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- References [127]
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- Product number
- 22586-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22586-1-AP, RRID:AB_11182588
- Product name
- TFAM antibody
- Antibody type
- Polyclonal
- Description
- TFAM antibody (Cat. #22586-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrative analysis identifies oxidative stress biomarkers in non-alcoholic fatty liver disease via machine learning and weighted gene co-expression network analysis.
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction.
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
Involvement of CKS1B in the anti-inflammatory effects of cannabidiol in experimental stroke models.
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes.
Integrative analysis of transcriptome and metabolome provide new insights into mechanisms of Capilliposide A against cisplatin-induced nephrotoxicity.
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis.
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Neuroprotective Effect of miR-483-5p Against Cardiac Arrest-Induced Mitochondrial Dysfunction Mediated Through the TNFSF8/AMPK/JNK Signaling Pathway.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity.
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species.
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy.
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Exploration of Reduced Mitochondrial Content-Associated Gene Signature and Immunocyte Infiltration in Colon Adenocarcinoma by an Integrated Bioinformatic Analysis.
Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses.
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1.
Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption.
miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α.
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α.
Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice.
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis.
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
A plant-derived natural photosynthetic system for improving cell anabolism.
Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids.
Renal tubular in TCE-sensitization-induced immune kidney injury: Role of mitochondrial DNA in activating the cGAS-STING signaling pathway.
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation.
BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis.
Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Vascular endothelial growth factor alleviates mitochondrial dysfunction and suppression of mitochondrial biogenesis in models of Alzheimer's disease.
Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss.
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken.
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Wang H, Cheng W, Hu P, Ling T, Hu C, Chen Y, Zheng Y, Wang J, Zhao T, You Q
Frontiers in immunology 2024;15:1335112
Frontiers in immunology 2024;15:1335112
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
Zhao M, Liu S, Wang Y, Lv K, Lou P, Zhou P, Zhu J, Li L, Cheng J, Lu Y, Liu J
Theranostics 2024;14(4):1517-1533
Theranostics 2024;14(4):1517-1533
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Xie H, Yang N, Lu L, Sun X, Li J, Wang X, Guo H, Zhou L, Liu J, Wu H, Yu C, Zhang W, Lu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction.
Ren YL, Jiang Z, Wang JY, He Q, Li SX, Gu XJ, Qi YR, Zhang M, Yang WJ, Cao B, Li JY, Wang Y, Chen YP
Molecular neurobiology 2024 Oct;61(10):7968-7988
Molecular neurobiology 2024 Oct;61(10):7968-7988
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
Yin H, Li X, Wang C, Li X, Liu J
Chemico-biological interactions 2024 May 1;394:110975
Chemico-biological interactions 2024 May 1;394:110975
Involvement of CKS1B in the anti-inflammatory effects of cannabidiol in experimental stroke models.
Chen K, Xu B, Xiao X, Long L, Zhao Q, Fang Z, Tu X, Wang J, Xu J, Wang H
Experimental neurology 2024 Mar;373:114654
Experimental neurology 2024 Mar;373:114654
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA.
Isaac RS, Tullius TW, Hansen KG, Dubocanin D, Couvillion M, Stergachis AB, Churchman LS
Nature structural & molecular biology 2024 Mar;31(3):568-577
Nature structural & molecular biology 2024 Mar;31(3):568-577
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
Yap C, Wanga S, Wüst RCI, van Os BW, Pijls MME, Keijzer S, van Zanten E, Koolbergen DR, Driessen AHG, Balm R, Yeung KK, de Vries CJM, Houtkooper RH, Lindeman JHN, de Waard V
Vascular pharmacology 2024 Mar;154:107279
Vascular pharmacology 2024 Mar;154:107279
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Zhang N, Ji Q, Chen Y, Wen X, Shan F
Cell death & disease 2024 Mar 7;15(3):193
Cell death & disease 2024 Mar 7;15(3):193
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
Zhang Z, Yuan Y, Zhang X, Gu L, Tang Y, Zhao Y, Dai J, Tao Y, Xie Z
Translational stroke research 2024 Mar 15;
Translational stroke research 2024 Mar 15;
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
Hu C, Li M, Chen Y, Cheng W, Wang H, Zhou Y, Teng F, Ling T, Pan J, Xu H, Zheng Y, Ji G, Zhao T, You Q
Cell death discovery 2024 Mar 1;10(1):107
Cell death discovery 2024 Mar 1;10(1):107
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
Feng X, Zheng Y, Mao N, Shen M, Chu L, Fang Y, Pang M, Wang Z, Lin Z
International immunopharmacology 2024 Jun 15;134:112257
International immunopharmacology 2024 Jun 15;134:112257
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes.
