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- References [12]
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- Western blot [2]
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- Product number
- NB100-165 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-165, RRID:AB_10000763
- Product name
- Rabbit Polyclonal XRCC3 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Drosophila, Hamster
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization.
Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity.
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.
The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction.
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C.
Role for RAD18 in homologous recombination in DT40 cells.
XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells.
Pae J, Cinalli RM, Marzio A, Pagano M, Lehmann R
Developmental cell 2017 Jul 24;42(2):130-142.e7
Developmental cell 2017 Jul 24;42(2):130-142.e7
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Parplys AC, Zhao W, Sharma N, Groesser T, Liang F, Maranon DG, Leung SG, Grundt K, Dray E, Idate R, Østvold AC, Schild D, Sung P, Wiese C
Nucleic acids research 2015 Nov 16;43(20):9817-34
Nucleic acids research 2015 Nov 16;43(20):9817-34
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
Park JY, Singh TR, Nassar N, Zhang F, Freund M, Hanenberg H, Meetei AR, Andreassen PR
Oncogene 2014 Oct 2;33(40):4803-12
Oncogene 2014 Oct 2;33(40):4803-12
Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization.
Girard PM, Graindorge D, Smirnova V, Rigolet P, Francesconi S, Scanlon S, Sage E
PloS one 2013;8(10):e75751
PloS one 2013;8(10):e75751
Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity.
Huang JW, Wang Y, Dhillon KK, Calses P, Villegas E, Mitchell PS, Tewari M, Kemp CJ, Taniguchi T
Molecular cancer research : MCR 2013 Dec;11(12):1564-73
Molecular cancer research : MCR 2013 Dec;11(12):1564-73
Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
Nicolay NH, Carter R, Hatch SB, Schultz N, Prevo R, McKenna WG, Helleday T, Sharma RA
Carcinogenesis 2012 Nov;33(11):2026-34
Carcinogenesis 2012 Nov;33(11):2026-34
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.
Al-Minawi AZ, Lee YF, Håkansson D, Johansson F, Lundin C, Saleh-Gohari N, Schultz N, Jenssen D, Bryant HE, Meuth M, Hinz JM, Helleday T
Nucleic acids research 2009 Oct;37(19):6400-13
Nucleic acids research 2009 Oct;37(19):6400-13
The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction.
Katsura M, Tsuruga T, Date O, Yoshihara T, Ishida M, Tomoda Y, Okajima M, Takaku M, Kurumizaka H, Kinomura A, Mishima HK, Miyagawa K
Nucleic acids research 2009 Jul;37(12):3959-68
Nucleic acids research 2009 Jul;37(12):3959-68
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Compton SA, Choi JH, Cesare AJ, Ozgür S, Griffith JD
Cancer research 2007 Feb 15;67(4):1513-9
Cancer research 2007 Feb 15;67(4):1513-9
Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C.
Nagaraju G, Odate S, Xie A, Scully R
Molecular and cellular biology 2006 Nov;26(21):8075-86
Molecular and cellular biology 2006 Nov;26(21):8075-86
Role for RAD18 in homologous recombination in DT40 cells.
Szüts D, Simpson LJ, Kabani S, Yamazoe M, Sale JE
Molecular and cellular biology 2006 Nov;26(21):8032-41
Molecular and cellular biology 2006 Nov;26(21):8032-41
XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells.
Yoshihara T, Ishida M, Kinomura A, Katsura M, Tsuruga T, Tashiro S, Asahara T, Miyagawa K
The EMBO journal 2004 Feb 11;23(3):670-80
The EMBO journal 2004 Feb 11;23(3):670-80
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: XRCC3 Antibody [NB100-165] - Detection of XRCC3 (38 kDa) from HeLa cell extract using NB100-165 (1:2500). Lanes 1 and 2 contain HTC116 and Hela whole cell extracts, respectively.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: XRCC3 Antibody [NB100-165] - (A) Human XRCC3 (hXRCC3) expression was down regulated by siRNA in human transofrmed fibroblasts. (B) XRCC3 was inactivated in human colon cancer cells by gene targeting [Yoshihara et all., 2004, EMBO J., 23 (3), 670-680]. hXRCC3 was detected by WB using XRCC3 antibody (NB100-165). The star indicates non-specific cross-reactivity of the antibody. Image provided by confirmed customer review.
