Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [227]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 22586-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22586-1-AP, RRID:AB_11182588
- Product name
- TFAM antibody
- Antibody type
- Polyclonal
- Description
- TFAM antibody (Cat. #22586-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SIRT6-Mediated Regulation of TFAM: A Central Mechanism Connecting Nuclear and Mitochondrial Transcriptional Processes and Mitophagy.
Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway.
Lentinan mitigates age-related sarcopenia through the promotion of mitochondrial biogenesis.
Butyrate extends health and lifespan in mice with mitochondrial deficiency.
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
Butyrate extends health and lifespan in mice with mitochondrial deficiency.
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
PM(10) Disrupts Mitochondrial Homeostasis in Corneal Epithelial Cells: Protective Effects of SKQ1.
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
Fumarate loss destabilizes mitochondria and activates cGAS-STING in OLP.
Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1-Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation.
Modified hTERT treatment ameliorates pressure overload-induced heart failure.
Enterovirus A71 3AB protein facilitates immune evasion by blocking cGAS recognition of mtDNA.
Astragaloside IV delays vascular aging by enhancing mitochondrial fatty acid β-oxidation via the MLXIPL-PPARα/PGC-1α axis.
Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair.
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
Astaxanthin alleviates oxidative stress and skeletal muscle damage by promoting mitochondrial biogenesis.
POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis.
Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity.
1,25(OH)(2)D(3) up-regulated mitochondrial dynamics and biogenesis to modulate steroidogenesis in the scent glands of muskrats (Ondatra zibethicus).
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling.
Gut microbiota modified by Mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway.
Non-esterified fatty acids disrupt hepatic lipid metabolism and mitochondrial function via TLR4/MyD88/IRAK2 signaling in bovine hepatocytes.
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation.
Electroacupuncture at Huantiao (GB30) and Zusanli (ST36) acupoints promotes peripheral nerve regeneration by enhancing energy metabolism in mice.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Inhalation of Ultrafine Carbon Black-Induced Mitochondrial Dysfunction in Mouse Heart Through Changes in Acetylation.
Astragaloside IV potentiates cisplatin sensitivity in triple-negative breast cancer via STING signaling pathway activation.
Phosphomimetic Experiments Do Not Support a Causal Role for TFAM Phosphorylation in mtDNA Elimination in Sperm.
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling.
Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the CK2/AKT pathway.
Histone Deacetylase 6 Controls Atrial Fibrosis and Remodeling in Postinfarction Mice Through the Modulation of Wnt3a/GSK-3β Signaling.
TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease.
Microalgae-Derived Extracellular Vesicles Synergize with Herbal Hydrogel for Energy Homeostasis in Osteoarthritis Treatment.
FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice.
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration.
Optically controllable nanoregulators enable tumor-specific pro-ferroptosis lipometabolic reprogramming for in-situ adjuvant-free vaccination.
IL-21 Loading CaMnCO(3) Vitality Backpacks Boost CAR-T Cell Synergistic Immunotherapy.
Electrical stimulation promotes peripheral nerve regeneration by upregulating glycolysis and oxidative phosphorylation.
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
Astrocytic HSP60 Deletion Induced Astrocyte Senescence and Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF Pathway.
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA.
Drp1 knockdown aggravates obesity-induced cardiac dysfunction and remodeling.
The role of mitochondrial dysfunction in the protective effect of ginger derived extracellular vesicles on hepatic stellate cells against cytotoxicity.
Bach1 Deficiency Ameliorates Radiation Pneumonitis via Activating TFAM Signaling Pathway.
Activation of spinal PGC-1α regulates microglial polarization through a feedback loop between ROS-mediated mitochondrial dysfunction and the NLRP3 inflammasome in neuropathic pain.
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine.
Effect of leucine on mitochondria and oxidative stress to reduce virulence and pathogenicity of Acinetobacter baumannii.
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos.
SARM1 deficiency induced depressive-like behavior via AMPKα/p-eEF2 axis to synapse dysfunction.
Correcting mitochondrial loss mitigates NOTCH1-related aortopathy in mice.
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
Zn(2 +) alleviates ischemia/reperfusion injury in H9c2 cells by modulating mitochondrial biogenesis and dynamics via MCU.
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Cedrol prevents UVB-induced photoaging by restoring mitochondrial function, metabolic homeostasis, and skin barrier integrity in HaCaT cells.
TFAM Deficiency Triggers mtDNA Leakage and cGAS-STING-Mediated Intestinal Ischemia-Reperfusion Injury.
Arfgef3 knockout ameliorates ischemia reperfusion-induced acute kidney injury via mitochondrial dysfunction alleviation in mice.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.
Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats.
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.
Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein.
Proliferator-Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy.
Hypomethylation in promoters of PGC-1α involved in exercise-driven skeletal muscular alterations in old age.
Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.
Integrative analysis identifies oxidative stress biomarkers in non-alcoholic fatty liver disease via machine learning and weighted gene co-expression network analysis.
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis.
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
Isoquercitrin alleviates OGD/R-induced oxidative stress and impaired mitochondrial biogenesis in SH-SY5Y cells via the NRF1/TFAM pathway.
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction.
Glycyrrhizin Protects Submandibular Gland Against Radiation Damage by Enhancing Antioxidant Defense and Preserving Mitochondrial Homeostasis.
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression.
Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection.
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
Involvement of CKS1B in the anti-inflammatory effects of cannabidiol in experimental stroke models.
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes.
Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state.
Zearalenone modulates the function of goat endometrial cells via the mitochondrial quality control system.
Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance.
Integrative analysis of transcriptome and metabolome provide new insights into mechanisms of Capilliposide A against cisplatin-induced nephrotoxicity.
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis.
High concentration hydrogen attenuates sepsis-induced acute kidney injury by promoting mitochondrial biogenesis and fusion.
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis.
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis.
Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression.
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway.
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle.
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis.
SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis.
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Neuroprotective Effect of miR-483-5p Against Cardiac Arrest-Induced Mitochondrial Dysfunction Mediated Through the TNFSF8/AMPK/JNK Signaling Pathway.
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity.
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species.
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy.
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease.
Exploration of Reduced Mitochondrial Content-Associated Gene Signature and Immunocyte Infiltration in Colon Adenocarcinoma by an Integrated Bioinformatic Analysis.
Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses.
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1.
Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption.
miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α.
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α.
Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice.
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis.
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
A plant-derived natural photosynthetic system for improving cell anabolism.
Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids.
Renal tubular in TCE-sensitization-induced immune kidney injury: Role of mitochondrial DNA in activating the cGAS-STING signaling pathway.
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation.
BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis.
Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Vascular endothelial growth factor alleviates mitochondrial dysfunction and suppression of mitochondrial biogenesis in models of Alzheimer's disease.
Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss.
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken.
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule.
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Jiang M, Li J, Ding N, Jia G, Wu S, Liu N, Kang Y, Zhang G, Wu J, Zhang L, Zhang Y
International journal of biological sciences 2026;22(1):178-200
International journal of biological sciences 2026;22(1):178-200
Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway.
Mao Y, Lin S, Wu M, Ma H, Ji J, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158020
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158020
Lentinan mitigates age-related sarcopenia through the promotion of mitochondrial biogenesis.
He Y, Zhang J, Sun X, Fang Y, Fu A, Han X, Zhang J
Food research international (Ottawa, Ont.) 2026 Mar 31;228:118449
Food research international (Ottawa, Ont.) 2026 Mar 31;228:118449
Butyrate extends health and lifespan in mice with mitochondrial deficiency.
Gabandé-Rodríguez E, Gómez de Las Heras MM, Ramírez-Ruiz de Erenchun P, Simó C, García-Cañas V, Inohara N, Berenguer-López I, Enríquez-Zarralanga V, Fernández-Almeida Á, Oller J, Soto-Heredero G, Carrasco E, Vázquez-Muñoz C, Delgado-Pulido S, Escrig-Larena JI, Francos-Quijorna I, Justo-Méndez R, Aranda JF, Poulton J, Lechuga-Vieco AV, Enríquez JA, Núñez G, Mittelbrunn M
Nature communications 2026 Mar 13;17(1)
Nature communications 2026 Mar 13;17(1)
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells.
Chen S, Jia S, Fan X, Zhu L, Qi B, Yan F, Gao X, Zhang L, Gao S, Shao J, Yang T, Li S, Chen G, Xiong H, Li Z, Hao Y, Meng C
Bioactive materials 2026 Jul;61:534-554
Bioactive materials 2026 Jul;61:534-554
Sodium tanshinone IIA sulfonate alleviates neuroinflammation-induced damage to hippocampal neurons by activating SIRT1 in mice with sepsis-associated encephalopathy.