Chen J, Feng Q, Qiao Y, Pan S, Liang L, Liu Y, Zhang X, Liu D, Liu Z, Liu Z
Diabetologia 2024 Jul;67(7):1429-1443
Diabetologia 2024 Jul;67(7):1429-1443
Integrative analysis of transcriptome and metabolome provide new insights into mechanisms of Capilliposide A against cisplatin-induced nephrotoxicity.
Fang J, Wang L, Zhang D, Liang Y, Li S, Tian J, He Q, Jin J, Zhu W
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115814
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115814
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Huang X, Deng Y, Xiao J, Wang H, Yang Q, Cao Z
Bioactive materials 2024 Feb;32:473-487
Bioactive materials 2024 Feb;32:473-487
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS
Nature cell biology 2024 Feb;26(2):194-206
Nature cell biology 2024 Feb;26(2):194-206
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Guan S, Qu X, Wang J, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway.
Zou R, Wang S, Cai H, Wang Y, Wang C
Cardiovascular therapeutics 2023;2023:2108584
Cardiovascular therapeutics 2023;2023:2108584
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Zou YY, Tang XB, Chen ZL, Liu B, Zheng L, Song MY, Xiao Q, Zhou ZQ, Peng XY, Tang CF
Frontiers in endocrinology 2023;14:1162485
Frontiers in endocrinology 2023;14:1162485
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Song X, Leonhard WN, Kanhai AA, Steinberg GR, Pei Y, Peters DJM
Frontiers in molecular biosciences 2023;10:1058825
Frontiers in molecular biosciences 2023;10:1058825
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Chen ZL, Guo C, Zou YY, Feng C, Yang DX, Sun CC, Wen W, Jian ZJ, Zhao Z, Xiao Q, Zheng L, Peng XY, Zhou ZQ, Tang CF
Experimental gerontology 2023 Sep;180:112265
Experimental gerontology 2023 Sep;180:112265
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Zhu A, Duan Z, Chen Y, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Guo H, Wu H, Hou Y, Hu P, Du J, Cao L, Yang R, Dong X, Li Z
International journal of biological macromolecules 2023 Sep 30;249:126039
International journal of biological macromolecules 2023 Sep 30;249:126039
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression.
Grotehans N, McGarry L, Nolte H, Xavier V, Kroker M, Narbona-Pérez ÁJ, Deshwal S, Giavalisco P, Langer T, MacVicar T
The EMBO journal 2023 Sep 18;42(18):e113256
The EMBO journal 2023 Sep 18;42(18):e113256
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q
Heliyon 2023 Nov;9(11):e21282
Heliyon 2023 Nov;9(11):e21282
Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Duan Y, Dai H, Zhang H, Huang Y, Fu W, Sun W, Zhao B
Chinese journal of natural medicines 2023 Nov;21(11):812-829
Chinese journal of natural medicines 2023 Nov;21(11):812-829
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Shen H, Lei Y, Xie W, Ma T, Bao L, Gao Q, Chen B, Dai B, Qin D
Adipocyte 2023 Nov 9;:2278213
Adipocyte 2023 Nov 9;:2278213
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle.
