BS6875

antibody from Bioworld Technology, Inc

Targeting: CCNT1 CCNT, CYCT1, HIVE1

Immunohistochemistry

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Validation data

Product number: BS6875 - Provider product page
Provider: Bioworld Technology, Inc
Product name: Cyclin T1 polyclonal antibody
Antibody type: Polyclonal
Antigen: Recombinant full length Human Cyclin T1.
Description: Cyclin T1 was identified as a partner for Cdk9, an RNA polymerase II (RNAPII) transcription elongation factor. Cyclin T1 interacts with the transactivation domain of the HIV-1 Tat protein. The interaction of Tat with cyclin T1 enhances the affinity of Tat for the viral TAR RNA stem-loop structure, suggesting that Tat can recruit cyclin T1/cdk9 to RNAPII through cooperative binding to TAR. The human positive transcription elongation factor b (P-TEFb) consists of a cyclin dependent kinase, cdk9, paired with a cyclin T. Cdk9 may be paired with either cyclin T1 or cyclin T2, in a mutually exclusive manner. Two forms of cyclin T2, T2a and T2b, are due to alternative splicing. The binding of Tat to TAR was shown to be facilitated by human cyclin T1, but not by cyclins T2a or T2b. Cyclin T2 binds to Cdk9 but not to Tat, and cyclin T2 can inhibit cyclin T1-mediated Tat activity.
Reactivity: Human
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

CCNT1 protein structure - BS6875 shown in red.