17373-1-AP

antibody from Proteintech Group

Targeting: PADI4 PAD, PADI5, PDI4, PDI5

Provider product page for 17373-1-AP

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ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
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Product number: 17373-1-AP - Provider product page
Provider: Proteintech Group
Product name: PADI4 antibody
Antibody type: Polyclonal
Description: KD/KO validated PADI4 antibody (Cat. #17373-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PADI4 protein structure - 17373-1-AP shown in red.

Submitted references Dihydroartemisinin is an inhibitor of trained immunity through Akt/mTOR/HIF1α signaling pathway.

Gao Y, Liu ZZ, Zhang JB, Zhou CK, Zhang JG, Lin XQ, Yin Q, Chen W, Yang YJ
Experimental cell research 2024 May 1;438(1):114052

SHED-exos promote saliva secretion by suppressing p-ERK1/2-mediated apoptosis in glandular cells.

Chu WX, Ding C, Du ZH, Wei P, Wang YX, Ge XJ, Yu GY
Oral diseases 2024 Jul;30(5):3066-3080

Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D.

Zhou L, Li Y, You J, Wu C, Zuo L, Chen Y, Kang L, Zhou Z, Huang R, Wu S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Jan;73(1):19-33

IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis.

Wang Y, Shi C, Guo J, Zhang D, Zhang Y, Zhang L, Gong Z
Cellular & molecular biology letters 2024 Jan 3;29(1):8

Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats.

Mead AJ, Ahluwalia K, Ebright B, Zhang Z, Dave P, Li Z, Zhou E, Naik AA, Ngu R, Chester C, Lu A, Asante I, Pollalis D, Martinez JC, Humayun M, Louie S
International journal of molecular sciences 2024 Feb 15;25(4)

hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50.

Osei-Amponsa V, Chandravanshi M, Lu X, Magidson V, Das S, Andresson T, Dyba M, Sabbasani VR, Swenson RE, Fromont C, Shrestha B, Zhao Y, Clapp ME, Chari R, Walters KJ
Molecular cell 2024 Feb 1;84(3):522-537.e8

The m6A methyltransferase METTL5 promotes neutrophil extracellular trap network release to regulate hepatocellular carcinoma progression.

Wang Q, Huang Y, Zhu Y, Zhang W, Wang B, Du X, Dai Q, Zhang F, Fang Z
Cancer medicine 2024 Apr;13(7):e7165

The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis.

Wang P, Liu D, Zhou Z, Liu F, Shen Y, You Q, Lu S, Wu J
Frontiers in immunology 2023;14:1144976

Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord.

Li T, Yue Y, Ma Y, Zhong Z, Guo M, Zhang J, Wang Z, Miao C
Cell communication and signaling : CCS 2023 Sep 21;21(1):250

Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis.

Jiang H, Lu Q, Xu J, Huo G, Cai Y, Geng S, Xu H, Zhang J, Li H, Yuan K, Huang G
Scientific reports 2023 Mar 9;13(1):3933

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression.

Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL, Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P, Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV, Karanicolas J, Murphy ME
Cancer discovery 2023 Jul 7;13(7):1696-1719

Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The Involvement of NETosis and Prdx Antioxidants.

Almási N, Török S, Al-Awar A, Veszelka M, Király L, Börzsei D, Szabó R, Varga C
Antioxidants (Basel, Switzerland) 2023 Jul 30;12(8)

Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis.

Han Y, Tomita T, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S
Nature communications 2023 Aug 24;14(1):4960

Tetrandrine Ameliorates Rheumatoid Arthritis in Mice by Alleviating Neutrophil Activities.

Lu Q, Jiang H, Zhu Q, Xu J, Cai Y, Huo G, Yuan K, Huang G, Xu A
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8589121

Forsythiaside B ameliorates coagulopathies in a rat model of sepsis through inhibition of the formation of PAD4-dependent neutrophil extracellular traps.

He W, Xi Q, Cui H, Zhang P, Huang R, Wang T, Wang D
Frontiers in pharmacology 2022;13:1022985

Neutrophil Extracellular Traps may be a Potential Target for Treating Early Brain Injury in Subarachnoid Hemorrhage.

Zeng H, Fu X, Cai J, Sun C, Yu M, Peng Y, Zhuang J, Chen J, Chen H, Yu Q, Xu C, Zhou H, Cao Y, Hu L, Li J, Cao S, Gu C, Yan F, Chen G
Translational stroke research 2022 Feb;13(1):112-131

Inhibition of PAD4-mediated NET formation by cl-amidine prevents diabetes development in nonobese diabetic mice.