Liang J, Wei X, Hou W, Wang H, Ma R, Gao Y, Du Y, Zhang Q
Chinese medicine 2023 Nov 30;18(1):157
Chinese medicine 2023 Nov 30;18(1):157
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889
Nature communications 2023 Nov 30;14(1):7889
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Liu W, Li F, Guo D, Du C, Zhao S, Li J, Yan Z, Hao J
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C
Nature communications 2023 Nov 18;14(1):7527
Nature communications 2023 Nov 18;14(1):7527
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P, Zhang Q, Ma W, Hu R, Gu Y, Bian Z, Yang D, Chen X, Wu H
European journal of pharmacology 2023 Nov 15;959:176085
European journal of pharmacology 2023 Nov 15;959:176085
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770
Nature communications 2023 Nov 1;14(1):6770
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
Wu J, Subbaiah KCV, Hedaya O, Chen S, Munger J, Tang WHW, Yan C, Yao P
bioRxiv : the preprint server for biology 2023 May 22;
bioRxiv : the preprint server for biology 2023 May 22;
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
Jiang Y, Li Y, Zhang Y, Hu D, Zhang S, Wang C, Huang S, Zhang A, Jia Z, You R
International immunopharmacology 2023 Mar;116:109847
International immunopharmacology 2023 Mar;116:109847
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Hong JR, Jin L, Zhang CY, Zhong WJ, Yang HH, Wang GM, Ma SC, Guan CX, Li Q, Zhou Y
Heliyon 2023 Jun;9(6):e17361
Heliyon 2023 Jun;9(6):e17361
SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis.
Dong C, Li Z, Wang X, Zou D, Duan H, Zhao C, Zhou Q, Shi W
Experimental eye research 2023 Jun;231:109464
Experimental eye research 2023 Jun;231:109464
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Koh YC, Chok D, Chang CH, Wei CC, Wu CT, Cheng KC, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Neuroprotective Effect of miR-483-5p Against Cardiac Arrest-Induced Mitochondrial Dysfunction Mediated Through the TNFSF8/AMPK/JNK Signaling Pathway.
Zhang Q, Zhan H, Liu C, Zhang C, Wei H, Li B, Zhou D, Lu Y, Huang S, Cheng J, Li S, Wang C, Hu C, Liao X
Cellular and molecular neurobiology 2023 Jul;43(5):2179-2202
Cellular and molecular neurobiology 2023 Jul;43(5):2179-2202
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP
Cell 2023 Jul 6;186(14):3013-3032.e22
Cell 2023 Jul 6;186(14):3013-3032.e22
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Li F, Xu M, Miao J, Hu N, Wang Y, Wang L
Toxicology letters 2023 Jul 1;383:98-111
Toxicology letters 2023 Jul 1;383:98-111
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
Huang S, Chen X, Pan J, Zhang H, Ke J, Gao L, Yu Chang AC, Zhang J, Zhang H
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity.
Qi XM, Qiao YB, Zhang YL, Wang AC, Ren JH, Wei HZ, Li QS
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113513
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113513
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, You J, Gao B, Sun X, La L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Tian Z, Li J, Song L, Xie L, Li D, Xia T, Wang A
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Gu S, Wu G, Lu D, Wang Y, Tang L, Zhang W
Toxicology letters 2023 Jan 15;373:172-183
Toxicology letters 2023 Jan 15;373:172-183
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.
Bai M, Wu M, Jiang M, He J, Deng X, Xu S, Fan J, Miao M, Wang T, Li Y, Yu X, Wang L, Zhang Y, Huang S, Yang L, Jia Z, Zhang A
EMBO molecular medicine 2023 Feb 8;15(2):e16581
EMBO molecular medicine 2023 Feb 8;15(2):e16581
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo MF, Wong KS, Barghash MM, Leung E, Chuang SHW, Ardalan A, Majaesic EM, Wong CJ, Zhang S, Lang H, Karanewsky DS, Iwanowicz AA, Graves LM, Iwanowicz EJ, Gingras AC, Houry WA
Structure (London, England : 1993) 2023 Feb 2;31(2):185-200.e10
Structure (London, England : 1993) 2023 Feb 2;31(2):185-200.e10
SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species.
Yu H, Yang L, Han Z, Zhou X, Zhang Z, Sun T, Zheng F, Yang J, Guan F, Xie J, Liu C
Journal of medical virology 2023 Dec;95(12):e29270
Journal of medical virology 2023 Dec;95(12):e29270
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Wan L, Qian Y, Ni W, Lu Y, Li W, Pan Y, Chen W
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Lou P, Liu S, Wang Y, Lv K, Zhou X, Li L, Zhang Y, Chen Y, Cheng J, Lu Y, Liu J
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy.
