13285-1-AP

antibody from Proteintech Group

Targeting: ZBP1 C20orf183, DAI, dJ718J7.3, DLM-1, DLM1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

13285-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#13285-1-AP, RRID:AB_2122651

Product name

ZBP1 antibody

Antibody type

Polyclonal

Description

KD/KO validated ZBP1 antibody (Cat. #13285-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Sangbaipi Decoction mitigates influenza pneumonia in mice by inhibiting ZBP1-mediated PANoptosis.

Zhang C, Yu G, Liu M, Du R, Ma J, Gu X, Rong L, Lv X, Cui Q
Journal of ethnopharmacology 2026 May 10;362:121348

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Natural panax notoginseng-derived nanovesicles trigger multiple cell death mechanisms and reprogram chemokine signaling to impede oral squamous cell carcinoma progression.

Chen X, Lin M, Zhan X, Zheng G, Lin S, Huang L, Zhang C, Yan Y, Li H, Zhang Z, Wang X, Lu Y, Zheng D
Journal of nanobiotechnology 2026 Mar 6;24(1)

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Study on the mechanism of action of HuaZhuoKeLi in modulating LCN2-mediated cellular pyroptosis to ameliorate ulcerative colitis.

Yang L, Wang S, Ma Y, Duan L, You J, Li B, Yang Y, Li D
Scientific reports 2026 Mar 28;16(1)

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Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy.

Wu L, Su J, Cao Y, Yuan H, Li Z, Ren J, Xiao M, Yu K, Liang B
Biomaterials 2026 Jun;329:123924

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Identification and validation of PANoptosis-related genes in ankylosing spondylitis.

Shan Z, Li J, Mu X, Zhang J, Ren S
BMC medical genomics 2026 Jan 12;19(1):28

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Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis.

Zhao Z, Liu Z, Wang Q, Gao H, Song N, Yang X
Journal of inflammation research 2025;18:12123-12143

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Pathogenicity and Transcriptomic Profiling Revealed Activation of Apoptosis and Pyroptosis in Brain of Mice Infected with the Beta Variant of SARS-CoV-2.

Li H, Huang BY, Zhang GQ, Ye F, Zhao L, Huo WB, Zhang ZX, Wang W, Wang WL, Shen XL, Wu CC, Tan WJ
Biomedical and environmental sciences : BES 2025 Sep 20;38(9):1082-1094

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AIM2-PANoptosome-driven PANoptosis in hepatic lipid dysregulation induced by β-HCH and nanoplastics co-exposure.

Lin Q, Cai H, Yu F, Gong C, Wu Y, Wu Q, Xie F, Xu W, Chen S, Yao X, Jin L, Peng R
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2340-2357

---

Mitochondrial dysfunction triggers Zbp1-mediated necroptosis and inflammation in acute lung injury.

Zhou M, Li Y, Ren Y, Li Y, Xiang J, Deng F, Geng G, Luo J, Yu J, Fu Z, Ding F, Liu B
Biomolecules & biomedicine 2025 Oct 29;26(5):814-829

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NLRC5-Mediated Epigenetic and Proteomic Regulation of Microglial Panoptosis Drives Neuroinflammation in Multiple Sclerosis.

Yan W, Jianhong W, Ping G
Molecular neurobiology 2025 Nov 28;63(1):194

---

Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA).

Wen HP, Yu C, Bi S, Jiang LH, Wang ZG, Yao Z, Pang DW, Liu SL
Nature communications 2025 Nov 28;16(1):10738

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Panoptosis Targets the Mechanism of PRDX1 Involvement in Acute Myocardial Infarction via ZBP1.

Sun Y, Ji C, Zhang Y, Liu S, Ye Y, Li T, Wu S, Sun T, Yin H, Yan W, Jin W
Journal of cellular biochemistry 2025 Mar;126(3):e70026

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Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells.

Cui Y, Lin H, Ma J, Zhao Y, Li J, Wang Y, Zhuang J, Yang Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167782

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Endoplasmic reticulum-mitochondria coupling prompts ZBP1-mediated RPE cell PANoptosis in age-related macular degeneration.

Zhang A, Wei TT, Yin H, Tan CY, Han C, Yao Y, Zhu L
Communications biology 2025 Jul 29;8(1):1118

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Changdiqing decoction (CDQD) ameliorates colitis via suppressing inflammatory macrophage activation and modulating gut microbiota.

