orb385897

antibody from Biorbyt
Targeting: FSCN1 FLJ38511, p55, SNL
Provider product page for orb385897
Western blot
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
orb385897 - Provider product page
Provider
Biorbyt
Product name
Fascin Antibody
Antibody type
Monoclonal
Description
Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin's disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
FAN55-1
Vial size
20 ug
Storage
Store the Fascin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
FSCN1 protein structure - orb385897 shown in red.