20403-1-AP

antibody from Proteintech Group

Targeting: SLC2A3 GLUT3

Provider product page for 20403-1-AP

Western blot

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [58]
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Validations
Western blot [1]

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Product number: 20403-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20403-1-AP, RRID:AB_10694437
Product name: GLUT3 antibody
Antibody type: Polyclonal
Description: GLUT3 antibody (Cat. #20403-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC2A3 protein structure - 20403-1-AP shown in red.

Submitted references Sympathetic nerve-enteroendocrine L cell communication modulates GLP-1 release, brain glucose utilization, and cognitive function.

Ren W, Chen J, Wang W, Li Q, Yin X, Zhuang G, Zhou H, Zeng W
Neuron 2024 Mar 20;112(6):972-990.e8

LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis by Regulating GLUT3.

Huang Y, Wang Y, Zhen Y, Liu W, Wang Y, Wang R, Wang N, Huang S, Yan J, Sun Q
The Journal of investigative dermatology 2024 Jul;144(7):1479-1490.e14

Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer.

Ji T, Fu H, Wang L, Chen J, Tian S, Wang G, Wang L, Wang Z
PLoS genetics 2024 Feb;20(2):e1011176

Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes.

Wu H, Zhang Y, Li Y, Sun S, Zhang J, Xie Q, Dong Y, Zhou S, Sha X, Li K, Chen J, Zhang X, Gao Y, Shen Q, Wang G, Zha X, Duan Z, Tang D, Xu C, Geng H, Lv M, Xu Y, Zhou P, Wei Z, Hua R, Cao Y, Liu M, He X
Science China. Life sciences 2024 Aug;67(8):1697-1714

Effects of down-regulated carbonic anhydrase 8 on cell survival and glucose metabolism in human colorectal cancer cell lines.

Wu CY, Yu JY, Chen YS, Chang HP, Hsieh BY, Lin YH, Ma CY, Tsai SF, Hsieh M
Cell biochemistry and function 2024 Apr;42(3):e4001

GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway.

Ding Y, Wang Z, Zhang Z, You R, Wu Y, Bian T
Respiratory research 2024 Apr 9;25(1):158

Embryonic diapause due to high glucose is related to changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism.

Hong J, Tong H, Wang X, Lv X, He L, Yang X, Wang Y, Xu K, Liang Q, Feng Q, Niu T, Niu X, Lu Y
Frontiers in endocrinology 2023;14:1135837

GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing.

Yu DM, Zhao J, Lee EE, Kim D, Mahapatra R, Rose EK, Zhou Z, Hosler C, El Kurdi A, Choe JY, Abel ED, Hoxhaj G, Westover KD, Cho RJ, Cheng JB, Wang RC
The Journal of clinical investigation 2023 Nov 1;133(21)

16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice.

Béland-Millar A, Kirby A, Truong Y, Ouellette J, Yandiev S, Bouyakdan K, Pileggi C, Naz S, Yin M, Carrier M, Kotchetkov P, St-Pierre MK, Tremblay MÈ, Courchet J, Harper ME, Alquier T, Messier C, Shuhendler AJ, Lacoste B
Cell reports 2023 May 30;42(5):112485

Ubiquitin-like protein MNSFβ regulates glycolysis and promotes cell proliferation with HSC70 assistance.

Nakamura M, Yamasaki K, Kono M
Biochemistry and biophysics reports 2023 Mar;33:101414

Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice.

Han S, He Z, Hu X, Li X, Zheng K, Huang Y, Xiao P, Xie Q, Ni J, Liu Q
Antioxidants (Basel, Switzerland) 2023 Mar 15;12(3)

The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression.

Yan B, Li X, Peng M, Zuo Y, Wang Y, Liu P, Ren W, Jin X
Experimental & molecular medicine 2023 Jun;55(6):1145-1158

Proteomic analysis reveals the potential positive effects of Mito-TEMPO on ram sperm motility and fertility during cryopreservation.

Shi L, Shi J, Feng J, Zhang P, Ren Y
Theriogenology 2023 Jul 15;205:27-39

Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.

Han S, Zhang H, Liu X, Wen F, Li B, Bie Z, Qiu H, Hu J
Ecotoxicology and environmental safety 2023 Jul 1;259:115063

Caffeic acid phenethyl ester inhibits MDA-MB-231 cell proliferation in inflammatory microenvironment by suppressing glycolysis and lipid metabolism.

Wu Q, Li J, Hao S, Guo Y, Li Z, Liu Z, Xuan H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115766

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells.

Hou Y, Zhang X, Yao H, Hou L, Zhang Q, Tao E, Zhu X, Jiang S, Ren Y, Hong X, Lu S, Leng X, Xie Y, Gao Y, Liang Y, Zhong T, Long B, Fang JY, Meng X
EMBO reports 2023 Apr 5;24(4):e56325

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc.

Johnston SN, Silagi ES, Madhu V, Nguyen DH, Shapiro IM, Risbud MV
JCI insight 2023 Apr 24;8(8)

Scavenging Reactive Oxygen Species Decreases Amyloid-β Levels via Activation of PI3K/Akt/GLUT1 Pathway in N2a/APP695swe Cells.

