Explore
Validate
Learn60027-1-Ig
antibody from Proteintech Group
Targeting: KEAP1
INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [171]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 60027-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60027-1-Ig, RRID:AB_2132623
- Product name
- KEAP1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated KEAP1 antibody (Cat. #60027-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgA
- Antibody clone number
- 4G10H9
- Vial size
- 20ul, 150ul
Submitted references Tianhuang formula attenuates cardiomyocyte pyroptosis in myocardial infarction by suppressing oxidative stress and the cGAS-STING-NLRP3 axis.
Fresh Dendrobium Officinale Polysaccharides Combine with Penicillamine to Attenuate Copper Overload-Induced Liver Injury in a Rat Model of Wilson's Disease Via Activation of the Nrf2/HO-1/Keap1 Signaling Pathway.
TIMP3 Suppresses Oxidative Stress and Ferroptosis of Lens Epithelial Cells in Cataract Through Regulating the Keap1/Nrf2 Pathway.
Cyanidin-3-O-Glucoside Protects Against Cognitive Impairment in D-Galactose-Induced Aging Mice by Regulating Nrf2 and NF-κB Pathways.
Mechanistic Study of HDAC6 Regulation of Iron Death in Ulcerative Colitis.
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Study on the potential mechanism of Artemisia integrifolia Linn. in diabetic nephropathy: multiscale analysis of network pharmacology and metabolomics.
Altered transposon element-derived genes distort oxygen-free radical scavenger systems in FXD.
Human amniotic mesenchymal stem cell-derived extracellular vesicles improve oocyte quality and embryonic development by increasing antioxidant capacity in aged mice.
Explore the chemical components of Angong Niuhuang Pill and its potential mechanisms for fever treatment based on UHPLC-Q-Exactive orbitrap HRMS, transcriptomics, and experiment verification.
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
The Protective Effect of Naringenin against Lead-Induced Hepatotoxicity in Rats: Mechanisms Involving Oxidative Stress Mitigation, Activation of PINK1/Parkin and Nrf2/NQO1 Pathways, and Autophagy Induction.
Antioxidant properties of low-molecular-weight Ulva prolifera polysaccharides against H₂O₂-induced oxidative damage in BRL 3A cells and zebrafish.
A coenzyme-based "interface-welding" hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics.
Comparative effects of dietary resveratrol and pterostilbene on meat quality, muscle antioxidant capacity, and muscle fiber composition in finishing pigs.
Epigallocatechin gallate ameliorates brain injuries after intracerebral hemorrhage by inhibiting ferroptosis through upregulation of Nrf2-Keap1 pathway.
Exploring the mechanism of Zishen Quyu Jiedu formula in treating endometriosis based on network pharmacology and experimental verification.
Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress.
Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway.
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress.
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation.
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Preprotective Effects of Cardamomin From Amomum villosum Lour. on H(2)O(2) -Induced Oxidative Damage In Vitro and Cerebral Ischemic Stroke In Vivo.
Fufang Huangqi Jianpi Oral Liquid alleviates spleen deficiency diarrhea via modulation of the NF-κB/Nrf2 signaling pathway and apoptosis.
Benzoylpaeoniflorin alleviates ulcerative colitis by inhibiting ferroptosis through targeting phosphogluconic dehydrogenase.
Palmitic Acid Induces Ferroptosis in Retinal Microvascular Endothelial Cells by Palmitoylation of Keap1 to Affect Diabetic Retinopathy.
Loading tea polyphenols enhances the repair of human umbilical cord mesenchymal stem cell sheet after spinal cord injury.
Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.
Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells.
A novel KEAP1 inhibitor, tiliroside, activates NRF2 to protect against acetaminophen-induced oxidative stress and acute liver injury.
Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease through suppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signaling pathways.
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation.
Suppression of NRF2 by photodynamic action to enhance bortezomib-triggered DNA damage for synergistic colorectal cancer therapy.
Identification of CD84 as a potent survival factor in acute myeloid leukemia.
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis.
Nephroprotective effects of Amomum kravanh essential oil by inhibition of ferroptosis regulated by Nrf2/HO-1 signaling pathway.
PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma.
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway.
Resveratrol Alleviated T-2 Toxin-Induced Liver Injury via Preservation of Nrf2 Pathway and GSH Synthesis.
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Protective Effects of Black Rice Anthocyanins on D-Galactose-Induced Renal Injury in Mice: The Role of Nrf2 and NF-κB Signaling and Gut Microbiota Modulation.
Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.
The therapeutic potential of Osmundacetone for rheumatoid arthritis: Effects and mechanisms on osteoclastogenesis.
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
Anti-inflammatory effect of echinacoside in collagen-induced arthritis via Nrf2/Drp1 pathway.
Remimazolam induced cytotoxicity mediated through multiple stress pathways and acted synergistically with tyrosine kinase inhibitors in hepatocellular carcinoma.
Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling.
Machine learning-driven screening of antioxidant peptides from macadamia nuts: In vitro experimental validation and mechanistic insights.
Deoxynivalenol induces liver injury by inhibiting the p62-Keap1-Nrf2 signaling pathway via overactivation of PINK1/Parkin-mediated mitophagy.
Synthesis and evaluation of lansiumamide B analogues to ameliorate acute lung injury by reducing oxidative stress and inflammation via Keap1/Nrf2/NF-κB pathway.
Volvariella volvacea polysaccharides alleviate acute liver injury by modulating Nrf2/NF-κB pathway in a dual manner.
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in Neonatal Mice.
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Citraconate promotes the malignant progression of colorectal cancer by inhibiting ferroptosis.
Vitamin D receptor alleviates lipid peroxidation in diabetic nephropathy by regulating ACLY/Nrf2/Keap1 pathway.
Role and Mechanism of Sialic Acid in Alleviating Acute Lung Injury through In Vivo and In Vitro Models.
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop.
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Salinomycin, a potent inhibitor of XOD and URAT1, ameliorates hyperuricemic nephropathy by activating NRF2, modulating the gut microbiota, and promoting SCFA production.
Arenobufagin inhibits lung metastasis of colorectal cancer by targeting c-MYC/Nrf2 axis.
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
LC-MS-based rheumatoid arthritis serum metabolomics reveals the role of deoxyinosine in attenuating collagen-induced arthritis in mice.
Electroacupuncture improves cognitive function in APP/PS1 mice by inhibiting oxidative stress related hippocampal neuronal ferroptosis.
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1.
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.
Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.
Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model.
Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathway in Mice.
Activation of the p62-Keap1-Nrf2 pathway improves pulmonary arterial hypertension in MCT-induced rats by inhibiting autophagy.
CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury.
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway.
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Curcumin inhibits PAT-induced renal ferroptosis via the p62/Keap1/Nrf2 signalling pathway.
Identification and anti-oxidative potential of milk fat globule membrane (MFGM)-derived bioactive peptides released through in vitro gastrointestinal digestion.
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Inhibition of COX-2 signaling favors E. coli during urinary tract infection.
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin-Induced Cardiotoxicity.
Neuroprotective effects of Lycium barbarum polysaccharide on light-induced oxidative stress and mitochondrial damage via the Nrf2/HO-1 pathway in mouse hippocampal neurons.
Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways.
Ligand impact on reactive oxygen species generation of Au(10) and Au(25) nanoclusters upon one- and two-photon excitation.
Nrf2 affects hydroquinone-induces cell cycle arrest through the p16/pRb signaling pathway and antioxidant enzymes.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Chloroquine is a safe autophagy inhibitor for sustaining the expression of antioxidant enzymes in trophoblasts.
Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway.
Ginsenoside Rh2 inhibits CBP/p300-mediated FOXO3a acetylation and epilepsy-induced oxidative damage via the FOXO3a-KEAP1-NRF2 pathway.
FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway.
Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress.
Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway.
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition.
Zinc Oxide Nanoparticle Improves the Intestinal Function of Intrauterine Growth Retardation Finishing Pigs via Regulating Intestinal Morphology, Inflammation, Antioxidant Status and Autophagy.
Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure.
Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway.
Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.
A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner.
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia.
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.
Apple Polyphenols Improve Intestinal Antioxidant Capacity and Barrier Function by Activating the Nrf2/Keap1 Signaling Pathway in a Pig Model.
Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1.
Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy.
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo.
Apple polyphenols improve intestinal barrier function by enhancing antioxidant capacity and suppressing inflammation in weaning piglets.
Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.
Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway.
Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway.
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in weaning piglets.
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages.
Identification of Agents That Ameliorate Hyperphosphatemia-Suppressed Myogenin Expression Involved in the Nrf2/p62 Pathway in C2C12 Skeletal Muscle Cells.
Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora.
Trehalose prevents glyphosate-induced testicular damage in roosters via its antioxidative properties.
Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice.
Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia of Ganoderma lingzhi.
Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.
Antioxidant Activity of Acanthopanax senticosus Flavonoids in H(2)O(2)-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.
Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.
Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.
The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression.
Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages.
Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats.
Dietary dihydromyricetin supplementation enhances antioxidant capacity and improves lipid metabolism in finishing pigs.
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway.
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia/reperfusion injury via p62/Keap1/Nrf2 signaling pathway.
Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.
Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury.
Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells.
Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells.
Chemical and genetic control of IFNγ-induced MHCII expression.
Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing.
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.
Restoration of Nrf2 Signaling Normalizes the Regenerative Niche.
Expression of LC3, LAMP2, KEAP1 and NRF2 in Salivary Adenoid Cystic Carcinoma.
Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue.
Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.
Increased protein oxidation and decreased expression of nuclear factor E2-related factor 2 protein in skin tissue of patients with diabetes.
NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma.
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Expression of nuclear factor erythroid 2 protein in malignant cutaneous tumors.
Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma.
Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line.
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Yan M, Chen Y, Cai G, Zhang X, Li K, Luo D, Wang L, Rong X, Guo J
Frontiers in immunology 2026;17:1761299
Frontiers in immunology 2026;17:1761299
Fresh Dendrobium Officinale Polysaccharides Combine with Penicillamine to Attenuate Copper Overload-Induced Liver Injury in a Rat Model of Wilson's Disease Via Activation of the Nrf2/HO-1/Keap1 Signaling Pathway.
Zhang S, Liu P, Jiang Y, Wu H, Cao S, Xuan S, Wu H, Zhou A
Biological trace element research 2026 Mar 5;
Biological trace element research 2026 Mar 5;
TIMP3 Suppresses Oxidative Stress and Ferroptosis of Lens Epithelial Cells in Cataract Through Regulating the Keap1/Nrf2 Pathway.
Duan Z, Zhuo B, Ma D, Hua Z, Han X, Cai L, Yang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71688
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71688
Cyanidin-3-O-Glucoside Protects Against Cognitive Impairment in D-Galactose-Induced Aging Mice by Regulating Nrf2 and NF-κB Pathways.
Sun D, Bao Y, Fan Q, Zhao L, Fu Z, Li H, Zhao L, Jiao H
Nutrients 2026 Mar 20;18(6)
Nutrients 2026 Mar 20;18(6)
Mechanistic Study of HDAC6 Regulation of Iron Death in Ulcerative Colitis.
Song JQ, Chen HX, Liu J, Wang YF, Yang ZW
Biological trace element research 2026 Mar 20;
Biological trace element research 2026 Mar 20;
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Wang J, Chen P, Li Y, Wang R, Ding W, Yu R, Qin Q, Wu R, Wei W, Shi J, Yuan H, Zhuang C, Sun Y
Free radical biology & medicine 2026 Jun;249:165-179
Free radical biology & medicine 2026 Jun;249:165-179
Study on the potential mechanism of Artemisia integrifolia Linn. in diabetic nephropathy: multiscale analysis of network pharmacology and metabolomics.
Liu M, Su F, Bai C, Sun M, Zhang W, Li B, Sun Y, Wang Q, Kuang H
Journal of ethnopharmacology 2026 Jul 15;366:121615
Journal of ethnopharmacology 2026 Jul 15;366:121615
Altered transposon element-derived genes distort oxygen-free radical scavenger systems in FXD.
Suganuma T, Hassan H, Swanson SK, Laxman S, Workman JL
NAR molecular medicine 2026 Jan;3(1):ugag010
NAR molecular medicine 2026 Jan;3(1):ugag010
Human amniotic mesenchymal stem cell-derived extracellular vesicles improve oocyte quality and embryonic development by increasing antioxidant capacity in aged mice.
La B, Jiang C, He J, Ni M, Zhou J, Wu H, Ning S, Dai W, Yan Z, Cui Y, Qin L, Liu J
Journal of ovarian research 2026 Jan 2;19(1):41
Journal of ovarian research 2026 Jan 2;19(1):41
Explore the chemical components of Angong Niuhuang Pill and its potential mechanisms for fever treatment based on UHPLC-Q-Exactive orbitrap HRMS, transcriptomics, and experiment verification.
Gao F, An J, Jia S, Zhu Z, Zhang Z, Li Y, Jiao J, Li S, Liu Y, Yin H, Xu B, Lei H
Journal of ethnopharmacology 2026 Jan 10;354:120542
Journal of ethnopharmacology 2026 Jan 10;354:120542
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
Xie X, Cai Y, Xu R, Yang C, Li P, Zhu Y, Luo X, Zhou L, Wang Q
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
The Protective Effect of Naringenin against Lead-Induced Hepatotoxicity in Rats: Mechanisms Involving Oxidative Stress Mitigation, Activation of PINK1/Parkin and Nrf2/NQO1 Pathways, and Autophagy Induction.
Ngwe PK, Zhu J, Ling H, Gao M, Guo C, Hu Y, Wang J
Biological trace element research 2026 Feb 19;
Biological trace element research 2026 Feb 19;
Antioxidant properties of low-molecular-weight Ulva prolifera polysaccharides against H₂O₂-induced oxidative damage in BRL 3A cells and zebrafish.
Tan J, Zheng Y, Ahn G, Wang L, Mao X
Food chemistry 2026 Feb 1;501:147475
Food chemistry 2026 Feb 1;501:147475
A coenzyme-based "interface-welding" hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics.
Duan Q, Geng W, He T, Yang J, Li K, Yang F, Fu Z, Liao X, Luo H, Zhao P, Cai K
Biomaterials 2026 Aug;331:124115
Biomaterials 2026 Aug;331:124115
Comparative effects of dietary resveratrol and pterostilbene on meat quality, muscle antioxidant capacity, and muscle fiber composition in finishing pigs.
Huang T, Chen X, Chen D, Yu B, Zheng P, Yan H, Luo Y, Huang Z
Meat science 2026 Aug;238:110113
Meat science 2026 Aug;238:110113
Epigallocatechin gallate ameliorates brain injuries after intracerebral hemorrhage by inhibiting ferroptosis through upregulation of Nrf2-Keap1 pathway.
Zhou SY, Guo ZN, Sun YY, Jia WB, Zhu HJ, Liu J, Qu Y, Jin H
Brain research bulletin 2026 Apr;237:111812
Brain research bulletin 2026 Apr;237:111812
Exploring the mechanism of Zishen Quyu Jiedu formula in treating endometriosis based on network pharmacology and experimental verification.
Wang R, Tian X, Liu P, Lian F
Frontiers in endocrinology 2025;16:1667486
Frontiers in endocrinology 2025;16:1667486
Fangchinoline attenuates hepatic fibrosis by regulating taurine metabolism and oxidative stress.
Yin H, Lian H, Wang Y, Chen L, Liu X, Liu Y
Frontiers in pharmacology 2025;16:1633519
Frontiers in pharmacology 2025;16:1633519
Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway.
Su J, Zhang Y, Wang X, Hu X, Zhou K, Zhu H, Liu E, Liu S
Frontiers in pharmacology 2025;16:1535352
Frontiers in pharmacology 2025;16:1535352
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Cheng Y, Zheng G, Huang H, Ni J, Zhao Y, Sun Y, Chang Y, Liu S, He F, Li D, Guo Y, Miao Y, Xu M, Wang D, Zhang Y, Hua Y, Yang S, Fan G, Ma C
Theranostics 2025;15(10):4345-4367
Theranostics 2025;15(10):4345-4367
Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress.
Xiao K, Li M, Mu Y, Sun Y, Wang S, Chen S, Ma J, Cao M, Yang Y, Shao H, Ding X, Cui G, Du Z
Frontiers in bioengineering and biotechnology 2025;13:1668524
Frontiers in bioengineering and biotechnology 2025;13:1668524
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation.
Xun Q, Yang Q, Wang W, Zhu G
Cellular signalling 2025 Oct;134:111929
Cellular signalling 2025 Oct;134:111929
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Liu J, Zhang ZZ, Yu GR, Han X
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Preprotective Effects of Cardamomin From Amomum villosum Lour. on H(2)O(2) -Induced Oxidative Damage In Vitro and Cerebral Ischemic Stroke In Vivo.
Zhu M, Sun D, Wang H, Li Y, Li H, Chen L
Phytotherapy research : PTR 2025 Nov;39(11):5378-5390
Phytotherapy research : PTR 2025 Nov;39(11):5378-5390
Fufang Huangqi Jianpi Oral Liquid alleviates spleen deficiency diarrhea via modulation of the NF-κB/Nrf2 signaling pathway and apoptosis.
Huang L, Qiu Z, Sun K, Yu C, Huang Q, Liu C, Pan X, Li S, Ge S, Shi X, Hu F, Xin R
3 Biotech 2025 Nov;15(11):377
3 Biotech 2025 Nov;15(11):377
Benzoylpaeoniflorin alleviates ulcerative colitis by inhibiting ferroptosis through targeting phosphogluconic dehydrogenase.
Tang Y, Wang Z, Zhou F, Li L, Sun C, Li L, Tang F, Huang D, Li Z, Tan Y, Pei G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157111
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157111
Palmitic Acid Induces Ferroptosis in Retinal Microvascular Endothelial Cells by Palmitoylation of Keap1 to Affect Diabetic Retinopathy.
Mao Z, Yang W, Chao Y, Chen Z, Zou Y
Investigative ophthalmology & visual science 2025 Nov 3;66(14):41
Investigative ophthalmology & visual science 2025 Nov 3;66(14):41
Loading tea polyphenols enhances the repair of human umbilical cord mesenchymal stem cell sheet after spinal cord injury.
Zhao Y, Ye C, Wang H, Chen C, Lu Y, Yang C, Xu T, Zhou Y, Wu Z, Song X, Zhu Z, Yang Z, Chen X
Stem cell research & therapy 2025 May 28;16(1):264
Stem cell research & therapy 2025 May 28;16(1):264
Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.
Cheng C, Zhang S, Chen C, Gong Y, Ding K, Li G, Jiang W, Zhang Z, He B, Hu Z, Li Y, Yao L
Scientific reports 2025 Mar 9;15(1):8141
Scientific reports 2025 Mar 9;15(1):8141
Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells.
Dai R, Qian Y, Liu S, Zou X, Sun S, Sun Z
Frontiers in bioscience (Landmark edition) 2025 Mar 18;30(3):27954
Frontiers in bioscience (Landmark edition) 2025 Mar 18;30(3):27954
A novel KEAP1 inhibitor, tiliroside, activates NRF2 to protect against acetaminophen-induced oxidative stress and acute liver injury.
Cai F, Zhou K, Wang P, Zhang W, Liu L, Yang Y
Hepatology communications 2025 Mar 1;9(3)
Hepatology communications 2025 Mar 1;9(3)
Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease through suppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signaling pathways.
Liu Z, Li Y, Bao J, Li S, Wen Y, Zhang P, Feng J, Wang Y, Tian L, Jie Y
Animal models and experimental medicine 2025 Jun;8(6):1056-1079
Animal models and experimental medicine 2025 Jun;8(6):1056-1079
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Wei HK, Qi JJ, Wang YQ, Qu HX, Yan CX, Li TT, Wang Y, Sun H, Sun BX, Liang S
Animal bioscience 2025 Jun;38(6):1160-1174
Animal bioscience 2025 Jun;38(6):1160-1174
Gastrodia elata polysaccharide alleviates depression via gut microbiota modulation and Keap1-Nrf2/BDNF-TrkB pathway activation.
Wen M, Liu M, Zhang Y, Qiao B, Luo T, Liu G, Li D, Zhou B
International journal of biological macromolecules 2025 Jun;317(Pt 1):144630
International journal of biological macromolecules 2025 Jun;317(Pt 1):144630
Suppression of NRF2 by photodynamic action to enhance bortezomib-triggered DNA damage for synergistic colorectal cancer therapy.
Li LG, Chen H, Yu TT, Liu RL, Kong C, Leng F, Xiao RC, Lu YH, Han N, Hu J, Hui YJ, Li TF
Journal of photochemistry and photobiology. B, Biology 2025 Jun;267:113162
Journal of photochemistry and photobiology. B, Biology 2025 Jun;267:113162
Identification of CD84 as a potent survival factor in acute myeloid leukemia.
Zhu Y, Murtadha M, Liu M, Caserta E, Napolitano O, Nguyen LXT, Wang H, Moloudizargari M, Nigam L, Tandoh T, Wang X, Pozhitkov A, Su R, Lin X, Estepa MD, Pillai R, Song J, Sanchez JF, Fu YH, Zhang L, Li M, Zhang B, Li L, Kuo YH, Rosen S, Marcucci G, Williams JC, Pichiorri F
The Journal of clinical investigation 2025 Jun 2;135(11)
The Journal of clinical investigation 2025 Jun 2;135(11)
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Chen W, Li D, Chen L, Fei J, Bian M, Zeng Q, Jiang Z, Wu J
Arthritis research & therapy 2025 Jun 19;27(1):128
Arthritis research & therapy 2025 Jun 19;27(1):128
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis.
Liao Q, Guo Z, Ding C, Zuo R, Liu G
Journal of food and drug analysis 2025 Jun 13;33(2):119-131
Journal of food and drug analysis 2025 Jun 13;33(2):119-131
Nephroprotective effects of Amomum kravanh essential oil by inhibition of ferroptosis regulated by Nrf2/HO-1 signaling pathway.
Cheng X, Hao W, Yu S, Gao X, Qu L, Liu C, Wang Y, Sun Y, Huang J, Yang L, Wang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156762
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156762
PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma.
