Antibody data
- Antibody Data
- Antigen structure
- References [60]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 12108-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12108-1-AP, RRID:AB_2209469
- Product name
- TRIM21 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM21 antibody (Cat. #12108-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway.
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21.
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway.
IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages.
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination.
PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity.
SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation.
USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.
TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC.
STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer.
TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.
UBE2L3 Reduces TRIM21 Expression and IL-1β Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.
TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1.
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner.
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.
UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer.
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.
Quantitative interactome proteomics identifies a proteostasis network for GABA(A) receptors.
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus.
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells.
TRIM21‑a potential biomarker for the prognosis of thyroid cancer.
Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3.
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA(A) R-Dependent TRIM21 Modulation of Src Expression.
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.
WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
Porcine TRIM21 RING-finger E3 ubiquitin ligase is essential for anti-PRRSV activity.
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein.
Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting.
Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C(pro).
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus.
TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.
Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.
Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.
Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Shu B, Zhou Y, Lei G, Peng Y, Ding C, Li Z, He C
Cancer science 2024 May;115(5):1476-1491
Cancer science 2024 May;115(5):1476-1491
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21.
Guo D, Zhou S, Liu R, Yao W, Li S, Zhang X, Shen W, Zhu S
Cancer cell international 2024 May 23;24(1):179
Cancer cell international 2024 May 23;24(1):179
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Qi H, Yu M, Fan X, Zhou Y, Zhang M, Gao X
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway.
Sun F, Sun Y, Wang X, Zhu J, Chen S, Yu Y, Zhu M, Xu W, Qian H
Bioactive materials 2024 Mar;33:444-459
Bioactive materials 2024 Mar;33:444-459
IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages.
Li D, Wang X, Chen K, Shan D, Cui G, Yuan W, Lin Q, Gimple RC, Dixit D, Lu C, Gu D, You H, Gao J, Li Y, Kang T, Yang J, Yu H, Song K, Shi Z, Fan X, Wu Q, Gao W, Zhu Z, Man J, Wang Q, Lin F, Tao W, Mack SC, Chen Y, Zhang J, Li C, Zhang N, You Y, Qian X, Yang K, Rich JN, Zhang Q, Wang X
Cell death and differentiation 2024 Jun;31(6):738-752
Cell death and differentiation 2024 Jun;31(6):738-752
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination.
Shi S, Zhang Q, Zhang K, Chen W, Xie H, Pan S, Xue Z, You B, Zhao J, You Y
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):283-301
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):283-301
PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity.
Sun R, Guo Y, Zhang L, Zhang H, Yin B, Li X, Li C, Yang L, Zhang L, Li Z, Huang J
Virologica Sinica 2024 Apr;39(2):264-276
Virologica Sinica 2024 Apr;39(2):264-276
SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation.
Yuan J, Zhu Z, Zhang P, Ashrafizadeh M, Abd El-Aty AM, Hacımüftüoğlu A, Linnebacher CS, Linnebacher M, Sethi G, Gong P, Zhang X
Cancer letters 2024 Apr 10;587:216733
Cancer letters 2024 Apr 10;587:216733
USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.
Liu Y, Ma J, Lu S, He P, Dong W
Chinese medical journal 2023 Sep 20;136(18):2229-2242
Chinese medical journal 2023 Sep 20;136(18):2229-2242
TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC.
Huang N, Li P, Sun X, Tong L, Dong X, Zhang X, Duan J, Sheng X, Xin H
NPJ breast cancer 2023 Oct 20;9(1):85
NPJ breast cancer 2023 Oct 20;9(1):85
STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer.
Huo C, Gu Y, Wang D, Zhang X, Tang F, Zhao B, Liu T, He W, Li Y
Journal of cancer research and clinical oncology 2023 Nov;149(17):15335-15348
Journal of cancer research and clinical oncology 2023 Nov;149(17):15335-15348
TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.
Yao Y, Pan L, Wei Y, Feng M, Li X, Sun L, Tang G, Wang Y
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 May;52(5):448-455
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 May;52(5):448-455
UBE2L3 Reduces TRIM21 Expression and IL-1β Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin.
Chen XY, Xu F, Chen JQ, Landeck L, Chen SQ, Zhou Y, Wang Z, Fu NC, Zheng M, Zhang X, Man XY
The Journal of investigative dermatology 2023 May;143(5):822-831.e4
The Journal of investigative dermatology 2023 May;143(5):822-831.e4
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
Zhang K, Yang C, Zhou X, Liang J, Guo J, Li M, Zhang Y, Shao S, Sun P, Li K, Huang J, Chen F, Liang X, Su D
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L
Cancer letters 2023 May 28;562:216158
Cancer letters 2023 May 28;562:216158
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
Sun X, Huang N, Li P, Dong X, Yang J, Zhang X, Zong WX, Gao S, Xin H
Life sciences 2023 May 15;321:121608
Life sciences 2023 May 15;321:121608
The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.
