345104

antibody from BioLegend
Targeting: NGFR CD271, p75NTR, TNFRSF16
Provider product page for 345104

Antibody data

Product number
345104 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#345104, RRID:AB_2282828
Product name
FITC anti-human CD271 (NGFR)
Antibody type
Monoclonal
Antigen
WM245 melanoma cells
Description
CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis.
Reactivity
Human
Host
Mouse
Conjugate
Green dye
Isotype
IgG
Vial size
100 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
NGFR protein structure - 345104 shown in red.