ABIN457963

antibody from antibodies-online

Targeting: SERPING1 C1-INH, C1IN, C1INH, C1NH, HAE1, HAE2

No application information provided.

Antibody Data

Product number

ABIN457963

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN457963, RRID:AB_10780012

Product name

anti-Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1) antibody

Antibody type

Polyclonal

Antigen

C1 esterase inhibitor is a single chain acid glycoprotein with a molecular weight of 110,000. The protein has a high carbohydrate content. In immunoelectrophoresis it ha an alpha mobility. The concentration in normal serum ranges from 150 to 350 μ g/ml. Reduced levels are observed in hereditary angioedema. It regulates the activation of complement factor C1 as well as the activity of activated C1 by coupling with the active catalytic site at the light chains of C1r and C1s. Moreover it also inhibits, kallikrein, Factor XI and Factor XII. Freund?s complete adjuvant is used in the first step of the immunization procedure.

Description

Adsorption: Immunoaffinity adsorbed using insolubilized antigens as required, to eliminate antibodies reacting with other plasma proteins. The use of insolubilized adsorption antigens prevents the presence of excess adsorbent protein or immune complexes in the antiserum.

Reactivity

Human

Host

Goat

Isotype

IgG

Vial size

1 mL

Concentration

Total protein and IgG concentrations in the antiserum are comparable to those of pooled normal goat serum. No foreign proteins added. Antibody titre: Precipitin titre 1:32 when tested against pooled normal human plasma in agar-block immunodiffusion titrat

Storage

4°C