Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations [0]
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- Product number
- 27286-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- BCRP,ABCG2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BCRP,ABCG2 antibody (Cat. #27286-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SiRNF8 Delivered by DNA Framework Nucleic Acid Effectively Sensitizes Chemotherapy in Colon Cancer.
Preventive effect of Lactobacillus johnsonii YH1136 against uric acid accumulation and renal damages.
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Eupatilin inhibits xanthine oxidase in vitro and attenuates hyperuricemia and renal injury in vivo.
Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice.
Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway.
Effects of a Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle.
Establishment and characterization of a multi-drug resistant cell line for canine mammary tumors.
A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance.
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer.
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer.
rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS.
RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5.
USP18 regulates the malignant phenotypes of glioblastoma stem cells.
Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.
Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis.
Naringenin Ameliorates Hyperuricemia by Regulating Renal Uric Acid Excretion via the PI3K/AKT Signaling Pathway and Renal Inflammation through the NF-κB Signaling Pathway.
The antihyperuricemia activity of Astragali Radix through regulating the expression of uric acid transporters via PI3K/Akt signalling pathway.
Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.
SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis.
Integrating network pharmacology and experimental validation to clarify the anti-hyperuricemia mechanism of cortex phellodendri in mice.
Live and pasteurized Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric acid metabolism, inflammation, and gut microbiota.
CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma.
Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway.
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer.
S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation.
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis.
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Influence of schisantherin A on the pharmacokinetics of lenvatinib in rats and its potential mechanism.
Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study.
Long non-coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9.
Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.
Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals.
Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells.
Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation.
LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p.
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters.
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition.
Guo Z, Song H, Tian Y, Xu J, Zhang G, Guo Y, Shen R, Wang D
International journal of nanomedicine 2024;19:171-188
International journal of nanomedicine 2024;19:171-188
Preventive effect of Lactobacillus johnsonii YH1136 against uric acid accumulation and renal damages.
Zhang X, Jiang J, Xin J, Sun N, Zhao Z, Gan B, Jiang Y, Gong X, Li H, Ma H, Ni X, Chen Y, Bai Y, Wang H
Frontiers in microbiology 2024;15:1364857
Frontiers in microbiology 2024;15:1364857
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Li R, Xiong Z, Ma Y, Li Y, Yang Y, Ma S, Ha C
World journal of surgical oncology 2024 Mar 21;22(1):81
World journal of surgical oncology 2024 Mar 21;22(1):81
Eupatilin inhibits xanthine oxidase in vitro and attenuates hyperuricemia and renal injury in vivo.
Xu G, Wu L, Yang H, Liu T, Tong Y, Wan J, Han B, Zhou L, Hu X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jan;183:114307
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Jan;183:114307
Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2/STAT3 signaling and NLRP3 inflammasome activation in mice.
Lu M, Yin J, Xu T, Dai X, Liu T, Zhang Y, Wang S, Liu Y, Shi H, Zhang Y, Mo F, Sukhorukov V, Orekhov AN, Gao S, Wang L, Zhang D
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117262
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117262
Lovastatin/SN38 co-loaded liposomes amplified ICB therapeutic effect via remodeling the immunologically-cold colon tumor and synergized stimulation of cGAS-STING pathway.
Yang Y, Qi J, Hu J, Zhou Y, Zheng J, Deng W, Inam M, Guo J, Xie Y, Li Y, Xu C, Deng W, Chen W
Cancer letters 2024 Apr 28;588:216765
Cancer letters 2024 Apr 28;588:216765
Effects of a Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle.
Li LZ, Wang XM, Feng XJ, Liu K, Li B, Zhu LJ, Xu WF, Zheng X, Dong YJ, He XL, Guan HR, Ding YY, Wu HS, Zhou CJ, Ye SY, Zhang BB, Lv GY, Chen SH
Evidence-based complementary and alternative medicine : eCAM 2023;2023:9990843
Evidence-based complementary and alternative medicine : eCAM 2023;2023:9990843
Establishment and characterization of a multi-drug resistant cell line for canine mammary tumors.
Zhou C, Lin Z, Li X, Zhang D, Song P
Frontiers in veterinary science 2023;10:1129756
Frontiers in veterinary science 2023;10:1129756
A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistance.
Hao J, Huang J, Hua C, Zuo Y, Yu W, Wu X, Li L, Xue G, Wan X, Ru L, Guo Z, Han S, Deng W, Lin F, Guo W
PLoS biology 2023 Sep;21(9):e3002256
PLoS biology 2023 Sep;21(9):e3002256
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Zhang Y, Li Y, Li C, Zhao Y, Xu L, Ma S, Lin F, Xie Y, An J, Wang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154957
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154957
Pleckstrin homology and RhoGEF domain containing G4 (PLEKHG4) leads to the activation of RhoGTPases promoting the malignant phenotypes of thyroid cancer.
