NB100-56745
antibody from Novus Biologicals
Targeting: NR4A1
GFRP1, HMR, N10, NAK-1, NGFIB, NUR77, TR3
Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- NB100-56745 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-56745, RRID:AB_2153757
- Product name
- Rabbit Polyclonal NGFI-B alpha/Nur77/NR4A1 Antibody
- Antibody type
- Polyclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes.
Transcriptional coactivator with PDZ-binding motif suppresses the expression of steroidogenic enzymes by nuclear receptor 4 A1 in Leydig cells.
Bis-Indole-Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis.
The orphan nuclear receptor NUR77 promotes trophoblast invasion at early pregnancy through paracrine placental growth factor.
Differential expression of a stress-regulated gene Nr4a2 characterizes early- and late-born hippocampal granule cells.
Nur77 promotes cigarette smoke‑induced autophagic cell death by increasing the dissociation of Bcl2 from Beclin-1.
The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.
The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1.
Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells.
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors.
Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.
Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth.
Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines.
Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.
p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells.
Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival.
1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Carpenter MD, Hu Q, Bond AM, Lombroso SI, Czarnecki KS, Lim CJ, Song H, Wimmer ME, Pierce RC, Heller EA
Nature communications 2020 Jan 24;11(1):504
Nature communications 2020 Jan 24;11(1):504
Transcriptional coactivator with PDZ-binding motif suppresses the expression of steroidogenic enzymes by nuclear receptor 4 A1 in Leydig cells.
Shin JH, Lee G, Jeong MG, Kim HK, Won HY, Choi Y, Lee JH, Nam M, Choi CS, Hwang GS, Hwang ES
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5332-5347
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5332-5347
Bis-Indole-Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis.
Mohankumar K, Li X, Sung N, Cho YJ, Han SJ, Safe S
Endocrinology 2020 Apr 1;161(4)
Endocrinology 2020 Apr 1;161(4)
The orphan nuclear receptor NUR77 promotes trophoblast invasion at early pregnancy through paracrine placental growth factor.
Li XC, Yin XJ, Hong W, Liu J, Jin F, Wang BY, Wang YM, Tian FJ
Journal of molecular medicine (Berlin, Germany) 2019 Sep;97(9):1359-1373
Journal of molecular medicine (Berlin, Germany) 2019 Sep;97(9):1359-1373
Differential expression of a stress-regulated gene Nr4a2 characterizes early- and late-born hippocampal granule cells.
Imura T, Kobayashi Y, Suzutani K, Ichikawa-Tomikawa N, Chiba H
Hippocampus 2019 Jun;29(6):539-549
Hippocampus 2019 Jun;29(6):539-549
Nur77 promotes cigarette smoke‑induced autophagic cell death by increasing the dissociation of Bcl2 from Beclin-1.
Qin H, Gao F, Wang Y, Huang B, Peng L, Mo B, Wang C
International journal of molecular medicine 2019 Jul;44(1):25-36
International journal of molecular medicine 2019 Jul;44(1):25-36
The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists.
Hedrick E, Lee SO, Safe S
Molecular carcinogenesis 2017 Sep;56(9):2066-2075
Molecular carcinogenesis 2017 Sep;56(9):2066-2075
The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1.
Li H, Zhao P, Xu Q, Shan S, Hu C, Qiu Z, Xu X
Scientific reports 2016 Jul 19;6:29878
Scientific reports 2016 Jul 19;6:29878
Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells.
Li X, Lee SO, Safe S
Biochemical pharmacology 2012 May 15;83(10):1445-55
Biochemical pharmacology 2012 May 15;83(10):1445-55
Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors.
Yoon K, Lee SO, Cho SD, Kim K, Khan S, Safe S
Carcinogenesis 2011 Jun;32(6):836-42
Carcinogenesis 2011 Jun;32(6):836-42
Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth.
Lee SO, Abdelrahim M, Yoon K, Chintharlapalli S, Papineni S, Kim K, Wang H, Safe S
Cancer research 2010 Sep 1;70(17):6824-36
Cancer research 2010 Sep 1;70(17):6824-36
Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth.
Cho SD, Lee SO, Chintharlapalli S, Abdelrahim M, Khan S, Yoon K, Kamat AM, Safe S
Molecular pharmacology 2010 Mar;77(3):396-404
Molecular pharmacology 2010 Mar;77(3):396-404
Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines.
Levin VA, Panchabhai SC, Shen L, Kornblau SM, Qiu Y, Baggerly KA
Journal of proteome research 2010 Jan;9(1):179-91
Journal of proteome research 2010 Jan;9(1):179-91
Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.
Ferlini C, Cicchillitti L, Raspaglio G, Bartollino S, Cimitan S, Bertucci C, Mozzetti S, Gallo D, Persico M, Fattorusso C, Campiani G, Scambia G
Cancer research 2009 Sep 1;69(17):6906-14
Cancer research 2009 Sep 1;69(17):6906-14
p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells.
Lee SO, Chintharlapalli S, Liu S, Papineni S, Cho SD, Yoon K, Safe S
Molecular cancer research : MCR 2009 Jul;7(7):1169-78
Molecular cancer research : MCR 2009 Jul;7(7):1169-78
Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival.
Tao R, Hancock WW
PloS one 2008 May 28;3(5):e2321
PloS one 2008 May 28;3(5):e2321
1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.
Inamoto T, Papineni S, Chintharlapalli S, Cho SD, Safe S, Kamat AM
Molecular cancer therapeutics 2008 Dec;7(12):3825-33
Molecular cancer therapeutics 2008 Dec;7(12):3825-33
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S
The Journal of biological chemistry 2005 Jul 1;280(26):24903-14
The Journal of biological chemistry 2005 Jul 1;280(26):24903-14
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: NGFI-B alpha/Nur77/NR4A1 Antibody [NB100-56745] - Analysis of Nur77 (Nak-1) in 15 ugs of NIH3T3 cell lysate using Nur77 antibody at 1:500 dilution