66335-1-Ig

antibody from Proteintech Group

Targeting: NUDT21 CFIM25, CPSF5

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66335-1-Ig

Provider

Proteintech Group

Product name

NUDT21 antibody

Antibody type

Monoclonal

Description

NUDT21 antibody (Cat. #66335-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1C4C8

Vial size

20ul, 150ul

References

Submitted references

Mycobacterium tuberculosis modulates NUDT21-mediated alternative polyadenylation to enhance FTH1 expression in macrophages and promotes intracellular growth.

Liu X, Cai N, Dai Y, Chen X, Zeng X
Frontiers in cellular and infection microbiology 2025;15:1578163

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Loss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAness.

Goldthorpe M, Hou J, Nadendla A, Osmanbeyoglu HU, Hwang HW
bioRxiv : the preprint server for biology 2025 Oct 21;

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Sustainability of shear stress conditioning in endothelial colony-forming cells compared to human aortic endothelial cells to underline suitability for tissue-engineered vascular grafts.

Renzelmann J, Heene S, Jonczyk R, Krüger J, Alnajjar S, Blume C
Microvascular research 2025 Jan;157:104746

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CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells.

Tietz KT, McCluskey BM, Miller CR, Li Y, Munro SA, Dehm SM
Cell reports 2025 Jan 28;44(1):115211

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E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages.

Lu X, Liu C, Wu R, Hu Z, Liu S, Li X, Liu Y, Li M, Liang J, Huang Y, Han Y, Ou X, Deng K, Liang C, Chen S, Fu Y, Xu A
Cell reports 2025 Feb 25;44(2):115276

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TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation.

Wei S, Huang X, Zhu Q, Chen T, Zhang Y, Tian J, Pan T, Zhang L, Xie T, Zhang Q, Kuang X, Lei E, Li Y
Cell death and differentiation 2024 Nov;31(11):1422-1438

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HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells.

Guedán A, Burley M, Caroe ER, Bishop KN
Viruses 2024 Apr 25;16(5)

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LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.

Zhang N, Liu X, Huang L, Zeng J, Ma C, Han L, Li W, Yu J, Yang M
Cell reports 2023 Dec 26;42(12):113479

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U1 snRNP proteins promote proximal alternative polyadenylation sites by directly interacting with 3' end processing core factors.

Hu Z, Li M, Huo Z, Chen L, Liu S, Deng K, Lu X, Chen S, Fu Y, Xu A
Journal of molecular cell biology 2022 Dec 26;14(8)

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A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.

Yang SW, Li L, Connelly JP, Porter SN, Kodali K, Gan H, Park JM, Tacer KF, Tillman H, Peng J, Pruett-Miller SM, Li W, Potts PR
Molecular cell 2020 Mar 19;77(6):1206-1221.e7