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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- PAB13440 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB13440, RRID:AB_10554350
- Product name
- LASS5 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of LASS5.
- Storage
- Store at 4°C for three months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells.
siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI
Anticancer research 2012 Mar;32(3):753-60
Anticancer research 2012 Mar;32(3):753-60
siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI
Anticancer research 2012 Jul;32(7):2479-85
Anticancer research 2012 Jul;32(7):2479-85
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.
Spassieva S, Seo JG, Jiang JC, Bielawski J, Alvarez-Vasquez F, Jazwinski SM, Hannun YA, Obeid LM
The Journal of biological chemistry 2006 Nov 10;281(45):33931-8
The Journal of biological chemistry 2006 Nov 10;281(45):33931-8
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
Lahiri S, Futerman AH
The Journal of biological chemistry 2005 Oct 7;280(40):33735-8
The Journal of biological chemistry 2005 Oct 7;280(40):33735-8
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.
Riebeling C, Allegood JC, Wang E, Merrill AH Jr, Futerman AH
The Journal of biological chemistry 2003 Oct 31;278(44):43452-9
The Journal of biological chemistry 2003 Oct 31;278(44):43452-9
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of LASS5 in rat brain tissue lysate with LASS5 polyclonal antibody (Cat # PAB13440) at (A) 1 and (B) 2 ug/mL .
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Immunohistochemical staining of human brain tissue with 2.5 ug/mL LASS5 polyclonal antibody (Cat # PAB13440).
- Validation comment
- Immunohistochemistry