Zhou J, Gao M, Zhang S, Guo WW, He W, Zhang M, Chen X, Dongzhi C, Li X, Yuan Y, Ma W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2501730
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2501730
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
Zhang S, Tang F, Zhou Z, Li L, Tang Y, Fu K, Tan Y, Li L
International journal of molecular sciences 2025 Jul 11;26(14)
International journal of molecular sciences 2025 Jul 11;26(14)
MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway.
Zhang J, He S, Wu K, Wei Y, Li C, Zhu Q, Lian S, Wang L, Wan F, Peng F, Zhang J, Chen Z, Zhang X
Scientific reports 2025 Jul 1;15(1):21199
Scientific reports 2025 Jul 1;15(1):21199
Resveratrol Alleviated T-2 Toxin-Induced Liver Injury via Preservation of Nrf2 Pathway and GSH Synthesis.
Jin H, He J, Wu M, Wang X, Jia L, Zhang L, Guo J
Environmental toxicology 2025 Jan;40(1):19-29
Environmental toxicology 2025 Jan;40(1):19-29
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Zhang X, Ji Z, He Q, Yang D, Wang X, Liu C, Zhang C, Yuan J, Xu N, Chu J
Journal of ethnopharmacology 2025 Jan 31;340:119290
Journal of ethnopharmacology 2025 Jan 31;340:119290
Protective Effects of Black Rice Anthocyanins on D-Galactose-Induced Renal Injury in Mice: The Role of Nrf2 and NF-κB Signaling and Gut Microbiota Modulation.
Sun D, Wang W, Fan Q, Wang X, Xu X, Jiang W, Zhao L, Li H, Fu Z, Zhao L, Jiao H
Nutrients 2025 Jan 29;17(3)
Nutrients 2025 Jan 29;17(3)
Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.
Pan D, Hu G, Li J, Wang Z, Chen Y, Cao J
Investigative ophthalmology & visual science 2025 Jan 2;66(1):3
Investigative ophthalmology & visual science 2025 Jan 2;66(1):3
The therapeutic potential of Osmundacetone for rheumatoid arthritis: Effects and mechanisms on osteoclastogenesis.
Wang Z, Liu Y, Feng C, Li T, Xu H, Ding Y, Liu W, Pu L, Li R, Ai C, Chen Z, Wang X
European journal of pharmacology 2025 Jan 15;987:177135
European journal of pharmacology 2025 Jan 15;987:177135
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Song Y, Zhu X, Wang B, Li Q, Song B
Scientific reports 2025 Jan 10;15(1):1614
Scientific reports 2025 Jan 10;15(1):1614
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
Jiang Y, He P, Sheng K, Peng Y, Wu H, Qian S, Ji W, Guo X, Shan X
eLife 2025 Jan 10;13
eLife 2025 Jan 10;13
Anti-inflammatory effect of echinacoside in collagen-induced arthritis via Nrf2/Drp1 pathway.
Wang X, Li L, Zhang M, Ji R, Li N, Wang K, Chen Z
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2025 Feb;34(2):199-209
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2025 Feb;34(2):199-209
Remimazolam induced cytotoxicity mediated through multiple stress pathways and acted synergistically with tyrosine kinase inhibitors in hepatocellular carcinoma.
Fan HL, Chen JL, Liu ST, Lee JT, Huang SM, Wu ZF, Lai HC
Redox report : communications in free radical research 2025 Dec;30(1):2475696
Redox report : communications in free radical research 2025 Dec;30(1):2475696
Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling.
Chen L, Wu Y, Lv T, Tuo R, Xiao Y
Redox report : communications in free radical research 2025 Dec;30(1):2455914
Redox report : communications in free radical research 2025 Dec;30(1):2455914
Machine learning-driven screening of antioxidant peptides from macadamia nuts: In vitro experimental validation and mechanistic insights.
Jiang W, Zhu Z, Pan F, Zhao L, Zhao L
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 2):117316
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 2):117316
Deoxynivalenol induces liver injury by inhibiting the p62-Keap1-Nrf2 signaling pathway via overactivation of PINK1/Parkin-mediated mitophagy.
Yu W, Zhang B, Yang M, Li Y, Cao Z
Journal of hazardous materials 2025 Dec 5;500:140486
Journal of hazardous materials 2025 Dec 5;500:140486
Synthesis and evaluation of lansiumamide B analogues to ameliorate acute lung injury by reducing oxidative stress and inflammation via Keap1/Nrf2/NF-κB pathway.
Song L, Li M, Li J, Liu L, Luo X, Wang J, Wu X, Huang B, Zhang G, Yao H
European journal of medicinal chemistry 2025 Dec 5;299:118052
European journal of medicinal chemistry 2025 Dec 5;299:118052
Volvariella volvacea polysaccharides alleviate acute liver injury by modulating Nrf2/NF-κB pathway in a dual manner.
Li X, Zhang F, Li Y, Cai J, Cai L, Ren Q, Fan A, Xu B, Fu J
NPJ science of food 2025 Dec 12;9(1):278
NPJ science of food 2025 Dec 12;9(1):278
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
Chen L, Zeng L, Pan S, Zu L, Pan H, Fan L
Cytotechnology 2025 Apr;77(2):76
Cytotechnology 2025 Apr;77(2):76
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in Neonatal Mice.
Zhao Y, Gai C, Yu S, Song Y, Gu B, Luo Q, Wang X, Hu Q, Liu W, Liu D, Wang Z
Antioxidants & redox signaling 2025 Apr;42(10-12):512-528
Antioxidants & redox signaling 2025 Apr;42(10-12):512-528
TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway.
Zhao J, Chen C, Ge L, Jiang Z, Hu Z, Yin L
Frontiers in immunology 2024;15:1386780
Frontiers in immunology 2024;15:1386780
Citraconate promotes the malignant progression of colorectal cancer by inhibiting ferroptosis.
Mai Z, Li Y, Zhang L, Zhang H
American journal of cancer research 2024;14(6):2790-2804
American journal of cancer research 2024;14(6):2790-2804
Vitamin D receptor alleviates lipid peroxidation in diabetic nephropathy by regulating ACLY/Nrf2/Keap1 pathway.
Zhou Y, Liao Q, Li D, Chen L, Zhang H, Yi B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70060
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 30;38(18):e70060
Role and Mechanism of Sialic Acid in Alleviating Acute Lung Injury through In Vivo and In Vitro Models.
Li D, Li F, Zhou Y, Tang Y, Hu Z, Wu Q, Xie T, Lin Q, Wang H, Luo F
Foods (Basel, Switzerland) 2024 Sep 20;13(18)
Foods (Basel, Switzerland) 2024 Sep 20;13(18)
Metformin attenuates PM(2.5)-induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells.
Cui J, Chen W, Zhang D, Lu M, Huang Z, Yi B
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
Toxicology mechanisms and methods 2024 Nov;34(9):1022-1034
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
ΔNp63α promotes radioresistance in esophageal squamous cell carcinoma through the PLEC-KEAP1-NRF2 feedback loop.
Tao J, Mao M, Lu Y, Deng L, Yu S, Zeng X, Jia W, Wu Z, Li C, Ma R, Chen H
Cell death & disease 2024 Nov 5;15(11):793
Cell death & disease 2024 Nov 5;15(11):793
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Gai C, Li T, Zhao Y, Cheng Y, Song Y, Luo Q, Liu D, Wang Z
Free radical biology & medicine 2024 Nov 20;225:528-545
Free radical biology & medicine 2024 Nov 20;225:528-545
Salinomycin, a potent inhibitor of XOD and URAT1, ameliorates hyperuricemic nephropathy by activating NRF2, modulating the gut microbiota, and promoting SCFA production.
Chen YJ, Guo ZT, Chen HQ, Zhang SF, Bao YX, Xie Z, Ke JL, Ye WJ, Liang JC, Chen JC, Li N, Zheng FX, Liao H, Wu T, Pang JX
Chemico-biological interactions 2024 Nov 1;403:111220
Chemico-biological interactions 2024 Nov 1;403:111220
Arenobufagin inhibits lung metastasis of colorectal cancer by targeting c-MYC/Nrf2 axis.
Wang M, Hu S, Yang J, Yuan L, Han L, Liang F, Zhang F, Zhao H, Liu Y, Gao N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155391
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155391
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
Dai L, Zhang C, Gao W, Pan J, Huang S, Zhang Y, Cheng Y, Wang Y, Tao J, Wang H, Feng Z, Su C, Zhang Y
Translational cancer research 2024 May 31;13(5):2372-2386
Translational cancer research 2024 May 31;13(5):2372-2386
LC-MS-based rheumatoid arthritis serum metabolomics reveals the role of deoxyinosine in attenuating collagen-induced arthritis in mice.
Xu D, Tang L, Wang Y, Pan J, Su C
Heliyon 2024 May 30;10(10):e30903
Heliyon 2024 May 30;10(10):e30903
Electroacupuncture improves cognitive function in APP/PS1 mice by inhibiting oxidative stress related hippocampal neuronal ferroptosis.
Chen Y, Li Y, Wu M, Li Z
Brain research 2024 May 15;1831:148744
Brain research 2024 May 15;1831:148744
Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury.
Shi W, Wang J, Li Z, Xu S, Wang J, Zhang L, Yang H
Free radical biology & medicine 2024 Mar;213:343-358
Free radical biology & medicine 2024 Mar;213:343-358
Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis.
Jiang Z, Qi G, He X, Yu Y, Cao Y, Zhang C, Zou W, Yuan H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(12):e2307388
TOM40 mediates the effect of TSPO on postpartum depression partially through regulating calcium homeostasis in microglia.
Zhai DS, Wang XS, Yang L, Jiang YL, Jin YC, Yan YX, Song DK, Zhang K, Han ZK, Liu MY, Wu YM, Ma X, Qi JY, Yang F, Tian F, Li XB, Liu SB
Journal of affective disorders 2024 Mar 1;348:283-296
Journal of affective disorders 2024 Mar 1;348:283-296
An ATPase-Mimicking MXene nanozyme pharmacologically breaks the ironclad defense system for ferroptosis cancer therapy.
Wang H, Liu X, Yan X, Du Y, Pu F, Ren J, Qu X
Biomaterials 2024 Jun;307:122523
Biomaterials 2024 Jun;307:122523
SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.
Chu WX, Ding C, Du ZH, Wei P, Wang YX, Ge XJ, Yu GY
Oral diseases 2024 Jul;30(5):3066-3080
Oral diseases 2024 Jul;30(5):3066-3080
Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1.
Ye S, Hu X, Sun S, Su B, Cai J, Jiang J
European journal of pharmacology 2024 Jul 5;974:176620
European journal of pharmacology 2024 Jul 5;974:176620
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells.
Xia Q, Xie J, Zhang J, Zhang L, Zhou Y, Zhu B, Wu Y, Yang Z, Li J
Chemico-biological interactions 2024 Jan 5;387:110819
Chemico-biological interactions 2024 Jan 5;387:110819
Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis.
Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, Favero G
International journal of molecular sciences 2024 Jan 16;25(2)
International journal of molecular sciences 2024 Jan 16;25(2)
Ameliorative effect of salidroside on the cyclophosphamide-induced premature ovarian failure in a rat model.
Chen L, Mo Q, Wu Y, Chen W, Deng K, Xiao Y
Free radical research 2024 Feb;58(2):107-116
Free radical research 2024 Feb;58(2):107-116
Huangqin Decoction Delays Progress of Colitis-Associated Carcinogenesis by Regulating Nrf2/HO-1 Antioxidant Signal Pathway in Mice.
Gu LM, Li HZ, Gao L, Li H, Wei LF, Pan CY, Wu KX, Tian YZ
Chinese journal of integrative medicine 2024 Feb;30(2):135-142
Chinese journal of integrative medicine 2024 Feb;30(2):135-142
Activation of the p62-Keap1-Nrf2 pathway improves pulmonary arterial hypertension in MCT-induced rats by inhibiting autophagy.
Jiang G, Shi LF, Li LJ, Duan XJ, Zheng ZF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 15;38(3):e23452
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 15;38(3):e23452
CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury.
Wang F, Yang Q, Wang X, Guo Y, Lin S
Hypertension in pregnancy 2024 Dec;43(1):2414976
Hypertension in pregnancy 2024 Dec;43(1):2414976
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
Wang YQ, Dong YW, Qu HX, Qi JJ, Yan CX, Wei HK, Sun H, Sun BX, Liang S
Theriogenology 2024 Dec;230:203-211
Theriogenology 2024 Dec;230:203-211
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Zhao Y, Zheng G, Yang S, Liu S, Wu Y, Miao Y, Liang Z, Hua Y, Zhang J, Shi J, Li D, Cheng Y, Zhang Y, Chen Y, Fan G, Ma C
British journal of pharmacology 2024 Dec;181(23):4822-4844
British journal of pharmacology 2024 Dec;181(23):4822-4844
Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway.
Liu Y, Wang Y, Wang J, Wang X, Chen L, Han T, Lian H, Gan M, Wang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156143
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156143
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Qi XM, Zhang WZ, Zuo YQ, Qiao YB, Zhang YL, Ren JH, Li QS
Cell biology and toxicology 2024 Dec 20;41(1):2
Cell biology and toxicology 2024 Dec 20;41(1):2
Curcumin inhibits PAT-induced renal ferroptosis via the p62/Keap1/Nrf2 signalling pathway.
Zhai J, Chen Z, Zhu Q, Guo Z, Sun X, Jiang L, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G
Toxicology 2024 Aug;506:153863
Toxicology 2024 Aug;506:153863
Identification and anti-oxidative potential of milk fat globule membrane (MFGM)-derived bioactive peptides released through in vitro gastrointestinal digestion.
Li H, Guan K, Liu M, Jiang W, Yan F, Zhu A, Zhou S
Bioorganic chemistry 2024 Apr;145:107232
Bioorganic chemistry 2024 Apr;145:107232
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Cai F, Li D, Zhou K, Zhang W, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.
Dong M, Yang Z, Gao Q, Deng Q, Li L, Chen H
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
Antioxidants (Basel, Switzerland) 2024 Apr 10;13(4)
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Chen T, Hu Y, Lu L, Zhao Q, Tao X, Ding B, Chen S, Zhu J, Guo X, Lin Z
Frontiers in pharmacology 2023;14:1134464
Frontiers in pharmacology 2023;14:1134464
Inhibition of COX-2 signaling favors E. coli during urinary tract infection.
Mohanty S, Lindelauf C, White JK, Scheffschick A, Ehrenborg E, Demirel I, Brauner H, Brauner A
Journal of inflammation (London, England) 2023 Sep 11;20(1):30
Journal of inflammation (London, England) 2023 Sep 11;20(1):30
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to Discover Cyanidin Chloride as a Novel Keap1 Inhibitor Against Doxorubicin-Induced Cardiotoxicity.
Liu C, Wang Y, Zeng Y, Kang Z, Zhao H, Qi K, Wu H, Zhao L, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2301136
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Oct;10(30):e2301136
Neuroprotective effects of Lycium barbarum polysaccharide on light-induced oxidative stress and mitochondrial damage via the Nrf2/HO-1 pathway in mouse hippocampal neurons.
