BS7802
antibody from Bioworld Technology, Inc
Targeting: IL3
IL-3, MCGF, MGC79398, MGC79399, MULTI-CSF
Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7802 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL3 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL3.
- Description
- Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific Ï« subunit and a signal transducing ÉÇ subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the ÉÇ subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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