632402

antibody from BioLegend

Targeting: CDK7 CAK, CAK1, CDKN7, MO15, STK1

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

632402

Provider

BioLegend

Proper citation

BioLegend Cat#632402, RRID:AB_2260283

Product name

Purified anti-CAK (cdk7) Phospho (Ser164/Thr170)

Antibody type

Polyclonal

Antigen

Modified peptide

Description

CAK (also known as CDK-activating kinase, CDK7 and cell division protein kinase 7 is a 40 kD nuclear protein that is a member of the serine/threonine family of protein kinases, CDC2/CDKX subfamily. CAK activates cyclin-associated kinases CDC2/CDK1, CDK2, CDK4, CDK6 by threonine phosphorylation and controls cell cycle progression, DNA repair, and RNA polymerase II transcription. CAK is activated by phosphorylation at Thr170 and is inactivated by phosphorylation at Ser164. CAK has been reported to interact with cyclin H and MAT1 to form the CAK complex, the CAK complex then interacts with core-TFIIH to form the TFIIH basal transcription factor. The Poly6324 antibody is useful for immunofluorescence microscopy of human CAK protein.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 µl

Storage

Upon receipt, store frozen at -20° C.