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Learn12259-1-AP
antibody from Proteintech Group
Targeting: SERPING1
C1-INH, C1IN, C1INH, C1NH, HAE1, HAE2
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 12259-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12259-1-AP, RRID:AB_2285663
- Product name
- SERPING1/C1 Inactivator antibody
- Antibody type
- Polyclonal
- Description
- SERPING1/C1 Inactivator antibody (Cat. #12259-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of a Biomarker Panel in Extracellular Vesicles Derived From Non-Small Cell Lung Cancer (NSCLC) Through Proteomic Analysis and Machine Learning.
Increased reactive astrocytes and NLRC4-mediated neuronal pyroptosis in advanced visual structures contralateral to the optic nerve crush eye in mice.
WNT inhibitor SP5-mediated SERPING1 suppresses lung adenocarcinoma progression via TSC2/mTOR pathway.
Proteomic profiling reveals the molecular signatures of chemotherapy-induced human ovarian damage.
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Uncovering a novel SERPING1 pathogenic variant: insights into the aggregation of C1-INH in hereditary angioedema.
β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.
New Mechanisms of Bromelain in Alleviating Non-Alcoholic Fatty Liver Disease-Induced Deregulation of Blood Coagulation.
Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update.
Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT(2B)R/β-arrestin2 pathway.
Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage.
A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.
Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.
Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.
Decreased expression of serine protease inhibitor family G1 (SERPING1) in prostate cancer can help distinguish high-risk prostate cancer and predicts malignant progression.
The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.
The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII: reply.
Yuan Y, Jiang H, Xue R, Feng XJ, Liu BF, Li L, Peng B, Ren CS, Li SM, Li N, Li M, Wang DB, Zhang XE
Journal of extracellular vesicles 2025 May;14(5):e70078
Journal of extracellular vesicles 2025 May;14(5):e70078
Increased reactive astrocytes and NLRC4-mediated neuronal pyroptosis in advanced visual structures contralateral to the optic nerve crush eye in mice.
Li D, Hu Q, Zhan Z, Zhang X, Zeng W, Liu L, Wu K, Yu M
Experimental eye research 2025 Feb;251:110235
Experimental eye research 2025 Feb;251:110235
WNT inhibitor SP5-mediated SERPING1 suppresses lung adenocarcinoma progression via TSC2/mTOR pathway.
Shen Y, Dong X, Li X, Shi Z, Shao T, Jiang J, Song J
Cell death & disease 2025 Feb 17;16(1):103
Cell death & disease 2025 Feb 17;16(1):103
Proteomic profiling reveals the molecular signatures of chemotherapy-induced human ovarian damage.
Grosbois J, Bisteau X, Imbault V, Conrard L, Condorelli M, Findikli N, Lybaert P, Demeestere I
Human reproduction (Oxford, England) 2025 Dec 1;40(12):2395-2408
Human reproduction (Oxford, England) 2025 Dec 1;40(12):2395-2408
Scutellarin Modulates Astrocyte-Microglia-Neuron Crosstalk to Mitigate Neuroinflammation and Apoptosis in Cerebral Ischemia.
Chen H, Duan Z, Jia Q, Zhang X, Xu D, Zheng L, Qi Z, Yang Y, Yang L, Wu C
Molecular neurobiology 2025 Aug;62(8):10834-10855
Molecular neurobiology 2025 Aug;62(8):10834-10855
Uncovering a novel SERPING1 pathogenic variant: insights into the aggregation of C1-INH in hereditary angioedema.
Jiang L, Dai C, Duan S, Wang T, Xie C, Zhang L, Ye Z, Ma X, Shi Y
Orphanet journal of rare diseases 2024 Sep 13;19(1):341
Orphanet journal of rare diseases 2024 Sep 13;19(1):341
β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.
Hua F, Zhu H, Yu W, Zheng Q, Zhang L, Liang W, Lin Y, Xiao F, Yi P, Xiong Y, Dong Y, Li H, Fang L, Liu H, Ying J, Wang X
Journal of neuroinflammation 2023 May 11;20(1):113
Journal of neuroinflammation 2023 May 11;20(1):113
New Mechanisms of Bromelain in Alleviating Non-Alcoholic Fatty Liver Disease-Induced Deregulation of Blood Coagulation.
Hu PA, Wang SH, Chen CH, Guo BC, Huang JW, Lee TS
Nutrients 2022 Jun 1;14(11)
Nutrients 2022 Jun 1;14(11)
Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update.
Roskoski R Jr
Pharmacological research 2022 Jan;175:106037
Pharmacological research 2022 Jan;175:106037
Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT(2B)R/β-arrestin2 pathway.
Fang Y, Ding X, Zhang Y, Cai L, Ge Y, Ma K, Xu R, Li S, Song M, Zhu H, Liu J, Ding J, Lu M, Hu G
Journal of neuroinflammation 2022 Jan 29;19(1):23
Journal of neuroinflammation 2022 Jan 29;19(1):23
Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage.
Shen Y, Yang W, Xiong X, Li X, Xiao Z, Yu J, Liu F, Gui S, Xie X, Lv F, Zhao L, Hu L, Manaenko A, Xie P, Li Q
Oxidative medicine and cellular longevity 2021;2021:2510847
Oxidative medicine and cellular longevity 2021;2021:2510847
A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.
Abe K, Shang J, Shi X, Yamashita T, Hishikawa N, Takemoto M, Morihara R, Nakano Y, Ohta Y, Deguchi K, Ikeda M, Ikeda Y, Okamoto K, Shoji M, Takatama M, Kojo M, Kuroda T, Ono K, Kimura N, Matsubara E, Osakada Y, Wakutani Y, Takao Y, Higashi Y, Asada K, Senga T, Lee LJ, Tanaka K
Journal of Alzheimer's disease : JAD 2020;73(1):217-227
Journal of Alzheimer's disease : JAD 2020;73(1):217-227
Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.
Shi X, Ohta Y, Liu X, Shang J, Morihara R, Nakano Y, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Abe K
Neuroscience 2019 Sep 15;416:126-136
Neuroscience 2019 Sep 15;416:126-136
Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.
Farfara D, Feierman E, Richards A, Revenko AS, MacLeod RA, Norris EH, Strickland S
Glia 2019 Jul;67(7):1359-1373
Glia 2019 Jul;67(7):1359-1373
Decreased expression of serine protease inhibitor family G1 (SERPING1) in prostate cancer can help distinguish high-risk prostate cancer and predicts malignant progression.
Peng S, Du T, Wu W, Chen X, Lai Y, Zhu D, Wang Q, Ma X, Lin C, Li Z, Guo Z, Huang H
Urologic oncology 2018 Aug;36(8):366.e1-366.e9
Urologic oncology 2018 Aug;36(8):366.e1-366.e9
The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII.
Zamolodchikov D, Renné T, Strickland S
Journal of thrombosis and haemostasis : JTH 2016 May;14(5):995-1007
Journal of thrombosis and haemostasis : JTH 2016 May;14(5):995-1007
The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII: reply.
Zamolodchikov D, Strickland S
Journal of thrombosis and haemostasis : JTH 2016 Jul;14(7):1489
Journal of thrombosis and haemostasis : JTH 2016 Jul;14(7):1489
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SERPING1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SERPING1. This antibody recognizes human, mouse, rat antigen. The SERPING1 antibody has been validated for the following applications: ELISA, WB analysis.
