332020

antibody from BioLegend

Targeting: ABCG2 ABCP, BCRP, CD338, EST157481, MXR

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

332020

Provider

BioLegend

Proper citation

BioLegend Cat#332020, RRID:AB_1227470

Product name

APC anti-human CD338 (ABCG2)

Antibody type

Monoclonal

Antigen

CD338 (ABCG2)

Description

CD338, known as ABCG2 (BCRP1), is a multi-drug resistance (MDR) family protein that is a member of ATP binding cassette (ABC) transporters. It is highly expressed on primitive ‘side population’ (SP) stem cells. This SP phenotype is based on the efflux of fluorescent dyes such as Rhodamine 123 and Hoechst 33342. The SP cells express low or undetectable levels of CD34.  In the bone marrow, about 0.05% population of cells displays the low fluorescence and are highly enriched for repopulating cells.  The highest levels of BCRP1 mRNA expression have been seen in KDR+ human stem cells.  The expression of ABCG2 appears to be highly conserved as it has been identified in various species.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

100 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.