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- Antigen structure
- References [244]
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- Product number
- 20886-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- AIFM2/ FSP1 antibody
- Antibody type
- Polyclonal
- Description
- AIFM2/ FSP1 antibody (Cat. #20886-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: Synergistic crosstalk between glucose homeostasis disruption and NADH/FSP1/COQ10 axis-driven ferroptosis.
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1.
Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells.
Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3.
RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.
Salidroside represses ovarian cancer progression by targeting FSP1-dependent ferroptosis.
Liproxstatin-1 Attenuates Retinal Ischemia-Reperfusion Injury by Suppressing EGR1-Mediated Ferroptosis.
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.
Repurposing the hERG activator NS-1643 as a ferroptosis-targeting therapeutic against doxorubicin cardiotoxicity.
Momordin Ic targets SREBP1 to disrupt lipid homeostasis and trigger synergistic apoptosis-ferroptosis in triple-negative breast cancer.
Targeting FSP1 triggers ferroptosis in lung cancer.
Lymph node environment drives FSP1 targetability in metastasizing melanoma.
Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.
Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition.
The origin of hepatocellular carcinoma depends on metabolic zonation.
Targeting mitochondrial phosphatase PGAM5 alleviates ferroptosis and acute pancreatitis by upregulating NRF2-mediated FSP1 expression.
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
Arsenic exposure reduces testosterone synthesis partially by evoking Leydig cell ferroptosis in mouse testes.
NUPR1 and LCN2: Potential Therapeutic Targets for Colorectal Cancer Via Modulating Cell Viability, Migration, and Ferroptosis-Related Pathways.
Bio-inspired spatiotemporal cascade reaction liposome for ferroptosis treatment following subarachnoid hemorrhage.
CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.
Sal-hDPSCs Transplantation Alleviates Hypoxic-Ischaemic Ferroptosis in Neonatal Rats Via the FSP1-CoQ(10) Axis.
Downregulation of SELENOS Suppresses the Progression of Renal Cell Carcinoma by Activating Ferroptosis.
Alpha-ketoglutarate alleviates Cadmium-induced ferroptosis in association with enhanced mitochondrial function in testes.
Deficiency in beclin1 alleviates doxorubicin-induced liver injury through inhibiting ferroptosis and autophagy.
Inhibition of iron overload and ferroptosis attenuates sepsis-induced myocardial injury in mice through STAT3/Lcn2 pathway.
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.
Vitamin K(2) Protects Against Glucocorticoid-Induced Osteoporosis by Activating the NRF2/FSP1 Pathway to Inhibit Osteoblast Ferroptosis.
Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy.
MFN2-a multifaceted guardian against Parkinson's pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.
The mutualistic relationship between M2c macrophages of TGFβ1 induction and gastric cancer cells: the correlation between protective mechanisms in the tumor microenvironment and polarization of subtypes of cells.
Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer.
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma.
Design, synthesis and biological evaluation of triazolothiadiazole derivatives as FSP1 inhibitors for sensitizing cancer cells to ferroptosis.
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer.
Acute cadmium exposure damaged granulosa cell structure and blocked oocyte maturation via ferroptosis caused by intracellular iron overload and oxidative stress in mice.
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
Deubiquitination by USP7 Stabilizes JunD and Activates AIFM2 (FSP1) to Inhibit Ferroptosis in Melanoma.
8-Hydroxy-2-Anilino-1,4-Naphthoquinone Prevents Against Ferroptotic Neuronal Death and Kainate-Induced Epileptic Seizures.
Apigenin Alleviates Fumonisin B1-Induced Hepatotoxicity by Suppressing Ferroptosis through the Nrf2/FSP1 Pathway.
Gut microbiota-bile acid metabolic disorder involved in the cognitive impairments in epilepsy through HO-1 dependent ferroptosis.
Suppressor of cytokine signaling 6 (SOCS6) mediates ubiquitination degradation of SLC7A11 to drive ferroptosis and block lipid metabolism in ovarian cancer cells.
The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis.