Peng Y, Zhang L, Zhou F, Wang Y, Zhang X, Fan J, Li S, Li X, Li Y
Journal of Alzheimer's disease : JAD 2022;90(1):185-198

Inhibition of hypoxia-inducible factor 1 by acriflavine renders glioblastoma sensitive for photodynamic therapy.

Ma S, Wang F, Dong J, Wang N, Tao S, Du J, Hu S
Journal of photochemistry and photobiology. B, Biology 2022 Sep;234:112537

A viral interferon regulatory factor degrades RNA-binding protein hnRNP Q1 to enhance aerobic glycolysis via recruiting E3 ubiquitin ligase KLHL3 and decaying GDPD1 mRNA.

Qi X, Yan Q, Shang Y, Zhao R, Ding X, Gao SJ, Li W, Lu C
Cell death and differentiation 2022 Nov;29(11):2233-2246

Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.

Liu X, Li N, Zhang C, Wu X, Zhang S, Dong G, Liu G
Translational oncology 2022 May;19:101389

GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors.

Ryniawec JM, Coope MR, Loertscher E, Bageerathan V, de Oliveira Pessoa D, Warfel NA, Cress AE, Padi M, Rogers GC
Diagnostics (Basel, Switzerland) 2022 Mar 10;12(3)

Angiopoietin-like 4 promotes glucose metabolism by regulating glucose transporter expression in colorectal cancer.

Mizuno S, Seishima R, Yamasaki J, Hattori K, Ogiri M, Matsui S, Shigeta K, Okabayashi K, Nagano O, Li L, Kitagawa Y
Journal of cancer research and clinical oncology 2022 Jun;148(6):1351-1361

CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.

Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, Bai B, Gu S, Zhao W, Zhan Q
Molecular cancer 2022 Jun 30;21(1):140

Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells.

Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH, Ding C
Autophagy 2022 Jul;18(7):1503-1521

Ginsenoside Rg3 inhibits angiogenesis in gastric precancerous lesions through downregulation of Glut1 and Glut4.

Zeng Z, Nian Q, Chen N, Zhao M, Zheng Q, Zhang G, Zhao Z, Chen Y, Wang J, Zeng J, Gong D, Tang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112086

Dependence of glucose transport on autophagy and GAPDH activity.

Craven RJ, Frazier HN, Thibault O
Brain research 2022 Feb 1;1776:147747

Altered glucose metabolism and its association with carbonic anhydrase 8 in Machado-Joseph Disease.

Lin GY, Ma CY, Kuo LC, Hsieh BY, Wang H, Liu CS, Hsieh M
Metabolic brain disease 2022 Aug;37(6):2103-2120

Metformin alleviates the cognitive impairment caused by aluminum by improving energy metabolism disorders in mice.

Song Y, Liu Z, Zhu X, Hao C, Hao W, Wu S, Yang J, Lu X, Jin C
Biochemical pharmacology 2022 Aug;202:115140

Gestational Diabetes Mellitus-Associated Hyperglycemia Impairs Glucose Transporter 3 Trafficking in Trophoblasts Through the Downregulation of AMP-Activated Protein Kinase.

Zhang L, Yu X, Wu Y, Fu H, Xu P, Zheng Y, Wen L, Yang X, Zhang F, Hu M, Wang H, Liu X, Qiao J, Peng C, Gao R, Saffery R, Fu Y, Qi H, Tong C, Kilby MD, Baker PN
Frontiers in cell and developmental biology 2021;9:722024

A Prognosis Marker SLC2A3 Correlates With EMT and Immune Signature in Colorectal Cancer.

Gao H, Liang J, Duan J, Chen L, Li H, Zhen T, Zhang F, Dong Y, Shi H, Han A
Frontiers in oncology 2021;11:638099

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism.

Ge X, Zuo Y, Xie J, Li X, Li Y, Thirupathi A, Yu P, Gao G, Zhou C, Chang Y, Shi Z
Aging 2021 Sep 21;13(18):22375-22389

In vitro fertilization causes excessive glycogen accumulation in mouse placenta.

Dong J, Guo X, Qian C, Wang J, Lei H, Chen S, Wang X
Placenta 2021 Oct;114:29-38

Identification and validation of a hypoxia-related prognostic and immune microenvironment signature in bladder cancer.

Sun X, Zhou Z, Zhang Y, Wang J, Zhao X, Jin L, Zhai T, Liu X, Zhang J, Mei W, Zhang B, Luo M, Yao X, Ye L
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The novel prognostic risk factor STC2 can regulate the occurrence and progression of osteosarcoma via the glycolytic pathway.

Yu B, Zhang F, Liu L, Liang Y, Tang X, Peng Y, Cai F, Zeng D, Yuan X, Li J, Guo Y, Lv B, Wang M, Liao Q, Lv XB
Biochemical and biophysical research communications 2021 May 21;554:25-32

Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal.