Song Y, Lin W, Yuan H, Hu H, Wu S, Lu Y, Li D, Jing L, Tu S, Zhu W
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120731
Butyrate extends health and lifespan in mice with mitochondrial deficiency.
Gabandé-Rodríguez E, Gómez de Las Heras MM, Ramírez-Ruiz de Erenchun P, Simó C, García-Cañas V, Inohara N, Berenguer-López I, Enríquez-Zarralanga V, Fernández-Almeida Á, Oller J, Soto-Heredero G, Carrasco E, Delgado-Pulido S, Escrig-Larena JI, Francos-Quijorna I, Justo-Méndez R, Aranda JF, Poulton J, Lechuga-Vieco AV, Enríquez JA, Núñez G, Mittelbrunn M
bioRxiv : the preprint server for biology 2026 Jan 14;
bioRxiv : the preprint server for biology 2026 Jan 14;
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
Wang Z, Ren X, Peng Z, Zeng M, Wang Z, Chen Q, Chen J, Dai X, Christian M, Qie X, He Z
Journal of ethnopharmacology 2026 Jan 10;354:120513
Journal of ethnopharmacology 2026 Jan 10;354:120513
PM(10) Disrupts Mitochondrial Homeostasis in Corneal Epithelial Cells: Protective Effects of SKQ1.
Somayajulu M, Wright R, Muhammed FS, McClellan SA, Ibrahim AS, Hazlett LD
Antioxidants (Basel, Switzerland) 2026 Feb 25;15(3)
Antioxidants (Basel, Switzerland) 2026 Feb 25;15(3)
Loganin, an Iridoid Glycoside, Alleviates Paclitaxel-Induced Skeletal Muscle Toxicity by Enhancing Mitochondrial Function, Boosting Antioxidant Defenses, and Reducing Cellular Senescence.
Chuang YF, Wu CR, Chang WH, Su YJ, Hsu HT, Lin FL, Lo YC
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
The Kaohsiung journal of medical sciences 2026 Apr;42(4):e70117
Fumarate loss destabilizes mitochondria and activates cGAS-STING in OLP.
Hu Y, Chen H, Ding C, Zhang S, Chen Q, Sun H, Yang Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026 Apr;197:119127
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026 Apr;197:119127
Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1-Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation.
Li L, Si C, Wang X, Wu X, Shang Y, Ge S, Wang Y, Zuo Y, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(21):e17108
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(21):e17108
Modified hTERT treatment ameliorates pressure overload-induced heart failure.
Zhao Y, Bao X, Xiong W, Wan X, Yu Q, Wang T, Chang ACH, Liu Y, Wang Y, Shang C, Wu M, Ashley EA, Lei M, Zhang J, Wu Y, Han W, Chang ACY
EBioMedicine 2026 Apr;126:106203
EBioMedicine 2026 Apr;126:106203
Enterovirus A71 3AB protein facilitates immune evasion by blocking cGAS recognition of mtDNA.
Sun P, Yang X, Cui J, Fang G, Wu Y, Chang J, Li X, Xie Y, Gan L, Ma L, Li Z
EMBO reports 2026 Apr 2;
EMBO reports 2026 Apr 2;
Astragaloside IV delays vascular aging by enhancing mitochondrial fatty acid β-oxidation via the MLXIPL-PPARα/PGC-1α axis.
Chen X, Chen X, Xiao N, Yang Y, Li C, Pan Y, Huang H, Duan X, Deng Y, Chen C, Zeng S, Yang S, Huang Y, Huang D, Yang Y, Shu Z, Zhang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 15;156:158183
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 15;156:158183
Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair.
Xu MR, Lin CH, Wang CH, Wang SY
Frontiers in pharmacology 2025;16:1619537
Frontiers in pharmacology 2025;16:1619537
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
Hu P, Liu M, Wu T, Zhang Y, Liu C, Wang L, Zhang W, Que Y, You J, Yu W, Tong X
Theranostics 2025;15(15):7567-7583
Theranostics 2025;15(15):7567-7583
Astaxanthin alleviates oxidative stress and skeletal muscle damage by promoting mitochondrial biogenesis.
Li C, Yan Y, Wang K, Jiang T
Frontiers in veterinary science 2025;12:1577408
Frontiers in veterinary science 2025;12:1577408
POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis.
Zhang T, Gao Y, Harhai M, Jourdain AA, Marti TM, Vassella E, Yang Z, Zhou Q, Dorn P, Peng RW
Redox biology 2025 Sep;85:103758
Redox biology 2025 Sep;85:103758
Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity.
Deng Y, Xu L, Jiang Z, Chen L, Zhu G, Xu C, Chu X, Wang L, Niu X, Chen L, Xiao Z, Hu J, Ge G
Redox biology 2025 Sep;85:103737
Redox biology 2025 Sep;85:103737
1,25(OH)(2)D(3) up-regulated mitochondrial dynamics and biogenesis to modulate steroidogenesis in the scent glands of muskrats (Ondatra zibethicus).
Gao Q, Shi K, Shi X, Liu Y, Zhang H, Weng Q
The Journal of steroid biochemistry and molecular biology 2025 Sep;252:106787
The Journal of steroid biochemistry and molecular biology 2025 Sep;252:106787
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
Wang L, Lv W, Mao H, Chen Q, Ma Y, Zhang L, Ruan Y, Zhang C
Free radical biology & medicine 2025 Sep;237:251-269
Free radical biology & medicine 2025 Sep;237:251-269
Lactate induces oxidative phosphorylation in osteoblasts via Gpr81-Stat3 signaling.
Hu X, Shen J, Wang R, Han C, Shi X, Hu J, Zhang M, Wang P, Zhang X, Wu Y
Cellular signalling 2025 Sep;133:111877
Cellular signalling 2025 Sep;133:111877
Gut microbiota modified by Mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway.
Du Y, He C, An Y, Zhao Y, Zhang H, Shan Z, Yang Y, Wang M, Xie J, Huang Y, Fu W, Yuan Y, Zhao B
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120408
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120408
Non-esterified fatty acids disrupt hepatic lipid metabolism and mitochondrial function via TLR4/MyD88/IRAK2 signaling in bovine hepatocytes.
Wen Y, Wang Y, Loor JJ, Zhao C, Wang J
The Journal of steroid biochemistry and molecular biology 2025 Oct;253:106813
The Journal of steroid biochemistry and molecular biology 2025 Oct;253:106813
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation.
Xun Q, Yang Q, Wang W, Zhu G
Cellular signalling 2025 Oct;134:111929
Cellular signalling 2025 Oct;134:111929
Electroacupuncture at Huantiao (GB30) and Zusanli (ST36) acupoints promotes peripheral nerve regeneration by enhancing energy metabolism in mice.
Ji Q, Zhang N, Zhang B, Chen Y, Zhang Q, Yao X, Zhang M, Zheng Q, Ni G, Shan F
Neuroreport 2025 Oct 1;36(14):874-885
Neuroreport 2025 Oct 1;36(14):874-885
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
Inhalation of Ultrafine Carbon Black-Induced Mitochondrial Dysfunction in Mouse Heart Through Changes in Acetylation.
Islam R, Stewart JE, Mullen WE, Lin D, Hussain S, Thapa D
Cells 2025 Nov 4;14(21)
Cells 2025 Nov 4;14(21)
Astragaloside IV potentiates cisplatin sensitivity in triple-negative breast cancer via STING signaling pathway activation.
Bai B, Zhang L, Zhang Y, Yue R, Lu Y, Shi R, Zhou Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157330
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157330
Phosphomimetic Experiments Do Not Support a Causal Role for TFAM Phosphorylation in mtDNA Elimination in Sperm.
Kozhukhar N, Bai Y, Alexeyev MF
Journal of molecular biology 2025 Nov 1;437(21):169433
Journal of molecular biology 2025 Nov 1;437(21):169433
SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.
Chen L, Tang J, Zuo X, Li B, Liu C, Hong S, Min J, Hu M, Li S, Zhou M, Chen M, He Y, Xiao Y, Huang X, Hong L
Cell proliferation 2025 May;58(5):e70009
Cell proliferation 2025 May;58(5):e70009
Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling.
