra120
Science signaling 2015 Nov 24;8(404):ra120
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R
Molecular and cellular biology 2015 Jul;35(14):2385-99
Molecular and cellular biology 2015 Jul;35(14):2385-99
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells.
Huang K, Chen C, Hao J, Huang J, Wang S, Liu P, Huang H
Molecular and cellular endocrinology 2015 Jan 5;399:178-89
Molecular and cellular endocrinology 2015 Jan 5;399:178-89
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.
Eino A, Kageyama S, Uemura T, Annoh H, Saito T, Narita I, Waguri S, Komatsu M
Journal of cell science 2015 Dec 1;128(23):4453-61
Journal of cell science 2015 Dec 1;128(23):4453-61
Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages.
Awuh JA, Haug M, Mildenberger J, Marstad A, Do CP, Louet C, Stenvik J, Steigedal M, Damås JK, Halaas Ø, Flo TH
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 4;112(31):E4272-80
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 4;112(31):E4272-80
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.
Darvekar SR, Elvenes J, Brenne HB, Johansen T, Sjøttem E
PloS one 2014;9(1):e85262
PloS one 2014;9(1):e85262
Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.
Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, Mishra L, Hung MC
American journal of translational research 2014;6(6):649-63
American journal of translational research 2014;6(6):649-63
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M
The Journal of biological chemistry 2014 Sep 5;289(36):24944-55
The Journal of biological chemistry 2014 Sep 5;289(36):24944-55
Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Tanji K, Miki Y, Ozaki T, Maruyama A, Yoshida H, Mimura J, Matsumiya T, Mori F, Imaizumi T, Itoh K, Kakita A, Takahashi H, Wakabayashi K
Acta neuropathologica communications 2014 May 3;2:50
Acta neuropathologica communications 2014 May 3;2:50
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
Ishimura R, Tanaka K, Komatsu M
FEBS letters 2014 Mar 3;588(5):822-8
FEBS letters 2014 Mar 3;588(5):822-8
Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.
Jo C, Gundemir S, Pritchard S, Jin YN, Rahman I, Johnson GV
Nature communications 2014 Mar 25;5:3496
Nature communications 2014 Mar 25;5:3496
MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).
Petrelli A, Perra A, Cora D, Sulas P, Menegon S, Manca C, Migliore C, Kowalik MA, Ledda-Columbano GM, Giordano S, Columbano A
Hepatology (Baltimore, Md.) 2014 Jan;59(1):228-41
Hepatology (Baltimore, Md.) 2014 Jan;59(1):228-41
The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.
Yamamoto S, Inoue J, Kawano T, Kozaki K, Omura K, Inazawa J
Molecular cancer research : MCR 2014 Jan;12(1):58-68
Molecular cancer research : MCR 2014 Jan;12(1):58-68
Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts.
Nordgren KK, Wallace KB
Toxicology and applied pharmacology 2014 Jan 1;274(1):107-16
Toxicology and applied pharmacology 2014 Jan 1;274(1):107-16
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.
Hast BE, Cloer EW, Goldfarb D, Li H, Siesser PF, Yan F, Walter V, Zheng N, Hayes DN, Major MB
Cancer research 2014 Feb 1;74(3):808-17
Cancer research 2014 Feb 1;74(3):808-17
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.
Goldfarb D, Hast BE, Wang W, Major MB
Journal of proteome research 2014 Dec 5;13(12):5944-55
Journal of proteome research 2014 Dec 5;13(12):5944-55
Association of p62/SQSTM1 excess and oral carcinogenesis.
Inui T, Chano T, Takikita-Suzuki M, Nishikawa M, Yamamoto G, Okabe H
PloS one 2013;8(9):e74398
PloS one 2013;8(9):e74398
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
Endo H, Niioka M, Kobayashi N, Tanaka M, Watanabe T
PloS one 2013;8(5):e63388
PloS one 2013;8(5):e63388
Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.
Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K, Johnson GV
PloS one 2013;8(3):e57932
PloS one 2013;8(3):e57932
Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.
Kwok SC
International journal of cell biology 2013;2013:162094
International journal of cell biology 2013;2013:162094
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M
Molecular cell 2013 Sep 12;51(5):618-31
Molecular cell 2013 Sep 12;51(5):618-31
Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.
Volonte D, Liu Z, Musille PM, Stoppani E, Wakabayashi N, Di YP, Lisanti MP, Kensler TW, Galbiati F
Molecular biology of the cell 2013 Jun;24(12):1852-62
Molecular biology of the cell 2013 Jun;24(12):1852-62
Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.
Tanji K, Maruyama A, Odagiri S, Mori F, Itoh K, Kakita A, Takahashi H, Wakabayashi K
Journal of neuropathology and experimental neurology 2013 Jan;72(1):18-28
Journal of neuropathology and experimental neurology 2013 Jan;72(1):18-28
Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue.
