25851-1-AP

antibody from Proteintech Group

Targeting: NR4A1 GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3

Provider product page for 25851-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [29]
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Product number: 25851-1-AP - Provider product page
Provider: Proteintech Group
Product name: NR4A1 antibody
Antibody type: Polyclonal
Description: KD/KO validated NR4A1 antibody (Cat. #25851-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

NR4A1 protein structure - 25851-1-AP shown in red.

Submitted references MCU knockdown mitigates post-stroke neuroinflammation through SLC33A1-mediated reduction of NR4A1 acetylation.

Zhou Z, Liu L, Zhou Y, Yan Y, Wang B, Lv X, Qin J, Liu Z, Liu Y, Meng Z, You L, Zhao M, Wang X, Pei G, Bai G, Meng C, Liu X
Brain research bulletin 2026 Jan;234:111676

Analysis and Validation of Autophagy-Related Gene Biomarkers and Immune Cell Infiltration Characteristic in Bronchopulmonary Dysplasia by Integrating Bioinformatics and Machine Learning.

Xiao S, Ding Y, Du C, Lv Y, Yang S, Zheng Q, Wang Z, Zheng Q, Huang M, Xiao Q, Ren Z, Bi G, Yang J
Journal of inflammation research 2025;18:549-563

Structure-Based Design and Optimization of Bi-Aryl Amide Derivatives as Nur77 Ligands for Nur77-Bcl-2-Dependent Apoptotic Cancer Therapy.

Zhao T, Chen J, Hong W, Zhong Y, Li H, Li X, Qiu Y, Wang L, Wu Z, Wang X, Chen X, Fang M
Journal of medicinal chemistry 2025 Nov 27;68(22):24168-24195

CARMN loss promotes VSMC-derived foam cell formation and atherosclerosis through transcriptional downregulation of autophagy.

Huang T, Tang Y, Su Q, Su C, Wang J, Fu L, Tang Y
Cell death & disease 2025 Nov 10;16(1):815

Baicalein attenuates ovalbumin-induced allergic rhinitis through the activation of nuclear receptor subfamily 4 group a member 1.

Xu Y, Xu L, Jian X, Wang Q, Li Z, Ge H
Immunologic research 2025 Jan 14;73(1):32

C-C motif chemokine ligand 5 contributes to radon exposure-induced lung injury by recruiting dendritic cells to activate effector T helper cells.

Ma L, Wang Y, Guo J, Zhang X, Xing S, Liu B, Chen G, Wang X, Hu J, Li G, Han G, Zhu M
Toxicology 2025 Feb;511:154044

Loss of Nr4a1 ameliorates endothelial cell injury and vascular leakage in lung transplantation from circulatory-death donor.

Kawana S, Okazaki M, Sakaue T, Hashimoto K, Nakata K, Choshi H, Tanaka S, Miyoshi K, Ohtani S, Ohara T, Sugimoto S, Matsukawa A, Toyooka S
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025 Feb;44(2):249-260

Design, synthesis, and evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as anti-HCC agents targeting Nur77.

Hu S, Li X, Yu M, Zhang H, Wang X, Qi C, Huang S, Xu Z, Hu H, Chen S, Fang M, Zeng J
Bioorganic chemistry 2025 Dec;167:109113

The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression.

Zhao Y, Li Y, Wang P, Zhu M, Wang J, Xie B, Tang C, Ma Y, Wang S, Jin S, Xu J, Li Z, Zhang X, Li L, Song X, Wang P
Frontiers in immunology 2024;15:1474564

CHIP drives proteasomal degradation of NUR77 to alleviate oxidative stress and intrinsic apoptosis in cisplatin-induced nephropathy.

Zhang H, Deng Z, Wang Y, Zheng X, Zhou L, Yan S, Wang Y, Dai Y, Kanwar YS, Chen F, Deng F
Communications biology 2024 Oct 26;7(1):1403

AIBP protects drug-induced liver injury by inhibiting MAPK-mediated NR4A1 expression.

Ma T, Huang W, Ding Y, Ji R, Ge S, Liu Q, Liu Y, Chen J, Yan Y, Lu S, Ren Q, Fan Y, Mao R, Lu C
iScience 2024 Oct 18;27(10):110873

Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement.

Ueda T, Matsuda S, Ninomiya Y, Nakashima F, Yasuda K, Furutama D, Memida T, Yoshimoto T, Kajiya M, Ohta K, Ouhara K, Mizuno N
BioFactors (Oxford, England) 2024 Nov-Dec;50(6):1192-1207

Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis.