Lin Z, Wang J, Luo H, Huang L, Pan Z, Yang S, Zhong C, Shan NC, Ye Z, Tan H, Yang X, Zhang B, Huang C, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156856

---

ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury.

Bi X, Li M, Guo Y, Hu M, Chen Y, Lian N, Chen S, Li M, Gu H, Chen X
Cell death & disease 2025 Jan 26;16(1):44

---

Dachengqi decoction dispensing granule ameliorates LPS-induced acute lung injury by inhibiting PANoptosis in vivo and in vitro.

Zhang M, Shang L, Zhou F, Li J, Wang S, Lin Q, Cai Y, Yang S
Journal of ethnopharmacology 2025 Jan 10;336:118699

---

Neutrophil CD11b is a pivotal PANoptosis marker correlated with disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.

Han XY, Zhao YY, Chen SF, Li ZY, Zhao MH, Chen M
Apoptosis : an international journal on programmed cell death 2025 Dec;30(11-12):3115-3128

---

F-53B exposure induced testicular premature aging through ZBP1-mediated programmed necrosis.

Kong Y, Tian X, Zhang R, Deng H, Wang G, Wu D, Xu C, Ma S, Lan H
Journal of hazardous materials 2025 Dec 5;500:140351

---

Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy.

Gu X, Li L, Duan T, Jin L, Sheng Q, Gao Q, Chen M, Sui X
Experimental hematology & oncology 2025 Dec 31;15(1):2

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Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.

Sun B, Wu J, Li Z, Zhang Y, Lu X, Wang J, Xu X
International immunopharmacology 2025 Dec 3;166:115639

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ZIKV infection causes placental inflammation through activating PANoptosis.

Zhang S, Chen D, Zhang K, Liu M, Liang H, Liang L, Liang J, Liang M, An S, Lyu M, Zhu J, Li S, Hu D, Zhu X, Wu J, He Z, Li M
Journal of virology 2025 Dec 23;99(12):e0175925

---

KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis.

Wang Z, Yang Y, Yao FT, Zhang F, Lin KY, Diao HT, Zhao QY, Kong X, Si W, Xie YT, Song JL, Zeng LH, Wang CL, Xiong YT, Zou KK, Wang XM, Zhang XY, Wu H, Jiang WT, Bian Y, Yang BF
Acta pharmacologica Sinica 2025 Aug;46(8):2282-2295

---

ZBP1 synchronized with periodontopathogenesis as the essential pattern recognition receptor.

Chen Y, You Y, Xie Y, Li X, Zhu Z, Li W, Du X, Yan Z
Microbial pathogenesis 2025 Aug;205:107678

---

RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis.

Wang X, Zhang Y, Chen X, Fu K, Cui J, Wu J, Sun Y, Ren J, Xue F, Dai J, Tang F
Nature communications 2025 Aug 7;16(1):7309

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Trimethylamine N-oxide Induced Chronic Kidney Injury by Triggering PANoptosis.

Shao D, Bai L, Chen Q, Chen Y, Qiu Z, Liu Y, Jin S, Wu Y, Dai J
Physiological research 2025 Aug 31;74(4):613-622

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Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40.

He Y, Lu J, Du Y, Zhao L, Gong L, Wu P, Shu Q, Peng H, Wang X
Scientific reports 2025 Apr 19;15(1):13514

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Inhibition of Zbp1-PANoptosome-mediated PANoptosis effectively attenuates acute pancreatitis.

Li J, Jia YC, Lu J, Zhang H, Wang Z, Xie X, Cao F, Li F
Cell death discovery 2025 Apr 16;11(1):180

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Arsenic exposure provoked prostatic PANoptosis by inducing mitochondrial dysfunction in mice and WPMY-1 cells.

Yang Y, Chen X, Deng L, Huang Y, Mo Y, Ye J, Liang R, Qin Y, Zhang Q, Wang S
Ecotoxicology and environmental safety 2025 Apr 15;295:118139

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KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.

Chen Y, Wu X, Jiang Z, Li X
Frontiers in pharmacology 2024;15:1461931

---

ZBP1 as a prognostic biomarker correlated with cell proliferation in clear cell renal cell carcinoma.

Zhang Y, Wang T, Mutailipu D, Li Y, Liang S, Yi Q, Zhu R, Ma J
Heliyon 2024 Oct 30;10(20):e39267

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Sensing of endogenous retroviruses-derived RNA by ZBP1 triggers PANoptosis in DNA damage and contributes to toxic side effects of chemotherapy.

