51009-2-AP

antibody from Proteintech Group

Targeting: BRD7 BP75, CELTIX1

Provider product page for 51009-2-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [38]
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Validations
Western blot [1]

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Product number: 51009-2-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#51009-2-AP, RRID:AB_2259226
Product name: BRD7 antibody
Antibody type: Polyclonal
Description: KD/KO validated BRD7 antibody (Cat. #51009-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

BRD7 protein structure - 51009-2-AP shown in red.

Submitted references Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer.

Fang J, Simon JM, Wang T, Gao Y, Bi X, Hu L, Liao C, Zhang C, Adachi Y, Zhou J, Liu H, Liang Q, Nathan JA, Mani R, Brugarolas J, Zhang Q
The Journal of clinical investigation 2026 May 15;136(10)

Targeted demethylation of the BRD7 promoter based on CRISPR/dCas9 system inhibits the malignant progression of nasopharyngeal carcinoma.

Wei J, Duan Y, Xue C, Zheng L, Wei Q, Wu Z, Xin H, Zeng T, Deng H, Fan S, Xiong W, Zeng Z, Li M, Zhou M
Clinical and translational medicine 2026 Jan;16(1):e70583

Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis.

Liu J, Han W, Tang J, Wan H, Wang H, Peng J, Ma W, Hu M, Hong L
Aging cell 2026 Apr;25(4):e70463

BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression.

Guo Y, Lu J, Li X, Yan S, Zhou J, Tian Z, Liu Y, Li N, Zhou Q, Li X, Shi L, Jiang S, Li M, Zhou X, Huang D, Zeng Z, Fan S, Xiong W, Zhou M, Li G, Zhang W
International journal of biological sciences 2025;21(5):1914-1931

Chromatin remodeler BRD9 represses transcription of PPARα target genes, including CPT1A to suppress lipid metabolism.

Yokoseki I, Nakano M, Kurosawa K, Higuchi Y, Uehara S, Yoneda N, Suemizu H, Fukami T, Nakajima M
Journal of lipid research 2025 Sep;66(9):100874

PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback.

Letkova D, Peticca A, Sery D, Seki M, Suzuki Y, Padmanabhan K
Nature communications 2025 Oct 9;16(1):9000

TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis.

Xue C, Wei Q, Li M, Wei J, Zheng L, Wu Z, Xin H, Duan Y, Fan S, Xiong W, Li G, Tang F, Deng H, Zhou M
Cell death & disease 2025 Nov 28;16(1):872

Targeted suppression of BRD7 with BI-9564 prevents seizure behaviors in pentylenetetrazol and pilocarpine-induced mouse model of epilepsy.

Chen J, Li Y, Huo X, Huang Z, Li S, Cao W, Zhou C, Xu Y
Behavioural brain research 2025 May 8;485:115549

BRD7 enhances the radiosensitivity of nasopharyngeal carcinoma cells by negatively regulating USP5/METTL3 axis-mediated homologous recombination repair.

Li M, Wei J, Xue C, Chen S, Zhou X, Zheng L, Duan Y, Deng H, Fan S, Xiong W, Tang F, Zhou M
International journal of biological sciences 2024;20(15):6130-6145

TRIM28 promotes tumor growth and metastasis in breast cancer by targeting the BRD7 protein for ubiquitination and degradation.

Xue C, Meng H, Niu W, Li M, Wei J, Chen S, Zheng L, Duan Y, Deng H, Tang F, Fan S, Tan M, Xiong W, Zhou M
Cellular oncology (Dordrecht, Netherlands) 2024 Oct;47(5):1973-1993

CircBRD7 attenuates tumor growth and metastasis in nasopharyngeal carcinoma via epigenetic activation of its host gene.

Wei J, Li M, Chen S, Xue C, Zheng L, Duan Y, Deng H, Fan S, Xiong W, Zhou M
Cancer science 2024 Jan;115(1):139-154

Aging-Associated ALKBH5-m(6)A Modification Exacerbates Doxorubicin-Induced Cardiomyocyte Apoptosis Via AT-Rich Interaction Domain 2.

Chen R, Zhang G, Sun K, Chen AF
Journal of the American Heart Association 2024 Jan 2;13(1):e031353

Absence of SMARCB1 in rhabdoid tumor cells increases sensitivity to translation inhibition and alters translation efficiency of specific mRNAs.

Nguyen LT, Hains AE, Aziz-Zanjani MO, Dalsass M, Farooqee SBUD, Lu Y, Jackson PK, Van Rechem C
The Journal of biological chemistry 2024 Dec;300(12):107988

BRD7 regulates cellular senescence and apoptosis in ALS by modulating p21 expression and p53 mitochondrial translocation respectively.

Tan X, Su X, Wang Y, Liang W, Wang D, Huo D, Wang H, Qi Y, Zhang W, Han L, Zhang D, Wang M, Xu J, Feng H
Neuroscience 2024 Dec 17;563:51-62

A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.

Bao K, Ma Y, Li Y, Shen X, Zhao J, Tian S, Zhang C, Liang C, Zhao Z, Yang Y, Zhang K, Yang N, Meng FL, Hao J, Yang J, Liu T, Yao Z, Ai D, Shi L
Molecular cell 2024 Apr 4;84(7):1206-1223.e15

FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.

Zhang Y, He B, Zhang D, Zhang Y, Chen C, Zhang W, Yang S, Yao M, Cui G, Gu J, Wang T, Lin Z, Fan Y, Xiong Z, Hao Y
Cell reports 2023 Mar 28;42(3):112188

BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.

