Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [2]
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Validation data
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- Product number
- NBP2-59596-100ug - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal Bcl-6 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. The specificity of this monoclonal antibody to human Bcl-6 was validated by HuProt(TM) Array, containing more than 19,000, full-length human proteins. Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (L&H) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- 0.2 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Bcl-6 Antibody (BCL6/1475) [NBP2-59596] - Analysis (A) Recombinant Protein (B) HepG2 Cell lysateUsing bcl-6 Monoclonal Antibody (BCL6/1475).
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: Bcl-6 Antibody (BCL6/1475) [NBP2-59596] - Western Blot Analysis (A) Recombinant Protein (B) HepG2 cell lysate Bcl-6 Antibody (BCL6/1475).