12681-1-AP

antibody from Proteintech Group

Targeting: GPHN KIAA1385

Provider product page for 12681-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]

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Product number: 12681-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12681-1-AP, RRID:AB_2247770
Product name: gephyrin antibody
Antibody type: Polyclonal
Description: gephyrin antibody (Cat. #12681-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GPHN protein structure - 12681-1-AP shown in red.

Submitted references Restoration of Extrasynaptic/Synaptic GABA(A)R-α5 Localization Improves Sevoflurane-Induced Early Memory Impairment in Aged Mice.

Zhang M, Wang X, Wang Z, Dong J, Wang S, Dong Y, Jiang C, Yin Y
Neuroscience bulletin 2026 Feb;42(2):301-318

Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.

Liu Z, Shen Y, Luo AD, Ao WL, Guan SQ, Lei F, Xu ZC, Yu CY, Xu P, Huang H
Neurochemical research 2026 Feb 17;51(2):74

RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.

Huo Y, Zhao D, Zhu X, Zheng N, Yang D, Meng J, Chen Y, Zhang YW
Theranostics 2025;15(4):1338-1352

MicroRNA-502-3p Modulates the GABA A Subunits, Synaptic Proteins, and Mitochondrial Morphology in Hippocampal Neurons.

Sharma B, Rodarte D, Goyal G, Rodriguez S, Kumar S
Molecular neurobiology 2025 Oct;62(10):13479-13499

Rutin alleviates preoperative anxiety stress-induced persistent postoperative pain by inhibiting microglia-mediated abnormal synaptic engulfment in the spinal cord dorsal horn.

Zhang Y, Yang H, Zhao Y, Ni K, Sun J, Ma Z
International immunopharmacology 2025 Oct 30;164:115309

GFAP mutation and astrocyte dysfunction lead to a neurodegenerative profile with impaired synaptic plasticity and cognitive deficits in a rat model of Alexander disease.

Berman RF, Matson MR, Bachman AM, Lin NH, Coyne S, Frelka A, Pearce RA, Messing A, Hagemann TL
eNeuro 2025 Mar 10;12(3)

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy.

Chen ZP, Zhao X, Wang S, Cai R, Liu Q, Ye H, Wang MJ, Peng SY, Xue WX, Zhang YX, Li W, Tang H, Huang T, Zhang Q, Li L, Gao L, Zhou H, Hang C, Zhu JN, Li X, Liu X, Cong Q, Yan C
Nature neuroscience 2025 Jul;28(7):1404-1417

nNOS/NO in nucleus accumbens medicates NKCC1 in neonatal repetitive pain.

Wang Y, Lv QR, Cai PP, Cheng SQ, Zou MJ, Wu JT, Cheng R, Yin CY
Biochemical and biophysical research communications 2025 Jul 8;769:151979

Increasing indoxyl sulfate induces iNOS expression via aryl hydrocarbon receptor leading to microglia hyperactivation in the prefrontal cortex of autism-like offspring rats.

Miao Y, Luo R, Lin F, Tong B, Yan J, Yang T, Sun Z, Li T, Xiao L, Chen J
Neuroscience letters 2025 Jul 27;862:138298

17β-Trenbolone modulates anxiety-related synaptic plasticity by affecting the interaction between hippocampal TACR3 and systemic testosterone in male mice.

Zuo X, Bai H, Qiu J, Li R, Kuang X, Zhao Y, Tuo J, Zhao Q, Zhao X, Feng X
Environmental research 2025 Aug 15;279(Pt 1):121796

Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice.

Zhao D, Huo Y, Zheng N, Zhu X, Yang D, Zhou Y, Wang S, Jiang Y, Wu Y, Zhang YW
PLoS biology 2025 Apr;23(4):e3003047

Anti-Gephyrin Antibodies: A Novel Specificity in Patients With Systemic Sclerosis and Lower Bowel Dysfunction.

McMahan ZH, Kulkarni S, Andrade F, Perin J, Zhang C, Hooper JE, Wigley FM, Rosen A, Pasricha PJ, Casciola-Rosen L
Arthritis & rheumatology (Hoboken, N.J.) 2024 Jan;76(1):92-99

Metabolically Glycoengineered Neural Stem Cells Boost Neural Repair After Cardiac Arrest.

Du J, Liu X, Marasini S, Wang Z, Dammen-Brower K, Yarema KJ, Jia X
Advanced functional materials 2024 Apr 25;34(17)

Triptolide injection reduces Alzheimer's disease-like pathology in mice.

Mao R, Xu S, Sun G, Yu Y, Zuo Z, Wang Y, Yang K, Zhang Z, Yang W
Synapse (New York, N.Y.) 2023 May;77(3):e22261

Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway.

Tan X, Wang J, Yao J, Yuan J, Dai Y, Sun M, Zhang T, Yang J, Cai W, Qiu L, Sun J
Neuroscience letters 2023 Feb 6;796:137049

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.

Meng J, Han L, Zheng N, Wang T, Xu H, Jiang Y, Wang Z, Liu Z, Zheng Q, Zhang X, Luo H, Can D, Lu J, Xu H, Zhang YW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 Jun 22;42(25):4958-4979

Optogenetic Activation of Striatopallidal Neurons Reveals Altered HCN Gating in DYT1 Dystonia.

Sciamanna G, Ponterio G, Vanni V, Laricchiuta D, Martella G, Bonsi P, Meringolo M, Tassone A, Mercuri NB, Pisani A
Cell reports 2020 May 19;31(7):107644

RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers.

Delker DA, McGettigan BM, Kanth P, Pop S, Neklason DW, Bronner MP, Burt RW, Hagedorn CH
PloS one 2014;9(2):e88367

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 12681-1-AP(GPHN antibody) at dilution of 1:400
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP result of anti-GPHN(12681-1-AP for IP and Detection).
Sample type: cell line