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- Product number
- 12108-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12108-1-AP, RRID:AB_2209469
- Product name
- TRIM21 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM21 antibody (Cat. #12108-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibiting TRIM21 Neddylation Rejuvenates Oocyte Quality in PCOS by Regulating Ubiquitination of CPT1A.
ATG16L1 Regulates Reparative Function of Peritoneal Macrophages During Acute Drug-induced Liver Injury.
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Upregulated ARMCX1 suppresses nasopharyngeal carcinoma progression by promoting TRIM21-mediated β-catenin degradation.
Therapeutic Potential of Curcumin in Diabetic Cardiomyopathy: Modulation of Pyroptosis Pathways.
A TRIM21-UCHL3-ITCH-SIPA1 axis promotes colorectal cancer growth and metastasis.
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.
FTO-mediated m6A demethylation of TRIM21 regulates macrophage polarization and attenuates myocardial ischemia-reperfusion injury.
Targeting IRF1-TRIM21 axis enhances anti-tumor immunity by promoting ubiquitin-mediated degradation of FGL1 in non-small cell lung cancer.
Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (As(3+))-Induced Malignant Transformation by Antagonizing TOX Expression.
Pseudorabies Virus UL41 Hijacks IFN Response via JAK/STAT Pathway While Cellular TRIM21 Blocks it Through K48 Ubiquitination.
Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production.
Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies.
Hypoxia promotes pancreatic adenocarcinoma progression by stabilizing ID1 via TRIM21 suppression.
TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis.
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
KDM1A-driven RNF81 downregulation promotes gastric cancer progression via KLF4 destabilization.
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.
CERKL Reduced PI3P/Autophagy to Promote Pancreatic Cancer.
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance.
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.
Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD-MASH Transition by Disrupting Carnitine Biosynthesis.
Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes.
UBE2C mediates follicular thyroid carcinoma invasion and metastasis via K29-Specific vimentin ubiquitination.
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65.
Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy.
RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma.
Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma.
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Platelet NLRP6 protects against microvascular thrombosis in sepsis.
Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates.
METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3.
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27.
Trim21 modulates endoplasmic reticulum-associated degradation and sensitizes cancer cells to ER stress-induced apoptosis by inhibiting VCP/Npl4/UFD1 assembly.
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.
The UP1 domain is essential for the facilitation effect of HnRNP A1 on PRRSV-2 replication.
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
RAB40C recruiting TRIM21 facilitates the progression of hepatocellular carcinoma by stabilizing EGFR.
TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.
Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function.
CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression.
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression.
RNF26-mediated ubiquitination of TRIM21 promotes bladder cancer progression.
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2.
Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis.
Chaperonin-containing TCP1 subunit 6A inhibition via TRIM21-mediated K48-linked ubiquitination suppresses triple-negative breast cancer progression through the AKT signalling pathway.
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.
TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway.
The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis.
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21.
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway.
IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages.
The MGF300-2R Protein of African Swine Fever Virus Promotes IKKβ Ubiquitination by Recruiting the E3 Ubiquitin Ligase TRIM21.
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination.
Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes.
NCAPH, ubiquitinated by TRIM21, promotes cell proliferation by inhibiting autophagy of cervical cancer through AKT/mTOR dependent signaling.
SERPINH1 modulates apoptosis by inhibiting P62 ubiquitination degradation to promote bone metastasis of prostate cancer.
PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity.
SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation.
USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.
TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC.
STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer.
TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.
UBE2L3 Reduces TRIM21 Expression and IL-1β Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin.
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.
TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1.
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner.
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.
UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer.
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.
Quantitative interactome proteomics identifies a proteostasis network for GABA(A) receptors.
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus.
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells.
TRIM21‑a potential biomarker for the prognosis of thyroid cancer.
Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3.
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA(A) R-Dependent TRIM21 Modulation of Src Expression.
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.
WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
Porcine TRIM21 RING-finger E3 ubiquitin ligase is essential for anti-PRRSV activity.
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein.
Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting.
Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C(pro).
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus.
TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.
Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.
Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.
Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Na X, Liu J, Tan Y, Meng L, Guo C, Zuo N, Dai W, Cong R, Zhang B, Shi W, Hu J, Liang J, Wei S, Zhao Z, Chen J, Qiao X, Li D
Research (Washington, D.C.) 2026;9:1223
Research (Washington, D.C.) 2026;9:1223
ATG16L1 Regulates Reparative Function of Peritoneal Macrophages During Acute Drug-induced Liver Injury.