Lang J, Bergner T, Zinngrebe J, Lepelley A, Vill K, Leiz S, Wlaschek M, Wagner M, Scharffetter-Kochanek K, Fischer-Posovszky P, Read C, Crow YJ, Hirschenberger M, Sparrer KMJ
EMBO reports 2025 May;26(9):2232-2261
EMBO reports 2025 May;26(9):2232-2261
Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the CK2/AKT pathway.
Zhang Y, Ye Y, Feng Y, Li X, Chen L, Zou X, Yan G, Chen Y, Nan L, Xu W, Chen L, Li H
Free radical biology & medicine 2025 May;232:353-366
Free radical biology & medicine 2025 May;232:353-366
Histone Deacetylase 6 Controls Atrial Fibrosis and Remodeling in Postinfarction Mice Through the Modulation of Wnt3a/GSK-3β Signaling.
Shu S, Fang J, Zhao L, Han J, Zhang M, Huang C, Cheng XW, Li S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70650
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70650
TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease.
He X, Chen M, Fan Y, Wu B, Dong Z
Genes & diseases 2025 Mar;12(2):101429
Genes & diseases 2025 Mar;12(2):101429
Microalgae-Derived Extracellular Vesicles Synergize with Herbal Hydrogel for Energy Homeostasis in Osteoarthritis Treatment.
Liang F, Zheng Y, Zhao C, Li L, Hu Y, Wang C, Wang R, Feng T, Liu X, Cui J, Zhong D, Zhou M
ACS nano 2025 Mar 4;19(8):8040-8057
ACS nano 2025 Mar 4;19(8):8040-8057
FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion.
Sainz AG, Rojas GR, Moyzis AG, Donnelly MP, Mangalhara KC, Johnson MA, Esparza-Moltó PB, Grae KJ, Shaw RJ, Shadel GS
The Journal of cell biology 2025 Mar 3;224(3)
The Journal of cell biology 2025 Mar 3;224(3)
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice.
Mas-Bargues C, Román-Domínguez A, Sanz-Ros J, Romero-García N, Huete-Acevedo J, Dromant M, Cuervo AM, Borrás C, Viña J
Science advances 2025 Mar 21;11(12):eadr1378
Science advances 2025 Mar 21;11(12):eadr1378
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration.
Chen X, Zhou Y, Yao W, Gao C, Sha Z, Yi J, Wang J, Liu X, Dai C, Zhang Y, Wu Z, Yao X, Zhou J, Liu H, Chen Y, Ouyang H
Bone research 2025 Mar 17;13(1):37
Bone research 2025 Mar 17;13(1):37
Optically controllable nanoregulators enable tumor-specific pro-ferroptosis lipometabolic reprogramming for in-situ adjuvant-free vaccination.
Li M, Li Y, Yao X, Liu Y, Cai K, Yang H, Luo Z
Biomaterials 2025 Jun;317:123096
Biomaterials 2025 Jun;317:123096
IL-21 Loading CaMnCO(3) Vitality Backpacks Boost CAR-T Cell Synergistic Immunotherapy.
Wang B, Xue Y, Jia Y, Duan Y, Li D, Sui M, Feng Y, Wang L, Ding H, Wang X, Zhang T, Sun Y, Liu H, Qi J, Duan J, Zhao S, Zhu Q
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(25):e2501645
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(25):e2501645
Electrical stimulation promotes peripheral nerve regeneration by upregulating glycolysis and oxidative phosphorylation.
Zhang N, Yao X, Zhang Q, Zhang C, Zheng Q, Wang Y, Shan F
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167804
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167804
GPR39 Agonist TC-G 1008 Promoted Mitochondrial Biogenesis and Improved Antioxidative Capability via CREB/PGC-1α Pathway Following Intracerebral Hemorrhage in Mice.
Zhang Z, Yuan Y, Zhang X, Gu L, Tang Y, Zhao Y, Dai J, Tao Y, Xie Z
Translational stroke research 2025 Jun;16(3):625-644
Translational stroke research 2025 Jun;16(3):625-644
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
Zhao M, Liu S, Wang Y, Lou P, Lv K, Wu T, Li L, Wu Q, Zhu J, Lu Y, Wan M, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
Astrocytic HSP60 Deletion Induced Astrocyte Senescence and Inhibited Neuroregeneration via Modulating the S1P/Truncated-BDNF Pathway.
Zhu W, Cheng Y, Lang Z, Li W, Wei X
Journal of neuroscience research 2025 Jun;103(6):e70054
Journal of neuroscience research 2025 Jun;103(6):e70054
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
Wu C, Miao H, Yi Z, Jia H, Huang A, Zhang H, Liu Z, Sun X, Zheng Y, Gao L, Ma S
International immunopharmacology 2025 Jun 5;157:114778
International immunopharmacology 2025 Jun 5;157:114778
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA.
Ji H, Jiang W, Zhang J, Liu M, Su D, Lei J, Li L, Zheng M, Liu T, Liu Z, Cao Q, Xu L, Xiong S, Wen Z
Cell reports 2025 Jun 24;44(6):115851
Cell reports 2025 Jun 24;44(6):115851
Drp1 knockdown aggravates obesity-induced cardiac dysfunction and remodeling.
Wu D, Hu Q, Li H, Yin Y, Wang P, Wang W
Mitochondrion 2025 Jul;83:102023
Mitochondrion 2025 Jul;83:102023
The role of mitochondrial dysfunction in the protective effect of ginger derived extracellular vesicles on hepatic stellate cells against cytotoxicity.
Yang J, Yang Y, Zhang X, Qin Y, Sato T, Qing S, Wang Y, Ye X, Xu M, Liu Y, He Q, Zheng Y
Molecular and cellular biochemistry 2025 Jul;480(7):4297-4309
Molecular and cellular biochemistry 2025 Jul;480(7):4297-4309
Bach1 Deficiency Ameliorates Radiation Pneumonitis via Activating TFAM Signaling Pathway.
Huang J, Zhang Y, Jiang F, Zhang Y, Li S, He S, Sun J, Chen D, Pang Q, Wu Y
Antioxidants & redox signaling 2025 Jul;43(1-3):75-91
Antioxidants & redox signaling 2025 Jul;43(1-3):75-91
Activation of spinal PGC-1α regulates microglial polarization through a feedback loop between ROS-mediated mitochondrial dysfunction and the NLRP3 inflammasome in neuropathic pain.
Chen Y, Ling G, Xu Q, Zhu Q, Huang T, Su T, Xie Y, Zhong Y
Brain research bulletin 2025 Jul;227:111365
Brain research bulletin 2025 Jul;227:111365
Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.
Luo Y, Ali T, Hu Y, Gong Q, Zheng C, Li L, Li S, Hao L
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 21;20(1):73
Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine.
Lou P, Zhou X, Zhang Y, Xie Y, Wang Y, Wang C, Liu S, Wan M, Lu Y, Liu J
Science advances 2025 Jul 18;11(29):eadt1318
Science advances 2025 Jul 18;11(29):eadt1318
Effect of leucine on mitochondria and oxidative stress to reduce virulence and pathogenicity of Acinetobacter baumannii.
Zhou J, Feng D, Chen Y, Li X, Cen J, Wu W, Zheng W, Gan W, Zhang T
Microbiological research 2025 Jan;290:127932
Microbiological research 2025 Jan;290:127932
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
Liu Z, Bai Y, Xu B, Wen H, Chen K, Lin J, Wang Y, Xu J, Wang H, Shi F, Wang J, Wang H
Journal of neuroinflammation 2025 Jan 22;22(1):14
Journal of neuroinflammation 2025 Jan 22;22(1):14
The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.
Song Y, Zhu X, Wang B, Li Q, Song B
Scientific reports 2025 Jan 10;15(1):1614
Scientific reports 2025 Jan 10;15(1):1614
Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos.
Zhou HL, Wang BB, Fan XL, Zhang XM, Song Y
Ecotoxicology and environmental safety 2025 Jan 1;289:117484
Ecotoxicology and environmental safety 2025 Jan 1;289:117484
SARM1 deficiency induced depressive-like behavior via AMPKα/p-eEF2 axis to synapse dysfunction.
Li W, Zhu W, Chen J, Ali T, Li S
Neuropharmacology 2025 Jan 1;262:110206
Neuropharmacology 2025 Jan 1;262:110206
Correcting mitochondrial loss mitigates NOTCH1-related aortopathy in mice.
