Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60717 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- BCL6 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human BCL6
- Description
- Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NF°ÙB expression, thereby inhibiting NF°ÙB-mediated cellular functions.HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin£ªs B cell lymphomas. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 480 amino acid nuclear protein that contains one BTB (POZ) domain and five l C2H2---type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of BCL6 pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate