60027-1-Ig

antibody from Proteintech Group

Targeting: KEAP1 INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454

Provider product page for 60027-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [95]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 60027-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#60027-1-Ig, RRID:AB_2132623
Product name: KEAP1 antibody
Antibody type: Monoclonal
Description: KD/KO validated KEAP1 antibody (Cat. #60027-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgA
Antibody clone number: 4G10H9
Vial size: 20ul, 150ul

KEAP1 protein structure - 60027-1-Ig shown in red.

Submitted references TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.

Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780

Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.

Cui J, Chen W, Zhang D, Lu M, Huang Z, Yi B
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034

Arenobufagin inhibits lung metastasis of colorectal cancer by targeting c-MYC/Nrf2 axis.

Wang M, Hu S, Yang J, Yuan L, Han L, Liang F, Zhang F, Zhao H, Liu Y, Gao N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155391

LC-MS-based rheumatoid arthritis serum metabolomics reveals the role of deoxyinosine in attenuating collagen-induced arthritis in mice.

Xu D, Tang L, Wang Y, Pan J, Su C
Heliyon 2024 May 30;10(10):e30903

Electroacupuncture improves cognitive function in APP/PS1 mice by inhibiting oxidative stress related hippocampal neuronal ferroptosis.

Chen Y, Li Y, Wu M, Li Z
Brain research 2024 May 15;1831:148744

Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.

Shi W, Wang J, Li Z, Xu S, Wang J, Zhang L, Yang H
Free radical biology & medicine 2024 Mar;213:343-358

TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.

Zhai DS, Wang XS, Yang L, Jiang YL, Jin YC, Yan YX, Song DK, Zhang K, Han ZK, Liu MY, Wu YM, Ma X, Qi JY, Yang F, Tian F, Li XB, Liu SB
Journal of affective disorders 2024 Mar 1;348:283-296

An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.

Wang H, Liu X, Yan X, Du Y, Pu F, Ren J, Qu X
Biomaterials 2024 Jun;307:122523

SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.

Chu WX, Ding C, Du ZH, Wei P, Wang YX, Ge XJ, Yu GY
Oral diseases 2024 Jul;30(5):3066-3080

Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1.

Ye S, Hu X, Sun S, Su B, Cai J, Jiang J
European journal of pharmacology 2024 Jul 5;974:176620

Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.

Xia Q, Xie J, Zhang J, Zhang L, Zhou Y, Zhu B, Wu Y, Yang Z, Li J
Chemico-biological interactions 2024 Jan 5;387:110819

Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.

Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, Favero G
International journal of molecular sciences 2024 Jan 16;25(2)

Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model.

Chen L, Mo Q, Wu Y, Chen W, Deng K, Xiao Y
Free radical research 2024 Feb;58(2):107-116

Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathway in Mice.

Gu LM, Li HZ, Gao L, Li H, Wei LF, Pan CY, Wu KX, Tian YZ
Chinese journal of integrative medicine 2024 Feb;30(2):135-142

Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.

Cai F, Li D, Zhou K, Zhang W, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407

Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.

Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789

Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.

Dong M, Yang Z, Gao Q, Deng Q, Li L, Chen H
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)

Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.

Chen T, Hu Y, Lu L, Zhao Q, Tao X, Ding B, Chen S, Zhu J, Guo X, Lin Z
Frontiers in pharmacology 2023;14:1134464

Inhibition of COX-2 signaling favors E. coli during urinary tract infection.

Mohanty S, Lindelauf C, White JK, Scheffschick A, Ehrenborg E, Demirel I, Brauner H, Brauner A
Journal of inflammation (London, England) 2023 Sep 11;20(1):30

Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin-Induced Cardiotoxicity.

Liu C, Wang Y, Zeng Y, Kang Z, Zhao H, Qi K, Wu H, Zhao L, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2301136

Neuroprotective effects of Lycium barbarum polysaccharide on light-induced oxidative stress and mitochondrial damage via the Nrf2/HO-1 pathway in mouse hippocampal neurons.