Yuan Q, Fan Y, Liu Z, Wang X, Jia M, Dong Y, Geng Z, Zheng J, Lu X
Apoptosis : an international journal on programmed cell death 2023 Oct;28(9-10):1315-1331
Apoptosis : an international journal on programmed cell death 2023 Oct;28(9-10):1315-1331
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer.
Zhang W, Fan Y, Zhang J, Shi D, Yuan J, Ashrafizadeh M, Li W, Hu M, Abd El-Aty AM, Hacimuftuoglu A, Linnebacher M, Cheng Y, Li W, Fang S, Gong P, Zhang X
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Nov;71:101005
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Nov;71:101005
rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS.
Qiao D, Liu Y, Lei Y, Zhang C, Bu Y, Tang Y, Zhang Y
Frontiers in bioscience (Landmark edition) 2023 May 25;28(5):102
Frontiers in bioscience (Landmark edition) 2023 May 25;28(5):102
RBM38 Reverses Sorafenib Resistance in Hepatocellular Carcinoma Cells by Combining and Promoting lncRNA-GAS5.
Gao X, Lu C, Liu Z, Lin Y, Huang J, Lu L, Li S, Huang X, Tang M, Huang S, He Z, She X, Liang R, Ye J
Cancers 2023 May 24;15(11)
Cancers 2023 May 24;15(11)
USP18 regulates the malignant phenotypes of glioblastoma stem cells.
Li L, Yin Y, Zhang J, Wu X, Liu J, Chai J, Yang Y, Li M, Jia Q, Liu Y
Pathology, research and practice 2023 Jul;247:154572
Pathology, research and practice 2023 Jul;247:154572
Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.
Guo XL, Gao YY, Yang YX, Zhu QF, Guan HY, He X, Zhang CL, Wang Y, Xu GB, Zou SH, Wei MC, Zhang J, Zhang JJ, Liao SG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154868
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154868
Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis.
Ai G, Huang R, Xie J, Zhong L, Wu X, Qin Z, Su Z, Chen J, Yang X, Dou Y
Journal of ethnopharmacology 2023 Jan 30;301:115775
Journal of ethnopharmacology 2023 Jan 30;301:115775
Naringenin Ameliorates Hyperuricemia by Regulating Renal Uric Acid Excretion via the PI3K/AKT Signaling Pathway and Renal Inflammation through the NF-κB Signaling Pathway.
Yang B, Xin M, Liang S, Huang Y, Li J, Wang C, Liu C, Song X, Sun J, Sun W
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1434-1446
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1434-1446
The antihyperuricemia activity of Astragali Radix through regulating the expression of uric acid transporters via PI3K/Akt signalling pathway.
Zhang MQ, Sun KX, Guo X, Chen YY, Feng CY, Chen JS, Barreira JCM, Prieto MA, Sun JY, Zhang JD, Li NY, Liu C
Journal of ethnopharmacology 2023 Dec 5;317:116770
Journal of ethnopharmacology 2023 Dec 5;317:116770
Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.
Hua L, Zhang S, Yang J, Zhou X, Shi S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114970
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114970
SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis.
Yuan H, Wu H, Cheng J, Xiong J
Cancer cell international 2023 Apr 16;23(1):71
Cancer cell international 2023 Apr 16;23(1):71
Integrating network pharmacology and experimental validation to clarify the anti-hyperuricemia mechanism of cortex phellodendri in mice.
Xu L, Cheng J, Lu J, Lin G, Yu Q, Li Y, Chen J, Xie J, Su Z, Zhou Q
Frontiers in pharmacology 2022;13:964593
Frontiers in pharmacology 2022;13:964593
Live and pasteurized Akkermansia muciniphila attenuate hyperuricemia in mice through modulating uric acid metabolism, inflammation, and gut microbiota.
Zhang L, Liu J, Jin T, Qin N, Ren X, Xia X
Food & function 2022 Nov 28;13(23):12412-12425
Food & function 2022 Nov 28;13(23):12412-12425
CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma.
Ma Y, Kang B, Li S, Xie G, Bi J, Li F, An G, Liu B, Li J, Shen Y, Xu X, Yang H, Yang Y, Gu Y, Wu N
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Nov 2;30(11):3341-3357
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Nov 2;30(11):3341-3357
Fufang Zhenzhu Tiaozhi capsule ameliorates hyperuricemic nephropathy by inhibition of PI3K/AKT/NF-κB pathway.
Li MH, Guan J, Chen Z, Mo JX, Wu KR, Hu XG, Lan T, Guo J
Journal of ethnopharmacology 2022 Nov 15;298:115644
Journal of ethnopharmacology 2022 Nov 15;298:115644
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer.
Gu J, Huang W, Wang X, Zhang J, Tao T, Zheng Y, Liu S, Yang J, Chen ZS, Cai CY, Li J, Wang H, Fan Y
Molecular cancer 2022 May 10;21(1):112
Molecular cancer 2022 May 10;21(1):112
S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation.