Yang Y, Yu L, Zhu T, Xu S, He J, Mao N, Liu Z, Wang D
International journal of biological macromolecules 2023 Nov 1;251:126315
International journal of biological macromolecules 2023 Nov 1;251:126315
Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways.
Liao D, Shangguan D, Wu Y, Chen Y, Liu N, Tang J, Yao D, Shi Y
Psychopharmacology 2023 May;240(5):1179-1190
Psychopharmacology 2023 May;240(5):1179-1190
Ligand impact on reactive oxygen species generation of Au(10) and Au(25) nanoclusters upon one- and two-photon excitation.
Fakhouri H, Bakulić MP, Zhang I, Yuan H, Bain D, Rondepierre F, Brevet PF, Maršić ŽS, Antoine R, Bonačić-Koutecký V, Maysinger D
Communications chemistry 2023 May 22;6(1):97
Communications chemistry 2023 May 22;6(1):97
Nrf2 affects hydroquinone-induces cell cycle arrest through the p16/pRb signaling pathway and antioxidant enzymes.
Chen L, Zhai L, Gao Y, Cui Z, Yu L, Zhu D, Tang H, Luo H
Ecotoxicology and environmental safety 2023 Jan 1;249:114389
Ecotoxicology and environmental safety 2023 Jan 1;249:114389
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Chloroquine is a safe autophagy inhibitor for sustaining the expression of antioxidant enzymes in trophoblasts.
Furuta A, Shima T, Yoshida-Kawaguchi M, Yamada K, Yasuda I, Tsuda S, Yamaki-Ushijima A, Yoneda S, Higashisaka K, Cheng SB, Matsumoto K, Tsutsumi Y, Sharma S, Saito S, Nakashima A
Journal of reproductive immunology 2023 Feb;155:103766
Journal of reproductive immunology 2023 Feb;155:103766
Neocryptotanshinone protects against myocardial ischemia-reperfusion injury by promoting autolysosome degradation of protein aggregates via the ERK1/2-Nrf2-LAMP2 pathway.
Yang Y, Shao M, Yao J, Yang S, Cheng W, Ma L, Li W, Cao J, Zhang Y, Hu Y, Li C, Wang Y, Wang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154625
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154625
Ginsenoside Rh2 inhibits CBP/p300-mediated FOXO3a acetylation and epilepsy-induced oxidative damage via the FOXO3a-KEAP1-NRF2 pathway.
Wu J, Wang S, Zhao W, Li M, Li S
European journal of pharmacology 2023 Feb 5;940:175391
European journal of pharmacology 2023 Feb 5;940:175391
FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway.
Zhou Y, Chen Y, Shi Y, Wu L, Tan Y, Li T, Chen Y, Xia J, Hu R
The Journal of clinical investigation 2023 Feb 1;133(3)
The Journal of clinical investigation 2023 Feb 1;133(3)
Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress.
Liu Q, Duan SB, Wang L, Luo XQ, Wang HS, Deng YH, Wu X, Wu T, Yan And P, Kang YX
Renal failure 2023 Dec;45(1):2179852
Renal failure 2023 Dec;45(1):2179852
Inhibition of SIRT1 promotes ultraviolet B induced cataract via downregulation of the KEAP1/NFE2L2 signaling pathway.
Wu F, Xia X, Lei T, Du H, Hua H, Liu W, Xu B, Yang T
Journal of photochemistry and photobiology. B, Biology 2023 Aug;245:112753
Journal of photochemistry and photobiology. B, Biology 2023 Aug;245:112753
Curcumin in vitro Neuroprotective Effects Are Mediated by p62/keap-1/Nrf2 and PI3K/AKT Signaling Pathway and Autophagy Inhibition.
Li X, Sung P, Zhang D, Yan L
Physiological research 2023 Aug 31;72(4):497-510
Physiological research 2023 Aug 31;72(4):497-510
Zinc Oxide Nanoparticle Improves the Intestinal Function of Intrauterine Growth Retardation Finishing Pigs via Regulating Intestinal Morphology, Inflammation, Antioxidant Status and Autophagy.
Zhou B, Zhang J, Liu H, Chen S, Wang T, Wang C
Frontiers in veterinary science 2022;9:884945
Frontiers in veterinary science 2022;9:884945
Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway.
Huang J, Ding J, Wang Z, Li Y, He Y, Wang X, Fan H, Xie Q, Qiu P
Oxidative medicine and cellular longevity 2022;2022:8400876
Oxidative medicine and cellular longevity 2022;2022:8400876
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Han GJ, Min XZ, Ma SS, Ding C, Wang XQ
Oxidative medicine and cellular longevity 2022;2022:5126042
Oxidative medicine and cellular longevity 2022;2022:5126042
Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure.
Jiang Z, Yang X, Han Y, Li J, Hu C, Liu C, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154337
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154337
Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway.
Li Y, Zhang E, Yang H, Chen Y, Tao L, Xu Y, Chen T, Shen X
Molecules (Basel, Switzerland) 2022 Sep 24;27(19)
Molecules (Basel, Switzerland) 2022 Sep 24;27(19)
Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.
Zhen D, Liu C, Huang T, Fu D, Bai X, Ma Q, Jiang M, Gong G
Journal of ethnopharmacology 2022 Oct 5;296:115497
Journal of ethnopharmacology 2022 Oct 5;296:115497
A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner.
Chung KM, Kim H, Roque CG, McCurdy EP, Nguyen TTT, Siegelin MD, Hwang JY, Hengst U
Cell reports 2022 Oct 18;41(3):111488
Cell reports 2022 Oct 18;41(3):111488
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Wang Y, Zhu M, Liang J, Zhang N, Sun D, Li H, Chen L
Bioorganic chemistry 2022 Nov;128:106067
Bioorganic chemistry 2022 Nov;128:106067
Neutrophil Nanovesicle Protects against Experimental Autoimmune Encephalomyelitis through Enhancing Myelin Clearance by Microglia.
Shen S, Cheng X, Zhou L, Zhao Y, Wang H, Zhang J, Sun X, Wang Y, Shu Y, Xu Y, Tao Y, Li M, Lu Z, Cai W, Nie G, Qiu W
ACS nano 2022 Nov 22;16(11):18886-18897
ACS nano 2022 Nov 22;16(11):18886-18897
Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway.
Ye J, Zheng J, Tian X, Xu B, Yuan F, Wang B, Yang Z, Huang F
Marine drugs 2022 Mar 25;20(4)
Marine drugs 2022 Mar 25;20(4)
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response.
Zhu L, He S, Huang L, Ren D, Nie T, Tao K, Xia L, Lu F, Mao Z, Yang Q
Aging cell 2022 Jun;21(6):e13616
Aging cell 2022 Jun;21(6):e13616
Apple Polyphenols Improve Intestinal Antioxidant Capacity and Barrier Function by Activating the Nrf2/Keap1 Signaling Pathway in a Pig Model.
Huang T, Che Q, Chen X, Chen D, Yu B, He J, Chen H, Yan H, Zheng P, Luo Y, Huang Z
Journal of agricultural and food chemistry 2022 Jun 22;70(24):7576-7585
Journal of agricultural and food chemistry 2022 Jun 22;70(24):7576-7585
Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1.
Xu Q, Liu M, Gu J, Ling S, Liu X, Luo Z, Jin Y, Chai R, Ou W, Liu S, Liu N
Cell death discovery 2022 Jun 16;8(1):291
Cell death discovery 2022 Jun 16;8(1):291
Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy.
