Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B11944 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Human anti-Human DCIR recombinant monoclonal antibody, clone SFB430 [FITC]
- Antibody type
- Monoclonal
- Description
- It recognozes the human dendritic cell immunoreceptor (DCIR) antigen, a single-pass type II membrane protein with a single carbohydrate recognition domain which is also known as C-type lectin domain family 4 member A (CLEC4A) or lectin-like immunoreceptor (LLIR). DCIR is expressed on dendritic cells (DCs), monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. It is mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-\u03b1. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation. Additional information: It displays negligible binding to Fc receptors.
- Reactivity
- Human
- Host
- Human
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- SFB430
- Vial size
- for 100 tests
- Storage
- Store protected from light at 2ÿ8 °C. Do not freeze.
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