Tang Y, Zhang J, Fang Y, Zhu K, Zhu J, Huang C, Xie Z, Zhang S, Ma W, Yan G, Liu S, Liu X, Han W, Xin Y, Yang C, Abudupataer M, Zhou P, He C, Lai H, Wang C, Liu Y, Lan F, Ye D, Yu FX, Xu Y, Zhang W
Nature cardiovascular research 2025 Feb;4(2):235-247
Nature cardiovascular research 2025 Feb;4(2):235-247
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
Wu J, Chen L, Wen P
Scientific reports 2025 Feb 4;15(1):4298
Scientific reports 2025 Feb 4;15(1):4298
Zn(2 +) alleviates ischemia/reperfusion injury in H9c2 cells by modulating mitochondrial biogenesis and dynamics via MCU.
Wang B, Xing B, Huang L, Li X, Bian X, Xi J
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127769
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127769
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function.
Yang X, Wang S, Liu H, Zhang T, Cheng S, Du M
Journal of advanced research 2025 Dec;78:47-62
Journal of advanced research 2025 Dec;78:47-62
Cedrol prevents UVB-induced photoaging by restoring mitochondrial function, metabolic homeostasis, and skin barrier integrity in HaCaT cells.
Xu MR, Lin CH, Lee HH, Wang SY
Pharmaceutical biology 2025 Dec;63(1):859-876
Pharmaceutical biology 2025 Dec;63(1):859-876
TFAM Deficiency Triggers mtDNA Leakage and cGAS-STING-Mediated Intestinal Ischemia-Reperfusion Injury.
Ding K, Zhang L, Zhang Y, Jing Y, Liao H, Chen R, Meng Q
Inflammation 2025 Dec;48(6):3942-3958
Inflammation 2025 Dec;48(6):3942-3958
Arfgef3 knockout ameliorates ischemia reperfusion-induced acute kidney injury via mitochondrial dysfunction alleviation in mice.
Wang L, Yao L, Xie D, Ding W
Renal failure 2025 Dec;47(1):2572359
Renal failure 2025 Dec;47(1):2572359
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS.
Cai D, Chen C, Meekrathok P, Zeng W, Wang Z, Peng Z, Mo Y, Xu X, Wang J, Qiu J
EMBO reports 2025 Dec;26(23):5959-5981
EMBO reports 2025 Dec;26(23):5959-5981
Bioactive peptides PDBSN improve mitochondrial function and suppression the oxidative stress in human adiposity cells.
Shen H, Lei Y, Xie W, Ma T, Bao L, Gao Q, Chen B, Dai B, Qin D
Adipocyte 2025 Dec;14(1):2278213
Adipocyte 2025 Dec;14(1):2278213
Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.
Wu H, Guo Z, Hu P, Du J, Wang P, Ma J, Zhao B, Wei J, Li Z
Food & function 2025 Dec 8;16(24):9593-9608
Food & function 2025 Dec 8;16(24):9593-9608
Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats.
Li RT, Lan BJ, Xiao ZY, Shi QH, Chen XY, Li F
World journal of psychiatry 2025 Dec 19;15(12):108867
World journal of psychiatry 2025 Dec 19;15(12):108867
Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.
Zhao Y, Hu W, Wang X, Ren Z, Gong Y, Liu L, Sun Y
International journal of molecular sciences 2025 Dec 12;26(24)
International journal of molecular sciences 2025 Dec 12;26(24)
NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway.
Zhao X, He M, He L, Han R, Liu Y
Scientific reports 2025 Aug 7;15(1):28975
Scientific reports 2025 Aug 7;15(1):28975
Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein.
Yang R, Wang Y, Kong M, Hu Z, Zhang Z, Shen K, Meng J, Zeng AP
Nature communications 2025 Aug 14;16(1):7540
Nature communications 2025 Aug 14;16(1):7540
Proliferator-Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy.
Li X, Liu A, Zhou Y, Qi H, Wang J, Chen M, Sun T, Wu J, Huang Y, Wang L
Investigative ophthalmology & visual science 2025 Apr 1;66(4):36
Investigative ophthalmology & visual science 2025 Apr 1;66(4):36
Hypomethylation in promoters of PGC-1α involved in exercise-driven skeletal muscular alterations in old age.
Li Q, Liu Q, Lin Z, Lin W, Huang F, Zhu P
Open life sciences 2024;19(1):20220959
Open life sciences 2024;19(1):20220959
Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.
Li W, Mou S, Ali T, Li T, Liu Y, Li S, Yu X, Yu ZJ
Frontiers in pharmacology 2024;15:1422693
Frontiers in pharmacology 2024;15:1422693
Integrative analysis identifies oxidative stress biomarkers in non-alcoholic fatty liver disease via machine learning and weighted gene co-expression network analysis.
Wang H, Cheng W, Hu P, Ling T, Hu C, Chen Y, Zheng Y, Wang J, Zhao T, You Q
Frontiers in immunology 2024;15:1335112
Frontiers in immunology 2024;15:1335112
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis.
Shao M, Cheng H, Li X, Qiu Y, Zhang Y, Chang Y, Fu J, Shen M, Xu X, Feng D, Han Y, Yue S, Zhou Y, Luo Z
Theranostics 2024;14(7):2687-2705
Theranostics 2024;14(7):2687-2705
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
Zhao M, Liu S, Wang Y, Lv K, Lou P, Zhou P, Zhu J, Li L, Cheng J, Lu Y, Liu J
Theranostics 2024;14(4):1517-1533
Theranostics 2024;14(4):1517-1533
Isoquercitrin alleviates OGD/R-induced oxidative stress and impaired mitochondrial biogenesis in SH-SY5Y cells via the NRF1/TFAM pathway.
Li X, Li Y, Wang K, Qi S, Zhang Z, Cai S
Cell biochemistry and biophysics 2024 Sep;82(3):2455-2464
Cell biochemistry and biophysics 2024 Sep;82(3):2455-2464
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome.
Li Y, Tian L, Li S, Chen X, Lei F, Bao J, Wu Q, Wen Y, Jie Y
Free radical biology & medicine 2024 Sep;222:106-121
Free radical biology & medicine 2024 Sep;222:106-121
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Xie H, Yang N, Lu L, Sun X, Li J, Wang X, Guo H, Zhou L, Liu J, Wu H, Yu C, Zhang W, Lu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Autophagy aggravates multi-walled carbon nanotube-induced ferroptosis by suppressing PGC-1 dependent-mitochondrial biogenesis in lung epithelial cells.
Zhu L, Zhu D, Ran J, Li M, Lai Z, Zhou Y, Luo L, Liu X, Mao K, Tian K
Chemico-biological interactions 2024 Sep 1;400:111158
Chemico-biological interactions 2024 Sep 1;400:111158
Loss of CHCHD2 Stability Coordinates with C1QBP/CHCHD2/CHCHD10 Complex Impairment to Mediate PD-Linked Mitochondrial Dysfunction.
Ren YL, Jiang Z, Wang JY, He Q, Li SX, Gu XJ, Qi YR, Zhang M, Yang WJ, Cao B, Li JY, Wang Y, Chen YP
Molecular neurobiology 2024 Oct;61(10):7968-7988
Molecular neurobiology 2024 Oct;61(10):7968-7988
Glycyrrhizin Protects Submandibular Gland Against Radiation Damage by Enhancing Antioxidant Defense and Preserving Mitochondrial Homeostasis.
Zhou XR, Wang XY, Sun YM, Zhang C, Liu KJ, Zhang FY, Xiang B
Antioxidants & redox signaling 2024 Oct;41(10-12):723-743
Antioxidants & redox signaling 2024 Oct;41(10-12):723-743
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Lan X, Wang Q, Liu Y, You Q, Wei W, Zhu C, Hai D, Cai Z, Yu J, Zhang J, Liu N
Redox biology 2024 Nov;77:103406
Redox biology 2024 Nov;77:103406
Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression.
Xavier V, Martinelli S, Corbyn R, Pennie R, Rakovic K, Powley IR, Officer-Jones L, Ruscica V, Galloway A, Carlin LM, Cowling VH, Le Quesne J, Martinou JC, MacVicar T
Life science alliance 2024 Nov;7(11)
Life science alliance 2024 Nov;7(11)
Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection.
Lauf T, Häder A, Hornung F, Reisser Y, Nietzsche S, Schanz F, Trümper V, Jeznach A, Brunke S, Doenst T, Skirecki T, Löffler B, Deinhardt-Emmer S
Immunity & ageing : I & A 2024 Nov 14;21(1):80
Immunity & ageing : I & A 2024 Nov 14;21(1):80
Alterations in coenzyme Q(10) status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis.
Yen HC, Hsu CT, Wu SY, Kan CC, Chang CW, Chang HM, Chien YA, Wei YH, Wu CY
Biochimica et biophysica acta. Bioenergetics 2024 Nov 1;1865(4):149492
Biochimica et biophysica acta. Bioenergetics 2024 Nov 1;1865(4):149492
Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission.
Yin H, Li X, Wang C, Li X, Liu J
Chemico-biological interactions 2024 May 1;394:110975
Chemico-biological interactions 2024 May 1;394:110975
Involvement of CKS1B in the anti-inflammatory effects of cannabidiol in experimental stroke models.
Chen K, Xu B, Xiao X, Long L, Zhao Q, Fang Z, Tu X, Wang J, Xu J, Wang H
Experimental neurology 2024 Mar;373:114654
Experimental neurology 2024 Mar;373:114654
Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA.
Isaac RS, Tullius TW, Hansen KG, Dubocanin D, Couvillion M, Stergachis AB, Churchman LS
Nature structural & molecular biology 2024 Mar;31(3):568-577
Nature structural & molecular biology 2024 Mar;31(3):568-577
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells.
Yap C, Wanga S, Wüst RCI, van Os BW, Pijls MME, Keijzer S, van Zanten E, Koolbergen DR, Driessen AHG, Balm R, Yeung KK, de Vries CJM, Houtkooper RH, Lindeman JHN, de Waard V
Vascular pharmacology 2024 Mar;154:107279
Vascular pharmacology 2024 Mar;154:107279
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Zhang N, Ji Q, Chen Y, Wen X, Shan F
Cell death & disease 2024 Mar 7;15(3):193
Cell death & disease 2024 Mar 7;15(3):193
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning.
Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
Clinical science (London, England : 1979) 2024 Mar 20;138(6):371-385
AIM2 regulates autophagy to mitigate oxidative stress in aged mice with acute liver injury.
Hu C, Li M, Chen Y, Cheng W, Wang H, Zhou Y, Teng F, Ling T, Pan J, Xu H, Zheng Y, Ji G, Zhao T, You Q
Cell death discovery 2024 Mar 1;10(1):107
Cell death discovery 2024 Mar 1;10(1):107
Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.
Feng X, Zheng Y, Mao N, Shen M, Chu L, Fang Y, Pang M, Wang Z, Lin Z
International immunopharmacology 2024 Jun 15;134:112257
International immunopharmacology 2024 Jun 15;134:112257
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes.
Chen J, Feng Q, Qiao Y, Pan S, Liang L, Liu Y, Zhang X, Liu D, Liu Z, Liu Z
Diabetologia 2024 Jul;67(7):1429-1443
Diabetologia 2024 Jul;67(7):1429-1443
Dapagliflozin improves skeletal muscle insulin sensitivity through SIRT1 activation induced by nutrient deprivation state.
Gao Q, Jiang Y, Song Z, Ren H, Kong Y, Wang C, Zheng M, Shan C, Yang Y
Scientific reports 2024 Jul 23;14(1):16878
Scientific reports 2024 Jul 23;14(1):16878
Zearalenone modulates the function of goat endometrial cells via the mitochondrial quality control system.
Zhang G, Zeng C, Sun X, Zhang Q, Wang Y, Xia R, Mai Q, Xue G, Huang H, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23701
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23701
Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance.
Yang J, Zou Y, Lv X, Chen J, Cui C, Song J, Yang M, Hu H, Gao J, Xia L, Wang L, Chen L, Hou X
Diabetology & metabolic syndrome 2024 Jan 3;16(1):7
Diabetology & metabolic syndrome 2024 Jan 3;16(1):7
Integrative analysis of transcriptome and metabolome provide new insights into mechanisms of Capilliposide A against cisplatin-induced nephrotoxicity.
Fang J, Wang L, Zhang D, Liang Y, Li S, Tian J, He Q, Jin J, Zhu W
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115814
Journal of pharmaceutical and biomedical analysis 2024 Jan 20;238:115814
Genetically engineered M2-like macrophage-derived exosomes for P. gingivalis-suppressed cementum regeneration: From mechanism to therapy.
Huang X, Deng Y, Xiao J, Wang H, Yang Q, Cao Z
Bioactive materials 2024 Feb;32:473-487
Bioactive materials 2024 Feb;32:473-487
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal.
Newman LE, Weiser Novak S, Rojas GR, Tadepalle N, Schiavon CR, Grotjahn DA, Towers CG, Tremblay MÈ, Donnelly MP, Ghosh S, Medina M, Rocha S, Rodriguez-Enriquez R, Chevez JA, Lemersal I, Manor U, Shadel GS
Nature cell biology 2024 Feb;26(2):194-206
Nature cell biology 2024 Feb;26(2):194-206
Myricanol represses renal fibrosis by activating TFAM and ZNRF1 to inhibit tubular epithelial cells ferroptosis.
Zheng M, Jiang Q, You J, Gao B, Cui W, Yao W, Su F, Sun X, La L
European journal of pharmacology 2024 Dec 5;984:176999
European journal of pharmacology 2024 Dec 5;984:176999
High concentration hydrogen attenuates sepsis-induced acute kidney injury by promoting mitochondrial biogenesis and fusion.
Pei S, Zheng L, Tian Z, Meng S, Wang Z, Fan Y, Liu J, Cui Y, Xie K
International immunopharmacology 2024 Dec 25;143(Pt 2):113410
International immunopharmacology 2024 Dec 25;143(Pt 2):113410
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Qi XM, Zhang WZ, Zuo YQ, Qiao YB, Zhang YL, Ren JH, Li QS
Cell biology and toxicology 2024 Dec 20;41(1):2
Cell biology and toxicology 2024 Dec 20;41(1):2
Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis.
Natarajan N, Florentin J, Johny E, Xiao H, O'Neil SP, Lei L, Shen J, Ohayon L, Johnson AR, Rao K, Li X, Zhao Y, Zhang Y, Tavakoli S, Shiva S, Das J, Dutta P
Nature communications 2024 Aug 26;15(1):7337
Nature communications 2024 Aug 26;15(1):7337
Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS.
Xu Y, Li G, Ge D, Chen Y, Hou B, Hao Z
Urolithiasis 2024 Aug 13;52(1):117
Urolithiasis 2024 Aug 13;52(1):117
Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD).
Xie B, Chen Q, Dai Z, Jiang C, Chen X
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
Molecular medicine (Cambridge, Mass.) 2024 Aug 13;30(1):123
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway.
Guan S, Qu X, Wang J, Zhang D, Lu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114525
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis.
Hassab AH, Hur DJ, Vallabhajosyula P, Tellides G, Assi R
JCI insight 2024 Apr 9;9(9)
JCI insight 2024 Apr 9;9(9)
Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway.
Zou R, Wang S, Cai H, Wang Y, Wang C
Cardiovascular therapeutics 2023;2023:2108584
Cardiovascular therapeutics 2023;2023:2108584
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Zou YY, Tang XB, Chen ZL, Liu B, Zheng L, Song MY, Xiao Q, Zhou ZQ, Peng XY, Tang CF
Frontiers in endocrinology 2023;14:1162485
Frontiers in endocrinology 2023;14:1162485
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Song X, Leonhard WN, Kanhai AA, Steinberg GR, Pei Y, Peters DJM
Frontiers in molecular biosciences 2023;10:1058825
Frontiers in molecular biosciences 2023;10:1058825
Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity.
Koh YC, Lin SJ, Hsu KY, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Molecular nutrition & food research 2023 Sep;67(18):e2300370
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Chen ZL, Guo C, Zou YY, Feng C, Yang DX, Sun CC, Wen W, Jian ZJ, Zhao Z, Xiao Q, Zheng L, Peng XY, Zhou ZQ, Tang CF
Experimental gerontology 2023 Sep;180:112265
Experimental gerontology 2023 Sep;180:112265
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Zhu A, Duan Z, Chen Y, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis.
Guo H, Wu H, Hou Y, Hu P, Du J, Cao L, Yang R, Dong X, Li Z
International journal of biological macromolecules 2023 Sep 30;249:126039
International journal of biological macromolecules 2023 Sep 30;249:126039
Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression.
Grotehans N, McGarry L, Nolte H, Xavier V, Kroker M, Narbona-Pérez ÁJ, Deshwal S, Giavalisco P, Langer T, MacVicar T
The EMBO journal 2023 Sep 18;42(18):e113256
The EMBO journal 2023 Sep 18;42(18):e113256
Mitochondrial miR-12294-5p regulated copper-induced mitochondrial oxidative stress and mitochondrial quality control imbalance by targeted inhibition of CISD1 in chicken livers.
Zhong G, Li Y, Li L, Huo Y, Zhang W, Li T, Ma F, Liao J, Li Y, Zhang H, Guo J, Pan J, Yu W, Hu L, Tang Z
Journal of hazardous materials 2023 Sep 15;458:131908
Journal of hazardous materials 2023 Sep 15;458:131908
Xanthohumol alleviates palmitate-induced inflammation and prevents osteoarthritis progression by attenuating mitochondria dysfunction/NLRP3 inflammasome axis.
Sun W, Yue J, Xu T, Cui Y, Huang D, Shi H, Xiong J, Sun W, Yi Q
Heliyon 2023 Nov;9(11):e21282
Heliyon 2023 Nov;9(11):e21282
Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Duan Y, Dai H, Zhang H, Huang Y, Fu W, Sun W, Zhao B
Chinese journal of natural medicines 2023 Nov;21(11):812-829
Chinese journal of natural medicines 2023 Nov;21(11):812-829
Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice.
Wang Z, Yang T, Zeng M, Wang Z, Chen Q, Chen J, Christian M, He Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Nov;181:114089
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle.
Liang J, Wei X, Hou W, Wang H, Ma R, Gao Y, Du Y, Zhang Q
Chinese medicine 2023 Nov 30;18(1):157
Chinese medicine 2023 Nov 30;18(1):157
The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses.
Meade N, Toreev HK, Chakrabarty RP, Hesser CR, Park C, Chandel NS, Walsh D
Nature communications 2023 Nov 30;14(1):7889
Nature communications 2023 Nov 30;14(1):7889
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Liu W, Li F, Guo D, Du C, Zhao S, Li J, Yan Z, Hao J
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.
Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C
Nature communications 2023 Nov 18;14(1):7527
Nature communications 2023 Nov 18;14(1):7527
Low-dose atorvastatin protects skeletal muscle mitochondria in high-fat diet-fed mice with mitochondrial autophagy inhibition and fusion enhancement.
Zheng P, Zhang Q, Ma W, Hu R, Gu Y, Bian Z, Yang D, Chen X, Wu H
European journal of pharmacology 2023 Nov 15;959:176085
European journal of pharmacology 2023 Nov 15;959:176085
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770
Nature communications 2023 Nov 1;14(1):6770
FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.
Wu J, Subbaiah KCV, Hedaya O, Chen S, Munger J, Tang WHW, Yan C, Yao P
bioRxiv : the preprint server for biology 2023 May 22;
bioRxiv : the preprint server for biology 2023 May 22;
NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation.
Jiang Y, Li Y, Zhang Y, Hu D, Zhang S, Wang C, Huang S, Zhang A, Jia Z, You R
International immunopharmacology 2023 Mar;116:109847
International immunopharmacology 2023 Mar;116:109847
HC067047 as a potent TRPV4 inhibitor repairs endotoxemia colonic injury.
Chen L, Mao M, Liu D, Liu W, Wang Y, Xie L, Deng Y, Lin Y, Xu Y, Zhong X, Cao W
International immunopharmacology 2023 Mar;116:109648
International immunopharmacology 2023 Mar;116:109648
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Hong JR, Jin L, Zhang CY, Zhong WJ, Yang HH, Wang GM, Ma SC, Guan CX, Li Q, Zhou Y
Heliyon 2023 Jun;9(6):e17361
Heliyon 2023 Jun;9(6):e17361
Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis.
Liu Q, Wang X, Hu Y, Zhao JN, Huang CH, Li T, Zhang BG, He Y, Wu YQ, Zhang ZJ, Wang GP, Liu GP
Redox biology 2023 Jun;62:102697
Redox biology 2023 Jun;62:102697
SRT1720 attenuates UVA-induced corneal endothelial damage via inhibition of oxidative stress and cellular apoptosis.
Dong C, Li Z, Wang X, Zou D, Duan H, Zhao C, Zhou Q, Shi W
Experimental eye research 2023 Jun;231:109464
Experimental eye research 2023 Jun;231:109464
Prevention of Glutamate-Induced Neurodegeneration by Piceatannol via Mitochondrial Rescue In Vitro and In Vivo.
Koh YC, Chok D, Chang CH, Wei CC, Wu CT, Cheng KC, Nagabhushanam K, Ho CT, Pan MH
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Molecular nutrition & food research 2023 Jul;67(13):e2300139
Neuroprotective Effect of miR-483-5p Against Cardiac Arrest-Induced Mitochondrial Dysfunction Mediated Through the TNFSF8/AMPK/JNK Signaling Pathway.
Zhang Q, Zhan H, Liu C, Zhang C, Wei H, Li B, Zhou D, Lu Y, Huang S, Cheng J, Li S, Wang C, Hu C, Liao X
Cellular and molecular neurobiology 2023 Jul;43(5):2179-2202
Cellular and molecular neurobiology 2023 Jul;43(5):2179-2202
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D, Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE, Upton JW, Li P, West AP
Cell 2023 Jul 6;186(14):3013-3032.e22
Cell 2023 Jul 6;186(14):3013-3032.e22
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract.
Li F, Xu M, Miao J, Hu N, Wang Y, Wang L
Toxicology letters 2023 Jul 1;383:98-111
Toxicology letters 2023 Jul 1;383:98-111
Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α.
Huang S, Chen X, Pan J, Zhang H, Ke J, Gao L, Yu Chang AC, Zhang J, Zhang H
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
Nitric oxide : biology and chemistry 2023 Jul 1;136-137:12-23
PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity.
Qi XM, Qiao YB, Zhang YL, Wang AC, Ren JH, Wei HZ, Li QS
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113513
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113513
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, You J, Gao B, Sun X, La L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Tian Z, Li J, Song L, Xie L, Li D, Xia T, Wang A
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Gu S, Wu G, Lu D, Wang Y, Tang L, Zhang W
Toxicology letters 2023 Jan 15;373:172-183
Toxicology letters 2023 Jan 15;373:172-183
Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction.
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, Zhu X, Zhang J, Chen P
Materials today. Bio 2023 Feb;18:100512
Materials today. Bio 2023 Feb;18:100512
Osthole: A potential AMPK agonist that inhibits NLRP3 inflammasome activation by regulating mitochondrial homeostasis for combating rheumatoid arthritis.
Jiang X, Lu Z, Zhang Q, Yu J, Han D, Liu J, Li P, Li F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154640
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease.
Bai M, Wu M, Jiang M, He J, Deng X, Xu S, Fan J, Miao M, Wang T, Li Y, Yu X, Wang L, Zhang Y, Huang S, Yang L, Jia Z, Zhang A
EMBO molecular medicine 2023 Feb 8;15(2):e16581
EMBO molecular medicine 2023 Feb 8;15(2):e16581
Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mabanglo MF, Wong KS, Barghash MM, Leung E, Chuang SHW, Ardalan A, Majaesic EM, Wong CJ, Zhang S, Lang H, Karanewsky DS, Iwanowicz AA, Graves LM, Iwanowicz EJ, Gingras AC, Houry WA
Structure (London, England : 1993) 2023 Feb 2;31(2):185-200.e10
Structure (London, England : 1993) 2023 Feb 2;31(2):185-200.e10
SARS-CoV-2 nucleocapsid protein enhances the level of mitochondrial reactive oxygen species.
Yu H, Yang L, Han Z, Zhou X, Zhang Z, Sun T, Zheng F, Yang J, Guan F, Xie J, Liu C
Journal of medical virology 2023 Dec;95(12):e29270
Journal of medical virology 2023 Dec;95(12):e29270
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Wan L, Qian Y, Ni W, Lu Y, Li W, Pan Y, Chen W
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis.
Yang JW, Zou Y, Chen J, Cui C, Song J, Yang MM, Gao J, Hu HQ, Xia LQ, Wang LM, Lv XY, Chen L, Hou XG
Journal of translational medicine 2023 Dec 19;21(1):921
Journal of translational medicine 2023 Dec 19;21(1):921
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Lou P, Liu S, Wang Y, Lv K, Zhou X, Li L, Zhang Y, Chen Y, Cheng J, Lu Y, Liu J
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy.
