12235-1-AP
antibody from Proteintech Group
Targeting: NR4A1
GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3
Antibody data
- Antibody Data
- Antigen structure
- References [28]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 12235-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12235-1-AP, RRID:AB_10644125
- Product name
- NR4A1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NR4A1 antibody (Cat. #12235-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Characterization of the Immune Microenvironment and Identification of Biomarkers in Chronic Rhinosinusitis with Nasal Polyps Using Single-Cell RNA Sequencing and Transcriptome Analysis.
Nur77 inhibition of β-catenin expression mediates Hepatoblastoma progression and enhances cisplatin's therapeutic effect.
Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway.
A Graphene Composite Film Based Wearable Far-Infrared Therapy Apparatus (GRAFT) for Effective Prevention of Postoperative Peritoneal Adhesion.
In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy.
Tasquinimod enhances the sensitivity of ovarian cancer cells to cisplatin by regulating the Nur77-Bcl-2 apoptotic pathway.
Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents.
CEBPA Overexpression Enhances β-Cell Proliferation and Survival.
A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages.
Design, synthesis, and biological evaluation of carbonyl-hydrazine-1-carboxamide derivatives as anti-hepatic fibrosis agents targeting Nur77.
β-Glucan produced by Lentinus edodes suppresses breast cancer progression via the inhibition of macrophage M2 polarization by integrating autophagy and inflammatory signals.
Hederagenin suppresses glioma cell biological activities via Nur77 in vitro study.
Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver.
HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma.
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms.
TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change.
A systematic dissection of human primary osteoblasts in vivo at single-cell resolution.
Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice.
Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibits inflammation by regulating Nur77 stability.
Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.
The E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2α.
Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress.
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Antitumor activity of SAHA, a novel histone deacetylase inhibitor, against murine B cell lymphoma A20 cells in vitro and in vivo.
The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.
Wang Y, Song X, Jin M, Lu J
Journal of inflammation research 2024;17:253-277
Journal of inflammation research 2024;17:253-277
Nur77 inhibition of β-catenin expression mediates Hepatoblastoma progression and enhances cisplatin's therapeutic effect.
Zhou J, Liu X, Yin H, Zhou Y, Xu Z, Zhou K, Li T, Fang Y, Shen Q
Gene 2024 May 25;908:148292
Gene 2024 May 25;908:148292
Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
Hong W, Xiao T, Lin G, Liu C, Li H, Li Y, Hu H, Wu S, Wang S, Liang Z, Lin T, Liu J, Chen X
Bioorganic chemistry 2024 Mar;144:107113
Bioorganic chemistry 2024 Mar;144:107113
Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway.
Lin G, Li W, Hong W, Zhu D, Hu H, Fu J, Gao Y, Chen S, Chai D, Zeng JZ
European journal of pharmacology 2024 Mar 5;966:176270
European journal of pharmacology 2024 Mar 5;966:176270
A Graphene Composite Film Based Wearable Far-Infrared Therapy Apparatus (GRAFT) for Effective Prevention of Postoperative Peritoneal Adhesion.
Lu X, Xu L, Song Y, Yu X, Li Q, Liu F, Li X, Xi J, Wang S, Wang L, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(22):e2309330
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(22):e2309330
In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPARγ Interaction and Its Anti-Breast-Cancer Efficacy.
Bian H, Liang X, Lu D, Lin J, Lu X, Jin J, Zhang L, Wu Y, Chen H, Zhang W, Luan X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2308435
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2308435
Tasquinimod enhances the sensitivity of ovarian cancer cells to cisplatin by regulating the Nur77-Bcl-2 apoptotic pathway.
Lin Y, Liu YQ, Zhu KA, Hu MQ, Li Z, Min XJ
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):151-161
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):151-161
Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents.
Lin G, Zhong Y, Hu S, He F, Zhang Z, Li W, Hu H, Zeng JZ
Bioorganic chemistry 2024 Feb;143:107022
Bioorganic chemistry 2024 Feb;143:107022
CEBPA Overexpression Enhances β-Cell Proliferation and Survival.
Ellsworth PN, Herring JA, Leifer AH, Ray JD, Elison WS, Poulson PD, Crabtree JE, Van Ry PM, Tessem JS
Biology 2024 Feb 9;13(2)
Biology 2024 Feb 9;13(2)
A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages.
Ji Y, Duan Y, Li Y, Lu Q, Liu D, Yang Y, Chang R, Tian J, Yao W, Yin J, Gao X
British journal of pharmacology 2024 Aug;181(16):2923-2946
British journal of pharmacology 2024 Aug;181(16):2923-2946
Design, synthesis, and biological evaluation of carbonyl-hydrazine-1-carboxamide derivatives as anti-hepatic fibrosis agents targeting Nur77.
Hu H, Lin G, He F, Liu J, Jia R, Li K, Hong W, Fang M, Zeng JZ
Bioorganic chemistry 2023 Nov;140:106795
Bioorganic chemistry 2023 Nov;140:106795
β-Glucan produced by Lentinus edodes suppresses breast cancer progression via the inhibition of macrophage M2 polarization by integrating autophagy and inflammatory signals.
