AGTO-L038S

antibody from Creative Biolabs

Targeting: NGFR CD271, p75NTR, TNFRSF16

Functional assay (Recommended by provider)

Antibody Data

Product number

AGTO-L038S

Provider

Creative Biolabs

Product name

anti-Ngfr immunotoxin MC-192 (IgG)-Sap

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-Ngfr monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to neurons and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Alzheimer's disease.

Reactivity

Rat

Host

Mouse

Antibody clone number

MC-192