Ito A, Nasako H, Akizuki R, Takashina Y, Eguchi H, Matsunaga T, Yoshino Y, Endo S, Ikari A
International journal of molecular sciences 2021 Jun 19;22(12)

Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells.

Zhang Y, Tang Y, Luo Y, Luo L, Shen F, Huang Z
Toxicology and applied pharmacology 2021 Aug 15;425:115606

YAP promotes the proliferation and migration of colorectal cancer cells through the Glut3/AMPK signaling pathway.

Jiang L, Zhang J, Xu Q, Wang B, Yao Y, Sun L, Wang X, Zhou D, Gao L, Song S, Zhu X
Oncology letters 2021 Apr;21(4):312

Effects of canagliflozin on growth and metabolic reprograming in hepatocellular carcinoma cells: Multi-omics analysis of metabolomics and absolute quantification proteomics (iMPAQT).

Nakano D, Kawaguchi T, Iwamoto H, Hayakawa M, Koga H, Torimura T
PloS one 2020;15(4):e0232283

Molecular mechanisms underlying altered neurobehavioural development of female offspring of mothers with polycystic ovary syndrome: FOS-mediated regulation of neurotrophins in placenta.

Wang F, Xie N, Zhou J, Dai M, Zhang Q, Hardiman PJ, Qu F
EBioMedicine 2020 Oct;60:102993

Effect of Zhenxin Xingshui Yizhi Fang on Aβ(25-35) induced expression of related transporters in HBMEC cell model.

Wu L, Zheng Q, Guo YY, Zhang KN, Luo J, Xiao S, Li WJ, Yang M
Journal of ethnopharmacology 2020 Oct 5;260:112783

Human herpesvirus 6A promotes glycolysis in infected T cells by activation of mTOR signaling.

Wu Z, Jia J, Xu X, Xu M, Peng G, Ma J, Jiang X, Yao J, Yao K, Li L, Tang H
PLoS pathogens 2020 Jun;16(6):e1008568

The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming.

Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M, Ye D
Cell reports 2020 Jul 14;32(2):107877

Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α.

Lee YZ, Guo HC, Zhao GH, Yang CW, Chang HY, Yang RB, Chen L, Lee SJ
Pharmacological research 2020 Feb;152:104581

Wnt1-inducible signaling protein 1 regulates laryngeal squamous cell carcinoma glycolysis and chemoresistance via the YAP1/TEAD1/GLUT1 pathway.

Wang L, Sun J, Gao P, Su K, Wu H, Li J, Lou W
Journal of cellular physiology 2019 Sep;234(9):15941-15950

Ginsenoside compound K ameliorates Alzheimer's disease in HT22 cells by adjusting energy metabolism.

Chen X, Li H, Yang Q, Lan X, Wang J, Cao Z, Shi X, Li J, Kan M, Qu X, Li N
Molecular biology reports 2019 Oct;46(5):5323-5332

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.

Huang X, Gan G, Wang X, Xu T, Xie W
Autophagy 2019 Jul;15(7):1258-1279

Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria.

Han X, Zhang Y, Guo J, You Y, Zhan J, Huang W
Journal of food science 2019 Dec;84(12):3815-3824

Up-regulated miR-29c inhibits cell proliferation and glycolysis by inhibiting SLC2A3 expression in prostate cancer.

Li J, Fu F, Wan X, Huang S, Wu D, Li Y
Gene 2018 Jul 30;665:26-34

CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.

Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.

Cheng L, Jin Y, Liu M, Ruan M, Chen L
Oncotarget 2017 Mar 21;8(12):19843-19854

Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction.

Xu P, Wu Z, Xi Y, Wang L
Toxicology 2016 Nov 30;372:34-41

Insulin signaling disruption in male mice due to perinatal bisphenol A exposure: Role of insulin signaling in the brain.

Fang F, Gao Y, Wang T, Chen D, Liu J, Qian W, Cheng J, Gao R, Wang J, Xiao H
Toxicology letters 2016 Mar 14;245:59-67

Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice.

Li J, Wang Y, Fang F, Chen D, Gao Y, Liu J, Gao R, Wang J, Xiao H
Environmental toxicology and pharmacology 2016 Apr;43:7-12

Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹⁸F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors.

Cho MH, Park CK, Park M, Kim WK, Cho A, Kim H
PloS one 2015;10(10):e0141413

Human brain proteins showing neuron-specific interactions with γ-secretase.

Inoue M, Hur JY, Kihara T, Teranishi Y, Yamamoto NG, Ishikawa T, Wiehager B, Winblad B, Tjernberg LO, Schedin-Weiss S
The FEBS journal 2015 Jul;282(14):2587-99

Effects of Bisphenol A on glucose homeostasis and brain insulin signaling pathways in male mice.

Fang F, Chen D, Yu P, Qian W, Zhou J, Liu J, Gao R, Wang J, Xiao H
General and comparative endocrinology 2015 Feb 1;212:44-50

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, Zhang H
Cell reports 2014 Sep 25;8(6):1930-1942

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GLUT3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human GLUT3. This antibody recognizes human, mouse antigen. The GLUT3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 20403-1-AP.pdf

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