19998-1-AP

antibody from Proteintech Group

Targeting: TFAM TCF6, TCF6L2

Provider product page for 19998-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [37]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

Submit

Product number: 19998-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19998-1-AP, RRID:AB_10638429
Product name: TFAM antibody
Antibody type: Polyclonal
Description: TFAM antibody (Cat. #19998-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TFAM protein structure - 19998-1-AP shown in red.

Submitted references Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome.

Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S
Frontiers in cell and developmental biology 2021;9:658112

A novel supplement with yeast β-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice.

Nehmi VA, Murata GM, Moraes RCM, Lima GCA, De Miranda DA, Radloff K, Costa RGF, Jesus JCR, De Freitas JA, Viana NI, Pimenta R, Leite KRM, Otoch JP, Pessoa AFM
Journal of integrative medicine 2021 Sep;19(5):439-450

Load-matched acute and chronic exercise induce changes in mitochondrial biogenesis and metabolic markers.

Rodrigues NA, Gobatto CA, Forte LDM, Sousa FAB, Torsoni AS, Fante T, Manchado-Gobatto FB
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Oct;46(10):1196-1206

Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.

Zhang Q, He X, Yao S, Lin T, Zhang L, Chen D, Chen C, Yang Q, Li F, Zhu YM, Guan MX
Nucleic acids research 2021 May 7;49(8):4689-4704

Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease.

Ishii K, Kobayashi H, Taguchi K, Guan N, Li A, Tong C, Davidoff O, Tran PV, Sharma M, Chandel NS, Kapp ME, Fogo AB, Brooks CR, Haase VH
Kidney international 2021 Mar;99(3):657-670

Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.

Crooks DR, Maio N, Lang M, Ricketts CJ, Vocke CD, Gurram S, Turan S, Kim YY, Cawthon GM, Sohelian F, De Val N, Pfeiffer RM, Jailwala P, Tandon M, Tran B, Fan TW, Lane AN, Ried T, Wangsa D, Malayeri AA, Merino MJ, Yang Y, Meier JL, Ball MW, Rouault TA, Srinivasan R, Linehan WM
Science signaling 2021 Jan 5;14(664)

Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3.

Li Y, Wei X, Liu SL, Zhao Y, Jin S, Yang XY
Phytotherapy research : PTR 2021 Aug;35(8):4579-4591

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy.

Wu H, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X, Qin Y, Liu L, Chen Q
Redox biology 2020 Sep;36:101661

Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes.

Zhang Y, Bian H, Ma Y, Xiao Y, Xiao F
The Biochemical journal 2020 Jul 31;477(14):2607-2619

Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes-Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue.

Kobayashi M, Uta S, Otsubo M, Deguchi Y, Tagawa R, Mizunoe Y, Nakagawa Y, Shimano H, Higami Y
Nutrients 2020 Jul 10;12(7)

Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.

Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671

Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.

Aras S, Purandare N, Gladyck S, Somayajulu-Nitu M, Zhang K, Wallace DC, Grossman LI
Proceedings of the National Academy of Sciences of the United States of America 2020 Dec 15;117(50):32056-32065

Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade.

Deng XH, Liu JJ, Sun XJ, Dong JC, Huang JH
Acta pharmacologica Sinica 2019 May;40(5):658-665

Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.

Chen D, Zhang Z, Chen C, Yao S, Yang Q, Li F, He X, Ai C, Wang M, Guan MX
Nucleic acids research 2019 Jun 4;47(10):5341-5355

Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro.

Lei P, Tian S, Teng C, Huang L, Liu X, Wang J, Zhang Y, Li B, Shan Y
Molecular nutrition & food research 2019 Feb;63(4):e1800795

Resveratrol Reduces Oxidative Stress and Apoptosis in Podocytes via Sir2-Related Enzymes, Sirtuins1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Co-Activator 1α (PGC-1α) Axis.

Zhang T, Chi Y, Ren Y, Du C, Shi Y, Li Y
Medical science monitor : international medical journal of experimental and clinical research 2019 Feb 15;25:1220-1231

Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.

Kang Y, Li Y, Zhang T, Chi Y, Liu M
International journal of molecular medicine 2019 Aug;44(2):447-456

Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress.

Zhang T, Chi Y, Kang Y, Lu H, Niu H, Liu W, Li Y
Journal of cellular physiology 2019 Apr;234(4):5033-5043

Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway.

