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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- AB-209-NA - Provider product page
- Provider
- R&D Systems
- Product name
- Human IL-9 Antibody
- Antibody type
- Polyclonal
- Description
- Protein A or G purified. Detects human IL-9 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 20% cross-reactivity with recombinant mouse IL-9 is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P15248- Isotype
- IgG
- Vial size
- 1 mg
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis.
Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells.
Liu J, Harberts E, Tammaro A, Girardi N, Filler RB, Fishelevich R, Temann A, Licona-Limón P, Girardi M, Flavell RA, Gaspari AA
The Journal of investigative dermatology 2014 Jul;134(7):1903-1911
The Journal of investigative dermatology 2014 Jul;134(7):1903-1911
Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells.
Qiu L, Lai R, Lin Q, Lau E, Thomazy DM, Calame D, Ford RJ, Kwak LW, Kirken RA, Amin HM
Blood 2006 Oct 1;108(7):2407-15
Blood 2006 Oct 1;108(7):2407-15
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by IL-9 and Neutralization by Human IL-9 Antibody. Recombinant Human IL-9 (Catalog # 209-IL) stimulates proliferation in the MO7e human megakaryocytic leukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-9 (5 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-9 Polyclonal Antibody (Catalog # AB-209-NA). The ND50 is typically 20-40 µg/mL.