Ninomiya Y, Matsuda S, Suzuki S, Hirata-Tsuchiya S, Ueda T, Nakashima F, Yasuda K, Shimada S, Memida T, Yoshimoto T, Yamada S, Ouhara K, Mizuno N
BMC oral health 2024 Nov 21;24(1):1422

NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.

Zhu J, Li J, Yang K, Chen Y, Wang J, He Y, Shen K, Wang K, Shi T, Chen W
Cancer letters 2024 Mar 31;585:216693

Oxygen-Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes.

Moriyama K, Horino A, Kohyama K, Nishito Y, Morio T, Sakuma H
Brain sciences 2024 Feb 29;14(3)

Identification of driving genes of recurrent miscarriage based on transcriptome sequencing and immunoinfiltration analysis.

Yang Y, Zhao A, Wang T, Tang Q, Qi S, Shi X, Wang F, Gao Y
International immunopharmacology 2024 Dec 25;143(Pt 1):113095

SLAMF7 Promotes Foam Cell Formation of Macrophage by Suppressing NR4A1 Expression During Carotid Atherosclerosis.

Yuan F, Wei J, Cheng Y, Wang F, Gu M, Li Y, Zhao X, Sun H, Ban R, Zhou J, Xia Z
Inflammation 2024 Apr;47(2):530-542

Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation.

Tao Y, Tang C, Wei J, Shan Y, Fang X, Li Y
Molecular medicine (Cambridge, Mass.) 2023 May 9;29(1):63

Tongqiao Huoxue Decoction ameliorates traumatic brain injury-induced gastrointestinal dysfunction by regulating CD36/15-LO/NR4A1 signaling, which fails when CD36 and CX3CR1 are deficient.

Wei C, Zhu F, Yu J, Gao F, Yuan Y, Zhang Y, Liu X, Chu S, Cui D, Fan H, Wang W
CNS neuroscience & therapeutics 2023 Jun;29 Suppl 1(Suppl 1):161-184

Sleeve Gastrectomy-Induced AMPK Activation Attenuates Diabetic Cardiomyopathy by Maintaining Mitochondrial Homeostasis via NR4A1 Suppression in Rats.

Li S, Dong S, Xu Q, Shi B, Li L, Zhang W, Zhu J, Cheng Y, Zhang G, Zhong M
Frontiers in physiology 2022;13:837798

Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling.

Zheng Y, Tao Y, Zhan X, Wu Q
Bioengineered 2022 Apr;13(4):8349-8359

Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.

Liu W, Chen Y, Zeng G, Yang S, Yang T, Ma M, Song W
Frontiers in molecular biosciences 2021;8:748360

The role of nuclear receptor 4A1 (NR4A1) in drug-induced gingival overgrowth.

Hatano S, Matsuda S, Okanobu A, Furutama D, Memida T, Kajiya M, Ouhara K, Fujita T, Mizuno N, Kurihara H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jul;35(7):e21693

Frequent and mild scrotal heat stress in mice epigenetically alters glucose metabolism in the male offspring.

Wan X, He X, Liu Q, Wang X, Ding X, Li H
American journal of physiology. Endocrinology and metabolism 2020 Aug 1;319(2):E291-E304

NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression.

Qin DD, Yang YF, Pu ZQ, Liu D, Yu C, Gao P, Chen JC, Zong C, Zhang YC, Li X, Wang XD, Liu YT
Journal of cellular and molecular medicine 2018 Oct;22(10):4709-4720

The orphan nuclear receptor NR4A1 attenuates oxidative stress-induced β cells apoptosis via up-regulation of glutathione peroxidase 1.

Yang Y, Xie F, Qin D, Zong C, Han F, Pu Z, Liu D, Li X, Zhang Y, Liu Y, Wang X
Life sciences 2018 Jun 15;203:225-232

Stigmasterol upregulates immediate early genes and promotes neuronal cytoarchitecture in primary hippocampal neurons as revealed by transcriptome analysis.

Haque MN, Moon IS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2018 Jul 15;46:164-175

The effect of NR4A1 on APP metabolism and tau phosphorylation.

Zhao LG, Tang Y, Tan JZ, Wang JW, Chen GJ, Zhu BL
Genes & diseases 2018 Dec;5(4):342-348

Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation.

Li Z, Wang Z, Yin Z, Zhang Y, Xue X, Han J, Zhu Y, Zhang J, Emmert MY, Wang H
Oncotarget 2017 Aug 8;8(32):53714-53729

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