Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF1965 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal IL-24 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human IL-24 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Effects of melanoma differentiation associated gene-7 (MDA-7/IL-24) on apoptosis of liver cancer cells via regulating the expression of B-cell lymphoma-2.
Enhanced tumor growth inhibition by mesenchymal stem cells derived from iPSCs with targeted integration of interleukin24 into rDNA loci.
T cell-derived microvesicles induce mast cell production of IL-24: relevance to inflammatory skin diseases.
Expansion of parasite-specific CD4+ and CD8+ T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic filariasis.
Induction of phenotype modifying cytokines by FERMT1 mutations.
Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.
Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24.
Mo Q, Liu L, Bao G, Li T
Oncology letters 2019 Jul;18(1):29-34
Oncology letters 2019 Jul;18(1):29-34
Enhanced tumor growth inhibition by mesenchymal stem cells derived from iPSCs with targeted integration of interleukin24 into rDNA loci.
Liu B, Chen F, Wu Y, Wang X, Feng M, Li Z, Zhou M, Wang Y, Wu L, Liu X, Liang D
Oncotarget 2017 Jun 20;8(25):40791-40803
Oncotarget 2017 Jun 20;8(25):40791-40803
T cell-derived microvesicles induce mast cell production of IL-24: relevance to inflammatory skin diseases.
Shefler I, Pasmanik-Chor M, Kidron D, Mekori YA, Hershko AY
The Journal of allergy and clinical immunology 2014 Jan;133(1):217-24.e1-3
The Journal of allergy and clinical immunology 2014 Jan;133(1):217-24.e1-3
Expansion of parasite-specific CD4+ and CD8+ T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic filariasis.
Anuradha R, George PJ, Hanna LE, Kumaran P, Chandrasekaran V, Nutman TB, Babu S
PLoS neglected tropical diseases 2014 Apr;8(4):e2762
PLoS neglected tropical diseases 2014 Apr;8(4):e2762
Induction of phenotype modifying cytokines by FERMT1 mutations.
Heinemann A, He Y, Zimina E, Boerries M, Busch H, Chmel N, Kurz T, Bruckner-Tuderman L, Has C
Human mutation 2011 Apr;32(4):397-406
Human mutation 2011 Apr;32(4):397-406
Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.
Maarof G, Bouchet-Delbos L, Gary-Gouy H, Durand-Gasselin I, Krzysiek R, Dalloul A
Blood 2010 Mar 4;115(9):1718-26
Blood 2010 Mar 4;115(9):1718-26
Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24.
Tahara I, Miyake K, Hanawa H, Kurai T, Hirai Y, Ishizaki M, Uchida E, Tajiri T, Shimada T
Molecular therapy : the journal of the American Society of Gene Therapy 2007 Oct;15(10):1805-11
Molecular therapy : the journal of the American Society of Gene Therapy 2007 Oct;15(10):1805-11
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Cell Proliferation Induced by IL-24 and Neutralization by Human IL-24 Antibody. Recombinant Human IL-24 (Catalog # 1965-IL) stimulates proliferation in the BaF3 mouse pro-B cell line co-transfected with human IL-20 R alpha and IL-20 R beta in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-24 (2 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-24 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1965). The ND50 is typically 0.2-0.6 µg/mL.