Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 21991-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- PKC Alpha antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PKC Alpha antibody (Cat. #21991-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Proteomic Analysis of Emodin Treatment in Neuropathic Pain Reveals Dysfunction of the Calcium Signaling Pathway.
Dephosphorylation of annexin A2 by protein phosphatase 1 regulates endothelial cell barrier.
LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Small molecule screening identified cepharanthine as an inhibitor of porcine reproductive and respiratory syndrome virus infection in vitro by suppressing integrins/ILK/RACK1/PKCα/NF-κB signalling axis.
MED13L integrates Mediator-regulated epigenetic control into lung cancer radiosensitivity.
Inhibition of porcine reproductive and respiratory syndrome virus by PKC inhibitor dequalinium chloride in vitro.
Reduced expression of annexin A1 promotes gemcitabine and 5-fluorouracil drug resistance of human pancreatic cancer.
Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis.
Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway.
HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma.
Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma.
Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis.
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Silencing Formin-like 2 inhibits growth and metastasis of gastric cancer cells through suppressing internalization of integrins.
Protein kinase C-mediated impairment of glutamine outward transport and SN1 transporter distribution by ammonia in mouse cortical astrocytes.
β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer.
Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma.
Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.
A comparative proteomics study on matrix vesicles of osteoblast-like Saos-2 and U2-OS cells.
Chen P, Lin D, Wang C, Song C, Wang W, Qu J, Wu Z
Journal of pain research 2021;14:613-622
Journal of pain research 2021;14:613-622
Dephosphorylation of annexin A2 by protein phosphatase 1 regulates endothelial cell barrier.
Király N, Thalwieser Z, Fonódi M, Csortos C, Boratkó A
IUBMB life 2021 Oct;73(10):1257-1268
IUBMB life 2021 Oct;73(10):1257-1268
LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through Degrading PKC-ζ and PKCι/λ to Reduce Expression of ZO1, ZO3, and Occludin.
Su X, Wei J, Qi H, Jin M, Zhang Q, Zhang Y, Zhang C, Yang R
Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315
Inflammatory bowel diseases 2021 Jul 27;27(8):1302-1315
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S
Oncogene 2021 Feb;40(7):1269-1283
Oncogene 2021 Feb;40(7):1269-1283
Small molecule screening identified cepharanthine as an inhibitor of porcine reproductive and respiratory syndrome virus infection in vitro by suppressing integrins/ILK/RACK1/PKCα/NF-κB signalling axis.
Yang C, Zuo Q, Liu X, Zhao Q, Pu H, Gao L, Zhao L, Guo Z, Lin Y, Liu J, Bi J, Yin G
Veterinary microbiology 2021 Apr;255:109016
Veterinary microbiology 2021 Apr;255:109016
MED13L integrates Mediator-regulated epigenetic control into lung cancer radiosensitivity.
Zhang N, Song Y, Xu Y, Liu J, Shen Y, Zhou L, Yu J, Yang M
Theranostics 2020;10(20):9378-9394
Theranostics 2020;10(20):9378-9394
Inhibition of porcine reproductive and respiratory syndrome virus by PKC inhibitor dequalinium chloride in vitro.
Liu X, Gao L, Zhao Q, Wang X, Yang C, Bi J, Yang R, Jin X, Lan R, Cui R, Wang X, Li W, Wang X, Yang Y, Yu X, Lin Y, Liu J, Yin G
Veterinary microbiology 2020 Dec;251:108913
Veterinary microbiology 2020 Dec;251:108913
Reduced expression of annexin A1 promotes gemcitabine and 5-fluorouracil drug resistance of human pancreatic cancer.
Liu QH, Yong HM, Zhuang QX, Zhang XP, Hou PF, Chen YS, Zhu MH, Bai J
Investigational new drugs 2020 Apr;38(2):350-359
Investigational new drugs 2020 Apr;38(2):350-359
Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis.