Liu W, Yan F, Xu Z, Chen Q, Ren J, Wang Q, Chen L, Ying J, Liu Z, Zhao J, Qiu J, Zhang C, Jiang M, Xiang L
Journal of photochemistry and photobiology. B, Biology 2022 Jul;232:112462
Journal of photochemistry and photobiology. B, Biology 2022 Jul;232:112462
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo.
Chen X, Zhang M, Xue Y, Liang D, An W, Jia G, Zhao H, Liu G, Huang Z
The Journal of nutritional biochemistry 2022 Jan;99:108859
The Journal of nutritional biochemistry 2022 Jan;99:108859
Apple polyphenols improve intestinal barrier function by enhancing antioxidant capacity and suppressing inflammation in weaning piglets.
Guo Z, Chen X, Huang Z, Chen D, Yu J, Yan H, Chen H, He J, Zheng P, Luo Y, Yu B
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13747
Animal science journal = Nihon chikusan Gakkaiho 2022 Jan-Dec;93(1):e13747
Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.
Li JW, Wang RL, Xu J, Sun KY, Jiang HM, Sun ZY, Lv ZY, Xu XQ, Wu R, Guo H, Jiang Q, Shi DQ
Acta pharmacologica Sinica 2022 Feb;43(2):417-428
Acta pharmacologica Sinica 2022 Feb;43(2):417-428
Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway.
Zhang Y, Liu M, Zhang Y, Tian M, Chen P, Lan Y, Zhou B
Phytotherapy research : PTR 2022 Feb;36(2):984-995
Phytotherapy research : PTR 2022 Feb;36(2):984-995
Interdisciplinary Study of the Effects of Dipeptidyl-Peptidase III Cancer Mutations on the KEAP1-NRF2 Signaling Pathway.
Matić S, Tomašić Paić A, Sobočanec S, Pinterić M, Pipalović G, Martinčić M, Matovina M, Tomić S
International journal of molecular sciences 2022 Feb 11;23(4)
International journal of molecular sciences 2022 Feb 11;23(4)
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in weaning piglets.
Chen X, Chen L, Qin Y, Mao Z, Jia G, Zhao H, Liu G, Huang Z
Animal biotechnology 2022 Dec;33(7):1389-1397
Animal biotechnology 2022 Dec;33(7):1389-1397
Defective autophagy triggered by arterial cyclic stretch promotes neointimal hyperplasia in vein grafts via the p62/nrf2/slc7a11 signaling pathway.
Chen Y, Bao M, Liu JT, Bao H, Zhang SM, Lou Y, Qi YX
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
Journal of molecular and cellular cardiology 2022 Dec;173:101-114
Epoxymicheliolide prevents dextran sulfate sodium-induced colitis in mice by inhibiting TAK1-NF-κB pathway and activating Keap1-NRF2 signaling in macrophages.
He J, Liu L, Liu X, Chen H, Liu K, Huang N, Wang Y
International immunopharmacology 2022 Dec;113(Pt A):109404
International immunopharmacology 2022 Dec;113(Pt A):109404
Identification of Agents That Ameliorate Hyperphosphatemia-Suppressed Myogenin Expression Involved in the Nrf2/p62 Pathway in C2C12 Skeletal Muscle Cells.
Hsieh Li SM, Liu ST, Chang YL, Chen GS, Huang SM
International journal of molecular sciences 2022 Dec 5;23(23)
International journal of molecular sciences 2022 Dec 5;23(23)
Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora.
Ren X, Miao B, Cao H, Tian X, Shen L, Yang Z, Yuan F, Ding Y
Molecules (Basel, Switzerland) 2022 Dec 28;28(1)
Molecules (Basel, Switzerland) 2022 Dec 28;28(1)
Trehalose prevents glyphosate-induced testicular damage in roosters via its antioxidative properties.
Chen K, Liu JB, Tie CZ, Wang L
Research in veterinary science 2022 Dec 20;152:314-322
Research in veterinary science 2022 Dec 20;152:314-322
Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice.
Li H, Cao T, Ding W, Liang L, Fan GC, Qu L, Peng T
Journal of cardiovascular translational research 2022 Aug;15(4):805-815
Journal of cardiovascular translational research 2022 Aug;15(4):805-815
Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia of Ganoderma lingzhi.
Huang P, Luo FJ, Ma YC, Wang SX, Huang J, Qin DD, Xue FF, Liu BY, Wu Q, Wang XL, Liu GQ
Food & function 2022 Aug 30;13(17):9032-9048
Food & function 2022 Aug 30;13(17):9032-9048
Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.
Wang Y, Zhang Y, Chen K, Liu J, Wu D, Cheng Y, Wang H, Li Y
Stem cell research & therapy 2022 Aug 13;13(1):418
Stem cell research & therapy 2022 Aug 13;13(1):418
Antioxidant Activity of Acanthopanax senticosus Flavonoids in H(2)O(2)-Induced RAW 264.7 Cells and DSS-Induced Colitis in Mice.
Su J, Zhang X, Kan Q, Chu X
Molecules (Basel, Switzerland) 2022 Apr 30;27(9)
Molecules (Basel, Switzerland) 2022 Apr 30;27(9)
Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.
Shao Y, Jia H, Li S, Huang L, Aikemu B, Yang G, Zhang S, Sun J, Zheng M
Oxidative medicine and cellular longevity 2021;2021:7007933
Oxidative medicine and cellular longevity 2021;2021:7007933
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway.
Liu H, Xu X, Wu R, Bi L, Zhang C, Chen H, Yang Y
BioMed research international 2021;2021:6616547
BioMed research international 2021;2021:6616547
Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.
Liu J, Wu Q, Yang T, Yang F, Guo T, Zhou Y, Han S, Luo Y, Guo T, Luo F, Lin Q
Oxidative medicine and cellular longevity 2021;2021:2637577
Oxidative medicine and cellular longevity 2021;2021:2637577
Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.
Zhao L, Zhou N, Zhang H, Pan F, Ai X, Wang Y, Hao S, Wang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112582
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112582
The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression.
Gao L, Liu Y, Du X, Ma S, Ge M, Tang H, Han C, Zhao X, Liu Y, Shao Y, Wu Z, Zhang L, Meng F, Xiao-Feng Qin F
Cell death & disease 2021 Jul 5;12(7):680
Cell death & disease 2021 Jul 5;12(7):680
Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages.
Dierckx T, Haidar M, Grajchen E, Wouters E, Vanherle S, Loix M, Boeykens A, Bylemans D, Hardonnière K, Kerdine-Römer S, Bogie JFJ, Hendriks JJA
Journal of neuroinflammation 2021 Jul 4;18(1):148
Journal of neuroinflammation 2021 Jul 4;18(1):148
Polydatin protects Schwann cells from methylglyoxal induced cytotoxicity and promotes crushed sciatic nerves regeneration of diabetic rats.
Chen L, Chen Z, Xu Z, Feng W, Yang X, Qi Z
Phytotherapy research : PTR 2021 Aug;35(8):4592-4604
Phytotherapy research : PTR 2021 Aug;35(8):4592-4604
Dietary dihydromyricetin supplementation enhances antioxidant capacity and improves lipid metabolism in finishing pigs.
Guo Z, Chen X, Huang Z, Chen D, Yu B, Chen H, Yu J, Yan H, Zheng P, Luo Y
Food & function 2021 Aug 2;12(15):6925-6935
Food & function 2021 Aug 2;12(15):6925-6935
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396
BMC cancer 2021 Apr 12;21(1):396
Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.