Wang Y, Xu J, Wang Y, Xiang L, He X
Food & function 2022 Feb 21;13(4):2200-2215
Food & function 2022 Feb 21;13(4):2200-2215
Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosis.
Chang X, Liu Z, Cao S, Bian J, Zheng D, Wang N, Guan Q, Wu Y, Zhang W, Li Z, Zuo D
Toxicology and applied pharmacology 2022 Feb 1;436:115883
Toxicology and applied pharmacology 2022 Feb 1;436:115883
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Zhu J, Liu L, Ma J, Fu Q, Zheng Z, Du E, Xu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Influence of schisantherin A on the pharmacokinetics of lenvatinib in rats and its potential mechanism.
Cui Y, Ma Y, Li Y, Song H, Dong Z
Journal of gastrointestinal oncology 2022 Apr;13(2):802-811
Journal of gastrointestinal oncology 2022 Apr;13(2):802-811
Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study.
Wang W, Zhou M, Xu Y, Peng W, Zhang S, Li R, Zhang H, Zhang H, Cheng S, Wang Y, Wei X, Yue C, Yang Q, Chen C
Frontiers in bioengineering and biotechnology 2021;9:762489
Frontiers in bioengineering and biotechnology 2021;9:762489
Long non-coding RNA DUXAP9 promotes hepatocellular carcinoma cell stemness via directly interacting with sox9.
Zeng R, Wang C, Wang W, Wang S
Environmental toxicology 2021 Sep;36(9):1793-1801
Environmental toxicology 2021 Sep;36(9):1793-1801
Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.
Liu C, Pan Z, Chen Q, Chen Z, Liu W, Wu L, Jiang M, Lin W, Zhang Y, Lin W, Zhou R, Zhao L
Journal of experimental & clinical cancer research : CR 2021 Sep 22;40(1):297
Journal of experimental & clinical cancer research : CR 2021 Sep 22;40(1):297
Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells.
Hu L, Liang Y, Wu K, Wang C, Zhang T, Peng R, Zou F
Annals of translational medicine 2021 Jan;9(2):114
Annals of translational medicine 2021 Jan;9(2):114
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Lin G, Yu Q, Xu L, Huang Z, Mai L, Jiang L, Su Z, Xie J, Li Y, Liu Y, Lin Z, Chen J
European journal of pharmacology 2021 Dec 5;912:174592
European journal of pharmacology 2021 Dec 5;912:174592
Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals.
Niu Y, Yang P, Li H, Li Q, Lin H, Gao L, Li L
Biological & pharmaceutical bulletin 2020 Nov 1;43(11):1653-1659
Biological & pharmaceutical bulletin 2020 Nov 1;43(11):1653-1659
Ginsenoside Rg3 attenuates the osimertinib resistance by reducing the stemness of non-small cell lung cancer cells.
Tan Q, Lin S, Zeng Y, Yao M, Liu K, Yuan H, Liu C, Jiang G
Environmental toxicology 2020 Jun;35(6):643-651
Environmental toxicology 2020 Jun;35(6):643-651
Preclinical Evaluation of the Novel Small-Molecule MSI-N1014 for Treating Drug-Resistant Colon Cancer via the LGR5/β-catenin/miR-142-3p Network and Reducing Cancer-Associated Fibroblast Transformation.
Yadav VK, Huang YJ, George TA, Wei PL, Sumitra MR, Ho CL, Chang TH, Wu ATH, Huang HS
Cancers 2020 Jun 16;12(6)
Cancers 2020 Jun 16;12(6)
LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p.
Jiang X, Guo S, Zhang Y, Zhao Y, Li X, Jia Y, Xu Y, Ma B
Cellular signalling 2020 Jan;65:109422
Cellular signalling 2020 Jan;65:109422
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Liu X, Ma F, Liu C, Zhu K, Li W, Xu Y, Li G, Niu Z, Liu J, Chen D, Li Z, Fu Y, Qian C
Cell death & disease 2020 Jan 6;11(1):10
Cell death & disease 2020 Jan 6;11(1):10
Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters.
Li Q, Lin H, Niu Y, Liu Y, Wang Z, Song L, Gao L, Li L
European journal of pharmacology 2020 Dec 5;888:173490
European journal of pharmacology 2020 Dec 5;888:173490
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Jia Z, Zhang Y, Yan A, Wang M, Han Q, Wang K, Wang J, Qiao C, Pan Z, Chen C, Hu D, Ding X
Cell death & disease 2020 Aug 20;11(8):670
Cell death & disease 2020 Aug 20;11(8):670
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, Wang J, Bao Y
Pharmacological research 2019 Sep;147:104387
Pharmacological research 2019 Sep;147:104387
Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition.
Lin H, Tu C, Niu Y, Li F, Yuan L, Li N, Xu A, Gao L, Li L
European journal of pharmacology 2019 Jun 15;853:371-380
European journal of pharmacology 2019 Jun 15;853:371-380
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