Bround MJ, Havens JR, York AJ, Sargent MA, Karch J, Molkentin JD
Science advances 2023 Aug 25;9(34):eadi2767
Science advances 2023 Aug 25;9(34):eadi2767
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y
The EMBO journal 2023 Aug 15;42(16):e113258
The EMBO journal 2023 Aug 15;42(16):e113258
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Ma Z, Liu Z, Li X, Zhang H, Han D, Xiong W, Zhou H, Yang X, Zeng Q, Ren H, Xu D
Biology 2023 Apr 11;12(4)
Biology 2023 Apr 11;12(4)
Exploration of Reduced Mitochondrial Content-Associated Gene Signature and Immunocyte Infiltration in Colon Adenocarcinoma by an Integrated Bioinformatic Analysis.
Kang J, Li N, Wang F, Wei Y, Zeng Y, Luo Q, Sun X, Xu H, Peng J, Zhou F
Frontiers in genetics 2022;13:832331
Frontiers in genetics 2022;13:832331
Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses.
Xu T, Yang D, Liu K, Gao Q, Liu Z, Li G
Frontiers in pharmacology 2022;13:816891
Frontiers in pharmacology 2022;13:816891
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Liang S, Zhu C, Suo C, Wei H, Yu Y, Gu X, Chen L, Yuan M, Shen S, Li S, Sun L, Gao P
Frontiers in oncology 2022;12:857968
Frontiers in oncology 2022;12:857968
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.
Zou M, Ke Q, Nie Q, Qi R, Zhu X, Liu W, Hu X, Sun Q, Fu JL, Tang X, Liu Y, Li DW, Gong L
Cell death and differentiation 2022 Sep;29(9):1816-1833
Cell death and differentiation 2022 Sep;29(9):1816-1833
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1.
Liu X, Chen J, Zhang S, Liu X, Long X, Lan J, Zhou M, Zheng L, Zhou J
EMBO reports 2022 Sep 5;23(9):e54128
EMBO reports 2022 Sep 5;23(9):e54128
Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption.
Mackert O, Wirth EK, Sun R, Winkler J, Liu A, Renko K, Kunz S, Spranger J, Brachs S
Molecular metabolism 2022 Oct;64:101563
Molecular metabolism 2022 Oct;64:101563
miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α.
Zhou H, Gan M, Jin X, Dai M, Wang Y, Lei Y, Lin Z, Ming J
International journal of oncology 2022 Oct;61(4)
International journal of oncology 2022 Oct;61(4)
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Wang F, Han J, Wang X, Liu Y, Zhang Z
Journal of molecular histology 2022 Oct;53(5):833-842
Journal of molecular histology 2022 Oct;53(5):833-842
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Zhang S, Li J, Shi X, Tan X, Si Q
Food & function 2022 Oct 3;13(19):9918-9930
Food & function 2022 Oct 3;13(19):9918-9930
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
Barsky ST, Monks DA
Biology of sex differences 2022 Oct 23;13(1):59
Biology of sex differences 2022 Oct 23;13(1):59
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Tai H, Cui XZ, He J, Lan ZM, Li SM, Li LB, Yao SC, Jiang XL, Meng XS, Kuang JS
Aging 2022 Oct 20;14(20):8302-8320
Aging 2022 Oct 20;14(20):8302-8320
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Lv Q, Han X, Ni J, Ma Q, Dai R, Liu J, Liu J, Zhai Y, Shen Q, Sun L, Liu H, Rao J, Xu H
Cell death & disease 2022 Oct 13;13(10):867
Cell death & disease 2022 Oct 13;13(10):867
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
Hu S, Feng J, Wang M, Wufuer R, Liu K, Zhang Z, Zhang Y
Redox biology 2022 Nov;57:102470
Redox biology 2022 Nov;57:102470
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α.
