Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 500811 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#500811, RRID:AB_315130
- Product name
- APC anti-human IL-4
- Antibody type
- Monoclonal
- Antigen
- CHO-expressed, recombinant human IL-4
- Description
- IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.
- Reactivity
- Human, Porcine, Simian
- Host
- Rat
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma.
Dzhagalov I, Chambon P, He YW
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 15;178(4):2113-21
Journal of immunology (Baltimore, Md. : 1950) 2007 Feb 15;178(4):2113-21
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- PMA + ionomycin-stimulated (6 hours) human peripheral blood lymphocytes intracellular stained with MP4-25D2 APC and CD3 (UCHT1) PE
- Conjugate
- Red dye