Yang Y, Yu L, Zhu T, Xu S, He J, Mao N, Liu Z, Wang D
International journal of biological macromolecules 2023 Nov 1;251:126315

Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways.

Liao D, Shangguan D, Wu Y, Chen Y, Liu N, Tang J, Yao D, Shi Y
Psychopharmacology 2023 May;240(5):1179-1190

Ligand impact on reactive oxygen species generation of Au(10) and Au(25) nanoclusters upon one- and two-photon excitation.

Fakhouri H, Bakulić MP, Zhang I, Yuan H, Bain D, Rondepierre F, Brevet PF, Maršić ŽS, Antoine R, Bonačić-Koutecký V, Maysinger D
Communications chemistry 2023 May 22;6(1):97

Nrf2 affects hydroquinone-induces cell cycle arrest through the p16/pRb signaling pathway and antioxidant enzymes.

Chen L, Zhai L, Gao Y, Cui Z, Yu L, Zhu D, Tang H, Luo H
Ecotoxicology and environmental safety 2023 Jan 1;249:114389

FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.

Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114

Chloroquine is a safe autophagy inhibitor for sustaining the expression of antioxidant enzymes in trophoblasts.

Furuta A, Shima T, Yoshida-Kawaguchi M, Yamada K, Yasuda I, Tsuda S, Yamaki-Ushijima A, Yoneda S, Higashisaka K, Cheng SB, Matsumoto K, Tsutsumi Y, Sharma S, Saito S, Nakashima A
Journal of reproductive immunology 2023 Feb;155:103766

Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway.

Yang Y, Shao M, Yao J, Yang S, Cheng W, Ma L, Li W, Cao J, Zhang Y, Hu Y, Li C, Wang Y, Wang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154625

Ginsenoside Rh2 inhibits CBP/p300-mediated FOXO3a acetylation and epilepsy-induced oxidative damage via the FOXO3a-KEAP1-NRF2 pathway.

Wu J, Wang S, Zhao W, Li M, Li S
European journal of pharmacology 2023 Feb 5;940:175391

FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway.

Zhou Y, Chen Y, Shi Y, Wu L, Tan Y, Li T, Chen Y, Xia J, Hu R
The Journal of clinical investigation 2023 Feb 1;133(3)

Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress.

Liu Q, Duan SB, Wang L, Luo XQ, Wang HS, Deng YH, Wu X, Wu T, Yan And P, Kang YX
Renal failure 2023 Dec;45(1):2179852

Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway.

Wu F, Xia X, Lei T, Du H, Hua H, Liu W, Xu B, Yang T
Journal of photochemistry and photobiology. B, Biology 2023 Aug;245:112753

Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition.

Li X, Sung P, Zhang D, Yan L
Physiological research 2023 Aug 31;72(4):497-510

Zinc Oxide Nanoparticle Improves the Intestinal Function of Intrauterine Growth Retardation Finishing Pigs via Regulating Intestinal Morphology, Inflammation, Antioxidant Status and Autophagy.

Zhou B, Zhang J, Liu H, Chen S, Wang T, Wang C
Frontiers in veterinary science 2022;9:884945

Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.

Huang J, Ding J, Wang Z, Li Y, He Y, Wang X, Fan H, Xie Q, Qiu P
Oxidative medicine and cellular longevity 2022;2022:8400876

Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.

Han GJ, Min XZ, Ma SS, Ding C, Wang XQ
Oxidative medicine and cellular longevity 2022;2022:5126042

Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure.

Jiang Z, Yang X, Han Y, Li J, Hu C, Liu C, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154337

Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway.

Li Y, Zhang E, Yang H, Chen Y, Tao L, Xu Y, Chen T, Shen X
Molecules (Basel, Switzerland) 2022 Sep 24;27(19)

Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.

Zhen D, Liu C, Huang T, Fu D, Bai X, Ma Q, Jiang M, Gong G
Journal of ethnopharmacology 2022 Oct 5;296:115497

A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner.

Chung KM, Kim H, Roque CG, McCurdy EP, Nguyen TTT, Siegelin MD, Hwang JY, Hengst U
Cell reports 2022 Oct 18;41(3):111488

Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.

Wang Y, Zhu M, Liang J, Zhang N, Sun D, Li H, Chen L
Bioorganic chemistry 2022 Nov;128:106067

Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia.

Shen S, Cheng X, Zhou L, Zhao Y, Wang H, Zhang J, Sun X, Wang Y, Shu Y, Xu Y, Tao Y, Li M, Lu Z, Cai W, Nie G, Qiu W
ACS nano 2022 Nov 22;16(11):18886-18897

Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.

Ye J, Zheng J, Tian X, Xu B, Yuan F, Wang B, Yang Z, Huang F
Marine drugs 2022 Mar 25;20(4)

Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.

Zhu L, He S, Huang L, Ren D, Nie T, Tao K, Xia L, Lu F, Mao Z, Yang Q
Aging cell 2022 Jun;21(6):e13616

Apple Polyphenols Improve Intestinal Antioxidant Capacity and Barrier Function by Activating the Nrf2/Keap1 Signaling Pathway in a Pig Model.

Huang T, Che Q, Chen X, Chen D, Yu B, He J, Chen H, Yan H, Zheng P, Luo Y, Huang Z
Journal of agricultural and food chemistry 2022 Jun 22;70(24):7576-7585

Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1.

Xu Q, Liu M, Gu J, Ling S, Liu X, Luo Z, Jin Y, Chai R, Ou W, Liu S, Liu N
Cell death discovery 2022 Jun 16;8(1):291

Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy.

Liu W, Yan F, Xu Z, Chen Q, Ren J, Wang Q, Chen L, Ying J, Liu Z, Zhao J, Qiu J, Zhang C, Jiang M, Xiang L
Journal of photochemistry and photobiology. B, Biology 2022 Jul;232:112462

Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo.

Chen X, Zhang M, Xue Y, Liang D, An W, Jia G, Zhao H, Liu G, Huang Z
The Journal of nutritional biochemistry 2022 Jan;99:108859

Apple polyphenols improve intestinal barrier function by enhancing antioxidant capacity and suppressing inflammation in weaning piglets.

Guo Z, Chen X, Huang Z, Chen D, Yu J, Yan H, Chen H, He J, Zheng P, Luo Y, Yu B
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13747

Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.

Li JW, Wang RL, Xu J, Sun KY, Jiang HM, Sun ZY, Lv ZY, Xu XQ, Wu R, Guo H, Jiang Q, Shi DQ
Acta pharmacologica Sinica 2022 Feb;43(2):417-428

Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway.

Zhang Y, Liu M, Zhang Y, Tian M, Chen P, Lan Y, Zhou B
Phytotherapy research : PTR 2022 Feb;36(2):984-995

Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway.

Matić S, Tomašić Paić A, Sobočanec S, Pinterić M, Pipalović G, Martinčić M, Matovina M, Tomić S
International journal of molecular sciences 2022 Feb 11;23(4)

Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in weaning piglets.

Chen X, Chen L, Qin Y, Mao Z, Jia G, Zhao H, Liu G, Huang Z
Animal biotechnology 2022 Dec;33(7):1389-1397

Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.

Chen Y, Bao M, Liu JT, Bao H, Zhang SM, Lou Y, Qi YX
Journal of molecular and cellular cardiology 2022 Dec;173:101-114

Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages.

He J, Liu L, Liu X, Chen H, Liu K, Huang N, Wang Y
International immunopharmacology 2022 Dec;113(Pt A):109404

Identification of Agents That Ameliorate Hyperphosphatemia-Suppressed Myogenin Expression Involved in the Nrf2/p62 Pathway in C2C12 Skeletal Muscle Cells.

Hsieh Li SM, Liu ST, Chang YL, Chen GS, Huang SM
International journal of molecular sciences 2022 Dec 5;23(23)

Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora.

Ren X, Miao B, Cao H, Tian X, Shen L, Yang Z, Yuan F, Ding Y
Molecules (Basel, Switzerland) 2022 Dec 28;28(1)

Trehalose prevents glyphosate-induced testicular damage in roosters via its antioxidative properties.

