20299-1-AP

antibody from Proteintech Group

Targeting: SLC6A8 CRTR, CT1

Provider product page for 20299-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 20299-1-AP - Provider product page
Provider: Proteintech Group
Product name: SLC6A8 antibody
Antibody type: Polyclonal
Description: SLC6A8 antibody (Cat. #20299-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC6A8 protein structure - 20299-1-AP shown in red.

Submitted references Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma.

Bao W, Yu Y, Yu G, Chen J, Li Y, Hai Y
Journal of cancer research and clinical oncology 2026 Mar 5;152(3)

Glioblastoma exploits ATP from leading-edge astrocytes to fuel its infiltrative growth revealed by spatially resolved chimeric analysis.

Yang G, Niu X, Gan J, Yu T, Li M, Xiao P, Zhang R, He P, Yang Y, Cui Y, Huang X, Wang Y, Mao Q, Zhou R
Science advances 2025 Sep 26;11(39):eadv5673

Effect of rumen-protected guanidinoacetic acid provision as a dietary supplement on the growth, slaughter performance, and meat quality in simmental bulls.

Zhang J, Xue C, Lang J, Pei C, Liu Q
Meat science 2025 Oct;228:109889

Creatine Supplementation Enhances Fat Graft Survival by Mitochondrial Protection and Revascularization Promotion.

Zhang MC, Zhu YZ, Wu S, Wu HY, Pei SJ, Zeng XH, Peng Y, Ding Y, Yi YY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e70969

Optically controllable nanoregulators enable tumor-specific pro-ferroptosis lipometabolic reprogramming for in-situ adjuvant-free vaccination.

Li M, Li Y, Yao X, Liu Y, Cai K, Yang H, Luo Z
Biomaterials 2025 Jun;317:123096

In Situ Delivery of Gasdermin E mRNA Promotes Antitumor Immunity via Creatine-Elicited Type I Interferon Signaling in Monocytes.

Li H, Lu J, Tan S, Jiang T, He X, Qiao W, Hu C, Dalangood S, Lin J, Gui J
Cancer immunology research 2025 Jun 4;13(6):939-956

Multi-omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma.

Staaf J, Ehinger D, Brunnström H, Jönsson M, Rosengren F, Kotevska M, Karlsson A, Aine M, Frezza C, Planck M, Arbajian E
Molecular oncology 2025 Dec;19(12):3806-3820

Strategically engineered Au(I) complexes for orchestrated tumor eradication via chemo-phototherapy and induced immunogenic cell death.

Feng N, Peng Z, Zhang X, Lin Y, Hu L, Zheng L, Tang BZ, Zhang J
Nature communications 2024 Sep 18;15(1):8187

Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway.

Bao Y, Qiao J, Gong W, Zhang R, Zhou Y, Xie Y, Xie Y, He J, Yin T
Acta pharmaceutica Sinica. B 2024 Oct;14(10):4461-4477

Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP.

Chen S, Ma X, Liu Y, Zhong Z, Wei C, Li M, Zhu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(38):e2403517

Lysosome Targeted Nanoparticle Aggregation Reverses Immunosuppressive Tumor Microenvironment for Cancer Immunotherapy.

Xing Y, Yang J, Peng A, Qian Y, Liu Y, Pan P, Liu Q
Advanced materials (Deerfield Beach, Fla.) 2024 Nov;36(47):e2412730

Intestinal Epithelial Creatine Transporter SLC6A8 Dysregulation in Inflammation and in Response to Adherent Invasive E. coli Infection.

Sawant H, Selvaraj R, Manogaran P, Borthakur A
International journal of molecular sciences 2024 Jun 13;25(12)

Self-Delivery Nanobooster to Enhance Immunogenic Cell Death for Cancer Chemoimmunotherapy.

Yan C, Zhao Y, Liu X, Jiang Y, Li Q, Yang L, Li X, Luo K
ACS applied materials & interfaces 2024 Jul 3;16(26):33169-33181

Myeloid cell-derived creatine in the hypoxic niche promotes glioblastoma growth.

Rashidi A, Billingham LK, Zolp A, Chia TY, Silvers C, Katz JL, Park CH, Delay S, Boland L, Geng Y, Markwell SM, Dmello C, Arrieta VA, Zilinger K, Jacob IM, Lopez-Rosas A, Hou D, Castro B, Steffens AM, McCortney K, Walshon JP, Flowers MS, Lin H, Wang H, Zhao J, Sonabend A, Zhang P, Ahmed AU, Brat DJ, Heiland DH, Lee-Chang C, Lesniak MS, Chandel NS, Miska J
Cell metabolism 2024 Jan 2;36(1):62-77.e8

Synergizing autophagic cell death and oxaliplatin-induced immunogenic death by a self-delivery micelle for enhanced tumor immunotherapy.

Deng T, Chen D, Chen F, Xu C, Zhang Q, Li M, Wang Y, He Z, Li M, He Q
Acta biomaterialia 2024 Dec;190:548-559

A manganese-oxide nano-rambutan as the intrinsic modifier for hypericin delivery and triple-negative breast cancer treatment.

Zhou W, Fan T, Yan Y, Chen Y, Ma X, Yang T, Xiang G, Lu Y
International journal of pharmaceutics 2024 Dec 5;666:124824

CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport.

Tian C, Yuan H, Lu Y, He H, Li Q, Li S, Yang J, Wang M, Xu R, Liu Q, Xiang M
Oncoimmunology 2023;12(1):2204015

Resveratrol alleviates DSS-induced IBD in mice by regulating the intestinal microbiota-macrophage-arginine metabolism axis.

Xu X, Ocansey DKW, Pei B, Zhang Y, Wang N, Wang Z, Mao F
European journal of medical research 2023 Sep 2;28(1):319

Thymidine kinase 1 as a target is regulated by the hsa-let-7b-5p/LINC00665 axis and affects NSCLC prognosis.

Zhu XD, Fan YF, Zhao Y, Song XY, Liu XS, Gao ZJ, Yuan K
Heliyon 2023 Nov;9(11):e21328

SLC6A8 is a Potential Biomarker for Poor Prognosis in Lung Adenocarcinoma.

Fan Y, Zhou Y, Lou M, Gao Z, Li X, Yuan K
Frontiers in genetics 2022;13:845373

Long Non-Coding RNA AL513318.2 as ceRNA Binding to hsa-miR-26a-5p Upregulates SLC6A8 Expression and Predicts Poor Prognosis in Non-Small Lung Cancer.

Fan Y, Zhou Y, Li X, Lou M, Gao Z, Tong J, Yuan K
Frontiers in oncology 2022;12:781903

SLC6A8 is involved in the progression of non-small cell lung cancer through the Notch signaling pathway.

Feng Y, Guo X, Tang H
Annals of translational medicine 2021 Feb;9(3):264

SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells.

Yuan L, Wu XJ, Li WC, Zhuo C, Xu Z, Tan C, Ma R, Wang J, Pu J
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820983029

Artepillin C, a Key Component of Brazilian Propolis, Induces Thermogenesis in Inguinal White Adipose Tissue of Mice through a Creatine-Metabolism-Related Thermogenic Pathway.

Nishikawa S, Hydo T, Aoyama H, Miyata R, Kumazawa S, Tsuda T
Journal of agricultural and food chemistry 2020 Jan 29;68(4):1007-1014

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SLC6A8 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SLC6A8. This antibody recognizes human antigen. The SLC6A8 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 20299-1-AP.pdf

: Show more