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- References [18]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11380-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11380-1-AP, RRID:AB_2088808
- Product name
- DDB1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DDB1 antibody (Cat. #11380-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma.
Interaction of CSN4 to DDB1 regulates its stability and function in DNA damage signaling.
Promotion of Cx26 mutants located in TM4 region for membrane translocation successfully rescued hearing loss.
MAZ Coordinates With HDAC1 to Promote Hepatocarcinoma Proliferation and Metastasis Through Transcriptional Repression of CSK.
Jaceosidin overcomes osimertinib resistance in lung cancer by inducing G2/M cycle arrest through targeting DDB1.
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice.
Cullin 4B-RING E3 ligase negatively regulates the immunosuppressive capacity of mesenchymal stem cells by suppressing iNOS.
Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.
DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis.
Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ.
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.
Ddb1 Is Essential for the Expansion of CD4(+) Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
Cul4 E3 ubiquitin ligase regulates ovarian cancer drug resistance by targeting the antiapoptotic protein BIRC3.
14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.
DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication.
Basili I, Bufalieri F, Conenna M, Navacci S, Li YR, Torrejon J, Bernardi F, Lospinoso Severini L, Marsaud V, Cancila G, Bourmeau G, Yu H, Lo Re V, Talbot J, Adabbo G, Di Pinto A, Agnoli F, Giovannini D, Leonardi S, Bordone R, Petroni M, Souphron J, Blauwblomme T, Beccaria K, Dufour C, D'Angelo L, De Smaele E, Canettieri G, Giannini G, Fimia GM, Maroder M, Guardavaccaro D, Pazzaglia S, Tsai JW, Infante P, Ayrault O, Di Marcotullio L
Developmental cell 2026 May 13;61(5):1111-1126.e9
Developmental cell 2026 May 13;61(5):1111-1126.e9
Interaction of CSN4 to DDB1 regulates its stability and function in DNA damage signaling.
Choi SH, Cho K, Kim ES, Yoo HY
Cellular and molecular life sciences : CMLS 2026 Feb 13;83(1):111
Cellular and molecular life sciences : CMLS 2026 Feb 13;83(1):111
Promotion of Cx26 mutants located in TM4 region for membrane translocation successfully rescued hearing loss.
Zong YJ, Liu XZ, Shi XY, Zhao ZD, Sun Y
Theranostics 2025;15(12):5801-5825
Theranostics 2025;15(12):5801-5825
MAZ Coordinates With HDAC1 to Promote Hepatocarcinoma Proliferation and Metastasis Through Transcriptional Repression of CSK.
Qiu R, Chen W, Zhao S, Zhao H, Qiu T, Hu Q, Xu Z, Zeng L, Kong C, Zhang C, Weng Q, Zhao A, Wang J, He Y, Tu J, Chen M, Zhao Z, Yang Y, Ji J
Molecular carcinogenesis 2025 Sep;64(9):1500-1513
Molecular carcinogenesis 2025 Sep;64(9):1500-1513
Jaceosidin overcomes osimertinib resistance in lung cancer by inducing G2/M cycle arrest through targeting DDB1.
Chen Z, Yang Z, Liu Y, Zhou Z, Men B, Yun L, Jiang J, Ge H, Dian M, He Y, Zhang R, Cai K, Rao X, Rao S
Toxicology and applied pharmacology 2025 Jun;499:117327
Toxicology and applied pharmacology 2025 Jun;499:117327
Renal tubular GSDME protects cisplatin nephrotoxicity by impeding OGT-STAT3-S100A7A axis in male mice.
Chen Q, Sun P, Zhou J, Long T, Xiao A, Liu Z, Xu S, Lei W, Zhang R, Tian J, Zhou M, Hu Z, Zhu F, Nie J
Nature communications 2025 Jul 24;16(1):6807
Nature communications 2025 Jul 24;16(1):6807
Cullin 4B-RING E3 ligase negatively regulates the immunosuppressive capacity of mesenchymal stem cells by suppressing iNOS.
Yu R, Han H, Chu S, Qin L, Du M, Ma Y, Wang Y, Jiang W, Song Y, Zou Y, Wang M, Liu Q, Jiang B, Gong Y, Sun G
Cell death and differentiation 2025 Jan;32(1):149-161
Cell death and differentiation 2025 Jan;32(1):149-161
Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.
Huang Z, Zhang K, Jiang Y, Wang M, Li M, Guo Y, Gao R, Li N, Wang C, Chen J, Wang J, Liu N, Liu X, Liu S, Wei M, Yang C, Yang G
Acta pharmaceutica Sinica. B 2024 Sep;14(9):4001-4013
Acta pharmaceutica Sinica. B 2024 Sep;14(9):4001-4013
DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis.
Zhang C, Li W, Liu L, Li M, Sun H, Zhang C, Zhong L, Huang J, Li T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23735
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23735
Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.
Carden S, Vitiello E, Rosa E Silva I, Holder J, Quarantotti V, Kishore K, Roamio Franklin VN, D'Santos C, Ochi T, van Breugel M, Gergely F
Developmental cell 2023 Nov 6;58(21):2393-2410.e9
Developmental cell 2023 Nov 6;58(21):2393-2410.e9
Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, Harvey CJB, Naughton BT, McFadden DG, Ready JM, De Brabander JK, Nijhawan D
Cell chemical biology 2023 Nov 16;30(11):1453-1467.e8
Cell chemical biology 2023 Nov 16;30(11):1453-1467.e8
CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ.
Yu R, Han H, Chu S, Ding Y, Jin S, Wang Y, Jiang W, Liu Y, Zou Y, Wang M, Liu Q, Sun G, Jiang B, Gong Y
Bone research 2023 Jun 2;11(1):29
Bone research 2023 Jun 2;11(1):29
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.
Zhou H, Feng W, Yu J, Shafiq TA, Paulo JA, Zhang J, Luo Z, Gygi SP, Moazed D
Cell reports 2023 Apr 25;42(4):112339
Cell reports 2023 Apr 25;42(4):112339
Ddb1 Is Essential for the Expansion of CD4(+) Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Yang L, Chen W, Li L, Xiao Y, Fan S, Zhang Q, Xia T, Li M, Hong Y, Zhao T, Li Q, Liu WH, Xiao N
Frontiers in immunology 2021;12:722273
Frontiers in immunology 2021;12:722273
A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.
Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL
iScience 2019 Jun 28;16:177-191
iScience 2019 Jun 28;16:177-191
Cul4 E3 ubiquitin ligase regulates ovarian cancer drug resistance by targeting the antiapoptotic protein BIRC3.
Hu X, Meng Y, Xu L, Qiu L, Wei M, Su D, Qi X, Wang Z, Yang S, Liu C, Han J
Cell death & disease 2019 Feb 4;10(2):104
Cell death & disease 2019 Feb 4;10(2):104
14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.
Tang S, Bao H, Zhang Y, Yao J, Yang P, Chen X
PloS one 2013;8(3):e55268
PloS one 2013;8(3):e55268
DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication.
Kang X, Chen X, He Y, Guo D, Guo L, Zhong J, Shu HB
Virology 2013 Jan 20;435(2):385-94
Virology 2013 Jan 20;435(2):385-94
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 11380-1-AP(DDB1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DDB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DDB1. This antibody recognizes human,mouse,rat antigen. The DDB1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
