Antibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [2]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- H00007019-B01P - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00007019-B01P, RRID:AB_2271679
- Product name
- Mouse Polyclonal mtTFA Antibody
- Antibody type
- Polyclonal
- Description
- Protein G purified. TFAM - transcription factor A, mitochondrial,
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.05 mg
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway.
Decreased mitochondrial copy numbers in oral squamous cell carcinoma.
Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.
Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells.
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion.
Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.
Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane.
Morishita M, Kawamoto T, Hara H, Onishi Y, Ueha T, Minoda M, Katayama E, Takemori T, Fukase N, Kurosaka M, Kuroda R, Akisue T
International journal of oncology 2017 Jan;50(1):23-30
International journal of oncology 2017 Jan;50(1):23-30
Decreased mitochondrial copy numbers in oral squamous cell carcinoma.
Takeda D, Hasegawa T, Ueha T, Sakakibara A, Kawamoto T, Minamikawa T, Sakai Y, Komori T
Head & neck 2016 Aug;38(8):1170-5
Head & neck 2016 Aug;38(8):1170-5
Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.
Akbari M, Sykora P, Bohr VA
Scientific reports 2015 Aug 10;5:12876
Scientific reports 2015 Aug 10;5:12876
Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells.
Gibellini L, Pinti M, Boraldi F, Giorgio V, Bernardi P, Bartolomeo R, Nasi M, De Biasi S, Missiroli S, Carnevale G, Losi L, Tesei A, Pinton P, Quaglino D, Cossarizza A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Dec;28(12):5122-35
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Dec;28(12):5122-35
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.
Akbari M, Keijzers G, Maynard S, Scheibye-Knudsen M, Desler C, Hickson ID, Bohr VA
DNA repair 2014 Apr;16:44-53
DNA repair 2014 Apr;16:44-53
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Gispert S, Parganlija D, Klinkenberg M, Dröse S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, Büchel F, Adler T, Hrabé de Angelis M, Busch DH, Zell A, Reichert AS, Brandt U, Osiewacz HD, Jendrach M, Auburger G
Human molecular genetics 2013 Dec 15;22(24):4871-87
Human molecular genetics 2013 Dec 15;22(24):4871-87
Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion.
Rolland SG, Motori E, Memar N, Hench J, Frank S, Winklhofer KF, Conradt B
Proceedings of the National Academy of Sciences of the United States of America 2013 Aug 6;110(32):E2967-76
Proceedings of the National Academy of Sciences of the United States of America 2013 Aug 6;110(32):E2967-76
Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.
Holmström MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM
American journal of physiology. Endocrinology and metabolism 2012 Mar 15;302(6):E731-9
American journal of physiology. Endocrinology and metabolism 2012 Mar 15;302(6):E731-9
Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.
Balliet RM, Capparelli C, Guido C, Pestell TG, Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Chiavarina B, Pestell RG, Howell A, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2011 Dec 1;10(23):4065-73
Cell cycle (Georgetown, Tex.) 2011 Dec 1;10(23):4065-73
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane.
Aamann MD, Sorensen MM, Hvitby C, Berquist BR, Muftuoglu M, Tian J, de Souza-Pinto NC, Scheibye-Knudsen M, Wilson DM 3rd, Stevnsner T, Bohr VA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul;24(7):2334-46
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul;24(7):2334-46
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: mtTFA Antibody [H00007019-B01P] - Analysis of TFAM expression in transfected 293T cell line by TFAM polyclonal antibody. Lane 1: TFAM transfected lysate(27.06 KDa). Lane 2: Non-transfected lysate.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: mtTFA Antibody [H00007019-B01P] - Analysis of TFAM expression in human kidney.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunocytochemistry/Immunofluorescence: mtTFA Antibody [H00007019-B01P] - Analysis of purified antibody to TFAM on HeLa cell. (antibody concentration 10 ug/ml)
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: mtTFA Antibody [H00007019-B01P] - Analysis of purified antibody to TFAM on formalin-fixed paraffin-embedded human small Intestine. (antibody concentration 3 ug/ml)