Wu H, Lu C, Li X, Xu X, Wu S
Annals of translational medicine 2022 Nov;10(22):1241
Annals of translational medicine 2022 Nov;10(22):1241
Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice.
Xie X, Zhou J, Hu L, Shu R, Zhang M, Sun L, Wu F, Fu Z, Li Z
Journal of hazardous materials 2022 May 15;430:128376
Journal of hazardous materials 2022 May 15;430:128376
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
Li Y, Jiang Y, Zhou W, Wu Y, Zhang S, Ding G, Zhang Y, Zhang A, Huang S, Jia Z, You R
Free radical biology & medicine 2022 Mar;181:270-287
Free radical biology & medicine 2022 Mar;181:270-287
ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis.
Zhu P, Ma H, Cui S, Zhou X, Xu W, Yu J, Li J
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Zhao K, Huang X, Zhao W, Lu B, Yang Z
Development (Cambridge, England) 2022 Mar 15;149(6)
Development (Cambridge, England) 2022 Mar 15;149(6)
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Dai H, Duan Y, Zhang H, Huang Y, Fu W, Meng Y, Zhao B
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Tai H, Tong YJ, Yu R, Yu Y, Yao SC, Li LB, Liu Y, Cui XZ, Kuang JS, Meng XS, Jiang XL
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Chen Z, Wang H, Hu B, Chen X, Zheng M, Liang L, Lyu J, Zeng Q
European journal of histochemistry : EJH 2022 Jun 21;66(3)
European journal of histochemistry : EJH 2022 Jun 21;66(3)
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Zhou M, Dai Y, Ma Y, Yan Y, Hua M, Gao Q, Geng X, Zhou Q
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Dogan AE, Hamid SM, Yildirim AD, Yildirim Z, Sen G, Riera CE, Gottlieb RA, Erbay E
The Journal of biological chemistry 2022 Jul;298(7):102050
The Journal of biological chemistry 2022 Jul;298(7):102050
Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K
International journal of molecular sciences 2022 Jul 29;23(15)
International journal of molecular sciences 2022 Jul 29;23(15)
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Liu J, Jiang J, Qiu J, Wang L, Zhuo J, Wang B, Sun D, Yu S, Lou H
Food & function 2022 Jan 4;13(1):375-385
Food & function 2022 Jan 4;13(1):375-385
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
Bryant JD, Lei Y, VanPortfliet JJ, Winters AD, West AP
Current protocols 2022 Feb;2(2):e372
Current protocols 2022 Feb;2(2):e372
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
Zhao YC, Guo W, Gao BH
Life sciences 2022 Feb 15;291:119340
Life sciences 2022 Feb 15;291:119340
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids.
Lee JH, Hussain M, Kim EW, Cheng SJ, Leung AKL, Fakouri NB, Croteau DL, Bohr VA
Experimental & molecular medicine 2022 Dec;54(12):2135-2147
Experimental & molecular medicine 2022 Dec;54(12):2135-2147
Renal tubular in TCE-sensitization-induced immune kidney injury: Role of mitochondrial DNA in activating the cGAS-STING signaling pathway.
Ma J, Liu Z, Zhou S, Chen M, Gao L, Zuo X, Zhang X, Zhang J, Zhu Q
International immunopharmacology 2022 Dec;113(Pt B):109432
International immunopharmacology 2022 Dec;113(Pt B):109432
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Sun J, Leng P, Li X, Guo Q, Zhao J, Liang Y, Zhang X, Yang X, Li J
Adipocyte 2022 Dec;11(1):562-571
Adipocyte 2022 Dec;11(1):562-571
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Chai X, Pan M, Wang J, Feng M, Wang Y, Zhang Q, Sun Y
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation.
Wang M, Wang L, Zhou Y, Feng X, Ye C, Wang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153947
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153947
BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis.
