10842-1-AP

antibody from Proteintech Group

Targeting: SNCA NACP, PARK1, PARK4, PD1

Provider product page for 10842-1-AP

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [63]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 10842-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10842-1-AP, RRID:AB_2192672
Product name: Alpha Synuclein antibody
Antibody type: Polyclonal
Description: Alpha Synuclein antibody (Cat. #10842-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SNCA protein structure - 10842-1-AP shown in red.

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Jiang P, Xiao Y, Hu X, Wang C, Gao H, Huang H, Lv J, Qi Z, Wang Z
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Combined exposure to manganese and iron decreases oxidative stress-induced nerve damage by increasing Nrf2/HO-1/NQO1 expression.

Fang YY, Teng MJ, Peng JC, Zheng XW, Mo YQ, Ho TT, Lin JJ, Luo JJ, Aschner M, Jiang YM
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Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson's disease in the Chinese population.

Li J, Duan S, Yang J, Zheng H, Yuan Y, Tang M, Wang Y, Liu Y, Xia Z, Luo H, Xu Y
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The role of NF-κB signaling pathway in reactive astrocytes among neurodegeneration after methamphetamine exposure by integrated bioinformatics.

Li K, Ling H, Wang X, Xie Q, Gu C, Luo W, Qiu P
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Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats.

Zhang L, Huang J, Dai L, Zhu G, Yang XL, He Z, Li YH, Yang H, Zhang CQ, Shen KF, Liang P
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The Role of Endophilin A1 in Lipopolysaccharide-Induced Parkinson's Disease Model Mice.

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FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.

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Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.

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Deficiency of RAB39B Activates ER Stress-Induced Pro-apoptotic Pathway and Causes Mitochondrial Dysfunction and Oxidative Stress in Dopaminergic Neurons by Impairing Autophagy and Upregulating α-Synuclein.

Chiu CC, Weng YH, Yeh TH, Lu JC, Chen WS, Li AH, Chen YL, Wei KC, Wang HL
Molecular neurobiology 2023 May;60(5):2706-2728

PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.

Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, Cai Z, Zhong J, Ming Q, Li M, Lu R, Liu X, Chen J
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Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models.

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Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein.

Ohgita T, Kono H, Morita I, Oyama H, Shimanouchi T, Kobayashi N, Saito H
Scientific reports 2023 Jul 5;13(1):10885

Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers.

Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R
eLife 2023 Jan 10;12

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.

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Neurobiology of disease 2023 Feb;177:105969

Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection.

Zou W, Zhang K, Qiu Z, Xin R, Wang G, Zhang J, Li J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Feb;172:113584

TRPV4-mediated Ca(2+) deregulation causes mitochondrial dysfunction via the AKT/α-synuclein pathway in dopaminergic neurons.

Sun X, Kong J, Dong S, Kato H, Sato H, Hirofuji Y, Ito Y, Wang L, Kato TA, Torio M, Sakai Y, Ohga S, Fukumoto S, Masuda K
FASEB bioAdvances 2023 Dec;5(12):507-520

Cdk5 phosphorylation-dependent C9orf72 degradation promotes neuronal death in Parkinson's disease models.

Xu X, Li M, Su Y, Wang Q, Qin P, Huang H, Zhang Y, Zhou Y, Yan J
CNS neuroscience & therapeutics 2023 Dec;29(12):3952-3966

Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway.

Medina CA, Vargas E, Munger SJ, Miller JE
PloS one 2022;17(5):e0265604

Early Dysbiosis and Dampened Gut Microbe Oscillation Precede Motor Dysfunction and Neuropathology in Animal Models of Parkinson's Disease.

Liang F, Chen CY, Li YP, Ke YC, Ho EP, Jeng CF, Lin CH, Chen SK
Journal of Parkinson's disease 2022;12(8):2423-2440

Transfer of neuron-derived α-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: Involving the regulation of nuclear receptor-associated protein 1.

Huang J, Ding J, Wang X, Gu C, He Y, Li Y, Fan H, Xie Q, Qi X, Wang Z, Qiu P
Brain, behavior, and immunity 2022 Nov;106:247-261

The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice.

Zhao M, Deng L, Lu X, Fan L, Zhu Y, Zhao L
Environmental science and pollution research international 2022 Jun;29(27):41151-41167

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson's disease by promoting Nrf2/NQO-1 pathway.

Huang L, Han Y, Zhou Q, Sun Z, Yan J
Translational neuroscience 2022 Jan 1;13(1):301-308

Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease.

Wen J, Zhang YQ, Liu DQ, Yao XT, Jiang H, Zhang YB
Chinese journal of natural medicines 2022 Feb;20(2):111-119

Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein.

Zhong J, Li M, Xu J, Dong W, Qin Y, Qiu S, Li X, Wang H
Toxicology and applied pharmacology 2022 Feb 1;436:115859

Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.

Watabe K, Niida-Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, Wakabayashi K, Yamada M, Kakita A, Shibata N
Neuropathology : official journal of the Japanese Society of Neuropathology 2022 Dec;42(6):488-504

Paraquat Inhibits Autophagy Via Intensifying the Interaction Between HMGB1 and α-Synuclein.

Wang K, Zhang B, Zhang B, Wu K, Tian T, Yan W, Huang M
Neurotoxicity research 2022 Apr;40(2):520-529

Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein.

Ohgita T, Namba N, Kono H, Shimanouchi T, Saito H
Scientific reports 2022 Apr 26;12(1):6770

Quantitative Proteomics Reveals the Dynamic Pathophysiology Across Different Stages in a Rat Model of Severe Traumatic Brain Injury.

Luo W, Yang Z, Zhang W, Zhou D, Guo X, Wang S, He F, Wang Y
Frontiers in molecular neuroscience 2021;14:785938

In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation.

Chang KH, Huang CY, Ou-Yang CH, Ho CH, Lin HY, Hsu CL, Chen YT, Chou YC, Chen YJ, Chen Y, Lin JL, Wang JK, Lin PW, Lin YR, Lin MH, Tseng CK, Lin CH
Stem cell research & therapy 2021 Sep 22;12(1):508

NF‑κB is negatively associated with Nurr1 to reduce the inflammatory response in Parkinson's disease.

Gao H, Wang D, Jiang S, Mao J, Yang X
Molecular medicine reports 2021 Jun;23(6)

Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson's disease models.

Dong WL, Zhong JH, Chen YQ, Xie JF, Qin YY, Xu JP, Cai NB, Li MF, Liu L, Wang HT
Acta pharmacologica Sinica 2021 Dec;42(12):1991-2003

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease.

Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F
Journal of neuroinflammation 2021 Dec 20;18(1):295

CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.

Liu B, Li H, Liu X, Li F, Chen W, Kuang Y, Zhao X, Li L, Yu B, Jin X, Li Q
Cellular signalling 2021 Aug;84:110012

MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease.

Xue C, Li X, Ba L, Zhang M, Yang Y, Gao Y, Sun Z, Han Q, Zhao RC
Aging and disease 2021 Aug;12(5):1211-1222

Pramipexole attenuates 6-OHDA-induced Parkinson's disease by mediating the Nurr1/NF-κB pathway.

Gao H, Wang D, Wang YL, Mao JP, Jiang S, Yang XL
Molecular biology reports 2021 Apr;48(4):3079-3087

Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.

Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR
Acta neuropathologica communications 2021 Apr 8;9(1):64

Myocardial cathepsin D is downregulated in sudden cardiac death.

Kakimoto Y, Sasaki A, Niioka M, Kawabe N, Osawa M
PloS one 2020;15(3):e0230375

The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.

Akintade DD, Chaudhuri B
Bioscience reports 2020 Sep 30;40(9)

Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria.

Akintade DD, Chaudhuri B
Cells 2020 Sep 29;9(10)

(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.

Chiu CC, Weng YH, Huang YZ, Chen RS, Liu YC, Yeh TH, Lu CS, Lin YW, Chen YJ, Hsu CC, Chiu CH, Wang YT, Chen WS, Liu SY, Wang HL
Cell death & disease 2020 Nov 30;11(11):1018

Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.

Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163

Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink.

Akintade DD, Chaudhuri B
Sensors (Basel, Switzerland) 2020 Jul 21;20(14)

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.

Chadchankar J, Korboukh V, Conway LC, Wobst HJ, Walker CA, Doig P, Jacobsen SJ, Brandon NJ, Moss SJ, Wang Q
PloS one 2019;14(11):e0225145

Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade.

Chiu CC, Yeh TH, Chen RS, Chen HC, Huang YZ, Weng YH, Cheng YC, Liu YC, Cheng AJ, Lu YC, Chen YJ, Lin YW, Hsu CC, Chen YL, Lu CS, Wang HL
Frontiers in cellular neuroscience 2019;13:399

Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery.