Active-targeting biomimetic nanosystem for prostate cancer enhances radiotherapy efficacy by inducing ferroptosis.
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
ALKBH5-mediated RNA N6-methyladenosine demethylation protects against myocardial I/R-induced injury via FSP1-dependent inhibition of ferroptosis.
L-Tetrahydropalmatine synergizes cytotoxic CD8(+) T mediated antitumor and ferroptosis in gastric cancer.
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance.
Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma.
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.
FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in Chronic Obstructive Pulmonary Disease.
Effects of extreme heat exposure on heatstroke and liver injury in mice: The role of PPARα.
GPX4-dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement.
ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1.
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma.
Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer.
Upregulated FSP1 by GPD1/1L mediated lipid droplet accumulation enhances ferroptosis resistance and peritoneal metastasis in gastric cancer.
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.
Heshuxiaoji pill suppresses steatohepatitis and fibrosis by regulating the AngII-BACH1 mediated vasoconstriction.
A CoQ10 analog ameliorates cognitive impairment and early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation.
CD36 promotes iron accumulation and dysfunction in CD8+ T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma.
The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein.
Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice.
NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis.
TBBPA-BDBPE induces ferroptosis in trophoblasts through chaperone-mediated autophagy of GPX4.
NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation.
Nuclear receptor subfamily 1 group D member 2 induces chemoresistance in ovarian cancer by regulating ferroptosis and immune infiltration.
SLC10A3 regulates ferroptosis of glioblastoma through the STAT3/GPX4 pathway.
Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition.
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis.
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
Temsirolimus inhibits FSP1 enzyme activity to induce ferroptosis and restrain liver cancer progression.
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.
Comprehensive Analysis Reveals Midnolin as a Potential Prognostic, Therapeutic, and Immunological Cancer Biomarker.
Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis.
Exploring Liraglutide's mechanism in reducing renal fibrosis: the Fsp1-CoQ10-NAD(P)H pathway.
AKRs confer oligodendrocytes resistance to differentiation-stimulated ferroptosis.
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis.
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia.
Development and Validation of a New Prediction Criteria for Neoadjuvant Chemotherapy Response in Locally Advanced Gastric Cancer Based on Ferroptosis-Related Biomarkers.
S100A4 regulates ferroptosis to suppress cell proliferation via the SLC7A11-GSH axis but facilitates Brucella infection in RAW264.7 macrophages.
Knockdown of TFB2M induces ferroptosis in lung adenocarcinoma via mitophagy-mediated GPX4 degradation.
EIF4A3-induced circFAT1 promotes high glucose-induced podocyte damage via miR-30e-5p/SOX4 axis.
LncPEDS1-AS promotes UTUC resistance to lipid peroxidation by regulating PEDS1 expression via DDX23.
Targeting the MIR4435-2HG/miR-29c-3p/FSP1 axis overcomes lenvatinib resistance by inducing ferroptosis in hepatocellular carcinoma.
Salidroside alleviates senile osteoporosis in SAMP8 mice by inhibiting the ferroptosis of bone marrow stromal cells via PI3K/AKT/mTOR signaling pathway.
The Nrf2/GPX4 antioxidant pathway suppresses ferroptosis to protect against hearing impairment in cochlear ischemia-reperfusion injury.
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
miR-134-3p Deficiency-Induced Methionine Metabolism Promotes Fibrosis via SLC25A33 in OSF.
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.
Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis.
FSP1 and CoQ10 have the potential to serve as biomarkers for severe preeclampsia.
Downregulation of Mg(2+) Efflux Protein CNNM3 Predicts Poor Prognosis but Enhances Ferroptosis Sensitivity in Kidney Renal Clear Cell Carcinoma via NCOA4-Mediated Ferritinophagy.
Targeting FSP1 triggers ferroptosis in lung cancer.
Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in TSC2-Deficient and Cancer Cells.
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury.
Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation.
Stress-mediated Activation of Ferroptosis, Pyroptosis, and Apoptosis Following Mild Traumatic Brain Injury Exacerbates Neurological Dysfunctions.
Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome.
Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis.
FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.
PDK4-mediated Nrf2 inactivation contributes to oxidative stress and diabetic kidney injury.
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism.
Cancer-associated fibroblast-derived exosome Leptin promotes malignant biological lineage in pancreatic ductal adenocarcinoma by regulating ABL2 via miR-224-3p.
Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator.
Engineering Biodegradable Hollow Silica/Iron Composite Nanozymes for Breast Tumor Treatment through Activation of the "Ferroptosis Storm".
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis.
Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.
FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy.
Tellurium-Doped Bioactive Glass Induces Ferroptosis in Osteosarcoma Cells Regardless of FSP1.
Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.
Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.
Short-term respiratory cadmium exposure partially activates pulmonary NLRP3 inflammasome by inducing ferroptosis in mice.
A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.
TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy.
New Treatment Modalities for Colorectal Cancer Through Simultaneous Suppression of FSP1 and GPX4.
Comprehensive cognition of yak (Bos grunniens) AIFM2 gene and its anti-ferroptosis role in bisphenol A-induced fetal fibroblast model.
Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice.
Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo/YAP signaling pathway.
Angiotensin II depends on hippo/YAP signaling to reprogram angiogenesis and promote liver fibrosis.
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury.
MT1G promotes iron autophagy and inhibits the function of gastric cancer cell lines by intervening in GPX4/SQSTM1.
Brucella Manipulates Host Cell Ferroptosis to Facilitate Its Intracellular Replication and Egress in RAW264.7 Macrophages.
Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis.
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells.
Fatal COVID-19 pulmonary disease involves ferroptosis.
Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance.
Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway.
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry.
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
Pitavastatin induces autophagy-dependent ferroptosis in MDA-MB-231 cells via the mevalonate pathway.
Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Ciprofloxacin is a novel anti-ferroptotic antibiotic.
Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis.
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells.
N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.
Dissecting cell death pathways in fed-batch bioreactors.
Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction.
CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury.
Inhibition of FSP1 impairs early embryo developmental competence in pigs.
Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis.
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
FSP1 is a predictive biomarker of osteosarcoma cells' susceptibility to ferroptotic cell death and a potential therapeutic target.
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury.
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.
CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury.
Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury.
MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway.
REV-ERBα inhibitor rescues MPTP/MPP(+)-induced ferroptosis of dopaminergic neuron through regulating FASN/SCD1 signaling pathway.
Alkaliptosis induction counteracts paclitaxel-resistant ovarian cancer cells via ATP6V0D1-mediated ABCB1 inhibition.
Ubiquitin-specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling.
Levosimendan Reverses Cardiac Malfunction and Cardiomyocyte Ferroptosis During Heart Failure with Preserved Ejection Fraction via Connexin 43 Signaling Activation.
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.
STC2 suppresses triple-negative breast cancer migration and invasion by inhibition on EMT and promotion on cell apoptosis.
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.
Biomineralization-Tuned Nanounits Reprogram the Signal Transducer and Activator of Transcription 3 Signaling for Ferroptosis-Immunotherapy in Cancer Stem Cells.
MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1.
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
Neuron-targeted liposomal coenzyme Q10 attenuates neuronal ferroptosis after subarachnoid hemorrhage by activating the ferroptosis suppressor protein 1/coenzyme Q10 system.
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling.
Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line.
Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer.
SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy.
Structural insights into FSP1 catalysis and ferroptosis inhibition.
ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions.
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma.
Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis.
The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.
Targeting ferroptosis by poly(acrylic) acid coated Mn(3)O(4) nanoparticles alleviates acute liver injury.
Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications.
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.
Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.
Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.
Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells.
Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.
A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2.
Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.
Bone Marrow-Derived Mesenchymal Stem Cells Transplantation Attenuates Renal Fibrosis Following Acute Kidney Injury in Rats by Diminishing Pericyte-Myofibroblast Transition and Extracellular Matrix Augment.
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.
Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.
Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage.
Dexpramipexole Attenuates White Matter Injury to Facilitate Locomotion and Motor Coordination Recovery via Reducing Ferroptosis after Intracerebral Hemorrhage.
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro.
Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells.
HOIP modulates the stability of GPx4 by linear ubiquitination.
SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling.
CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis.
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents.
The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.
Farrerol alleviates collagenase-induced tendinopathy by inhibiting ferroptosis in rats.
Abrogation of ARF6 in promoting erastin-induced ferroptosis and mitigating capecitabine resistance in gastric cancer cells.
LncRNA LINC00961 regulates endothelial‑mesenchymal transition via the PTEN‑PI3K‑AKT pathway.
Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.
Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction.
RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner.
Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.
Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.
LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination.
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.
Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice.
Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.
Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.
Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects.
Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells.
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Impact of Wortmannilactone F and G31P on Clonorchis Sinensis-infected mice.
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition.
Chen H, Dai X, Xiong Z, Cao H, Xing C, Li H, Gao X, Hu M, Yang F
International journal of biological sciences 2026;22(1):43-59
International journal of biological sciences 2026;22(1):43-59
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1.
Wu T, Wu X, Cai J, Tang CY, Wang XF, Zeng MY, Liu YT, Tang Y, Liu ZW, Meng W, Duan SB
Autophagy 2026 May;22(5):1081-1096
Autophagy 2026 May;22(5):1081-1096
Liquiritigenin targets transferrin receptor to potentiate ferroptosis sensitivity in colorectal cancer cells.
Li R, Song C, Jia T, Xia T, Guo M, Wang Q, Yao Y, Xu X, Bao X, Yang P, Li Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158057
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158057
Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3.
Luo N, Xiao Y, Zhai Y, Li J, Lv L, Yin H, Lin F, Wan B, Zhang K, Hu J, Liu J, Dang Y, He Y, Zhao Y, Zhang Z, Nie S, Yuan HX
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1510-1529
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1510-1529
RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.
Zhao J, Wang L, Shao N, Qu Y, Chen W, Sun H
Histology and histopathology 2026 Mar 6;:25056
Histology and histopathology 2026 Mar 6;:25056
Salidroside represses ovarian cancer progression by targeting FSP1-dependent ferroptosis.
Hua T, Wu X, Liu W, Jia Z, Ma Y, Li L, Zhu X, Muhetaer M, Wang X, Tuerxun M, Zhang C, Wang W, Abulaite A, Ma F
Journal of ovarian research 2026 Mar 27;19(1)
Journal of ovarian research 2026 Mar 27;19(1)
Liproxstatin-1 Attenuates Retinal Ischemia-Reperfusion Injury by Suppressing EGR1-Mediated Ferroptosis.
Huang W, Dong Y, Zhou X, Lin H, Yao J, Wu Z, Tam WI, Tan Y, Zuo C, Lin M
Antioxidants (Basel, Switzerland) 2026 Mar 19;15(3)
Antioxidants (Basel, Switzerland) 2026 Mar 19;15(3)
CXCL12 Promotes Peripheral Nerve Injury Repair by Inhibiting the Ferroptosis-Inflammation Axis via the ERK/Nrf2 Pathway.
Yuan Y, Jiang Y, Du S, Yuan G, Yang Z, Wang P
Inflammation 2026 Mar 12;49(1)
Inflammation 2026 Mar 12;49(1)
AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling.
Liu C, Hu C, Cheng J, Xin D, Jin S, Tian W, Li S, Jin Y, Liu Y, Wu W, Hao S, Ren H, Dai X, Liu L, Ruan J, Fang W, Bao X, Xin S, Zhao P
Journal for immunotherapy of cancer 2026 Mar 10;14(3)
Journal for immunotherapy of cancer 2026 Mar 10;14(3)
Repurposing the hERG activator NS-1643 as a ferroptosis-targeting therapeutic against doxorubicin cardiotoxicity.
Sheng XH, Teng LS, Wang XH, Jiang LQ, Sun XC, Mao JL, Zhang L
Free radical biology & medicine 2026 Jun;249:14-26
Free radical biology & medicine 2026 Jun;249:14-26
Momordin Ic targets SREBP1 to disrupt lipid homeostasis and trigger synergistic apoptosis-ferroptosis in triple-negative breast cancer.
