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- References [14]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12486-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12486-1-AP, RRID:AB_2090661
- Product name
- CYP46A1 antibody
- Antibody type
- Polyclonal
- Description
- CYP46A1 antibody (Cat. #12486-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Artificial intelligence-driven drug repositioning uncovers efavirenz as a modulator of α-synuclein propagation: Implications in Parkinson's disease.
The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet.
Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis.
Cholesterol-24-hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes.
Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.
Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS.
Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.
Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma.
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.
H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.
Kim JB, Kim SJ, So M, Kim DK, Noh HR, Kim BJ, Choi YR, Kim D, Koo H, Kim T, Woo HG, Park SM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116442
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116442
The PPARα/CYP4A14 bile acid pathway is associated with lipid metabolism disorders caused by low birth weight with high-fat diet.
Zhou F, Yang L, Sun W, Wang X, Guo N, Ma H, Yang L
Food & nutrition research 2023;67
Food & nutrition research 2023;67
Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis.
Tsitsou-Kampeli A, Suzzi S, Kenigsbuch M, Satomi A, Strobelt R, Singer O, Feldmesser E, Purnapatre M, Colaiuta SP, David E, Cahalon L, Hahn O, Wyss-Coray T, Shaul Y, Amit I, Schwartz M
Cell reports. Medicine 2023 Nov 21;4(11):101278
Cell reports. Medicine 2023 Nov 21;4(11):101278
Cholesterol-24-hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes.
Cataldi GG, Elorza SD, Toledano-Zaragoza A, de Olmos S, Cragnolini AB, Martín MG
The Journal of comparative neurology 2023 Feb;531(3):486-499
The Journal of comparative neurology 2023 Feb;531(3):486-499
Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging.
Sodero AO, Castagna VC, Elorza SD, Gonzalez-Rodulfo SM, Paulazo MA, Ballestero JA, Martin MG, Gomez-Casati ME
PLoS biology 2023 Aug;21(8):e3002257
PLoS biology 2023 Aug;21(8):e3002257
Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.
Hu Z, Yuan Y, Tong Z, Liao M, Yuan S, Wu W, Tang Y, Wang Y, Tang C, Liu W
International journal of molecular sciences 2023 Aug 16;24(16)
International journal of molecular sciences 2023 Aug 16;24(16)
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X
Nature communications 2022 Mar 2;13(1):1121
Nature communications 2022 Mar 2;13(1):1121
Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS.
Shinohara Y, Ando H, Maekawa M, Arai M, Horibata Y, Satou M, Jojima T, Usui I, Aso Y, Sugimoto H
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Jun;1867(6):159136
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Jun;1867(6):159136
Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.
Kosaka S, Miyashita M, McNamala K, Nomura M, Shima H, Kawai M, Sato I, Harada-Shoji N, Ishida T, Choi MH, Sasano H
The Journal of steroid biochemistry and molecular biology 2022 Jul;221:106103
The Journal of steroid biochemistry and molecular biology 2022 Jul;221:106103
Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma.
Yang R, Zhao Y, Gu Y, Yang Y, Gao X, Yuan Y, Xiao L, Zhang J, Sun C, Yang H, Qin J, Li J, Zhang F, Zhang L, Ye J
Oncogene 2020 Oct;39(40):6340-6353
Oncogene 2020 Oct;39(40):6340-6353
NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation.
Mitroi DN, Pereyra-Gómez G, Soto-Huelin B, Senovilla F, Kobayashi T, Esteban JA, Ledesma MD
EMBO reports 2019 Nov 5;20(11):e48143
EMBO reports 2019 Nov 5;20(11):e48143
24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure.
Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y
Scientific reports 2016 Sep 22;6:33886
Scientific reports 2016 Sep 22;6:33886
H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.
Ali-Rahmani F, Grigson PS, Lee S, Neely E, Connor JR, Schengrund CL
Neurobiology of aging 2014 Jun;35(6):1511.e1-12
Neurobiology of aging 2014 Jun;35(6):1511.e1-12
Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate.
Zhou M, Li P, Tan L, Qu S, Ying QL, Song H
Journal of cellular biochemistry 2010 Feb 15;109(3):606-14
Journal of cellular biochemistry 2010 Feb 15;109(3):606-14
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 12486-1-AP(CYP46A1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP46A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYP46A1. This antibody recognizes human,mouse,rat antigen. The CYP46A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
