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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN374069 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide from the C Terminus of the protein Genename: DDB1
- Description
- Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
- Reactivity
- Human, Mouse, Rat, Bovine, Canine
- Host
- Goat
- Antigen sequence
C-DLIKVVEELTRIH- Epitope
- C-Term
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.
DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.
Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.
A genetic screen for candidate tumor suppressors identifies REST.
Li T, Robert EI, van Breugel PC, Strubin M, Zheng N
Nature structural & molecular biology 2010 Jan;17(1):105-11
Nature structural & molecular biology 2010 Jan;17(1):105-11
DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.
Leung-Pineda V, Huh J, Piwnica-Worms H
Cancer research 2009 Mar 15;69(6):2630-7
Cancer research 2009 Mar 15;69(6):2630-7
Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
Alekseev S, Luijsterburg MS, Pines A, Geverts B, Mari PO, Giglia-Mari G, Lans H, Houtsmuller AB, Mullenders LH, Hoeijmakers JH, Vermeulen W
Molecular and cellular biology 2008 Dec;28(24):7402-13
Molecular and cellular biology 2008 Dec;28(24):7402-13
Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.
Luijsterburg MS, Goedhart J, Moser J, Kool H, Geverts B, Houtsmuller AB, Mullenders LH, Vermeulen W, van Driel R
Journal of cell science 2007 Aug 1;120(Pt 15):2706-16
Journal of cell science 2007 Aug 1;120(Pt 15):2706-16
A genetic screen for candidate tumor suppressors identifies REST.
Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ
Cell 2005 Jun 17;121(6):837-48
Cell 2005 Jun 17;121(6):837-48
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