Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
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- Product number
- NBP2-44874-0.1mg - Provider product page
- Provider
- Novus Biologicals
- Product name
- Mouse Monoclonal NGFR/TNFRSF16/p75NTR Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified. It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
- Reactivity
- Human, Mouse, Rat, Feline, Rabbit, Simian
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.2 mg/ml
- Storage
- Store at 4C.
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: NGFR/TNFRSF16/p75NTR Antibody (NGFR5) [NBP2-44874] - Analysis of (lane 1), SW480 (lane 2) and PC12 (lane 3) cell lysates.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NGFR/TNFRSF16/p75NTR Antibody (NGFR5) [NBP2-44874] - Formalin-fixed, paraffin-embedded human Adrenal Gland stained with NGFR/TNFRSF16/p75NTR Antibody (NGFR5).
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NGFR/TNFRSF16/p75NTR Antibody (NGFR5) [NBP2-44874] - Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR/TNFRSF16/p75NTR Antibody (NGFR5).
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: NGFR/TNFRSF16/p75NTR Antibody (NGFR5) [NBP2-44874] - Analysis of Neurotrophin Receptor /NGF-Receptor (p75NGFR) in SW480 cells (green) compared to an isotype control (blue).