Wang X, Zhan X, Gao Y, Wang H, Liu Z, Liu M, Lu L, Zhou H
Cellular and molecular gastroenterology and hepatology 2026;20(2):101674
Cellular and molecular gastroenterology and hepatology 2026;20(2):101674
TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma.
Guan B, Tang H, Yuan Z, Yao J, Cui D, Hao Z, Li X
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 21;83(1)
Upregulated ARMCX1 suppresses nasopharyngeal carcinoma progression by promoting TRIM21-mediated β-catenin degradation.
Hu Z, Zhuo E, Guo J, Wu Y, Sun X, Qiu H, Zhou Y, Tan X, Zhang X
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 14;49(1):25
Cellular oncology (Dordrecht, Netherlands) 2026 Jan 14;49(1):25
Therapeutic Potential of Curcumin in Diabetic Cardiomyopathy: Modulation of Pyroptosis Pathways.
Wang F, Liu L, Wang J, Zhou Y, Feng X, Liu K
Cardiovascular drugs and therapy 2026 Feb;40(1):53-64
Cardiovascular drugs and therapy 2026 Feb;40(1):53-64
A TRIM21-UCHL3-ITCH-SIPA1 axis promotes colorectal cancer growth and metastasis.
Lou S, Wang H, Mo G, Li H, Xie H, Huang Y, Li H, Ma K, Zhang X, Yan M, Zhang J, Pi Y, Han P
Cancer letters 2026 Feb 28;639:218221
Cancer letters 2026 Feb 28;639:218221
KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.
Zhang Z, Li Y, Hu J, Tang X, Li Z, Sun X, Feng D, Yao Y, Mao C, Tao Y, Xie L, Luo H, Li Y, Yu X, Peng X, Cong L, Jiang Y
Cell death & disease 2026 Feb 11;17(1):218
Cell death & disease 2026 Feb 11;17(1):218
E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.
Han T, Wen X, Guo Y, Zhao X, Zhang J, Chen Y, Xu F
JCI insight 2026 Apr 8;11(7)
JCI insight 2026 Apr 8;11(7)
FTO-mediated m6A demethylation of TRIM21 regulates macrophage polarization and attenuates myocardial ischemia-reperfusion injury.
Wan Z, Ding Y
Immunologic research 2026 Apr 25;74(1)
Immunologic research 2026 Apr 25;74(1)
Targeting IRF1-TRIM21 axis enhances anti-tumor immunity by promoting ubiquitin-mediated degradation of FGL1 in non-small cell lung cancer.
Zhang Y, Zhou P, Guo Y, Zhang H, Zhao G, Yin J, Ge D, Liu R, Gu J, Zhang C
Communications biology 2026 Apr 22;
Communications biology 2026 Apr 22;
Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (As(3+))-Induced Malignant Transformation by Antagonizing TOX Expression.
Zhang W, Wang Z, Fu Y, Thakur C, Ji H, Bi Z, Qiu Y, Elangbam M, Haley J, Chen F
International journal of biological sciences 2025;21(6):2747-2761
International journal of biological sciences 2025;21(6):2747-2761
Pseudorabies Virus UL41 Hijacks IFN Response via JAK/STAT Pathway While Cellular TRIM21 Blocks it Through K48 Ubiquitination.
Li X, Zheng J, Zhang G, Li P, Dong M, Liu Q, Ren L
Transboundary and emerging diseases 2025;2025:3468674
Transboundary and emerging diseases 2025;2025:3468674
Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production.
Tang W, Chen W, Li N, Li W, Lei Z, Sun W, Xie X, Jiang Y, Chen Y, Xu L, Zhu J, Li Y, Sha J, Dai Y, Zhou S, Chen X, Su C
Frontiers in immunology 2025;16:1684836
Frontiers in immunology 2025;16:1684836
Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies.
Zhang X, Zhu Z, Zhai P, Lv P, Yang Y, Cheng C, Wang B, Fang T, Zhang G, Chi X, Li J, Chen W, Dong Y
Frontiers in immunology 2025;16:1613945
Frontiers in immunology 2025;16:1613945
Hypoxia promotes pancreatic adenocarcinoma progression by stabilizing ID1 via TRIM21 suppression.
Cheng R, Tang Y, Cao X, Huang Z, Guo Y, Jin R, Wang Y, Liu Y, Xue L, Wang Y
Frontiers in oncology 2025;15:1616968
Frontiers in oncology 2025;15:1616968
TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis.
Zhang X, Yao H, Hou Y, Zhou K, Liang Y, Hou L, Zhang X, Wang W, Du L, Yao M, Wang J, Meng X
Cell death discovery 2025 Sep 25;11(1):422
Cell death discovery 2025 Sep 25;11(1):422
IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.
Guo N, Xia Y, He N, Zhang L, Liu J
Inflammation 2025 Oct;48(5):3282-3299
Inflammation 2025 Oct;48(5):3282-3299
KDM1A-driven RNF81 downregulation promotes gastric cancer progression via KLF4 destabilization.
Wang F, Hao P, Pu Y, He X, He Q, Cui H, Jiang S
Oncogene 2025 Oct;44(40):3864-3878
Oncogene 2025 Oct;44(40):3864-3878
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.
Huang H, Shi W, Yan H, Fan L, Lu J, Long Z, Li X, Li J, Wang J, Liu L, Qian J
Autophagy 2025 Oct;21(10):2148-2167
Autophagy 2025 Oct;21(10):2148-2167
CERKL Reduced PI3P/Autophagy to Promote Pancreatic Cancer.
Zeng W, Yang Y, Li W, Pan J, Huang B, Zhang P, Xiao J
Cancer medicine 2025 Nov;14(22):e71402
Cancer medicine 2025 Nov;14(22):e71402
CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair.
Li Y, Cui L, Wang S, Zhao Q, Du F, Du S, Yu C, Xia M, Zhao S, Luan T, Liu Y, Cui B
Cell death & disease 2025 Nov 17;16(1):833
Cell death & disease 2025 Nov 17;16(1):833
Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance.
Zhang J, Chen B, Xu F, Wang R, Zhao X, Yao Z, Zhang J, Zhou S, Xu A, Wu L, Zhao G
Oncogene 2025 May;44(16):1106-1117
Oncogene 2025 May;44(16):1106-1117
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.
Sha N, Zhou B, Hou G, Xi Z, Wang W, Yan M, He J, Zhou Y, Xia Q, Jiang Y, Zhao Q
Oncogene 2025 May;44(16):1078-1092
Oncogene 2025 May;44(16):1078-1092
Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD-MASH Transition by Disrupting Carnitine Biosynthesis.
Lian S, Lu M, Jiajing L, Zhang B, Fang Y, Wang X, Zheng M, Ni Y, Xu G, Yang Y, Jiang R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2410602
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2410602
Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes.
Feng R, Hu L, Yang W, Liang P, Li Y, Tian K, Wang K, Qiu T, Zhang J, Sun X, Yao X
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126101
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126101
UBE2C mediates follicular thyroid carcinoma invasion and metastasis via K29-Specific vimentin ubiquitination.
Xu L, Dai B, Zhang L, Chen W, Rong S, Chen J, Song M, Lan Z, Liu Y, Wang L, Li J, Chen J, Wu Z
Cancer letters 2025 May 1;617:217624
Cancer letters 2025 May 1;617:217624
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65.
Zhang J, Cao Y, Shu W, Dong S, Sun Y, Ma X
Cell biology and toxicology 2025 Mar 5;41(1):55
Cell biology and toxicology 2025 Mar 5;41(1):55
Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy.
Shi J, Zhang Z, Chen HY, Yao Y, Ke S, Yu K, Shi J, Xiao X, He C, Xiang B, Sun Y, Gao M, Xing X, Yu H, Wang X, Yuan WC, Budiarto BR, Chen SY, Zhang T, Lee YR, Zhu H, Zhang J
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Mar 5;33(3):1073-1090
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Mar 5;33(3):1073-1090
RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma.
Zhu J, Wang L, Nie X, Ou S, Shen J, Zhang S, Wu G
Oncogene 2025 Jun;44(21):1620-1633
Oncogene 2025 Jun;44(21):1620-1633
Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma.
Li A, Gong Z, Long Y, Li Y, Liu C, Lu X, Li Q, He X, Lu H, Wu K, Nie Y, Tan J, Ye J, You H
Developmental cell 2025 Jul 21;60(14):1974-1990.e11
Developmental cell 2025 Jul 21;60(14):1974-1990.e11
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Zhang D, Song S, Lin J, Ye T, Yang X, Jiang Q, Mi Y, Zhang M, Ge X, Shen Y, Du P, Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang Y, Gao S, Ye Q
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Platelet NLRP6 protects against microvascular thrombosis in sepsis.
Jiang H, Chen S, Gui X, Li Y, Sun Y, Zhu H, Dai Y, Zhang J, Li X, Ju W, Li Z, Zeng L, Xu K, Qiao J
Blood 2025 Jul 17;146(3):382-395
Blood 2025 Jul 17;146(3):382-395
Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates.
Scemama de Gialluly MA, Allen AR, Hayes EH, Zhuang P, Goldfarb RB, Farrar AN, Fedorov Y, Adams DJ
Nature communications 2025 Jul 16;16(1):6548
Nature communications 2025 Jul 16;16(1):6548
METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3.
Zhan P, Cheng Y, Wu Y, Lu J, Wen J, Chi X, Luo C, Peng Y, Chen X, Wang F, Yin Z, Xie C
NPJ precision oncology 2025 Jul 10;9(1):234
NPJ precision oncology 2025 Jul 10;9(1):234
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization.
Zhang J, Zhan Y, Deng Z, Chen S, Yang R, Zhang Y, Fu H, Huang Q, Wu J, Gu Y, Xie J
Respiratory research 2025 Jul 10;26(1):238
Respiratory research 2025 Jul 10;26(1):238
TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27.
Ramar V, Sidhu RS, Pako O, Cisse CR, Guo AA, Li J, Stapleton K, Guo S, Wang G, Liu M
Cell communication and signaling : CCS 2025 Jul 1;23(1):313
Cell communication and signaling : CCS 2025 Jul 1;23(1):313
Trim21 modulates endoplasmic reticulum-associated degradation and sensitizes cancer cells to ER stress-induced apoptosis by inhibiting VCP/Npl4/UFD1 assembly.
Yuan C, Liao Y, Si W, Huang M, Li D, Wang F, Quan Y, Yu X, Liao S
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167533
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167533
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.
Cao M, Shao Z, Qian X, Chen M, Deng C, Chen X, Tang T, Zhang K, Chu S, Zheng J, Bai J, Li Z
Cell death & disease 2025 Jan 31;16(1):56
Cell death & disease 2025 Jan 31;16(1):56
The UP1 domain is essential for the facilitation effect of HnRNP A1 on PRRSV-2 replication.
Jing H, Liu Y, Peng Z, Duan E, Liu J, Lv Y, Sun Y, Dong W, Li X, Wang J, Cao S, Wang H, Zhang Y, Li H
Virology 2025 Feb;603:110378
Virology 2025 Feb;603:110378
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Cai T, Liang Z, Chen Z, Li Y, Xiao W, Liang W, Xie H, Liu H, Zeng Z, Yang X, Luo S, Zheng X, Zhong K, Huang L, Xiong L, Kang L
Autophagy 2025 Dec;21(12):2982-3003
Autophagy 2025 Dec;21(12):2982-3003
RAB40C recruiting TRIM21 facilitates the progression of hepatocellular carcinoma by stabilizing EGFR.
Wang Y, Yu R, Yan J, Shao L, Zhao J, Xu Q, Wen D, Di X, Dong Z, Dai R, Li H, Zhang S, Jiang H
Cell communication and signaling : CCS 2025 Dec 5;24(1):14
Cell communication and signaling : CCS 2025 Dec 5;24(1):14
TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.
Feng A, He L, Li Z, Wang Z, Sun M, Zhao Z, Zhang Z, Fang K, Wu H, Wang X, Zhang S, Chen Z, Zhang L, Chen T, Xu M
Communications biology 2025 Dec 18;8(1):1783
Communications biology 2025 Dec 18;8(1):1783
Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function.
Yu X, Su N, Luo J, Zhang D, Zhang H, Duan M, Shi N
Veterinary microbiology 2025 Apr;303:110444
Veterinary microbiology 2025 Apr;303:110444
CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression.
Mo J, Su C, Li P, Yang Z, Tao R, Liu Q, Yuan C, Xu L, Ge Q, Ning D, Liang H, Zhu H, Luo Y, Chen X, Chen J, Zhang B
Autophagy 2025 Apr;21(4):840-859
Autophagy 2025 Apr;21(4):840-859
IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression.
Luo X, Xie L, Ma X, Chen N, Xu J, Jiang X, Liu X, Yang Y, Liu T, Yi P, Xu J
Communications biology 2025 Apr 29;8(1):680
Communications biology 2025 Apr 29;8(1):680
RNF26-mediated ubiquitination of TRIM21 promotes bladder cancer progression.
Yao D, Xin F, He X
American journal of cancer research 2024;14(8):4082-4095
American journal of cancer research 2024;14(8):4082-4095
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2.
