ABIN360142

antibody from antibodies-online

Targeting: LIMK1 LIMK

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN360142

Provider

antibodies-online

Product name

anti-LIM Domain Kinase 1 (LIMK1) (N-Term) antibody

Antibody type

Polyclonal

Description

Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Reactivity

Human

Host

Rabbit

Epitope

N-Term

Vial size

0.4 mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.

Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K
The Journal of biological chemistry 2000 Feb 4;275(5):3577-82

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Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S
Science (New York, N.Y.) 1999 Aug 6;285(5429):895-8

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Structural features of LIM kinase that control effects on the actin cytoskeleton.

Edwards DC, Gill GN
The Journal of biological chemistry 1999 Apr 16;274(16):11352-61

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Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.

Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC
Genomics 1996 Sep 1;36(2):328-36

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LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.

Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT
Cell 1996 Jul 12;86(1):59-69