Bround MJ, Havens JR, York AJ, Sargent MA, Karch J, Molkentin JD
Science advances 2023 Aug 25;9(34):eadi2767
Science advances 2023 Aug 25;9(34):eadi2767
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y
The EMBO journal 2023 Aug 15;42(16):e113258
The EMBO journal 2023 Aug 15;42(16):e113258
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
Tang H, Zheng Z, Wang H, Wang L, Zhao G, Wang P
Nutrients 2023 Aug 11;15(16)
Nutrients 2023 Aug 11;15(16)
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Ma Z, Liu Z, Li X, Zhang H, Han D, Xiong W, Zhou H, Yang X, Zeng Q, Ren H, Xu D
Biology 2023 Apr 11;12(4)
Biology 2023 Apr 11;12(4)
AKAP1 contributes to impaired mtDNA replication and mitochondrial dysfunction in podocytes of diabetic kidney disease.
Feng J, Chen Z, Ma Y, Yang X, Zhu Z, Zhang Z, Hu J, Liang W, Ding G
International journal of biological sciences 2022;18(10):4026-4042
International journal of biological sciences 2022;18(10):4026-4042
Exploration of Reduced Mitochondrial Content-Associated Gene Signature and Immunocyte Infiltration in Colon Adenocarcinoma by an Integrated Bioinformatic Analysis.
Kang J, Li N, Wang F, Wei Y, Zeng Y, Luo Q, Sun X, Xu H, Peng J, Zhou F
Frontiers in genetics 2022;13:832331
Frontiers in genetics 2022;13:832331
Miya Improves Osteoarthritis Characteristics via the Gut-Muscle-Joint Axis According to Multi-Omics Analyses.
Xu T, Yang D, Liu K, Gao Q, Liu Z, Li G
Frontiers in pharmacology 2022;13:816891
Frontiers in pharmacology 2022;13:816891
Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.
Liang S, Zhu C, Suo C, Wei H, Yu Y, Gu X, Chen L, Yuan M, Shen S, Li S, Sun L, Gao P
Frontiers in oncology 2022;12:857968
Frontiers in oncology 2022;12:857968
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.
Zou M, Ke Q, Nie Q, Qi R, Zhu X, Liu W, Hu X, Sun Q, Fu JL, Tang X, Liu Y, Li DW, Gong L
Cell death and differentiation 2022 Sep;29(9):1816-1833
Cell death and differentiation 2022 Sep;29(9):1816-1833
LINC00839 promotes colorectal cancer progression by recruiting RUVBL1/Tip60 complexes to activate NRF1.
Liu X, Chen J, Zhang S, Liu X, Long X, Lan J, Zhou M, Zheng L, Zhou J
EMBO reports 2022 Sep 5;23(9):e54128
EMBO reports 2022 Sep 5;23(9):e54128
Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption.
Mackert O, Wirth EK, Sun R, Winkler J, Liu A, Renko K, Kunz S, Spranger J, Brachs S
Molecular metabolism 2022 Oct;64:101563
Molecular metabolism 2022 Oct;64:101563
miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC‑1α.
Zhou H, Gan M, Jin X, Dai M, Wang Y, Lei Y, Lin Z, Ming J
International journal of oncology 2022 Oct;61(4)
International journal of oncology 2022 Oct;61(4)
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Wang F, Han J, Wang X, Liu Y, Zhang Z
Journal of molecular histology 2022 Oct;53(5):833-842
Journal of molecular histology 2022 Oct;53(5):833-842
Inhibition of High-Temperature Requirement Protein A2 Protease Activity Represses Myogenic Differentiation via UPRmt.
Sun H, Shen L, Zhang P, Lin F, Ma J, Wu Y, Yu H, Sun L
International journal of molecular sciences 2022 Oct 4;23(19)
International journal of molecular sciences 2022 Oct 4;23(19)
Naringenin activates beige adipocyte browning in high fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Zhang S, Li J, Shi X, Tan X, Si Q
Food & function 2022 Oct 3;13(19):9918-9930
Food & function 2022 Oct 3;13(19):9918-9930
Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.
Barsky ST, Monks DA
Biology of sex differences 2022 Oct 23;13(1):59
Biology of sex differences 2022 Oct 23;13(1):59
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Tai H, Cui XZ, He J, Lan ZM, Li SM, Li LB, Yao SC, Jiang XL, Meng XS, Kuang JS
Aging 2022 Oct 20;14(20):8302-8320
Aging 2022 Oct 20;14(20):8302-8320
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Lv Q, Han X, Ni J, Ma Q, Dai R, Liu J, Liu J, Zhai Y, Shen Q, Sun L, Liu H, Rao J, Xu H
Cell death & disease 2022 Oct 13;13(10):867
Cell death & disease 2022 Oct 13;13(10):867
Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by integrating multi-hierarchical regulatory networks.
Hu S, Feng J, Wang M, Wufuer R, Liu K, Zhang Z, Zhang Y
Redox biology 2022 Nov;57:102470
Redox biology 2022 Nov;57:102470
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α.
Wu H, Lu C, Li X, Xu X, Wu S
Annals of translational medicine 2022 Nov;10(22):1241
Annals of translational medicine 2022 Nov;10(22):1241
Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice.
Xie X, Zhou J, Hu L, Shu R, Zhang M, Sun L, Wu F, Fu Z, Li Z
Journal of hazardous materials 2022 May 15;430:128376
Journal of hazardous materials 2022 May 15;430:128376
Maintaining homeostasis of mitochondria and endoplasmic reticulum with NSC228155 alleviates cisplatin-induced acute kidney injury.
Li Y, Jiang Y, Zhou W, Wu Y, Zhang S, Ding G, Zhang Y, Zhang A, Huang S, Jia Z, You R
Free radical biology & medicine 2022 Mar;181:270-287
Free radical biology & medicine 2022 Mar;181:270-287
ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis.
Zhu P, Ma H, Cui S, Zhou X, Xu W, Yu J, Li J
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
Pharmaceuticals (Basel, Switzerland) 2022 Mar 31;15(4)
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Zhao K, Huang X, Zhao W, Lu B, Yang Z
Development (Cambridge, England) 2022 Mar 15;149(6)
Development (Cambridge, England) 2022 Mar 15;149(6)
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Dai H, Duan Y, Zhang H, Huang Y, Fu W, Meng Y, Zhao B
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Tai H, Tong YJ, Yu R, Yu Y, Yao SC, Li LB, Liu Y, Cui XZ, Kuang JS, Meng XS, Jiang XL
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Journal of cellular and molecular medicine 2022 Jun;26(12):3423-3445
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.
Chen Z, Wang H, Hu B, Chen X, Zheng M, Liang L, Lyu J, Zeng Q
European journal of histochemistry : EJH 2022 Jun 21;66(3)
European journal of histochemistry : EJH 2022 Jun 21;66(3)
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Zhou M, Dai Y, Ma Y, Yan Y, Hua M, Gao Q, Geng X, Zhou Q
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
Molecules (Basel, Switzerland) 2022 Jun 14;27(12)
PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c.
Dogan AE, Hamid SM, Yildirim AD, Yildirim Z, Sen G, Riera CE, Gottlieb RA, Erbay E
The Journal of biological chemistry 2022 Jul;298(7):102050
The Journal of biological chemistry 2022 Jul;298(7):102050
Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice.
Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K
International journal of molecular sciences 2022 Jul 29;23(15)
International journal of molecular sciences 2022 Jul 29;23(15)
Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway.
Liu J, Jiang J, Qiu J, Wang L, Zhuo J, Wang B, Sun D, Yu S, Lou H
Food & function 2022 Jan 4;13(1):375-385
Food & function 2022 Jan 4;13(1):375-385
Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.
Bryant JD, Lei Y, VanPortfliet JJ, Winters AD, West AP
Current protocols 2022 Feb;2(2):e372
Current protocols 2022 Feb;2(2):e372
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
Zhao YC, Guo W, Gao BH
Life sciences 2022 Feb 15;291:119340
Life sciences 2022 Feb 15;291:119340
A plant-derived natural photosynthetic system for improving cell anabolism.
Chen P, Liu X, Gu C, Zhong P, Song N, Li M, Dai Z, Fang X, Liu Z, Zhang J, Tang R, Fan S, Lin X
Nature 2022 Dec;612(7940):546-554
Nature 2022 Dec;612(7940):546-554
Mitochondrial PARP1 regulates NAD(+)-dependent poly ADP-ribosylation of mitochondrial nucleoids.
Lee JH, Hussain M, Kim EW, Cheng SJ, Leung AKL, Fakouri NB, Croteau DL, Bohr VA
Experimental & molecular medicine 2022 Dec;54(12):2135-2147
Experimental & molecular medicine 2022 Dec;54(12):2135-2147
Renal tubular in TCE-sensitization-induced immune kidney injury: Role of mitochondrial DNA in activating the cGAS-STING signaling pathway.