Chang LC, Fan CW, Tseng WK, Chen JR, Chein HP, Hwang CC, Hua CC
Applied immunohistochemistry & molecular morphology : AIMM 2013 Dec;21(6):511-7
Applied immunohistochemistry & molecular morphology : AIMM 2013 Dec;21(6):511-7
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB
Cancer research 2013 Apr 1;73(7):2199-210
Cancer research 2013 Apr 1;73(7):2199-210
Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Solis LM, Nunez MI, Behrens C, Yee J, English J, Murray N, Tsao MS, Minna JD, Gazdar AF, Wistuba II, MacAulay CE, Lam S, Lam WL
PloS one 2012;7(5):e37775
PloS one 2012;7(5):e37775
Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma.
Matulis SM, Morales AA, Yehiayan L, Lee KP, Cai Y, Boise LH
PloS one 2012;7(12):e52662
PloS one 2012;7(12):e52662
[Keap1 expression for predicting the chemoresistance and prognosis of advanced non-small cell lung cancer].
Cao B, Zhu X, Chen S, Xiao Y, Liang L
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2012 Oct;15(10):591-6
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2012 Oct;15(10):591-6
Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.
Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
Biochemical and biophysical research communications 2012 May 4;421(2):280-5
Biochemical and biophysical research communications 2012 May 4;421(2):280-5
Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.
Miller CJ, Gounder SS, Kannan S, Goutam K, Muthusamy VR, Firpo MA, Symons JD, Paine R 3rd, Hoidal JR, Rajasekaran NS
Biochimica et biophysica acta 2012 Jun;1822(6):1038-50
Biochimica et biophysica acta 2012 Jun;1822(6):1038-50
Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.
Muthusamy VR, Kannan S, Sadhaasivam K, Gounder SS, Davidson CJ, Boeheme C, Hoidal JR, Wang L, Rajasekaran NS
Free radical biology & medicine 2012 Jan 15;52(2):366-76
Free radical biology & medicine 2012 Jan 15;52(2):366-76
Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.
Agyeman AS, Chaerkady R, Shaw PG, Davidson NE, Visvanathan K, Pandey A, Kensler TW
Breast cancer research and treatment 2012 Feb;132(1):175-87
Breast cancer research and treatment 2012 Feb;132(1):175-87
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT
The Journal of biological chemistry 2012 Feb 24;287(9):6539-50
The Journal of biological chemistry 2012 Feb 24;287(9):6539-50
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Kwon J, Han E, Bui CB, Shin W, Lee J, Lee S, Choi YB, Lee AH, Lee KH, Park C, Obin MS, Park SK, Seo YJ, Oh GT, Lee HW, Shin J
EMBO reports 2012 Feb 1;13(2):150-6
EMBO reports 2012 Feb 1;13(2):150-6
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL
Cancer research 2012 Dec 1;72(23):6227-35
Cancer research 2012 Dec 1;72(23):6227-35
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.
Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL, Benjamin IJ
Antioxidants & redox signaling 2011 Mar 15;14(6):957-71
Antioxidants & redox signaling 2011 Mar 15;14(6):957-71
Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2.
Sumi D, Sasaki T, Miyataka H, Himeno S
Archives of toxicology 2011 Dec;85(12):1509-16
Archives of toxicology 2011 Dec;85(12):1509-16
Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.
Bui CB, Shin J
Biochemical and biophysical research communications 2011 Aug 26;412(2):347-52
Biochemical and biophysical research communications 2011 Aug 26;412(2):347-52
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M
The Journal of cell biology 2011 Apr 18;193(2):275-84
The Journal of cell biology 2011 Apr 18;193(2):275-84
Autophagy-deficient mice develop multiple liver tumors.
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N
Genes & development 2011 Apr 15;25(8):795-800
Genes & development 2011 Apr 15;25(8):795-800
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M
Nature cell biology 2010 Mar;12(3):213-23
Nature cell biology 2010 Mar;12(3):213-23
CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.
Kang HJ, Hong YB, Kim HJ, Bae I
The Journal of biological chemistry 2010 Jul 9;285(28):21258-68
The Journal of biological chemistry 2010 Jul 9;285(28):21258-68
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.
Solis LM, Behrens C, Dong W, Suraokar M, Ozburn NC, Moran CA, Corvalan AH, Biswal S, Swisher SG, Bekele BN, Minna JD, Stewart DJ, Wistuba II
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jul 15;16(14):3743-53
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jul 15;16(14):3743-53
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC
Molecular cell 2009 Oct 9;36(1):131-40
Molecular cell 2009 Oct 9;36(1):131-40
Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis.
Morales AA, Gutman D, Cejas PJ, Lee KP, Boise LH
The Journal of biological chemistry 2009 May 8;284(19):12886-95
The Journal of biological chemistry 2009 May 8;284(19):12886-95
Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.
Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA Jr
Circulation research 2007 Sep 28;101(7):723-33
Circulation research 2007 Sep 28;101(7):723-33
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 10503-2-AP(KEAP1 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-KEAP1 (IP:10503-2-AP, 5ug; Detection:10503-2-AP 1:600) with mouse skeletal muscle tissue lysate 8000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 10503-2-AP(KEAP1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KEAP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human KEAP1. This antibody recognizes human,mouse,rat antigen. The KEAP1 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