Cheng Y, Shi YZ, Zheng JY, Liu YB, Chen YT, Bao JX, He XY, Chen JQ, Li Q, Dai XX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158190
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158190
Targeting FSP1 triggers ferroptosis in lung cancer.
Wu K, Vaughan AJ, Bossowski JP, Hao Y, Ziogou A, Kim SM, Kim TH, Nakamura MN, Pillai R, Mancini M, Rajalingam S, Han M, Nakamura T, Wang L, Chung S, Simeone D, Shackelford D, Kang YP, Conrad M, Papagiannakopoulos T
Nature 2026 Jan;649(8096):487-495
Nature 2026 Jan;649(8096):487-495
Lymph node environment drives FSP1 targetability in metastasizing melanoma.
Palma M, Chaufan M, Breuer CB, Müller S, Sabatier M, Fraser CS, Szylo KJ, Yavari M, Carmona A, Kaur M, Melo LMN, Cansiz F, Monge-Lorenzo J, Flores M, Mishima E, Nakamura T, Proneth B, Labrado M, Liang Y, Cayting N, Zheng L, Cañeque T, Colombeau L, Wahida A, Friedmann Angeli JP, Tasdogan A, Hui S, Rodriguez R, Conrad M, Reticker-Flynn NE, Ubellacker JM
Nature 2026 Jan;649(8096):477-486
Nature 2026 Jan;649(8096):477-486
Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.
Yu C, Zhang T, Yuan J, Su Y, Zhang H, Xu L, Li X, Cui J, Xu R, Zhou Y, Huang H, Zhou X, Zhou Y, Zhang E
Cancer cell international 2026 Jan 6;26(1):64
Cancer cell international 2026 Jan 6;26(1):64
Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition.
Bi T, Chen L, Wang T, Miao W, Zhai S, Huang R, Sun Q, Chen Y, Su H, Zhou J, Li R, Huang W, Yao X, Luo P, Liu Z
Journal of nanobiotechnology 2026 Jan 30;24(1)
Journal of nanobiotechnology 2026 Jan 30;24(1)
The origin of hepatocellular carcinoma depends on metabolic zonation.
Guo J, Liang R, Chung A, Li Z, Li B, Chen E, Li L, Wang J, Hsieh MH, Fang IX, Kroger B, Wang Y, Zhu M, Ren X, Mannino G, Jia Y, Wei Y, Moore S, Siegwart DJ, Chung SS, Wang Z, Sharma T, Komjeti S, Han Y, Gopal P, Xiao G, Wang T, Zhu H
Science (New York, N.Y.) 2026 Jan 29;391(6784):eadv7129
Science (New York, N.Y.) 2026 Jan 29;391(6784):eadv7129
Targeting mitochondrial phosphatase PGAM5 alleviates ferroptosis and acute pancreatitis by upregulating NRF2-mediated FSP1 expression.
Ma S, Qin J, Luan J, Hou G, He J, Gao M
Cell death & disease 2026 Feb 21;17(1)
Cell death & disease 2026 Feb 21;17(1)
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
Zhu L, He C, Shi H, Shao G, Sun L
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
Arsenic exposure reduces testosterone synthesis partially by evoking Leydig cell ferroptosis in mouse testes.
Zhang XY, Luo Y, Liang NN, Li QS, Zhang ZH, Huang YC, Xu DX
Environmental pollution (Barking, Essex : 1987) 2026 Feb 1;390:127547
Environmental pollution (Barking, Essex : 1987) 2026 Feb 1;390:127547
NUPR1 and LCN2: Potential Therapeutic Targets for Colorectal Cancer Via Modulating Cell Viability, Migration, and Ferroptosis-Related Pathways.
Luo D, Luo X, Qian S, Liu J
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70809
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70809
Bio-inspired spatiotemporal cascade reaction liposome for ferroptosis treatment following subarachnoid hemorrhage.