Xu C, Hou B, He P, Ma P, Yang X, Yang X, Zhang L, Qiang G, Li W, Du G
Oxidative medicine and cellular longevity 2020;2020:6431459
Oxidative medicine and cellular longevity 2020;2020:6431459
Role of Nrf2 in Lipopolysaccharide-Induced Acute Kidney Injury: Protection by Human Umbilical Cord Blood Mononuclear Cells.
Feng LX, Zhao F, Liu Q, Peng JC, Duan XJ, Yan P, Wu X, Wang HS, Deng YH, Duan SB
Oxidative medicine and cellular longevity 2020;2020:6123459
Oxidative medicine and cellular longevity 2020;2020:6123459
La(2)O(3) Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice.
Yuan L, Li Q, Bai D, Shang X, Hu F, Chen Z, An T, Chen Y, Zhang X
International journal of nanomedicine 2020;15:3415-3431
International journal of nanomedicine 2020;15:3415-3431
Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway.
Chen Z, Xiao J, Liu H, Yao K, Hou X, Cao Y, Liu X
Food & function 2020 Sep 23;11(9):8099-8111
Food & function 2020 Sep 23;11(9):8099-8111
Brain Dicer1 Is Down-Regulated in a Mouse Model of Alzheimer's Disease Via Aβ42-Induced Repression of Nuclear Factor Erythroid 2-Related Factor 2.
Wang Y, Lian M, Zhou J, Wu S
Molecular neurobiology 2020 Nov;57(11):4417-4437
Molecular neurobiology 2020 Nov;57(11):4417-4437
Urolithin B, a gut microbiota metabolite, protects against myocardial ischemia/reperfusion injury via p62/Keap1/Nrf2 signaling pathway.
Zheng D, Liu Z, Zhou Y, Hou N, Yan W, Qin Y, Ye Q, Cheng X, Xiao Q, Bao Y, Luo J, Wu X
Pharmacological research 2020 Mar;153:104655
Pharmacological research 2020 Mar;153:104655
Autophagy inducer activates Nrf2-ARE pathway to attenuate aberrant alveolarization in neonatal rats with bronchopulmonary dysplasia.
Zhao X, Shi Y, Zhang D, Tong X, Sun Y, Xue X, Fu J
Life sciences 2020 Jul 1;252:117662
Life sciences 2020 Jul 1;252:117662
Overexpression of Mfsd2a attenuates blood brain barrier dysfunction via Cav-1/Keap-1/Nrf-2/HO-1 pathway in a rat model of surgical brain injury.
Eser Ocak P, Ocak U, Sherchan P, Gamdzyk M, Tang J, Zhang JH
Experimental neurology 2020 Apr;326:113203
Experimental neurology 2020 Apr;326:113203
Repair Effects of Astragalus Polysaccharides with Different Molecular Weights on Oxidatively Damaged HK-2 Cells.
Han J, Guo D, Sun XY, Wang JM, Ouyang JM, Gui BS
Scientific reports 2019 Jul 8;9(1):9871
Scientific reports 2019 Jul 8;9(1):9871
Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells.
Rabbani PS, Soares MA, Hameedi SG, Kadle RL, Mubasher A, Kowzun M, Ceradini DJ
Diabetes 2019 Jan;68(1):141-155
Diabetes 2019 Jan;68(1):141-155
Chemical and genetic control of IFNγ-induced MHCII expression.
Wijdeven RH, van Luijn MM, Wierenga-Wolf AF, Akkermans JJ, van den Elsen PJ, Hintzen RQ, Neefjes J
EMBO reports 2018 Sep;19(9)
EMBO reports 2018 Sep;19(9)
Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing.
Rabbani PS, Zhou A, Borab ZM, Frezzo JA, Srivastava N, More HT, Rifkin WJ, David JA, Berens SJ, Chen R, Hameedi S, Junejo MH, Kim C, Sartor RA, Liu CF, Saadeh PB, Montclare JK, Ceradini DJ
Biomaterials 2017 Jul;132:1-15
Biomaterials 2017 Jul;132:1-15
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.
Duleh S, Wang X, Komirenko A, Margeta M
Acta neuropathologica communications 2016 Oct 31;4(1):115
Acta neuropathologica communications 2016 Oct 31;4(1):115
Restoration of Nrf2 Signaling Normalizes the Regenerative Niche.
Soares MA, Cohen OD, Low YC, Sartor RA, Ellison T, Anil U, Anzai L, Chang JB, Saadeh PB, Rabbani PS, Ceradini DJ
Diabetes 2016 Mar;65(3):633-46
Diabetes 2016 Mar;65(3):633-46
Expression of LC3, LAMP2, KEAP1 and NRF2 in Salivary Adenoid Cystic Carcinoma.
Huang CF, Deng WW, Zhang L, Zhang WF, Sun ZJ
Pathology oncology research : POR 2016 Jan;22(1):109-14
Pathology oncology research : POR 2016 Jan;22(1):109-14
Oxidative Damage and Nuclear Factor Erythroid 2-Related Factor 2 Protein Expression in Normal Skin and Keloid Tissue.
Lee YJ, Kwon SB, Kim CH, Cho HD, Nam HS, Lee SH, Lee MW, Nam DH, Choi CY, Cho MK
Annals of dermatology 2015 Oct;27(5):507-16
Annals of dermatology 2015 Oct;27(5):507-16
Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.
Jimenez-Blasco D, Santofimia-Castaño P, Gonzalez A, Almeida A, Bolaños JP
Cell death and differentiation 2015 Nov;22(11):1877-89
Cell death and differentiation 2015 Nov;22(11):1877-89
Increased protein oxidation and decreased expression of nuclear factor E2-related factor 2 protein in skin tissue of patients with diabetes.
Lee YJ, Kwon SB, An JM, Kim CH, Lee SH, Choi CY, Nam DH, Park JW, Nam HS, Lee SH, Lee MW, Cho MK
Clinical and experimental dermatology 2015 Mar;40(2):192-200
Clinical and experimental dermatology 2015 Mar;40(2):192-200
NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma.
Cescon DW, She D, Sakashita S, Zhu CQ, Pintilie M, Shepherd FA, Tsao MS
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Jun 1;21(11):2499-505
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Jun 1;21(11):2499-505
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R
Molecular and cellular biology 2015 Jul;35(14):2385-99
Molecular and cellular biology 2015 Jul;35(14):2385-99
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S
International journal of clinical and experimental pathology 2014;7(6):2780-9
International journal of clinical and experimental pathology 2014;7(6):2780-9
Expression of nuclear factor erythroid 2 protein in malignant cutaneous tumors.
Choi CY, Kim JY, Wee SY, Lee JH, Nam DH, Kim CH, Cho MK, Lee YJ, Nam HS, Lee SH, Cho SW
Archives of plastic surgery 2014 Nov;41(6):654-60
Archives of plastic surgery 2014 Nov;41(6):654-60
Clinical significance of Keap1 and Nrf2 in oral squamous cell carcinoma.
Huang CF, Zhang L, Ma SR, Zhao ZL, Wang WM, He KF, Zhao YF, Zhang WF, Liu B, Sun ZJ
PloS one 2013;8(12):e83479
PloS one 2013;8(12):e83479
Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line.
Chandiramani N, Wang X, Margeta M
PloS one 2011 Jan 4;6(1):e14485
PloS one 2011 Jan 4;6(1):e14485
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC
Molecular cell 2009 Oct 9;36(1):131-40
Molecular cell 2009 Oct 9;36(1):131-40
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 60027-1-Ig(KEAP1 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas cancer using 60027-1-Ig(KEAP1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The KEAP1 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human KEAP1. This antibody recognizes human, mouse antigen. The KEAP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