Liu J, Zhang C, Xu D, Zhang T, Chang CY, Wang J, Liu J, Zhang L, Haffty BG, Zong WX, Hu W, Feng Z
The Journal of clinical investigation 2023 Mar 15;133(6)
The Journal of clinical investigation 2023 Mar 15;133(6)
TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1.
Lin L, Wang X, Chen Z, Deng T, Yan Y, Dong W, Huang Y, Zhou J
PLoS pathogens 2023 Jun;19(6):e1011472
PLoS pathogens 2023 Jun;19(6):e1011472
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Li J, Xiao X, Ou Y, Cao L, Guo M, Qi C, Wang Z, Liu Y, Shuai Q, Wang H, Sun P, Shi Y, Yang G, Yang S
Cancer communications (London, England) 2023 Jul;43(7):765-787
Cancer communications (London, England) 2023 Jul;43(7):765-787
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y
Autophagy 2023 Jul;19(7):1934-1951
Autophagy 2023 Jul;19(7):1934-1951
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
Xiao K, Peng S, Lu J, Zhou T, Hong X, Chen S, Liu G, Li H, Huang J, Chen X, Lin T
Cell death & disease 2023 Jul 8;14(7):408
Cell death & disease 2023 Jul 8;14(7):408
AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner.
Wang L, Li D, Su X, Zhao Y, Huang A, Li H, Li J, Xia W, Jia T, Zhang H, Dong J, Liu X, Shao N
Oncogene 2023 Jan;42(1):62-77
Oncogene 2023 Jan;42(1):62-77
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).
de Rivero Vaccari JP, Mim C, Hadad R, Cyr B, Stefansdottir TA, Keane RW
Translational research : the journal of laboratory and clinical medicine 2023 Jan;251:27-40
Translational research : the journal of laboratory and clinical medicine 2023 Jan;251:27-40
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y
Science advances 2023 Jan 6;9(1):eadd6626
Science advances 2023 Jan 6;9(1):eadd6626
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.
Wang L, Li H, Huang A, Zhao Y, Xiao C, Dong J, Liu X, Shao N
Oncogene 2023 Dec;42(50):3708-3718
Oncogene 2023 Dec;42(50):3708-3718
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.
Hu Q, Xu J, Wang L, Yuan Y, Luo R, Gan M, Wang K, Zhao T, Wang Y, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303535
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303535
UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
Lu X, Kong X, Wu H, Hao J, Li S, Gu Z, Zeng X, Shen Y, Wang S, Chen J, Fei X, Sun Y, Li X, Jiang L, Yang F, Wang J, Cai Z
Cell metabolism 2023 Aug 8;35(8):1390-1405.e8
Cell metabolism 2023 Aug 8;35(8):1390-1405.e8
DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer.
Zhang Y, Kong R, Yang W, Hu K, Zhao Z, Li L, Geng X, Liu L, Chen H, Xiao P, Liu D, Luo Y, Chen H, Hu J, Sun B
Cancer letters 2023 Aug 1;568:216288
Cancer letters 2023 Aug 1;568:216288
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.
Gui Z, Li J, Li J, Li X, Chen L, Ma Z, Tang X, Gong X, Chai X, Lu F, Li M, Ma H, Li X, Ye X
Chemico-biological interactions 2023 Apr 1;374:110408
Chemico-biological interactions 2023 Apr 1;374:110408
Quantitative interactome proteomics identifies a proteostasis network for GABA(A) receptors.
Wang YJ, Di XJ, Mu TW
The Journal of biological chemistry 2022 Oct;298(10):102423
The Journal of biological chemistry 2022 Oct;298(10):102423
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Wen P, Wang H, Li Y, Sui X, Hou Z, Guo X, Xue W, Liu D, Wang Y, Gao J
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus.
Gomez-Bañuelos E, Wahadat MJ, Li J, Paz M, Antiochos B, Celia AI, Andrade V, Ferris DP, Goldman DW, Darrah E, Petri M, Andrade F
JCI insight 2022 Oct 10;7(19)
JCI insight 2022 Oct 10;7(19)
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Zhang J, Gan Y, Li H, Yin J, He X, Lin L, Xu S, Fang Z, Kim BW, Gao L, Ding L, Zhang E, Ma X, Li J, Li L, Xu Y, Horne D, Xu R, Yu H, Gu Y, Huang W
Nature communications 2022 May 20;13(1):2835
Nature communications 2022 May 20;13(1):2835
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Qi H, Wang L, Zhang M, Wang Z, Gao X, Li M
The Journal of nutritional biochemistry 2022 Mar;101:108924
The Journal of nutritional biochemistry 2022 Mar;101:108924
TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Fang M, Zhang A, Du Y, Lu W, Wang J, Minze LJ, Cox TC, Li XC, Xing J, Zhang Z
Journal of biomedical science 2022 Jul 31;29(1):55
Journal of biomedical science 2022 Jul 31;29(1):55
Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells.
Yang L, Liu X, Zhang L, Li X, Zhang X, Niu G, Ji W, Chen S, Ouyang H, Ren L
Viruses 2022 Jan 15;14(1)
Viruses 2022 Jan 15;14(1)
TRIM21‑a potential biomarker for the prognosis of thyroid cancer.
Wu Z, Wang Y, Yu Z, Meng Z, Duan W, Zhang W, Fang J
Experimental and therapeutic medicine 2022 Dec;24(6):761
Experimental and therapeutic medicine 2022 Dec;24(6):761
Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.
Yao L, Xu L, Zhou L, Wu S, Zou W, Chen M, Chen J, Peng H
Frontiers in cell and developmental biology 2021;9:685913
Frontiers in cell and developmental biology 2021;9:685913
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, Wang Y, Du Z, Peng K, Liu H, Zhang Q, Tang F, Wang P, Gao S, Wang Y, Ding WX, Guo G, Wang F, Zong WX
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3.
Wang Y, Cui S, Xin T, Wang X, Yu H, Chen S, Jiang Y, Gao X, Jiang Y, Guo X, Jia H, Zhu H
Frontiers in cellular and infection microbiology 2021;11:818969
Frontiers in cellular and infection microbiology 2021;11:818969
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA(A) R-Dependent TRIM21 Modulation of Src Expression.
Liu Q, Sheng Z, Cheng C, Zheng H, Lanuti M, Liu R, Wang P, Shen Y, Xie Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2102079
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2102079
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.
Gao L, Xia L, Ji W, Zhang Y, Xia W, Lu S
Translational oncology 2021 Sep;14(9):101148
Translational oncology 2021 Sep;14(9):101148
WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
Zhao Y, Li WF, Li QJ, He SW, He QM, Long LF, Liu N, Ma J
Oral oncology 2021 Nov;122:105576
Oral oncology 2021 Nov;122:105576
Porcine TRIM21 RING-finger E3 ubiquitin ligase is essential for anti-PRRSV activity.
Wei Y, Zeng S, Zou C, Zhang H, Peng O, Xue C, Cao Y
Veterinary microbiology 2021 May;256:109043
Veterinary microbiology 2021 May;256:109043
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein.
Hsu JC, Laurent-Rolle M, Pawlak JB, Wilen CB, Cresswell P
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 15;118(24)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 15;118(24)
Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting.
Jin J, Meng X, Huo Y, Deng H
Cell death & disease 2021 Jul 13;12(7):697
Cell death & disease 2021 Jul 13;12(7):697
Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.
Yang L, Zhang T, Zhang C, Xiao C, Bai X, Wang G
The British journal of dermatology 2021 Jan;184(1):111-122
The British journal of dermatology 2021 Jan;184(1):111-122
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Tan CT, Chang HC, Zhou Q, Yu C, Fu NY, Sabapathy K, Yu VC
EMBO reports 2021 Jan 7;22(1):e50854
EMBO reports 2021 Jan 7;22(1):e50854
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C(pro).
Xiao H, Li J, Yang X, Li Z, Wang Y, Rui Y, Liu B, Zhang W
Virologica Sinica 2021 Dec;36(6):1363-1374
Virologica Sinica 2021 Dec;36(6):1363-1374
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Li Z, Huan C, Wang H, Liu Y, Liu X, Su X, Yu J, Zhao Z, Yu XF, Zheng B, Zhang W
EMBO reports 2020 Jan 7;21(1):e47528
EMBO reports 2020 Jan 7;21(1):e47528
TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.
Zhang P, Li X, He Q, Zhang L, Song K, Yang X, He Q, Wang Y, Hong X, Ma J, Liu N
Journal of biomedical science 2020 Jan 31;27(1):30
Journal of biomedical science 2020 Jan 31;27(1):30
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Liu XF, Tang CX, Zhang L, Tong SY, Wang Y, Abdulrahman AA, Ji GQ, Gao Y, Gao DS, Zhang BL
Neurochemical research 2020 Dec;45(12):2915-2925
Neurochemical research 2020 Dec;45(12):2915-2925
Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus.
Wei W, Wang Y, Sun Q, Jiang C, Zhu M, Song C, Li C, Du G, Deng Y, Nie H, Tang G
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2020 Apr;49(4):350-356
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2020 Apr;49(4):350-356
TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.
Li L, Wei J, Mallampalli RK, Zhao Y, Zhao J
American journal of respiratory cell and molecular biology 2019 Dec;61(6):776-785
American journal of respiratory cell and molecular biology 2019 Dec;61(6):776-785
Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.
Ahn Y, Hwang JH, Zheng Z, Bang D, Kim DY
Scientific reports 2017 Jun 7;7(1):3018
Scientific reports 2017 Jun 7;7(1):3018
Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.
Fan W, Zhang D, Qian P, Qian S, Wu M, Chen H, Li X
Antiviral research 2016 Mar;127:32-40
Antiviral research 2016 Mar;127:32-40
Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M
The Journal of biological chemistry 2015 Nov 20;290(47):28428-28437
The Journal of biological chemistry 2015 Nov 20;290(47):28428-28437
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 12108-1-AP(TRIM21 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIM21 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIM21. This antibody recognizes human, mouse, rat antigen. The TRIM21 antibody has been validated for the following applications: ELISA, WB, IHC analysis.