Ye P, Li W, Huang X, Zhao S, Chen W, Xia Y, Yu W, Rao T, Ning J, Zhou X, Ruan Y, Cheng F
Journal of cellular and molecular medicine 2022 Apr;26(7):1994-2009
Journal of cellular and molecular medicine 2022 Apr;26(7):1994-2009
Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT
eLife 2022 Apr 6;11
eLife 2022 Apr 6;11
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
He H, Li C, Lu X, Li Y, Li X, Sun X, Tang B, Wu Y, Li C
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
Mu Q, Zhang Y, Gu L, Gerner ST, Qiu X, Tao Q, Pang J, Dipritu G, Zhang L, Yin S, Jiang Y, Peng J
Frontiers in neurology 2021;12:728984
Frontiers in neurology 2021;12:728984
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Yang Y, Wu Y, Zou J, Wang YH, Xu MX, Huang W, Yu DJ, Zhang L, Zhang YY, Sun XD
Frontiers in pharmacology 2021;12:687095
Frontiers in pharmacology 2021;12:687095
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.
Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Redondo JM, Mittelbrunn M
Circulation 2021 May 25;143(21):2091-2109
Circulation 2021 May 25;143(21):2091-2109
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Yang M, Cui Y, Song J, Cui C, Wang L, Liang K, Wang C, Sha S, He Q, Hu H, Guo X, Zang N, Sun L, Chen L
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Wu Y, Yang Y, Li F, Zou J, Wang YH, Xu MX, Wang YL, Li RX, Sun YT, Lu S, Zhang YY, Sun XD
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.
Zhiyin L, Jinliang C, Qiunan C, Yunfei Y, Qian X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111590
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111590
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538
ACS nano 2021 Jan 26;15(1):1519-1538
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Kou G, Li P, Hu Y, Chen H, Nyantakyiwaa Amoah A, Seydou Traore S, Cui Z, Lyu Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
Vascular endothelial growth factor alleviates mitochondrial dysfunction and suppression of mitochondrial biogenesis in models of Alzheimer's disease.
Liu X, Chu B, Jin S, Li M, Xu Y, Yang H, Feng Z, Bi J, Wang P
The International journal of neuroscience 2021 Feb;131(2):154-162
The International journal of neuroscience 2021 Feb;131(2):154-162
Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
Liu W, Fan Y, Ding H, Han D, Yan Y, Wu R, Lv Y, Zheng X
Journal of cellular and molecular medicine 2021 Dec;25(24):11310-11321
Journal of cellular and molecular medicine 2021 Dec;25(24):11310-11321
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
Chen N, Ge MM, Li DY, Wang XM, Liu DQ, Ye DW, Tian YK, Zhou YQ, Chen JP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss.
Ullah F, Rauf W, Khan K, Khan S, Bell KM, de Oliveira VC, Tariq M, Bakhshalizadeh S, Touraine P, Katsanis N, Sinclair A, He S, Tucker EJ, Baig SM, Davis EE
Human genetics 2021 Dec;140(12):1733-1751
Human genetics 2021 Dec;140(12):1733-1751
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
Zhou H, Yao L, Jiang X, Sumayyah G, Tu B, Cheng S, Qin X, Zhang J, Zou Z, Chen C
Neurotoxicity research 2021 Aug;39(4):1160-1170
Neurotoxicity research 2021 Aug;39(4):1160-1170
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z
The EMBO journal 2021 Apr 15;40(8):e106283
The EMBO journal 2021 Apr 15;40(8):e106283
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
Zhang Q, Guo D, Wang Y, Wang X, Wang Q, Wu Y, Li C, Wang W, Wang Y
Frontiers in pharmacology 2020;11:458
Frontiers in pharmacology 2020;11:458
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Zhao Q, Tian Z, Zhou G, Niu Q, Chen J, Li P, Dong L, Xia T, Zhang S, Wang A
Theranostics 2020;10(11):4822-4838
Theranostics 2020;10(11):4822-4838
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Rey T, Zaganelli S, Cuillery E, Vartholomaiou E, Croisier M, Martinou JC, Manley S
Nature cell biology 2020 Oct;22(10):1180-1186
Nature cell biology 2020 Oct;22(10):1180-1186
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Guo A, Li K, Xiao Q
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 22586-1-AP(TFAM antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TFAM antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TFAM. This antibody recognizes human antigen. The TFAM antibody has been validated for the following applications: ELISA, WB, IHC analysis.