Liu XM, Wang ZH, Wei QX, Song Y, Ma XX
Biology direct 2024 Sep 6;19(1):78
Biology direct 2024 Sep 6;19(1):78
Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis.
Yang L, Hu C, Chen X, Zhang J, Feng Z, Xiao Y, He W, Cui T, Zhang X, Yang Y, Zhang Y, Yan Y
eLife 2024 Sep 12;13
eLife 2024 Sep 12;13
Chaperonin-containing TCP1 subunit 6A inhibition via TRIM21-mediated K48-linked ubiquitination suppresses triple-negative breast cancer progression through the AKT signalling pathway.
Yang M, Cao J, Liu T, Li B, Wang J, Pan S, Guo D, Tao Z, Hu X
Clinical and translational medicine 2024 Nov;14(11):e70097
Clinical and translational medicine 2024 Nov;14(11):e70097
MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.
Liu J, Wei X, Xie Y, Yan Y, Xue S, Wang X, Chen H, Pan Q, Yan S, Zheng X, Huang Q
Cell death & disease 2024 Nov 14;15(11):825
Cell death & disease 2024 Nov 14;15(11):825
TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway.
Shu B, Zhou Y, Lei G, Peng Y, Ding C, Li Z, He C
Cancer science 2024 May;115(5):1476-1491
Cancer science 2024 May;115(5):1476-1491
The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis.
Zhang R, Zhang D, Han F, Song X, Zhang Y, Zhang J, Zhu Q, Qin Y
Journal of experimental & clinical cancer research : CR 2024 May 4;43(1):135
Journal of experimental & clinical cancer research : CR 2024 May 4;43(1):135
NEK2 contributes to radioresistance in esophageal squamous cell carcinoma by inducing protective autophagy via regulating TRIM21.
Guo D, Zhou S, Liu R, Yao W, Li S, Zhang X, Shen W, Zhu S
Cancer cell international 2024 May 23;24(1):179
Cancer cell international 2024 May 23;24(1):179
Methionine and Leucine Promote mTOR Gene Transcription and Milk Synthesis in Mammary Epithelial Cells through the eEF1Bα-UBR5-ARID1A Signaling.
Qi H, Yu M, Fan X, Zhou Y, Zhang M, Gao X
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Journal of agricultural and food chemistry 2024 May 22;72(20):11733-11745
Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway.
Sun F, Sun Y, Wang X, Zhu J, Chen S, Yu Y, Zhu M, Xu W, Qian H
Bioactive materials 2024 Mar;33:444-459
Bioactive materials 2024 Mar;33:444-459
IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages.
Li D, Wang X, Chen K, Shan D, Cui G, Yuan W, Lin Q, Gimple RC, Dixit D, Lu C, Gu D, You H, Gao J, Li Y, Kang T, Yang J, Yu H, Song K, Shi Z, Fan X, Wu Q, Gao W, Zhu Z, Man J, Wang Q, Lin F, Tao W, Mack SC, Chen Y, Zhang J, Li C, Zhang N, You Y, Qian X, Yang K, Rich JN, Zhang Q, Wang X
Cell death and differentiation 2024 Jun;31(6):738-752
Cell death and differentiation 2024 Jun;31(6):738-752
The MGF300-2R Protein of African Swine Fever Virus Promotes IKKβ Ubiquitination by Recruiting the E3 Ubiquitin Ligase TRIM21.
Lu Z, Luo R, Lan J, Chen S, Qiu HJ, Wang T, Sun Y
Viruses 2024 Jun 12;16(6)
Viruses 2024 Jun 12;16(6)
TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.
Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6
Journal of translational medicine 2024 Jan 2;22(1):6
FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination.
Shi S, Zhang Q, Zhang K, Chen W, Xie H, Pan S, Xue Z, You B, Zhao J, You Y
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):283-301
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):283-301
Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes.
Shi X, Xu J, Zhong X, Qian Y, Lin L, Fang Z, Ye B, Lyu Y, Zhang R, Zheng Z, Han J
Cell communication and signaling : CCS 2024 Dec 18;22(1):593
Cell communication and signaling : CCS 2024 Dec 18;22(1):593
NCAPH, ubiquitinated by TRIM21, promotes cell proliferation by inhibiting autophagy of cervical cancer through AKT/mTOR dependent signaling.
Wang S, Qiao X, Cui Y, Liu L, Cooper T, Hu Y, Lin J, Liu H, Wang M, Hayball J, Wang X
Cell death & disease 2024 Aug 6;15(8):565
Cell death & disease 2024 Aug 6;15(8):565
SERPINH1 modulates apoptosis by inhibiting P62 ubiquitination degradation to promote bone metastasis of prostate cancer.
