ABIN117954

antibody from antibodies-online

Targeting: DDB1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

ABIN117954

Provider

antibodies-online

Product name

anti-Damage-Specific DNA Binding Protein 1, 127kDa (DDB1) (AA 198-213) antibody

Antibody type

Polyclonal

Antigen

This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 198-213 of Human DDB1 (internal) coupled to KLH.

Description

Delipidation and defibrination.

Reactivity

Human, Mouse

Host

Rabbit

Antigen sequence

Human DDB1 (1140 aa 127.0. kDa): 1
msynyvvtaq kptavngcvt ghftsaedln ll
iakntrle iyvvtaeglr pvkevgmygk 61 i
avmelfrpk geskdllfil takynacile ykq
sgesidi itrahgnvqd rigrpsetgi 121 i
giidpecrm iglrlydglf kvipldrdnk elk
afnirle elhvidvkfl ygcqapticf 181 v
yqdpqgrhv ktyevslrek efnkgpwkqe nve
aeasmvi avpepfggai iigqesityh 241 n
gdkylaiap piikqstivc hnrvdpngsr yll
gdmegrl fmlllekeeq mdgtvtlkdl 301 r
vellgetsi aecltyldng vvfvgsrlgd sql
vklnvds neqgsyvvam etftnlgpiv 361 d
mcvvdlerq gqgqlvtcsg afkegslrii rng
igiheha sidlpgikgl wplrsdpnre --- 6
61 ssnhklvfsn vnlkevnymc plnsdgypds
lalannstlt igtideiqkl hirtvplyes 7
21 prkicyqevs qcfgvlssri evqdtsggtt
alrpsastqa lsssvssskl fssstaphet 7
81 sfgeevevhn lliidqhtfe vlhahqflqn
eyalslvsck lgkdpntyfi vgtamvypee 8
41 aepkqgrivv fqysdgklqt vaekevkgav
ysmvefngkl lasinstvrl yewttekdvr 9
01 tecnhynnim alylktkgdf ilvgdlmrsv
lllaykpmeg nfeeiardfn pnwmsaveil 9
61 dddnflgaen afnlfvcqkd saattdeerq
hlqevglfhl gefvnvfchg slvmqnlget 1
021 stptqgsvlf gtvngmiglv tslseswyn
l lldmqnrlnk viksvgkieh sfwrsfhter
1081 ktepatgfid gdliesfldi srpkmqev
va nlqyddgsgm kreataddli kvveeltrih


Epitope

AA 198-213

Vial size

0.1 mL

Concentration

85 mg/mL (by Refractometry)

Storage

Store undiluted at 2-8°C.

References

Submitted references

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.

Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM
Science (New York, N.Y.) 2004 Feb 27;303(5662):1371-4

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Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities.

Leupin O, Bontron S, Strubin M
Journal of virology 2003 Jun;77(11):6274-83

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Ubiquitin and its kin: how close are the family ties?

Jentsch S, Pyrowolakis G
Trends in cell biology 2000 Aug;10(8):335-42

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The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription.

Shiyanov P, Hayes SA, Donepudi M, Nichols AF, Linn S, Slagle BL, Raychaudhuri P
Molecular and cellular biology 1999 Jul;19(7):4935-43

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Cullin 4A associates with the UV-damaged DNA-binding protein DDB.

Shiyanov P, Nag A, Raychaudhuri P
The Journal of biological chemistry 1999 Dec 10;274(50):35309-12