Yin J, Guo J, Zhang Q, Cui L, Zhang L, Zhang T, Zhao J, Li J, Middleton A, Carmichael PL, Peng S
Toxicology in vitro : an international journal published in association with BIBRA 2018 Sep;51:1-10

Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.

Kou G, Li Z, Wu C, Liu Y, Hu Y, Guo L, Xu X, Zhou Z
Journal of agricultural and food chemistry 2018 Nov 14;66(45):11917-11925

Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring.

Liu J, Lee I, Feng HZ, Galen SS, Hüttemann PP, Perkins GA, Jin JP, Hüttemann M, Malek MH
Journal of strength and conditioning research 2018 May;32(5):1391-1403

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.

Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005

A Novel Non-Apoptotic Role of Procaspase-3 in the Regulation of Mitochondrial Biogenesis Activators.

Kim JS, Ha JY, Yang SJ, Son JH
Journal of cellular biochemistry 2018 Jan;119(1):347-357

Inhibition of mitochondrial translation in fibroblasts from a patient expressing the KARS p.(Pro228Leu) variant and presenting with sensorineural deafness, developmental delay, and lactic acidosis.

Ruzzenente B, Assouline Z, Barcia G, Rio M, Boddaert N, Munnich A, Rötig A, Metodiev MD
Human mutation 2018 Dec;39(12):2047-2059

Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice.

Foote K, Reinhold J, Yu EPK, Figg NL, Finigan A, Murphy MP, Bennett MR
Aging cell 2018 Aug;17(4):e12773

Sco2 deficient mice develop increased adiposity and insulin resistance.

Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H
Molecular and cellular endocrinology 2017 Nov 5;455:103-114

Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity.

Cui L, Guo J, Zhang Q, Yin J, Li J, Zhou W, Zhang T, Yuan H, Zhao J, Zhang L, Carmichael PL, Peng S
Toxicology letters 2017 Jun 5;275:28-38

Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.

Zhao X, Sun K, Lan Z, Song W, Cheng L, Chi W, Chen J, Huo Y, Xu L, Liu X, Deng H, Siegenthaler JA, Chen L
Scientific reports 2017 Apr 11;7:46344

Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells.

Zhang T, Zhang Q, Guo J, Yuan H, Peng H, Cui L, Yin J, Zhang L, Zhao J, Li J, White A, Carmichael PL, Westmoreland C, Peng S
Environmental toxicology and pharmacology 2016 Sep;46:71-79

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.

Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92

Mitochondrial transcription factor A contributes to cisplatin resistance in patients with estrogen receptor‑positive breast cancer.

Gao W, Wu MH, Wang N, Ying MZ, Zhang YY, Hua J, Chuan L, Wang YJ
Molecular medicine reports 2016 Dec;14(6):5304-5310

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D
Nature immunology 2015 Nov;16(11):1142-52

Salidroside stimulates mitochondrial biogenesis and protects against H₂O₂-induced endothelial dysfunction.

Xing S, Yang X, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y, Jin S
Oxidative medicine and cellular longevity 2014;2014:904834

Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer.

Liu Y, Lan L, Huang K, Wang R, Xu C, Shi Y, Wu X, Wu Z, Zhang J, Chen L, Wang L, Yu X, Zhu H, Lu B
Oncotarget 2014 Nov 30;5(22):11209-24

Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: the role of AMP-activated protein kinase α2 subunit.

Lin D, He H, Ji H, Willis J, Willard L, Jiang Y, Medeiros DM, Wark L, Han J, Liu Y, Lu B
Molecular nutrition & food research 2014 May;58(5):1005-15

MicroRNA directly enhances mitochondrial translation during muscle differentiation.

Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD
Cell 2014 Jul 31;158(3):607-19

Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice.

Yu H, Wark L, Ji H, Willard L, Jaing Y, Han J, He H, Ortiz E, Zhang Y, Medeiros DM, Lin D
Molecular nutrition & food research 2013 Jul;57(7):1158-69

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 19998-1-AP(TFAM antibody) at dilution of 1:600
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver cancer using 19998-1-AP(TFAM antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The TFAM antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TFAM. This antibody recognizes human antigen. The TFAM antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 19998-1-AP.pdf

: Show more