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- References [25]
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- Product number
- 51009-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#51009-2-AP, RRID:AB_2259226
- Product name
- BRD7 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BRD7 antibody (Cat. #51009-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aging-Associated ALKBH5-m(6)A Modification Exacerbates Doxorubicin-Induced Cardiomyocyte Apoptosis Via AT-Rich Interaction Domain 2.
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
BRD7 Stabilizes P53 via Dephosphorylation of MDM2 to Inhibit Tumor Growth in Breast Cancer Harboring Wild-type P53.
Transforming Stimulated Clone 22 (TSC-22) Interacts Directly with Bromodomain-Containing Protein 7 (BRD7) to Enhance the Inhibition of Extracellular Signal-Regulate Kinase (ERK) Pathway in Ovarian Cancer.
BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer.
A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction.
SS18 regulates pluripotent-somatic transition through phase separation.
BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition.
Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein.
Clinical significance of bromodomain-containing protein 7 and its association with tumor progression in prostate cancer.
BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer.
BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141.
BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway.
Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma.
miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma.
Knockout of BRD7 results in impaired spermatogenesis and male infertility.
Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.
Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex.
BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.
Preparation of polyclonal antibody specific for BRD7 and detection of its expression pattern in the human fetus.
Chen R, Zhang G, Sun K, Chen AF
Journal of the American Heart Association 2024 Jan 2;13(1):e031353
Journal of the American Heart Association 2024 Jan 2;13(1):e031353
A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis.
Bao K, Ma Y, Li Y, Shen X, Zhao J, Tian S, Zhang C, Liang C, Zhao Z, Yang Y, Zhang K, Yang N, Meng FL, Hao J, Yang J, Liu T, Yao Z, Ai D, Shi L
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
Molecular cell 2024 Apr 4;84(7):1206-1223.e15
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
Zhang Y, He B, Zhang D, Zhang Y, Chen C, Zhang W, Yang S, Yao M, Cui G, Gu J, Wang T, Lin Z, Fan Y, Xiong Z, Hao Y
Cell reports 2023 Mar 28;42(3):112188
Cell reports 2023 Mar 28;42(3):112188
BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.
Li M, Wei Y, Liu Y, Wei J, Zhou X, Duan Y, Chen S, Xue C, Zhan Y, Zheng L, Deng H, Tang F, Fan S, Xiong W, Li G, Tan M, Zhou M
Cell death & disease 2023 Feb 14;14(2):121
Cell death & disease 2023 Feb 14;14(2):121
BRD7 Stabilizes P53 via Dephosphorylation of MDM2 to Inhibit Tumor Growth in Breast Cancer Harboring Wild-type P53.
Luo Y, Wang X, Niu W, Zhou Y, Li M, Ma J, Yang J, Fan S, Zeng Z, Xiong W, Li X, Li G, Xiao J, Zhou M
Journal of Cancer 2022;13(5):1436-1448
Journal of Cancer 2022;13(5):1436-1448
Transforming Stimulated Clone 22 (TSC-22) Interacts Directly with Bromodomain-Containing Protein 7 (BRD7) to Enhance the Inhibition of Extracellular Signal-Regulate Kinase (ERK) Pathway in Ovarian Cancer.
Lee SH, Choi D
Development & reproduction 2022 Sep;26(3):117-126
Development & reproduction 2022 Sep;26(3):117-126
BRD7 restrains TNF-α-induced proliferation and migration of airway smooth muscle cells by inhibiting notch signaling.
Li H, Yang T, Chen T, Liu Y, Pang Y, Yang L
Experimental lung research 2022 Sep-Oct;48(7-8):199-212
Experimental lung research 2022 Sep-Oct;48(7-8):199-212
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Yu X, Jiang N, Li J, Li X, He S
Tissue & cell 2022 Jun;76:101813
Tissue & cell 2022 Jun;76:101813
BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer.
Zhao R, Liu Y, Wu C, Li M, Wei Y, Niu W, Yang J, Fan S, Xie Y, Li H, Wang W, Zeng Z, Xiong W, Li X, Li G, Zhou M
Frontiers in cell and developmental biology 2021;9:659392
Frontiers in cell and developmental biology 2021;9:659392
A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction.
Li J, Mulvihill TS, Li L, Barrott JJ, Nelson ML, Wagner L, Lock IC, Pozner A, Lambert SL, Ozenberger BB, Ward MB, Grossmann AH, Liu T, Banito A, Cairns BR, Jones KB
Cancer discovery 2021 Oct;11(10):2620-2637
Cancer discovery 2021 Oct;11(10):2620-2637
SS18 regulates pluripotent-somatic transition through phase separation.
Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B, Li W, Wu Z, Li X, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J, Pei D
Nature communications 2021 Jul 2;12(1):4090
Nature communications 2021 Jul 2;12(1):4090
BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial-mesenchymal transition.