Li M, Wei Y, Liu Y, Wei J, Zhou X, Duan Y, Chen S, Xue C, Zhan Y, Zheng L, Deng H, Tang F, Fan S, Xiong W, Li G, Tan M, Zhou M
Cell death & disease 2023 Feb 14;14(2):121

BRD7 Stabilizes P53 via Dephosphorylation of MDM2 to Inhibit Tumor Growth in Breast Cancer Harboring Wild-type P53.

Luo Y, Wang X, Niu W, Zhou Y, Li M, Ma J, Yang J, Fan S, Zeng Z, Xiong W, Li X, Li G, Xiao J, Zhou M
Journal of Cancer 2022;13(5):1436-1448

Transforming Stimulated Clone 22 (TSC-22) Interacts Directly with Bromodomain-Containing Protein 7 (BRD7) to Enhance the Inhibition of Extracellular Signal-Regulate Kinase (ERK) Pathway in Ovarian Cancer.

Lee SH, Choi D
Development & reproduction 2022 Sep;26(3):117-126

BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.

Li H, Yang T, Chen T, Liu Y, Pang Y, Yang L
Experimental lung research 2022 Sep-Oct;48(7-8):199-212

Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.

Yu X, Jiang N, Li J, Li X, He S
Tissue & cell 2022 Jun;76:101813

BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer.

Zhao R, Liu Y, Wu C, Li M, Wei Y, Niu W, Yang J, Fan S, Xie Y, Li H, Wang W, Zeng Z, Xiong W, Li X, Li G, Zhou M
Frontiers in cell and developmental biology 2021;9:659392

A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction.

Li J, Mulvihill TS, Li L, Barrott JJ, Nelson ML, Wagner L, Lock IC, Pozner A, Lambert SL, Ozenberger BB, Ward MB, Grossmann AH, Liu T, Banito A, Cairns BR, Jones KB
Cancer discovery 2021 Oct;11(10):2620-2637

SS18 regulates pluripotent-somatic transition through phase separation.

Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B, Li W, Wu Z, Li X, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J, Pei D
Nature communications 2021 Jul 2;12(1):4090

BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition.

Niu W, Luo Y, Zhou Y, Li M, Wu C, Duan Y, Wang H, Fan S, Li Z, Xiong W, Li X, Li G, Ren C, Li H, Zhou M
Journal of experimental & clinical cancer research : CR 2020 Feb 7;39(1):30

Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein.

Ma J, Niu W, Wang X, Zhou Y, Wang H, Liu F, Liu Y, Guo J, Xiong W, Zeng Z, Fan S, Li X, Nie X, Li G, Gui R, Luo Y, Zhou M
Oncology reports 2019 Mar;41(3):1487-1496

Clinical significance of bromodomain-containing protein 7 and its association with tumor progression in prostate cancer.

Liang Y, Dong B, Shen J, Ma C, Ma Z
Oncology letters 2019 Jan;17(1):849-856

BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer.

Niu W, Luo Y, Wang X, Zhou Y, Li H, Wang H, Fu Y, Liu S, Yin S, Li J, Zhao R, Liu Y, Fan S, Li Z, Xiong W, Li X, Li G, Ren C, Tan M, Zhou M
Cell death & disease 2018 May 1;9(5):519

BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141.

Liu Y, Zhao R, Wei Y, Li M, Wang H, Niu W, Zhou Y, Qiu Y, Fan S, Zhan Y, Xiong W, Zhou Y, Li X, Li Z, Li G, Zhou M
Journal of experimental & clinical cancer research : CR 2018 Mar 20;37(1):64

BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway.

Zhao R, Liu Y, Wang H, Yang J, Niu W, Fan S, Xiong W, Ma J, Li X, Phillips JB, Tan M, Qiu Y, Li G, Zhou M
Cellular & molecular immunology 2017 Oct;14(10):830-841

Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma.

Chen CL, Wang Y, Pan QZ, Tang Y, Wang QJ, Pan K, Huang LX, He J, Zhao JJ, Jiang SS, Zhang XF, Zhang HX, Zhou ZQ, Weng de S, Xia JC
Oncotarget 2016 Mar 29;7(13):16248-61

miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma.

Liu Y, Zhao R, Wang H, Luo Y, Wang X, Niu W, Zhou Y, Wen Q, Fan S, Li X, Xiong W, Ma J, Li X, Tan M, Li G, Zhou M
Cell death & disease 2016 Mar 24;7(3):e2156

Knockout of BRD7 results in impaired spermatogenesis and male infertility.

Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M
Scientific reports 2016 Feb 16;6:21776

Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.

Zhang Q, Wei L, Yang H, Yang W, Yang Q, Zhang Z, Wu K, Wu J
Cancer letters 2016 Feb 1;371(1):107-16

Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex.

Xu Y, Cao W, Zhou M, Li C, Luo Y, Wang H, Zhao R, Jiang S, Yang J, Liu Y, Wang X, Li X, Xiong W, Ma J, Peng S, Zeng Z, Li X, Tan M, Li G
Behavioural brain research 2015 Jun 1;286:1-10

BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.

Harte MT, O'Brien GJ, Ryan NM, Gorski JJ, Savage KI, Crawford NT, Mullan PB, Harkin DP
Cancer research 2010 Mar 15;70(6):2538-47

BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.

Kaeser MD, Aslanian A, Dong MQ, Yates JR 3rd, Emerson BM
The Journal of biological chemistry 2008 Nov 21;283(47):32254-63

Preparation of polyclonal antibody specific for BRD7 and detection of its expression pattern in the human fetus.

Liu H, Li X, Niu Z, Zhang L, Zhou M, Huang H, He J, Zhang W, Xiao L, Tang Y, Wang L, Li G
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Jun;56(6):531-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The BRD7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BRD7. This antibody recognizes human, mouse, rat antigen. The BRD7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 51009-2-AP.pdf

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