Zhu F, Zhang Q, Feng J, Zhang X, Li T, Liu S, Chen Y, Li X, Wu Q, Xue Y, Alitongbieke G, Pan Y
Immunity, inflammation and disease 2023 May;11(5):e876
Immunity, inflammation and disease 2023 May;11(5):e876
Hederagenin suppresses glioma cell biological activities via Nur77 in vitro study.
Dai Y, Masra N, Zhou L, Yu C, Jin W, Ni H
Food science & nutrition 2023 Mar;11(3):1283-1296
Food science & nutrition 2023 Mar;11(3):1283-1296
Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver.
Sheng M, Weng Y, Cao Y, Zhang C, Lin Y, Yu W
Cell death discovery 2023 Mar 28;9(1):106
Cell death discovery 2023 Mar 28;9(1):106
HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma.
Chen QT, Zhang ZY, Huang QL, Chen HZ, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q
Nature metabolism 2022 Oct;4(10):1306-1321
Nature metabolism 2022 Oct;4(10):1306-1321
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Gerosa L, Mazzoleni S, Rusconi F, Longaretti A, Lewerissa E, Pelucchi S, Murru L, Giannelli SG, Broccoli V, Marcello E, Kasri NN, Battaglioli E, Passafaro M, Bassani S
Cell reports 2022 May 24;39(8):110857
Cell reports 2022 May 24;39(8):110857
hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms.
Luo Q, Tang Y, Jiang Z, Bao H, Fu Q, Zhang H
Reproductive biology and endocrinology : RB&E 2022 Aug 19;20(1):125
Reproductive biology and endocrinology : RB&E 2022 Aug 19;20(1):125
TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change.
Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, Kerr A, Simpson KL, Blackhall F, Dive C, Malliri A
Cell reports 2021 Nov 9;37(6):109979
Cell reports 2021 Nov 9;37(6):109979
A systematic dissection of human primary osteoblasts in vivo at single-cell resolution.
Gong Y, Yang J, Li X, Zhou C, Chen Y, Wang Z, Qiu X, Liu Y, Zhang H, Greenbaum J, Cheng L, Hu Y, Xie J, Yang X, Li Y, Bai Y, Wang YP, Chen Y, Tan LJ, Shen H, Xiao HM, Deng HW
Aging 2021 Aug 24;13(16):20629-20650
Aging 2021 Aug 24;13(16):20629-20650
Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice.
Yan J, Liu A, Fan H, Qiao L, Wu J, Shen M, Lai X, Huang J
Cellular and molecular neurobiology 2020 Oct;40(7):1155-1164
Cellular and molecular neurobiology 2020 Oct;40(7):1155-1164
Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibits inflammation by regulating Nur77 stability.
Pei HZ, Huang B, Chang HW, Baek SH
Cellular signalling 2019 Jul;59:85-95
Cellular signalling 2019 Jul;59:85-95
Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.
Kameda H, Yamamoto M, Tone Y, Tone M, Melmed S
Endocrinology 2019 Feb 1;160(2):276-291
Endocrinology 2019 Feb 1;160(2):276-291
The E3 ubiquitin ligase Trim13 regulates Nur77 stability via casein kinase 2α.
Huang B, Pei HZ, Chang HW, Baek SH
Scientific reports 2018 Sep 17;8(1):13895
Scientific reports 2018 Sep 17;8(1):13895
Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress.
Gao H, Chen Z, Fu Y, Yang X, Weng R, Wang R, Lu J, Pan M, Jin K, McElroy C, Tang B, Xia Y, Wang Q
Scientific reports 2016 Sep 29;6:34403
Scientific reports 2016 Sep 29;6:34403
Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
Wei X, Gao H, Zou J, Liu X, Chen D, Liao J, Xu Y, Ma L, Tang B, Zhang Z, Cai X, Jin K, Xia Y, Wang Q
Molecular neurobiology 2016 Nov;53(9):5876-5892
Molecular neurobiology 2016 Nov;53(9):5876-5892
NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B.
Zhang Y, Chen G, Gao B, Li Y, Liang S, Wang X, Wang X, Zhu B
Scientific reports 2016 Nov 23;6:37713
Scientific reports 2016 Nov 23;6:37713
Antitumor activity of SAHA, a novel histone deacetylase inhibitor, against murine B cell lymphoma A20 cells in vitro and in vivo.
Yang B, Yu D, Liu J, Yang K, Wu G, Liu H
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jul;36(7):5051-61
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Jul;36(7):5051-61
The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.
Yu C, Cui S, Zong C, Gao W, Xu T, Gao P, Chen J, Qin D, Guan Q, Liu Y, Fu Y, Li X, Wang X
The Journal of biological chemistry 2015 Aug 21;290(34):20687-20699
The Journal of biological chemistry 2015 Aug 21;290(34):20687-20699
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NUR77 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NUR77. This antibody recognizes human,mouse,rat antigen. The NUR77 antibody has been validated for the following applications: ELISA, WB analysis.