Chen K, Liu JB, Tie CZ, Wang L
Research in veterinary science 2022 Dec 20;152:314-322

Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice.

Li H, Cao T, Ding W, Liang L, Fan GC, Qu L, Peng T
Journal of cardiovascular translational research 2022 Aug;15(4):805-815

Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia of Ganoderma lingzhi.

Huang P, Luo FJ, Ma YC, Wang SX, Huang J, Qin DD, Xue FF, Liu BY, Wu Q, Wang XL, Liu GQ
Food & function 2022 Aug 30;13(17):9032-9048

Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.

Wang Y, Zhang Y, Chen K, Liu J, Wu D, Cheng Y, Wang H, Li Y
Stem cell research & therapy 2022 Aug 13;13(1):418

Antioxidant Activity of Acanthopanax senticosus Flavonoids in H(2)O(2)-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.

Su J, Zhang X, Kan Q, Chu X
Molecules (Basel, Switzerland) 2022 Apr 30;27(9)

Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.

Shao Y, Jia H, Li S, Huang L, Aikemu B, Yang G, Zhang S, Sun J, Zheng M
Oxidative medicine and cellular longevity 2021;2021:7007933

Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.

Liu H, Xu X, Wu R, Bi L, Zhang C, Chen H, Yang Y
BioMed research international 2021;2021:6616547

Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.

Liu J, Wu Q, Yang T, Yang F, Guo T, Zhou Y, Han S, Luo Y, Guo T, Luo F, Lin Q
Oxidative medicine and cellular longevity 2021;2021:2637577

Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.

Zhao L, Zhou N, Zhang H, Pan F, Ai X, Wang Y, Hao S, Wang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112582

The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression.

Gao L, Liu Y, Du X, Ma S, Ge M, Tang H, Han C, Zhao X, Liu Y, Shao Y, Wu Z, Zhang L, Meng F, Xiao-Feng Qin F
Cell death & disease 2021 Jul 5;12(7):680

Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages.

Dierckx T, Haidar M, Grajchen E, Wouters E, Vanherle S, Loix M, Boeykens A, Bylemans D, Hardonnière K, Kerdine-Römer S, Bogie JFJ, Hendriks JJA
Journal of neuroinflammation 2021 Jul 4;18(1):148

Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats.

Chen L, Chen Z, Xu Z, Feng W, Yang X, Qi Z
Phytotherapy research : PTR 2021 Aug;35(8):4592-4604

Dietary dihydromyricetin supplementation enhances antioxidant capacity and improves lipid metabolism in finishing pigs.

Guo Z, Chen X, Huang Z, Chen D, Yu B, Chen H, Yu J, Yan H, Zheng P, Luo Y
Food & function 2021 Aug 2;12(15):6925-6935

Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.

Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396

Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.

Xu C, Hou B, He P, Ma P, Yang X, Yang X, Zhang L, Qiang G, Li W, Du G
Oxidative medicine and cellular longevity 2020;2020:6431459

Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.

Feng LX, Zhao F, Liu Q, Peng JC, Duan XJ, Yan P, Wu X, Wang HS, Deng YH, Duan SB
Oxidative medicine and cellular longevity 2020;2020:6123459

La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.

Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431

Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway.

Chen Z, Xiao J, Liu H, Yao K, Hou X, Cao Y, Liu X
Food & function 2020 Sep 23;11(9):8099-8111

Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.

Wang Y, Lian M, Zhou J, Wu S
Molecular neurobiology 2020 Nov;57(11):4417-4437

Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia/reperfusion injury via p62/Keap1/Nrf2 signaling pathway.

Zheng D, Liu Z, Zhou Y, Hou N, Yan W, Qin Y, Ye Q, Cheng X, Xiao Q, Bao Y, Luo J, Wu X
Pharmacological research 2020 Mar;153:104655

Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.

Zhao X, Shi Y, Zhang D, Tong X, Sun Y, Xue X, Fu J
Life sciences 2020 Jul 1;252:117662

Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury.

Eser Ocak P, Ocak U, Sherchan P, Gamdzyk M, Tang J, Zhang JH
Experimental neurology 2020 Apr;326:113203

Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells.

Han J, Guo D, Sun XY, Wang JM, Ouyang JM, Gui BS
Scientific reports 2019 Jul 8;9(1):9871

Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells.

Rabbani PS, Soares MA, Hameedi SG, Kadle RL, Mubasher A, Kowzun M, Ceradini DJ
Diabetes 2019 Jan;68(1):141-155

Chemical and genetic control of IFNγ-induced MHCII expression.

Wijdeven RH, van Luijn MM, Wierenga-Wolf AF, Akkermans JJ, van den Elsen PJ, Hintzen RQ, Neefjes J
EMBO reports 2018 Sep;19(9)

Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing.

Rabbani PS, Zhou A, Borab ZM, Frezzo JA, Srivastava N, More HT, Rifkin WJ, David JA, Berens SJ, Chen R, Hameedi S, Junejo MH, Kim C, Sartor RA, Liu CF, Saadeh PB, Montclare JK, Ceradini DJ
Biomaterials 2017 Jul;132:1-15

Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.

Duleh S, Wang X, Komirenko A, Margeta M
Acta neuropathologica communications 2016 Oct 31;4(1):115

Restoration of Nrf2 Signaling Normalizes the Regenerative Niche.

Soares MA, Cohen OD, Low YC, Sartor RA, Ellison T, Anil U, Anzai L, Chang JB, Saadeh PB, Rabbani PS, Ceradini DJ
Diabetes 2016 Mar;65(3):633-46

Expression of LC3, LAMP2, KEAP1 and NRF2 in Salivary Adenoid Cystic Carcinoma.

Huang CF, Deng WW, Zhang L, Zhang WF, Sun ZJ
Pathology oncology research : POR 2016 Jan;22(1):109-14

Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue.

Lee YJ, Kwon SB, Kim CH, Cho HD, Nam HS, Lee SH, Lee MW, Nam DH, Choi CY, Cho MK
Annals of dermatology 2015 Oct;27(5):507-16

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.

Jimenez-Blasco D, Santofimia-Castaño P, Gonzalez A, Almeida A, Bolaños JP
Cell death and differentiation 2015 Nov;22(11):1877-89

Increased protein oxidation and decreased expression of nuclear factor E2-related factor 2 protein in skin tissue of patients with diabetes.

Lee YJ, Kwon SB, An JM, Kim CH, Lee SH, Choi CY, Nam DH, Park JW, Nam HS, Lee SH, Lee MW, Cho MK
Clinical and experimental dermatology 2015 Mar;40(2):192-200

NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma.

Cescon DW, She D, Sakashita S, Zhu CQ, Pintilie M, Shepherd FA, Tsao MS
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Jun 1;21(11):2499-505

RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.

Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R
Molecular and cellular biology 2015 Jul;35(14):2385-99

Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.

Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S
International journal of clinical and experimental pathology 2014;7(6):2780-9

Expression of nuclear factor erythroid 2 protein in malignant cutaneous tumors.

Choi CY, Kim JY, Wee SY, Lee JH, Nam DH, Kim CH, Cho MK, Lee YJ, Nam HS, Lee SH, Cho SW
Archives of plastic surgery 2014 Nov;41(6):654-60

Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma.

Huang CF, Zhang L, Ma SR, Zhao ZL, Wang WM, He KF, Zhao YF, Zhang WF, Liu B, Sun ZJ
PloS one 2013;8(12):e83479

Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line.

Chandiramani N, Wang X, Margeta M
PloS one 2011 Jan 4;6(1):e14485

KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.

Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC
Molecular cell 2009 Oct 9;36(1):131-40

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 60027-1-Ig(KEAP1 antibody) at dilution of 1:400
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas cancer using 60027-1-Ig(KEAP1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
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Experimental details: The KEAP1 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human KEAP1. This antibody recognizes human, mouse antigen. The KEAP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 60027-1-Ig.pdf

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