Niu W, Luo Y, Zhou Y, Li M, Wu C, Duan Y, Wang H, Fan S, Li Z, Xiong W, Li X, Li G, Ren C, Li H, Zhou M
Journal of experimental & clinical cancer research : CR 2020 Feb 7;39(1):30
Journal of experimental & clinical cancer research : CR 2020 Feb 7;39(1):30
Bromodomain‑containing protein 7 sensitizes breast cancer cells to paclitaxel by activating Bcl2‑antagonist/killer protein.
Ma J, Niu W, Wang X, Zhou Y, Wang H, Liu F, Liu Y, Guo J, Xiong W, Zeng Z, Fan S, Li X, Nie X, Li G, Gui R, Luo Y, Zhou M
Oncology reports 2019 Mar;41(3):1487-1496
Oncology reports 2019 Mar;41(3):1487-1496
Clinical significance of bromodomain-containing protein 7 and its association with tumor progression in prostate cancer.
Liang Y, Dong B, Shen J, Ma C, Ma Z
Oncology letters 2019 Jan;17(1):849-856
Oncology letters 2019 Jan;17(1):849-856
BRD7 inhibits the Warburg effect and tumor progression through inactivation of HIF1α/LDHA axis in breast cancer.
Niu W, Luo Y, Wang X, Zhou Y, Li H, Wang H, Fu Y, Liu S, Yin S, Li J, Zhao R, Liu Y, Fan S, Li Z, Xiong W, Li X, Li G, Ren C, Tan M, Zhou M
Cell death & disease 2018 May 1;9(5):519
Cell death & disease 2018 May 1;9(5):519
BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141.
Liu Y, Zhao R, Wei Y, Li M, Wang H, Niu W, Zhou Y, Qiu Y, Fan S, Zhan Y, Xiong W, Zhou Y, Li X, Li Z, Li G, Zhou M
Journal of experimental & clinical cancer research : CR 2018 Mar 20;37(1):64
Journal of experimental & clinical cancer research : CR 2018 Mar 20;37(1):64
BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway.
Zhao R, Liu Y, Wang H, Yang J, Niu W, Fan S, Xiong W, Ma J, Li X, Phillips JB, Tan M, Qiu Y, Li G, Zhou M
Cellular & molecular immunology 2017 Oct;14(10):830-841
Cellular & molecular immunology 2017 Oct;14(10):830-841
Bromodomain-containing protein 7 (BRD7) as a potential tumor suppressor in hepatocellular carcinoma.
Chen CL, Wang Y, Pan QZ, Tang Y, Wang QJ, Pan K, Huang LX, He J, Zhao JJ, Jiang SS, Zhang XF, Zhang HX, Zhou ZQ, Weng de S, Xia JC
Oncotarget 2016 Mar 29;7(13):16248-61
Oncotarget 2016 Mar 29;7(13):16248-61
miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma.
Liu Y, Zhao R, Wang H, Luo Y, Wang X, Niu W, Zhou Y, Wen Q, Fan S, Li X, Xiong W, Ma J, Li X, Tan M, Li G, Zhou M
Cell death & disease 2016 Mar 24;7(3):e2156
Cell death & disease 2016 Mar 24;7(3):e2156
Knockout of BRD7 results in impaired spermatogenesis and male infertility.
Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M
Scientific reports 2016 Feb 16;6:21776
Scientific reports 2016 Feb 16;6:21776
Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.
Zhang Q, Wei L, Yang H, Yang W, Yang Q, Zhang Z, Wu K, Wu J
Cancer letters 2016 Feb 1;371(1):107-16
Cancer letters 2016 Feb 1;371(1):107-16
Inactivation of BRD7 results in impaired cognitive behavior and reduced synaptic plasticity of the medial prefrontal cortex.
Xu Y, Cao W, Zhou M, Li C, Luo Y, Wang H, Zhao R, Jiang S, Yang J, Liu Y, Wang X, Li X, Xiong W, Ma J, Peng S, Zeng Z, Li X, Tan M, Li G
Behavioural brain research 2015 Jun 1;286:1-10
Behavioural brain research 2015 Jun 1;286:1-10
BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.
Harte MT, O'Brien GJ, Ryan NM, Gorski JJ, Savage KI, Crawford NT, Mullan PB, Harkin DP
Cancer research 2010 Mar 15;70(6):2538-47
Cancer research 2010 Mar 15;70(6):2538-47
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.
Kaeser MD, Aslanian A, Dong MQ, Yates JR 3rd, Emerson BM
The Journal of biological chemistry 2008 Nov 21;283(47):32254-63
The Journal of biological chemistry 2008 Nov 21;283(47):32254-63
Preparation of polyclonal antibody specific for BRD7 and detection of its expression pattern in the human fetus.
Liu H, Li X, Niu Z, Zhang L, Zhou M, Huang H, He J, Zhang W, Xiao L, Tang Y, Wang L, Li G
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Jun;56(6):531-8
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Jun;56(6):531-8
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The BRD7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BRD7. This antibody recognizes human, mouse, rat antigen. The BRD7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