Yu Q, Wang P, Yang L, Wu Z, Li S, Xu Y, Wu B, Ma A, Gan X, Xu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109134
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109134
Influence of Wilms' tumor suppressor gene WT1 on bovine Sertoli cells polarity and tight junctions via non-canonical WNT signaling pathway.
Wang X, Adegoke EO, Ma M, Huang F, Zhang H, Adeniran SO, Zheng P, Zhang G
Theriogenology 2019 Oct 15;138:84-93
Theriogenology 2019 Oct 15;138:84-93
HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma.
Jiang H, Fu Q, Song X, Ge C, Li R, Li Z, Zeng B, Li C, Wang Y, Xue Y, Luo R, Fang W
Oncology letters 2019 Nov;18(5):4936-4946
Oncology letters 2019 Nov;18(5):4936-4946
Silencing of Transcription Factor Sp1 Promotes SN1 Transporter Regulation by Ammonia in Mouse Cortical Astrocytes.
Dąbrowska K, Zielińska M
International journal of molecular sciences 2019 Jan 9;20(2)
International journal of molecular sciences 2019 Jan 9;20(2)
Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma.
Sano H, Namekata K, Kimura A, Shitara H, Guo X, Harada C, Mitamura Y, Harada T
Cell death & disease 2019 Jan 28;10(2):75
Cell death & disease 2019 Jan 28;10(2):75
Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis.
Zhou X, Wang S, Zheng M, Kuver A, Wan X, Dai K, Li X
Biochimica et biophysica acta. Molecular cell research 2019 Feb;1866(2):214-224
Biochimica et biophysica acta. Molecular cell research 2019 Feb;1866(2):214-224
Sensory plasticity of carotid body is correlated with oxidative stress in paraventricular nucleus during chronic intermittent hypoxia.
Liu P, Zhang HM, Hu K, Zhou XF, Tang S
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Journal of cellular physiology 2019 Aug;234(8):13534-13543
Silencing Formin-like 2 inhibits growth and metastasis of gastric cancer cells through suppressing internalization of integrins.
Zhong B, Wang K, Xu H, Kong F
Cancer cell international 2018;18:79
Cancer cell international 2018;18:79
Protein kinase C-mediated impairment of glutamine outward transport and SN1 transporter distribution by ammonia in mouse cortical astrocytes.
Dąbrowska K, Albrecht J, Zielińska M
Neurochemistry international 2018 Sep;118:225-232
Neurochemistry international 2018 Sep;118:225-232
β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer.
Ma J, Lu Y, Zhang S, Li Y, Huang J, Yin Z, Ren J, Huang K, Liu L, Yang K, Wu G, Xu S
Cell death and differentiation 2018 Aug;25(8):1473-1485
Cell death and differentiation 2018 Aug;25(8):1473-1485
Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma.
Akaiwa K, Namekata K, Azuchi Y, Sano H, Guo X, Kimura A, Harada C, Mitamura Y, Harada T
Investigative ophthalmology & visual science 2018 Apr 1;59(5):2080-2089
Investigative ophthalmology & visual science 2018 Apr 1;59(5):2080-2089
Dioscin Inhibits HSC-T6 Cell Migration via Adjusting SDC-4 Expression: Insights from iTRAQ-Based Quantitative Proteomics.
Yin L, Qi Y, Xu Y, Xu L, Han X, Tao X, Song S, Peng J
Frontiers in pharmacology 2017;8:665
Frontiers in pharmacology 2017;8:665
A comparative proteomics study on matrix vesicles of osteoblast-like Saos-2 and U2-OS cells.
Jiang L, Cui Y, Luan J, Zhou X, Zhou X, Han J
Intractable & rare diseases research 2013 May;2(2):59-62
Intractable & rare diseases research 2013 May;2(2):59-62
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PKC alpha antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PKC alpha. This antibody recognizes human, mouse antigen. The PKC alpha antibody has been validated for the following applications: ELISA, WB analysis.