Ma J, Liu Z, Zhou S, Chen M, Gao L, Zuo X, Zhang X, Zhang J, Zhu Q
International immunopharmacology 2022 Dec;113(Pt B):109432
International immunopharmacology 2022 Dec;113(Pt B):109432
Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Sun J, Leng P, Li X, Guo Q, Zhao J, Liang Y, Zhang X, Yang X, Li J
Adipocyte 2022 Dec;11(1):562-571
Adipocyte 2022 Dec;11(1):562-571
Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway.
Chai X, Pan M, Wang J, Feng M, Wang Y, Zhang Q, Sun Y
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Biochemical and biophysical research communications 2022 Dec 31;637:127-135
Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α activation.
Wang M, Wang L, Zhou Y, Feng X, Ye C, Wang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153947
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153947
BMAL1 regulates mitochondrial homeostasis in renal ischaemia-reperfusion injury by mediating the SIRT1/PGC-1α axis.
Ye P, Li W, Huang X, Zhao S, Chen W, Xia Y, Yu W, Rao T, Ning J, Zhou X, Ruan Y, Cheng F
Journal of cellular and molecular medicine 2022 Apr;26(7):1994-2009
Journal of cellular and molecular medicine 2022 Apr;26(7):1994-2009
Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria.
Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT
eLife 2022 Apr 6;11
eLife 2022 Apr 6;11
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Tai H, Jiang XL, Song N, Xiao HH, Li Y, Cheng MJ, Yin XM, Chen YR, Yang GL, Jiang XY, Kuang JS, Lan ZM, Jia LQ
Frontiers in medicine 2021;8:617393
Frontiers in medicine 2021;8:617393
RNA-Seq Profiling to Investigate the Mechanism of Qishen Granules on Regulating Mitochondrial Energy Metabolism of Heart Failure in Rats.
He H, Li C, Lu X, Li Y, Li X, Sun X, Tang B, Wu Y, Li C
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5779307
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
Mu Q, Zhang Y, Gu L, Gerner ST, Qiu X, Tao Q, Pang J, Dipritu G, Zhang L, Yin S, Jiang Y, Peng J
Frontiers in neurology 2021;12:728984
Frontiers in neurology 2021;12:728984
Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK.
Yang Y, Wu Y, Zou J, Wang YH, Xu MX, Huang W, Yu DJ, Zhang L, Zhang YY, Sun XD
Frontiers in pharmacology 2021;12:687095
Frontiers in pharmacology 2021;12:687095
Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm.
Oller J, Gabandé-Rodríguez E, Ruiz-Rodríguez MJ, Desdín-Micó G, Aranda JF, Rodrigues-Diez R, Ballesteros-Martínez C, Blanco EM, Roldan-Montero R, Acuña P, Forteza Gil A, Martín-López CE, Nistal JF, Lino Cardenas CL, Lindsay ME, Martín-Ventura JL, Briones AM, Redondo JM, Mittelbrunn M
Circulation 2021 May 25;143(21):2091-2109
Circulation 2021 May 25;143(21):2091-2109
Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1.
Yang M, Cui Y, Song J, Cui C, Wang L, Liang K, Wang C, Sha S, He Q, Hu H, Guo X, Zang N, Sun L, Chen L
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Biochemical and biophysical research communications 2021 Mar 26;546:74-82
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
Tai H, Jiang XL, Lan ZM, Li Y, Kong L, Yao SC, Song N, Lv MJ, Wu J, Yang P, Xiao XS, Yang GL, Kuang JS, Jia LQ
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
BMC complementary medicine and therapies 2021 Mar 22;21(1):100
Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK.
Wu Y, Yang Y, Li F, Zou J, Wang YH, Xu MX, Wang YL, Li RX, Sun YT, Lu S, Zhang YY, Sun XD
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Journal of clinical and translational hepatology 2021 Jun 28;9(3):373-383
Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy.
Zhiyin L, Jinliang C, Qiunan C, Yunfei Y, Qian X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111590
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111590
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538
ACS nano 2021 Jan 26;15(1):1519-1538
Nobiletin activates thermogenesis of brown and white adipose tissue in high-fat diet-fed C57BL/6 mice by shaping the gut microbiota.
Kou G, Li P, Hu Y, Chen H, Nyantakyiwaa Amoah A, Seydou Traore S, Cui Z, Lyu Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21267
Vascular endothelial growth factor alleviates mitochondrial dysfunction and suppression of mitochondrial biogenesis in models of Alzheimer's disease.
Liu X, Chu B, Jin S, Li M, Xu Y, Yang H, Feng Z, Bi J, Wang P
The International journal of neuroscience 2021 Feb;131(2):154-162
The International journal of neuroscience 2021 Feb;131(2):154-162
Normothermic machine perfusion attenuates hepatic ischaemia-reperfusion injury by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
Liu W, Fan Y, Ding H, Han D, Yan Y, Wu R, Lv Y, Zheng X
Journal of cellular and molecular medicine 2021 Dec;25(24):11310-11321
Journal of cellular and molecular medicine 2021 Dec;25(24):11310-11321
β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.
Chen N, Ge MM, Li DY, Wang XM, Liu DQ, Ye DW, Tian YK, Zhou YQ, Chen JP
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112331
A recessive variant in TFAM causes mtDNA depletion associated with primary ovarian insufficiency, seizures, intellectual disability and hearing loss.
Ullah F, Rauf W, Khan K, Khan S, Bell KM, de Oliveira VC, Tariq M, Bakhshalizadeh S, Touraine P, Katsanis N, Sinclair A, He S, Tucker EJ, Baig SM, Davis EE
Human genetics 2021 Dec;140(12):1733-1751
Human genetics 2021 Dec;140(12):1733-1751
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
Zhou H, Yao L, Jiang X, Sumayyah G, Tu B, Cheng S, Qin X, Zhang J, Zou Z, Chen C
Neurotoxicity research 2021 Aug;39(4):1160-1170
Neurotoxicity research 2021 Aug;39(4):1160-1170
ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA.
Shu L, Hu C, Xu M, Yu J, He H, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z
The EMBO journal 2021 Apr 15;40(8):e106283
The EMBO journal 2021 Apr 15;40(8):e106283
Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway.
Zhang Q, Guo D, Wang Y, Wang X, Wang Q, Wu Y, Li C, Wang W, Wang Y
Frontiers in pharmacology 2020;11:458
Frontiers in pharmacology 2020;11:458
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Zhao Q, Tian Z, Zhou G, Niu Q, Chen J, Li P, Dong L, Xia T, Zhang S, Wang A
Theranostics 2020;10(11):4822-4838
Theranostics 2020;10(11):4822-4838
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Rey T, Zaganelli S, Cuillery E, Vartholomaiou E, Croisier M, Martinou JC, Manley S
Nature cell biology 2020 Oct;22(10):1180-1186
Nature cell biology 2020 Oct;22(10):1180-1186
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Guo A, Li K, Xiao Q
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.
Chung KW, Dhillon P, Huang S, Sheng X, Shrestha R, Qiu C, Kaufman BA, Park J, Pei L, Baur J, Palmer M, Susztak K
Cell metabolism 2019 Oct 1;30(4):784-799.e5
Cell metabolism 2019 Oct 1;30(4):784-799.e5
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G
Aging 2019 Nov 22;11(22):10356-10373
Aging 2019 Nov 22;11(22):10356-10373
Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken.
Surugihalli C, Porter TE, Chan A, Farley LS, Maguire M, Zhang C, Kattapuram N, Muyyarikkandy MS, Liu HC, Sunny NE
Scientific reports 2019 Dec 27;9(1):20167
Scientific reports 2019 Dec 27;9(1):20167
Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Deng X, Zhang S, Wu J, Sun X, Shen Z, Dong J, Huang J
Journal of food science 2019 Aug;84(8):2101-2111
Journal of food science 2019 Aug;84(8):2101-2111
Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule.
Hu Q, Wu D, Ma F, Yang S, Tan B, Xin H, Gu X, Chen X, Chen S, Mao Y, Zhu YZ
Antioxidants & redox signaling 2016 Sep 10;25(8):498-514
Antioxidants & redox signaling 2016 Sep 10;25(8):498-514
Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro.
Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, Sun B
Oncotarget 2016 Dec 6;7(49):81077-81089
Oncotarget 2016 Dec 6;7(49):81077-81089
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 22586-1-AP(TFAM antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TFAM antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TFAM. This antibody recognizes human antigen. The TFAM antibody has been validated for the following applications: ELISA, WB, IHC analysis.