Tang C, Lai Y, Li L, Situ MY, Li S, Cheng B, Chen Y, Lei Z, Ren Y, Zhou J, Wu Y, Zhong H, Li K, Zeng L, Guo Z, Peng S, Huang H
iScience 2024 Aug 16;27(8):110427
iScience 2024 Aug 16;27(8):110427
PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity.
Sun R, Guo Y, Zhang L, Zhang H, Yin B, Li X, Li C, Yang L, Zhang L, Li Z, Huang J
Virologica Sinica 2024 Apr;39(2):264-276
Virologica Sinica 2024 Apr;39(2):264-276
SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation.
Yuan J, Zhu Z, Zhang P, Ashrafizadeh M, Abd El-Aty AM, Hacımüftüoğlu A, Linnebacher CS, Linnebacher M, Sethi G, Gong P, Zhang X
Cancer letters 2024 Apr 10;587:216733
Cancer letters 2024 Apr 10;587:216733
USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.
Liu Y, Ma J, Lu S, He P, Dong W
Chinese medical journal 2023 Sep 20;136(18):2229-2242
Chinese medical journal 2023 Sep 20;136(18):2229-2242
TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC.
Huang N, Li P, Sun X, Tong L, Dong X, Zhang X, Duan J, Sheng X, Xin H
NPJ breast cancer 2023 Oct 20;9(1):85
NPJ breast cancer 2023 Oct 20;9(1):85
STAT1 suppresses the transcriptional activity of TRIM21 in gastric cancer.
Huo C, Gu Y, Wang D, Zhang X, Tang F, Zhao B, Liu T, He W, Li Y
Journal of cancer research and clinical oncology 2023 Nov;149(17):15335-15348
Journal of cancer research and clinical oncology 2023 Nov;149(17):15335-15348
TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.
Yao Y, Pan L, Wei Y, Feng M, Li X, Sun L, Tang G, Wang Y
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 May;52(5):448-455
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 May;52(5):448-455
UBE2L3 Reduces TRIM21 Expression and IL-1β Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin.
Chen XY, Xu F, Chen JQ, Landeck L, Chen SQ, Zhou Y, Wang Z, Fu NC, Zheng M, Zhang X, Man XY
The Journal of investigative dermatology 2023 May;143(5):822-831.e4
The Journal of investigative dermatology 2023 May;143(5):822-831.e4
TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.
Zhang K, Yang C, Zhou X, Liang J, Guo J, Li M, Zhang Y, Shao S, Sun P, Li K, Huang J, Chen F, Liang X, Su D
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168
HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma.
Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L, Shen L
Cancer letters 2023 May 28;562:216158
Cancer letters 2023 May 28;562:216158
TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury.
Sun X, Huang N, Li P, Dong X, Yang J, Zhang X, Zong WX, Gao S, Xin H
Life sciences 2023 May 15;321:121608
Life sciences 2023 May 15;321:121608
The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer.
Liu J, Zhang C, Xu D, Zhang T, Chang CY, Wang J, Liu J, Zhang L, Haffty BG, Zong WX, Hu W, Feng Z
The Journal of clinical investigation 2023 Mar 15;133(6)
The Journal of clinical investigation 2023 Mar 15;133(6)
TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1.
Lin L, Wang X, Chen Z, Deng T, Yan Y, Dong W, Huang Y, Zhou J
PLoS pathogens 2023 Jun;19(6):e1011472
PLoS pathogens 2023 Jun;19(6):e1011472
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Li J, Xiao X, Ou Y, Cao L, Guo M, Qi C, Wang Z, Liu Y, Shuai Q, Wang H, Sun P, Shi Y, Yang G, Yang S
Cancer communications (London, England) 2023 Jul;43(7):765-787
Cancer communications (London, England) 2023 Jul;43(7):765-787
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y
Autophagy 2023 Jul;19(7):1934-1951
Autophagy 2023 Jul;19(7):1934-1951
UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.
Xiao K, Peng S, Lu J, Zhou T, Hong X, Chen S, Liu G, Li H, Huang J, Chen X, Lin T
Cell death & disease 2023 Jul 8;14(7):408
Cell death & disease 2023 Jul 8;14(7):408
AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner.
Wang L, Li D, Su X, Zhao Y, Huang A, Li H, Li J, Xia W, Jia T, Zhang H, Dong J, Liu X, Shao N
Oncogene 2023 Jan;42(1):62-77
Oncogene 2023 Jan;42(1):62-77
Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).
de Rivero Vaccari JP, Mim C, Hadad R, Cyr B, Stefansdottir TA, Keane RW
Translational research : the journal of laboratory and clinical medicine 2023 Jan;251:27-40
Translational research : the journal of laboratory and clinical medicine 2023 Jan;251:27-40
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity.
Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y
Science advances 2023 Jan 6;9(1):eadd6626
Science advances 2023 Jan 6;9(1):eadd6626
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Mutual regulation between TRIM21 and TRIM8 via K48-linked ubiquitination.
Wang L, Li H, Huang A, Zhao Y, Xiao C, Dong J, Liu X, Shao N
Oncogene 2023 Dec;42(50):3708-3718
Oncogene 2023 Dec;42(50):3708-3718
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.
Hu Q, Xu J, Wang L, Yuan Y, Luo R, Gan M, Wang K, Zhao T, Wang Y, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303535
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303535
UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders.
Lu X, Kong X, Wu H, Hao J, Li S, Gu Z, Zeng X, Shen Y, Wang S, Chen J, Fei X, Sun Y, Li X, Jiang L, Yang F, Wang J, Cai Z
Cell metabolism 2023 Aug 8;35(8):1390-1405.e8
Cell metabolism 2023 Aug 8;35(8):1390-1405.e8
DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer.
Zhang Y, Kong R, Yang W, Hu K, Zhao Z, Li L, Geng X, Liu L, Chen H, Xiao P, Liu D, Luo Y, Chen H, Hu J, Sun B
Cancer letters 2023 Aug 1;568:216288
Cancer letters 2023 Aug 1;568:216288
Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.
Gui Z, Li J, Li J, Li X, Chen L, Ma Z, Tang X, Gong X, Chai X, Lu F, Li M, Ma H, Li X, Ye X
Chemico-biological interactions 2023 Apr 1;374:110408
Chemico-biological interactions 2023 Apr 1;374:110408
Quantitative interactome proteomics identifies a proteostasis network for GABA(A) receptors.
Wang YJ, Di XJ, Mu TW
The Journal of biological chemistry 2022 Oct;298(10):102423
The Journal of biological chemistry 2022 Oct;298(10):102423
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Wen P, Wang H, Li Y, Sui X, Hou Z, Guo X, Xue W, Liu D, Wang Y, Gao J
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
Cell communication and signaling : CCS 2022 Oct 28;20(1):170
Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus.
Gomez-Bañuelos E, Wahadat MJ, Li J, Paz M, Antiochos B, Celia AI, Andrade V, Ferris DP, Goldman DW, Darrah E, Petri M, Andrade F
JCI insight 2022 Oct 10;7(19)
JCI insight 2022 Oct 10;7(19)
Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells.
Zhang J, Gan Y, Li H, Yin J, He X, Lin L, Xu S, Fang Z, Kim BW, Gao L, Ding L, Zhang E, Ma X, Li J, Li L, Xu Y, Horne D, Xu R, Yu H, Gu Y, Huang W
Nature communications 2022 May 20;13(1):2835
Nature communications 2022 May 20;13(1):2835
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Qi H, Wang L, Zhang M, Wang Z, Gao X, Li M
The Journal of nutritional biochemistry 2022 Mar;101:108924
The Journal of nutritional biochemistry 2022 Mar;101:108924
TRIM18 is a critical regulator of viral myocarditis and organ inflammation.
Fang M, Zhang A, Du Y, Lu W, Wang J, Minze LJ, Cox TC, Li XC, Xing J, Zhang Z
Journal of biomedical science 2022 Jul 31;29(1):55
Journal of biomedical science 2022 Jul 31;29(1):55
Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells.
Yang L, Liu X, Zhang L, Li X, Zhang X, Niu G, Ji W, Chen S, Ouyang H, Ren L
Viruses 2022 Jan 15;14(1)
Viruses 2022 Jan 15;14(1)
TRIM21‑a potential biomarker for the prognosis of thyroid cancer.
Wu Z, Wang Y, Yu Z, Meng Z, Duan W, Zhang W, Fang J
Experimental and therapeutic medicine 2022 Dec;24(6):761
Experimental and therapeutic medicine 2022 Dec;24(6):761
Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.
Yao L, Xu L, Zhou L, Wu S, Zou W, Chen M, Chen J, Peng H
Frontiers in cell and developmental biology 2021;9:685913
Frontiers in cell and developmental biology 2021;9:685913
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, Wang Y, Du Z, Peng K, Liu H, Zhang Q, Tang F, Wang P, Gao S, Wang Y, Ding WX, Guo G, Wang F, Zong WX
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3.
Wang Y, Cui S, Xin T, Wang X, Yu H, Chen S, Jiang Y, Gao X, Jiang Y, Guo X, Jia H, Zhu H
Frontiers in cellular and infection microbiology 2021;11:818969
Frontiers in cellular and infection microbiology 2021;11:818969
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA(A) R-Dependent TRIM21 Modulation of Src Expression.
Liu Q, Sheng Z, Cheng C, Zheng H, Lanuti M, Liu R, Wang P, Shen Y, Xie Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2102079
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2102079
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.
Gao L, Xia L, Ji W, Zhang Y, Xia W, Lu S
Translational oncology 2021 Sep;14(9):101148
Translational oncology 2021 Sep;14(9):101148
WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
Zhao Y, Li WF, Li QJ, He SW, He QM, Long LF, Liu N, Ma J
Oral oncology 2021 Nov;122:105576
Oral oncology 2021 Nov;122:105576
Porcine TRIM21 RING-finger E3 ubiquitin ligase is essential for anti-PRRSV activity.
Wei Y, Zeng S, Zou C, Zhang H, Peng O, Xue C, Cao Y
Veterinary microbiology 2021 May;256:109043
Veterinary microbiology 2021 May;256:109043
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein.
Hsu JC, Laurent-Rolle M, Pawlak JB, Wilen CB, Cresswell P
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 15;118(24)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 15;118(24)
Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting.
Jin J, Meng X, Huo Y, Deng H
Cell death & disease 2021 Jul 13;12(7):697
Cell death & disease 2021 Jul 13;12(7):697
Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.
Yang L, Zhang T, Zhang C, Xiao C, Bai X, Wang G
The British journal of dermatology 2021 Jan;184(1):111-122
The British journal of dermatology 2021 Jan;184(1):111-122
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Tan CT, Chang HC, Zhou Q, Yu C, Fu NY, Sabapathy K, Yu VC
EMBO reports 2021 Jan 7;22(1):e50854
EMBO reports 2021 Jan 7;22(1):e50854
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3C(pro).
Xiao H, Li J, Yang X, Li Z, Wang Y, Rui Y, Liu B, Zhang W
Virologica Sinica 2021 Dec;36(6):1363-1374
Virologica Sinica 2021 Dec;36(6):1363-1374
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Li Z, Huan C, Wang H, Liu Y, Liu X, Su X, Yu J, Zhao Z, Yu XF, Zheng B, Zhang W
EMBO reports 2020 Jan 7;21(1):e47528
EMBO reports 2020 Jan 7;21(1):e47528
TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.
Zhang P, Li X, He Q, Zhang L, Song K, Yang X, He Q, Wang Y, Hong X, Ma J, Liu N
Journal of biomedical science 2020 Jan 31;27(1):30
Journal of biomedical science 2020 Jan 31;27(1):30
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Liu XF, Tang CX, Zhang L, Tong SY, Wang Y, Abdulrahman AA, Ji GQ, Gao Y, Gao DS, Zhang BL
Neurochemical research 2020 Dec;45(12):2915-2925
Neurochemical research 2020 Dec;45(12):2915-2925
Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus.
Wei W, Wang Y, Sun Q, Jiang C, Zhu M, Song C, Li C, Du G, Deng Y, Nie H, Tang G
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2020 Apr;49(4):350-356
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2020 Apr;49(4):350-356
TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.
Li L, Wei J, Mallampalli RK, Zhao Y, Zhao J
American journal of respiratory cell and molecular biology 2019 Dec;61(6):776-785
American journal of respiratory cell and molecular biology 2019 Dec;61(6):776-785
Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.
Ahn Y, Hwang JH, Zheng Z, Bang D, Kim DY
Scientific reports 2017 Jun 7;7(1):3018
Scientific reports 2017 Jun 7;7(1):3018
Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.
Fan W, Zhang D, Qian P, Qian S, Wu M, Chen H, Li X
Antiviral research 2016 Mar;127:32-40
Antiviral research 2016 Mar;127:32-40
Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M
The Journal of biological chemistry 2015 Nov 20;290(47):28428-28437
The Journal of biological chemistry 2015 Nov 20;290(47):28428-28437
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 12108-1-AP(TRIM21 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIM21 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIM21. This antibody recognizes human, mouse, rat antigen. The TRIM21 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