Peng Z, Li XJ, Xi YL, Zhu XL, Lu Y, Zhou Y, Yan HY, Wang J, Yang ZM, Hang CH, Ding YN, Wang JL, Li W
Materials today. Bio 2026 Apr;37:102979
Materials today. Bio 2026 Apr;37:102979
CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.
Zhou H, Fu W, Liu S, Zhang Z, Luo H, Zhong Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e02239
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e02239
Sal-hDPSCs Transplantation Alleviates Hypoxic-Ischaemic Ferroptosis in Neonatal Rats Via the FSP1-CoQ(10) Axis.
Xu K, Li Y, Gao S, Fang X, Zhang X, Zhang X, Wang F, Wang X
International dental journal 2026 Apr 29;76(4):109573
International dental journal 2026 Apr 29;76(4):109573
Downregulation of SELENOS Suppresses the Progression of Renal Cell Carcinoma by Activating Ferroptosis.
Li Q, Wu Y, Xu Y, Shi H, Xu J, Xu S
Biological trace element research 2026 Apr 22;
Biological trace element research 2026 Apr 22;
Alpha-ketoglutarate alleviates Cadmium-induced ferroptosis in association with enhanced mitochondrial function in testes.
Wang X, Dong W, Zhao J, Chen N, Zheng T, Liu Y, Li Q, Ye H, Li H, Xie L
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr 16;143:109249
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr 16;143:109249
Deficiency in beclin1 alleviates doxorubicin-induced liver injury through inhibiting ferroptosis and autophagy.
Zhang L, He Y, Zhao A, Han H, Li Y, Li L, Zhang Y, Gao Q, Ye H
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 15;1274:124971
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 15;1274:124971
Inhibition of iron overload and ferroptosis attenuates sepsis-induced myocardial injury in mice through STAT3/Lcn2 pathway.
Huang Y, Zhang L, Wang Y, He Y, Du R, Yun Q, Gao Q, Ye H
Journal of cardiothoracic surgery 2026 Apr 15;
Journal of cardiothoracic surgery 2026 Apr 15;
Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells.
Dai X, Xu Z, Lv X, Li C, Jiang R, Wang D, Xi M, Li T
International journal of biological sciences 2025;21(2):874-892
International journal of biological sciences 2025;21(2):874-892
Vitamin K(2) Protects Against Glucocorticoid-Induced Osteoporosis by Activating the NRF2/FSP1 Pathway to Inhibit Osteoblast Ferroptosis.
Zhang Z, Rong X, Ren Q, Kou Y, Guo J, Li M
Drug design, development and therapy 2025;19:11525-11545
Drug design, development and therapy 2025;19:11525-11545
Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy.
Ma J, Ding L, Zang X, Yang Y, Zhang W, Li X, Zhao D, Zhang Z, Wang Z, Zhao L, Tong X
Journal of inflammation research 2025;18:8447-8475
Journal of inflammation research 2025;18:8447-8475
MFN2-a multifaceted guardian against Parkinson's pathophysiology: mitochondria, ferroptosis, inflammation and oxidative stress.
Cheng Y, Zhai H, Liu Y, Yang Y, Fang B, Song M, Wang X, Zhong P
Frontiers in aging neuroscience 2025;17:1611958
Frontiers in aging neuroscience 2025;17:1611958
The mutualistic relationship between M2c macrophages of TGFβ1 induction and gastric cancer cells: the correlation between protective mechanisms in the tumor microenvironment and polarization of subtypes of cells.
Meng K, Song J, Qi F, Li J, Fang Z, Song L, Shi S
Journal of Cancer 2025;16(5):1598-1617
Journal of Cancer 2025;16(5):1598-1617
Targeting GJB4 to inhibit tumor growth and induce ferroptosis in pancreatic cancer.
