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Learn20987-1-AP
antibody from Proteintech Group
Targeting: TRPV4
CMT2C, OTRPC4, TRP12, VR-OAC, VRL-2, VROAC
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 20987-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20987-1-AP, RRID:AB_10926386
- Product name
- TRPV4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRPV4 antibody (Cat. #20987-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references High humidity and NO(2) co-exposure exacerbates allergic asthma by increasing oxidative stress, inflammatory and TRP protein expressions in lung tissue.
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma.
Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice.
TET1-TRPV4 Signaling Contributes to Bone Cancer Pain in Rats.
The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea.
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Decrease in AQP4 expression level in atrophied skeletal muscles with innervation.
TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model.
Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice.
Significance of transient receptor potential vanilloid 4 and aquaporin 5 co-expression in the rat uterus at term.
The mechanosensitive ion channel TRPV4 is a regulator of lung development and pulmonary vasculature stabilization.
Expressions of TRPVs in the cholesteatoma epithelium.
Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.
Lu C, Liu Q, Qiao Z, Yang X, Baghani AN, Wang F
Environmental pollution (Barking, Essex : 1987) 2024 Jul 15;353:124127
Environmental pollution (Barking, Essex : 1987) 2024 Jul 15;353:124127
HC067047 Ameliorates Sepsis-associated Encephalopathy by Suppressing Endoplasmic Reticulum Stress and Oxidative Stress-Induced Pyroptosis in the Hippocampi of Mice.
Zhong X, Wang Y, Liu D, Liang Y, Liu W, Huang Y, Xie L, Cao W, Xu Y, Chen L
Neuroscience 2023 May 1;517:117-127
Neuroscience 2023 May 1;517:117-127
Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma.
Liu J, Guo Y, Zhang R, Xu Y, Luo C, Wang R, Xu S, Wei L
Cell death & disease 2023 Jun 28;14(6):379
Cell death & disease 2023 Jun 28;14(6):379
Hyperactivation of TRPV4 causes the hippocampal pyroptosis pathway and results in cognitive impairment in LPS-treated mice.
Guo D, Xu Y, Wang Y, Zhong X, Liu Z, Li S, Xu X, Zhang J, Xiong T, Cao W, Liang J
Behavioural brain research 2023 Feb 15;439:114223
Behavioural brain research 2023 Feb 15;439:114223
TET1-TRPV4 Signaling Contributes to Bone Cancer Pain in Rats.
Xu ZH, Niu Z, Liu Y, Liu PL, Lin XL, Zhang L, Chen L, Song Y, Sun R, Zhang HL
Brain sciences 2023 Apr 10;13(4)
Brain sciences 2023 Apr 10;13(4)
The temperature-sensitive receptors TRPV4 and TRPM8 have important roles in the pruritus of rosacea.
Zhou X, Su Y, Wu S, Wang H, Jiang R, Jiang X
Journal of dermatological science 2022 Nov;108(2):68-76
Journal of dermatological science 2022 Nov;108(2):68-76
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606
Autophagy 2021 Nov;17(11):3592-3606
Decrease in AQP4 expression level in atrophied skeletal muscles with innervation.
Ishido M, Yoshikado T
Physiological reports 2021 May;9(9):e14856
Physiological reports 2021 May;9(9):e14856
TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model.
Li W, Xu Y, Liu Z, Shi M, Zhang Y, Deng Y, Zhong X, Chen L, He J, Zeng J, Luo M, Cao W, Wan W
Neuropharmacology 2021 Dec 15;201:108834
Neuropharmacology 2021 Dec 15;201:108834
Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice.
Duan J, Xie J, Deng T, Xie X, Liu H, Li B, Chen M
Environmental pollution (Barking, Essex : 1987) 2020 Jan;256:113375
Environmental pollution (Barking, Essex : 1987) 2020 Jan;256:113375
Significance of transient receptor potential vanilloid 4 and aquaporin 5 co-expression in the rat uterus at term.
Ducza E, Csányi A, Szőke É, Pohóczky K, Hajagos-Tóth J, Kothencz A, Tiszai Z, Gáspár R
Heliyon 2019 Oct;5(10):e02697
Heliyon 2019 Oct;5(10):e02697
The mechanosensitive ion channel TRPV4 is a regulator of lung development and pulmonary vasculature stabilization.
Morgan JT, Stewart WG, McKee RA, Gleghorn JP
Cellular and molecular bioengineering 2018 Oct;11(5):309-320
Cellular and molecular bioengineering 2018 Oct;11(5):309-320
Expressions of TRPVs in the cholesteatoma epithelium.
Do BH, Koizumi H, Ohbuchi T, Kawaguchi R, Suzuki H
Acta oto-laryngologica 2017 Oct;137(10):1039-1045
Acta oto-laryngologica 2017 Oct;137(10):1039-1045
Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.
Ahmad F, Chung YW, Tang Y, Hockman SC, Liu S, Khan Y, Huo K, Billings E, Amar MJ, Remaley AT, Manganiello VC
Scientific reports 2016 Jun 20;6:28056
Scientific reports 2016 Jun 20;6:28056
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 20987-1-AP(TRPV4 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRPV4 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TRPV4. This antibody recognizes human,mouse,rat antigen. The TRPV4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