Wang F, Li K, Wang W, Jiang H, He J, Cai J, Ren W, Zhao Y, Song Q, He Y, Ma Y, Feng X, Liu Y, Yu J, Jitkaew S, Ma D, Cai Z
Cell death & disease 2024 Oct 27;15(10):779

---

Trimethylamine Induced Chronic Kidney Injury by Activating the ZBP1-NLRP3 Inflammasome Pathway.

Bai L, Chen Q, Li Y, Wu F, Jin M, Chen Y, Teng X, Jin S, Fan H, Wu Y
Physiological research 2024 Nov 15;73(5):779-789

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Integrative Gut Microbiota and Metabolomic Analyses Reveal the PANoptosis- and Ferroptosis-Related Mechanisms of Chrysoeriol in Inhibiting Melanoma.

Liu Y, Wang L, Huang T, Li Y, Zhang H
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25173-25185

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Tumors cells with mismatch repair deficiency induce hyperactivation of pyroptosis resistant to cell membrane damage but are more sensitive to co-treatment of IFN-γ and TNF-α to PANoptosis.

Li H, Ni H, Li Y, Zhou A, Qin X, Li Y, Che L, Mo H, Qin C, Li J
Cell death discovery 2024 May 13;10(1):227

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Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis.

Zheng Z, Li K, Yang Z, Wang X, Shen C, Zhang Y, Lu H, Yin Z, Sha M, Ye J, Zhu L
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jun;73(6):961-978

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S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis.

Wang Y, Shi Y, Shao Y, Lu X, Zhang H, Miao C
Cell death & disease 2024 Jun 28;15(6):462

---

The anti-cancer drug candidate CBL0137 induced necroptosis via forming left-handed Z-DNA and its binding protein ZBP1 in liver cells.

Li J, Tang M, Ke RX, Li PL, Sheng ZG, Zhu BZ
Toxicology and applied pharmacology 2024 Jan;482:116765

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Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation.

Liu Y, Chang Y, Jiang X, Mei H, Cao Y, Wu D, Xie R, Jiang W, Vasquez E, Wu Y, Lin S, Cao Y
Heliyon 2024 Feb 29;10(4):e26219

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PANoptosis in vascular smooth muscle cells regulated by TNF-α/IL-1β can be a new target for alleviating the progression of abdominal aortic aneurysm.

Li K, Wei M, Zhang D, Zhai S, Liu H
Physiological genomics 2024 Feb 1;56(2):158-166

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SARS-CoV-2 infection of polarized human airway epithelium induces necroptosis that causes airway epithelial barrier dysfunction.

Hao S, Ning K, Kuz CA, Xiong M, Zou W, Park SY, McFarlin S, Yan Z, Qiu J
Journal of medical virology 2023 Sep;95(9):e29076

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DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids.

Flood P, Fanning A, Woznicki JA, Crowley T, Christopher A, Vaccaro A, Houston A, McSweeney S, Ross S, Hogan A, Brint E, Skowyra A, Bustamante M, Ambrose M, Moloney G, MacSharry J, Hammarström ML, Hurley M, Fitzgibbons C, Quigley EMM, Shanahan F, Zulquernain SA, McCarthy J, Dodson GS, Dabbagh K, McRae BL, Melgar S, Nally K
American journal of physiology. Gastrointestinal and liver physiology 2022 Nov 1;323(5):G439-G460

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Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway.

Gui R, Zheng H, Ma L, Liu R, Lin X, Ke X, Ye C, Jian X, Chen Q
mBio 2022 Jun 28;13(3):e0061522

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Oxidative stress induces Z-DNA-binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells.

Saada J, McAuley RJ, Marcatti M, Tang TZ, Motamedi M, Szczesny B
The Journal of biological chemistry 2022 Jan;298(1):101523

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Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells.

Szczesny B, Marcatti M, Ahmad A, Montalbano M, Brunyánszki A, Bibli SI, Papapetropoulos A, Szabo C
Scientific reports 2018 Jan 17;8(1):914

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Jurkat cells were subjected to SDS PAGE followed by western blot with 13285-1-AP(ZBP1 antibody) at dilution of 1:400

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human liver cancer using 13285-1-AP(ZBP1 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The ZBP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ZBP1. This antibody recognizes human antigen. The ZBP1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

13285-1-AP.pdf

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