Shen Y, You Q, Wu Y, Wu J
European journal of pharmacology 2022 Feb 5;916:174623

Extracellular trap can be trained as a memory response.

Gao Y, Zhang JG, Liu ZZ, Ma K, Lin XQ, Zhang JB, Chen W, Yang YJ
Virulence 2022 Dec;13(1):471-482

TREM1 Regulates Neuroinflammatory Injury by Modulate Proinflammatory Subtype Transition of Microglia and Formation of Neutrophil Extracellular Traps via Interaction With SYK in Experimental Subarachnoid Hemorrhage.

Wu X, Zeng H, Xu C, Chen H, Fan L, Zhou H, Yu Q, Fu X, Peng Y, Yan F, Yu X, Chen G
Frontiers in immunology 2021;12:766178

Neutrophil Extracellular Traps Caused by Gut Leakage Trigger the Autoimmune Response in Nonobese Diabetic Mice.

You Q, Shen Y, Wu Y, Li Y, Liu C, Huang F, Gu HF, Wu J
Frontiers in immunology 2021;12:711423

Investigation of H(2)S Donor Treatment on Neutrophil Extracellular Traps in Experimental Colitis.

Török S, Almási N, Valkusz Z, Pósa A, Varga C, Kupai K
International journal of molecular sciences 2021 Nov 25;22(23)

Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration.

Osada A, Matsumoto I, Mikami N, Ohyama A, Kurata I, Kondo Y, Tsuboi H, Ishigami A, Sano Y, Arai T, Ise N, Sumida T
Clinical and experimental immunology 2021 Mar;203(3):385-399

Innate and Autoimmunity in the Pathogenesis of Inherited Retinal Dystrophy.

Hollingsworth TJ, Gross AK
Cells 2020 Mar 5;9(3)

Tumour necrosis factor alpha promotes secretion of 14-3-3η by inducing necroptosis in macrophages.

Trimova G, Yamagata K, Iwata S, Hirata S, Zhang T, Uemura F, Satoh M, Biln N, Nakayamada S, Maksymowych WP, Tanaka Y
Arthritis research & therapy 2020 Feb 12;22(1):24

IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis.

Yahagi A, Saika T, Hirano H, Takai-Imamura M, Tsuji F, Aono H, Iseki M, Morita Y, Igarashi H, Saeki Y, Ishihara K
RMD open 2019;5(2):e000853

Increased Protein Citrullination as a Trigger for Resident Immune System Activation, Intraretinal Inflammation, and Promotion of Anti-retinal Autoimmunity: Intersecting Paths in Retinal Degenerations of Potential Therapeutic Relevance.

Iannaccone A, Radic MZ
Advances in experimental medicine and biology 2019;1185:175-179

Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination.

Nagar M, Tilvawala R, Thompson PR
Frontiers in immunology 2019;10:244

Cold-inducible RNA-binding Protein Induces Neutrophil Extracellular Traps in the Lungs during Sepsis.

Ode Y, Aziz M, Jin H, Arif A, Nicastro JG, Wang P
Scientific reports 2019 Apr 18;9(1):6252

Activity-dependent Synaptic Recruitment of Neuroligin 1 in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Zhao JY, Duan XL, Yang L, Liu JP, He YT, Guo Z, Hu XD, Suo ZW
Neuroscience 2018 Sep 15;388:1-10

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4).

Hollingsworth TJ, Radic MZ, Beranova-Giorgianni S, Giorgianni F, Wang Y, Iannaccone A
Investigative ophthalmology & visual science 2018 Aug 1;59(10):3808-3815

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway.

Ledet MM, Anderson R, Harman R, Muth A, Thompson PR, Coonrod SA, Van de Walle GR
BMC cancer 2018 Apr 12;18(1):412

Neutrophil extracellular traps are critical for pregnancy loss in sphingosine kinase-deficient mice on 129Sv/C57BL/6 background.

Mizugishi K, Yamashita K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Dec;31(12):5577-5591

Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.

Suzuki A, Kochi Y, Shoda H, Seri Y, Fujio K, Sawada T, Yamada R, Yamamoto K
BMC musculoskeletal disorders 2016 May 5;17:205

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