Zheng X, Li W, Li X, Yao Q, Zheng L, Fan R, Bie P
Frontiers in oncology 2025;15:1585236
Frontiers in oncology 2025;15:1585236
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Lan J, Zhang W, Zeng K, Li C, He J, Li X, Yang R, Chi J, Hong Z, Wang W, Zhou C, Xiao B, Fan W, Lin J, Ou Q, Fang Y, Pan Z, Peng J, Li W, Wu X
Clinical and translational medicine 2025 Sep;15(9):e70438
Clinical and translational medicine 2025 Sep;15(9):e70438
USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma.
Zhang D, Wang X, Lu S, Gao Y, Zhu G, Li G, Yu Z, Hou J, Yan H, Yuan W, Zhang X, Hung MC, Liu Z, Liu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e12271
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e12271
Design, synthesis and biological evaluation of triazolothiadiazole derivatives as FSP1 inhibitors for sensitizing cancer cells to ferroptosis.
Liu W, Xie X, Zong H, Li Y, Ding Y, Liu Z, Wan B, Xiao T, Lv F, Tang C, Yu L, Wang P, Lai Z
European journal of medicinal chemistry 2025 Sep 5;293:117737
European journal of medicinal chemistry 2025 Sep 5;293:117737
SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer.
Zhou X, Wang G, Wu Y, Wu M, Zhai X, Tian C, Prochownik EV, Jiang C, Li Y
Cell reports 2025 Sep 23;44(9):116139
Cell reports 2025 Sep 23;44(9):116139
Acute cadmium exposure damaged granulosa cell structure and blocked oocyte maturation via ferroptosis caused by intracellular iron overload and oxidative stress in mice.
Wu M, Li W, He M, Jiang J, Shi H, Huang Y, Xu D, Zhang J
Ecotoxicology and environmental safety 2025 Sep 15;303:118851
Ecotoxicology and environmental safety 2025 Sep 15;303:118851
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
Chen J, Peng W, Yang W, You Z, Zou Y
Experimental eye research 2025 Oct;259:110531
Experimental eye research 2025 Oct;259:110531
Deubiquitination by USP7 Stabilizes JunD and Activates AIFM2 (FSP1) to Inhibit Ferroptosis in Melanoma.
Xie J, Ma C, Zhao S, Wu D, Zhang P, Tang Q, Ni T, Yan W, Qi M
The Journal of investigative dermatology 2025 Oct;145(10):2562-2575.e5
The Journal of investigative dermatology 2025 Oct;145(10):2562-2575.e5
8-Hydroxy-2-Anilino-1,4-Naphthoquinone Prevents Against Ferroptotic Neuronal Death and Kainate-Induced Epileptic Seizures.
Lee D, Na EJ, Heo Y, Yu J, Kim HJ
Pharmaceutics 2025 Oct 31;17(11)
Pharmaceutics 2025 Oct 31;17(11)
Apigenin Alleviates Fumonisin B1-Induced Hepatotoxicity by Suppressing Ferroptosis through the Nrf2/FSP1 Pathway.
Zhou J, Li Y, Xi C, Pan W, Yu Q, Wu Z
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26999-27011
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26999-27011
Gut microbiota-bile acid metabolic disorder involved in the cognitive impairments in epilepsy through HO-1 dependent ferroptosis.
Li X, Ji J, Li J, Li S, Luo Q, Gu M, Yin X, Zhang M, Fan H, Yao R
Journal of pharmaceutical analysis 2025 Nov;15(11):101291
Journal of pharmaceutical analysis 2025 Nov;15(11):101291
Suppressor of cytokine signaling 6 (SOCS6) mediates ubiquitination degradation of SLC7A11 to drive ferroptosis and block lipid metabolism in ovarian cancer cells.
Fan Y, Suo Y
Gene 2025 Nov 5;971:149819
Gene 2025 Nov 5;971:149819
The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis.
Yao L, Yan J, Gan L, Zheng L, Liu P, Lei L, Huang Y
Hereditas 2025 Nov 4;162(1):223
Hereditas 2025 Nov 4;162(1):223
Active-targeting biomimetic nanosystem for prostate cancer enhances radiotherapy efficacy by inducing ferroptosis.