Lin CJ, Lin CY, Lin YT, Huang CY, Wei KC, Chen JC, Lee-Chen GJ, Liu HL
Biochemical and biophysical research communications 2019 Sep 10;517(1):77-83

Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation.

Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, da Luz Scheffer D, Andia DC, Portinho D, de Souza AP, de Oliveira PA, Prediger RD, Torres AI, Linhares RMM, Walz R, Ronsoni MF, Hohl A, Rafacho A, Aguiar AS Jr, De Paul AL, Latini A
Molecular neurobiology 2019 Mar;56(3):1539-1557

Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X.

So LY, Munger SJ, Miller JE
Behavioural brain research 2019 Mar 15;360:103-112

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model.

Chiu CC, Lu CS, Weng YH, Chen YL, Huang YZ, Chen RS, Cheng YC, Huang YC, Liu YC, Lai SC, Lin KJ, Lin YW, Chen YJ, Chen CL, Yeh TH, Wang HL
Molecular neurobiology 2019 Jun;56(6):3835-3853

Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model.

Zhou P, Homberg JR, Fang Q, Wang J, Li W, Meng X, Shen J, Luan Y, Liao P, Swaab DF, Shan L, Liu C
Brain, behavior, and immunity 2019 Feb;76:61-73

RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease.

Su J, Wang H, Yang Y, Wang J, Li H, Huang D, Huang L, Bai X, Yu M, Fei J, Huang F
Neurochemistry international 2018 Sep;118:195-204

Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease.

Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F
Cell death & disease 2018 Jun 13;9(6):700

Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats.

Wang SJ, Wang Q, Ma J, Yu PH, Wang ZM, Wang B
Neural regeneration research 2018 Jan;13(1):112-118

TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions.

Koga S, Lin WL, Walton RL, Ross OA, Dickson DW
Neuropathology and applied neurobiology 2018 Dec;44(7):707-721

Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra.

Huang C, Zhu L, Li H, Shi FG, Wang GQ, Wei YZ, Liu J, Zhang F
Frontiers in molecular neuroscience 2017;10:131

α-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells.

Duan J, Ying Z, Su Y, Lin F, Deng Y
Neuroscience letters 2017 Mar 6;642:148-152

Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.

Tayebi N, Parisiadou L, Berhe B, Gonzalez AN, Serra-Vinardell J, Tamargo RJ, Maniwang E, Sorrentino Z, Fujiwara H, Grey RJ, Hassan S, Blech-Hermoni YN, Chen C, McGlinchey R, Makariou-Pikis C, Brooks M, Ginns EI, Ory DS, Giasson BI, Sidransky E
Molecular genetics and metabolism 2017 Dec;122(4):198-208

Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis.

Marques F, Tenney J, Duran I, Martin J, Nevarez L, Pogue R, Krakow D, Cohn DH, Li B
PLoS genetics 2016 Sep;12(9):e1006307

Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein.

Rodríguez-Nogales C, Garbayo E, Martínez-Valbuena I, Sebastián V, Luquin MR, Blanco-Prieto MJ
International journal of pharmaceutics 2016 Nov 30;514(1):142-149

Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration.

Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, Zhang G, Yang J, Zhang Z, Zhang Z, Lin Z, Xiong N, Wang T
Molecular neurobiology 2016 Mar;53(2):995-1008

Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.

Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 May 27;35(21):8345-58

Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.

Xiang W, Menges S, Schlachetzki JC, Meixner H, Hoffmann AC, Schlötzer-Schrehardt U, Becker CM, Winkler J, Klucken J
Molecular neurodegeneration 2015 Mar 11;10:8

Alpha-synuclein overexpression induced mitochondrial damage by the generation of endogenous neurotoxins in PC12 cells.

Zhang Y, Ma H, Xie B, Han C, Wang C, Qing H, Deng Y
Neuroscience letters 2013 Jun 28;547:65-9

α-Synuclein increases U251 cells vulnerability to hydrogen peroxide by disrupting calcium homeostasis.

Ying Z, Lin F, Gu W, Su Y, Arshad A, Qing H, Deng Y
Journal of neural transmission (Vienna, Austria : 1996) 2011 Aug;118(8):1165-72

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 10842-1-AP(SNCA antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human brain using 10842-1-AP(SNCA antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The alpha-synuclein antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human alpha-synuclein. This antibody recognizes human,mouse,rat antigen. The alpha-synuclein antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 10842-1-AP.pdf

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