11650-2-AP

antibody from Proteintech Group

Targeting: CBX3 HP1Hs-gamma

Provider product page for 11650-2-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11650-2-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11650-2-AP, RRID:AB_2071136
Product name: CBX3 antibody
Antibody type: Polyclonal
Description: KD/KO validated CBX3 antibody (Cat. #11650-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CBX3 protein structure - 11650-2-AP shown in red.

Submitted references m5C modification of LINC00324 promotes angiogenesis in glioma through CBX3/VEGFR2 pathway.

Pan A, Xue Y, Ruan X, Dong W, Wang D, Liu Y, Liu L, Lin Y, E T, Lin H, Xu H, Liu X, Wang P
International journal of biological macromolecules 2024 Feb;257(Pt 1):128409

Inhibition of tiRNA-Gly-GCC ameliorates neointimal formation via CBX3-mediated VSMCs phenotypic switching.

Rong Z, Li F, Zhang R, Niu S, Di X, Ni L, Liu C
Frontiers in cardiovascular medicine 2023;10:1030635

CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.

Chen J, Lin Y, Zheng S, Chen Q, Tang S, Zhong X
Journal of translational medicine 2023 Sep 6;21(1):600

LncRNA TYMSOS facilitates breast cancer metastasis and immune escape through downregulating ULBP3.

Zhang KJ, Tan XL, Guo L
iScience 2023 Sep 15;26(9):107556

Inhibition of annexin A7 suppresses senescence-associated heterochromatin foci formation and senescence through the AMPK/mTOR pathway in human dermal fibroblasts.

Li N, Yan X, Cui X, Zhao C, Lin Z, Miao J
Journal of cellular biochemistry 2023 Oct;124(10):1603-1614

Retrospective analysis of enhancer activity and transcriptome history.

Boers R, Boers J, Tan B, van Leeuwen ME, Wassenaar E, Sanchez EG, Sleddens E, Tenhagen Y, Mulugeta E, Laven J, Creyghton M, Baarends W, van IJcken WFJ, Gribnau J
Nature biotechnology 2023 Nov;41(11):1582-1592

Targeting CBX3 with a Dual BET/PLK1 Inhibitor Enhances the Antitumor Efficacy of CDK4/6 Inhibitors in Prostate Cancer.

Liang H, Yang C, Zeng R, Song Y, Wang J, Xiong W, Yan B, Jin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2302368

POGZ suppresses 2C transcriptional program and retrotransposable elements.

Sun X, Zhang T, Tong B, Cheng L, Jiang W, Sun Y
Cell reports 2023 Aug 29;42(8):112867

CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.

Zhang H, Yu H, Ren D, Sun Y, Guo F, Cai H, Zhou C, Zhou Y, Jin X, Wu H
International journal of biological sciences 2022;18(8):3484-3497

Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer.

Fang X, Wang J, Chen J, Zhuang M, Huang T, Chen Z, Huang Y, Zheng B, Wang X
Frontiers in genetics 2022;13:851390

Expression and Prognostic Value of Chromobox Family Proteins in Esophageal Cancer.

Liu J, Shen H, Chen X, Ding Y, Wang H, Xu N, Teng L
Genes 2022 Sep 3;13(9)

Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence.

Cui X, Hao X, Wen J, Zhang S, Zhao B, Miao J
Genes 2022 Sep 14;13(9)

PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes.

Ito S, Ueda T, Yokoyama A, Fujihara A, Hongo F, Ukimura O
Cancer gene therapy 2022 Mar;29(3-4):358-368

NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer.

Wang D, Li Y, Liu Y, Cheng S, Liu F, Zuo R, Ding C, Shi S, Liu G
The international journal of biochemistry & cell biology 2022 Jun;147:106233

Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF.

Sun X, Cheng L, Sun Y
Molecular autism 2022 Jun 1;13(1):24

Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.

Jin X, Zhang B, Zhang H, Yu H
Oncogene 2022 Jan;41(4):538-549

Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma.

Li Q, Fu L, Wu D, Wang J
Journal of gastrointestinal oncology 2021 Oct;12(5):2310-2324

The LncRNA RP11-279C4.1 Enhances the Malignant Behaviour of Glioma Cells and Glioma Stem-Like Cells by Regulating the miR-1273g-3p/CBX3 Axis.

Wang F, Zhang L, Luo Y, Zhang Q, Zhang Y, Shao Y, Yuan L
Molecular neurobiology 2021 Jul;58(7):3362-3373

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M
The Journal of experimental medicine 2021 Dec 6;218(12)

PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.

He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H
Journal of virology 2020 May 4;94(10)

ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.

Zhang L, Huo Q, Ge C, Zhao F, Zhou Q, Chen X, Tian H, Chen T, Xie H, Cui Y, Yao M, Li H, Li J
Cancer research 2020 Jun 15;80(12):2599-2611

CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.

Zhong X, Kan A, Zhang W, Zhou J, Zhang H, Chen J, Tang S
Aging 2019 Aug 2;11(15):5483-5497

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M
Cell 2018 Sep 20;175(1):186-199.e19

CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma.

Zhang H, Chen W, Fu X, Su X, Yang A
Gene 2018 May 15;654:49-56

A pH probe inhibits senescence in mesenchymal stem cells.

Wang L, Han X, Qu G, Su L, Zhao B, Miao J
Stem cell research & therapy 2018 Dec 7;9(1):343

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Yang G, Weng X, Zhao Y, Zhang X, Hu Y, Dai X, Liang P, Wang P, Ma L, Sun X, Hou L, Xu H, Fang M, Li Y, Jenuwein T, Xu Y, Sun A
Nature communications 2017 Mar 31;8:14941

RNA sequencing identifies novel markers of non-small cell lung cancer.

Han SS, Kim WJ, Hong Y, Hong SH, Lee SJ, Ryu DR, Lee W, Cho YH, Lee S, Ryu YJ, Won JY, Rhee H, Park JH, Jang SJ, Lee JS, Choi CM, Lee JC, Lee SD, Oh YM
Lung cancer (Amsterdam, Netherlands) 2014 Jun;84(3):229-35

Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.

Jiang WQ, Zhong ZH, Nguyen A, Henson JD, Toouli CD, Braithwaite AW, Reddel RR
The Journal of cell biology 2009 Jun 1;185(5):797-810

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11650-2-AP(CBX3 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using CBX3 antibody 11650-2-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 11650-2-AP(CBX3 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue