67136-1-Ig

antibody from Proteintech Group

Targeting: TRIM21 RNF81, RO52, SSA1

Provider product page for 67136-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
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Product number: 67136-1-Ig - Provider product page
Provider: Proteintech Group
Product name: TRIM21 antibody
Antibody type: Monoclonal
Description: TRIM21 antibody (Cat. #67136-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1E8B9
Vial size: 20ul, 150ul

TRIM21 protein structure - 67136-1-Ig shown in red.

Submitted references Inhibiting TRIM21 Neddylation Rejuvenates Oocyte Quality in PCOS by Regulating Ubiquitination of CPT1A.

Na X, Liu J, Tan Y, Meng L, Guo C, Zuo N, Dai W, Cong R, Zhang B, Shi W, Hu J, Liang J, Wei S, Zhao Z, Chen J, Qiao X, Li D
Research (Washington, D.C.) 2026;9:1223

Environmental ciprofloxacin triggers pregnancy loss: senescence-driven miscarriage via TRIM21-mediated MFF degradation.

Sun 孙义 Y, Lin 林晏冰 Y, Xing 幸帅帅 S, Huang 黄文欣 W, Wang Y, Guo G, Yan H, Zhao D, Cheng W, Wu Z, Huang C, Zhang Z, Wu 吴琳琳 L, Hou 侯青芝 Q, Zhang 张慧东 H
EBioMedicine 2026 Mar;125:106146

Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.

Tang R, Zhang Z, Liu X, Liao Y, Chen Y, Xiao M, Li Y, Zhou C, Tan Z, Zhang C, Chen C, Rong Z, Liu Y, Li P, Du Q, He Q, Lei Y, Wu Z, Lu S, Xu J, Wang W, Shi S, Yu X
Gastroenterology 2025 Sep;169(4):615-631.e32

IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.

Guo N, Xia Y, He N, Zhang L, Liu J
Inflammation 2025 Oct;48(5):3282-3299

FUT11-Driven fucosylation coordinates K63 ubiquitination of keratin 17 to sustain psoriatic keratinocytes hyperproliferation.

Li X, Li G, Miao H, Yue L, Gao J, Li Q, Shao S, Wang G, Dang E
Cell communication and signaling : CCS 2025 Oct 22;23(1):456

Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway.

Wu F, Liu Q, Zhang J, Xu D, Jiang X, Zhang K, Chen Y, Xia X, Jiang Z, Shi Y, Tu W
Cell death & disease 2025 May 17;16(1):395

TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs.

Wang S, Li Z, Chang Y, He D, Dong K, Cheng X
Scientific reports 2025 May 14;15(1):16731

Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis.

Huang Y, Lu H, Liu Y, Wang J, Xia Q, Shi X, Jin Y, Liang X, Wang W, Ma X, Wang Y, Gong M, Li C, Cang C, Cui Q, Chen C, Shen T, Liu L, Wang X
The EMBO journal 2025 Mar;44(5):1414-1441

Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy.

Shi J, Zhang Z, Chen HY, Yao Y, Ke S, Yu K, Shi J, Xiao X, He C, Xiang B, Sun Y, Gao M, Xing X, Yu H, Wang X, Yuan WC, Budiarto BR, Chen SY, Zhang T, Lee YR, Zhu H, Zhang J
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Mar 5;33(3):1073-1090

LTK deficiency induces macrophage M2 polarization and ameliorates Sjogren's syndrome by reducing chemokine CXCL13.

Feng X, Lu J, Cheng W, Zhao P, Chang X, Wu J
Cytokine 2025 Jun;190:156905

Lactate programs PBX1 lactylation and mesangial proliferation in lupus nephritis.

Liu E, Weng C, Yan C, Zhu X, Li X, Liu M, Wen Z, Liu Z
JCI insight 2025 Jun 9;10(11)

ENC1 Promotes the Malignant Progression and Metastasis by Suppressing TRIM21 Mediated Vimentin Degradation in Wilms Tumor.

Lu Z, Gao H, Huang F, Zhao Z, Chen J, Sun F
Molecular carcinogenesis 2025 Jul;64(7):1182-1194

Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.

Zhang D, Song S, Lin J, Ye T, Yang X, Jiang Q, Mi Y, Zhang M, Ge X, Shen Y, Du P, Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang Y, Gao S, Ye Q
Developmental cell 2025 Jul 21;60(14):1958-1973.e9

Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins.

Jiang H, Wang Y, Wang C, Yang L, Wang S, Wang F, Xue S, Zhang Z, Fu H, Dong T, Yuan J, Li Z, Li K
Cell death & disease 2025 Aug 12;16(1):611

TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury.

Zhang Z, Li Z, Peng Y, Li Z, Xv N, Jin L, Cao Y, Jiang C, Chen Z
Experimental neurology 2024 Nov;381:114916

TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis.

Hao XL, Lv YF, Li DF, Bai FH, Gong J, Pan GQ, Su LX, Wang YL, Fu WL, Liu B, Huang L, Yan D, Tan QL, Liu JY, Guo QN
Journal of translational medicine 2024 Jan 2;22(1):6

E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma.

Li Y, Bao L, Zheng H, Geng M, Chen T, Dai X, Xiao H, Yang L, Mao C, Qiu Y, Xu Y, Wang D, Li MX, Chen Q
Theranostics 2023;13(14):4919-4935

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.

Zhang K, Yang C, Zhou X, Liang J, Guo J, Li M, Zhang Y, Shao S, Sun P, Li K, Huang J, Chen F, Liang X, Su D
Cellular and molecular life sciences : CMLS 2023 May 30;80(6):168

TRIM21 Promotes Rabies Virus Production by Degrading IRF7 through Ubiquitination.

Zhang B, Cai T, He H, Huang X, Chen G, Lai Y, Luo Y, Huang S, Luo J, Guo X
International journal of molecular sciences 2023 Jun 30;24(13)

Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.

Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, Liu Y
Autophagy 2023 Jul;19(7):1934-1951

TRIM21 promotes ubiquitination of SARS-CoV-2 nucleocapsid protein to regulate innate immunity.

Mao S, Cai X, Niu S, Wei J, Jiang N, Deng H, Wang W, Zhang J, Shen S, Ma Y, Wu X, Peng Q, Huang A, Wang D
Journal of medical virology 2023 Apr;95(4):e28719

Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus.

Gomez-Bañuelos E, Wahadat MJ, Li J, Paz M, Antiochos B, Celia AI, Andrade V, Ferris DP, Goldman DW, Darrah E, Petri M, Andrade F
JCI insight 2022 Oct 10;7(19)

RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.

Fu Y, Gao J, Li Y, Yang X, Zhang Y
International immunopharmacology 2022 Feb;103:108414

RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding.

Feng X, Jiang T, Yang C, Pang S, Ding Z, Hu H, Wang H, Dong L, Yang N
Cell death & disease 2021 Dec 17;13(1):6

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