Hu Z, Li H, Gan K, Li Y, Jiang Y, Zhang K, Li Z, Zhou Y, Lu T, Xu C, Liu S, He L, Yang F, Jiang J, Song H, Wang Y, Guo L, Shi C, Wen W, Han D, Qin W
Journal of nanobiotechnology 2025 Nov 30;24(1):9
Journal of nanobiotechnology 2025 Nov 30;24(1):9
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
Zhang GY, Zhang F, Xie LP, Han X, Wang ZX, Wang WL, Peng Y, Xu HL, Xu T, Pang MJ, Liu B, Wang D, Zhou YC, Wu YT
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
ALKBH5-mediated RNA N6-methyladenosine demethylation protects against myocardial I/R-induced injury via FSP1-dependent inhibition of ferroptosis.
Tian Z, Zhou J, Kuang L, Wang L, Hua H, Tan W, Hua Y, Yan H, Liu Z, Wen T
Journal of molecular histology 2025 Nov 24;57(1):5
Journal of molecular histology 2025 Nov 24;57(1):5
L-Tetrahydropalmatine synergizes cytotoxic CD8(+) T mediated antitumor and ferroptosis in gastric cancer.
Zhou L, Wei Y, Lin K, Lu Y
Cell death discovery 2025 Nov 24;11(1):541
Cell death discovery 2025 Nov 24;11(1):541
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance.
Ye L, Zhu J, Wang X, Chen N, Sun Y, Zeng X, Liu S, Yan S
Journal of nanobiotechnology 2025 Nov 19;23(1):722
Journal of nanobiotechnology 2025 Nov 19;23(1):722
Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma.
Tang C, He C, Wang D, Guo J, Yin X, Ye H, Wu L, Zhang Y, Zeng S, Zeng X, Liu C, Chen J, Fang C
Nature communications 2025 Nov 18;16(1):10096
Nature communications 2025 Nov 18;16(1):10096
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury.
Teng LS, Ying ZD, Sun XH, Hou HC, Qiu SD, Liu P, Li KJ, Zhang L, Sheng XH
Chemico-biological interactions 2025 Nov 1;421:111724
Chemico-biological interactions 2025 Nov 1;421:111724
FSP1 Acts in Parallel with GPX4 to Inhibit Ferroptosis in Chronic Obstructive Pulmonary Disease.
Yang Y, Shen W, Zhang Z, Dai Y, Zhang Z, Liu T, Yu J, Huang S, Ding Y, You R, Wang Z, Wu Y, Bian T
American journal of respiratory cell and molecular biology 2025 May;72(5):551-562
American journal of respiratory cell and molecular biology 2025 May;72(5):551-562
Effects of extreme heat exposure on heatstroke and liver injury in mice: The role of PPARα.
Zhang G, Zhao L, Wang J, Wang K, Ji X, Hu R, Hou T, Zhang L, Li R, Sun Q, Zhang K, Liu C
Environmental health perspectives 2025 May 30;
Environmental health perspectives 2025 May 30;
GPX4-dependent ferroptosis sensitivity is a fitness trade-off for cell enlargement.
Chan KY, Yu Y, Kong Y, Cheng L, Yao R, Yin Chair PS, Wang P, Wang R, Sun WY, He RR, Min J, Wang F, Björklund M
iScience 2025 May 16;28(5):112363
iScience 2025 May 16;28(5):112363
ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1.
Yang JS, Morris AJ, Kamizaki K, Chen J, Stark J, Oldham WM, Nakamura T, Mishima E, Loscalzo J, Minami Y, Conrad M, Henry WS, Hsu VW
Cell 2025 May 15;188(10):2569-2585.e20
Cell 2025 May 15;188(10):2569-2585.e20
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Li W, Han J, Huang B, Xu T, Wan Y, Luo D, Kong W, Yu Y, Zhang L, Nian Y, Chu B, Yin C
The EMBO journal 2025 Mar;44(6):1641-1662
The EMBO journal 2025 Mar;44(6):1641-1662
Targeting YBX1-m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma.
Li O, An K, Wang H, Li X, Wang Y, Huang L, Du Y, Qin N, Dong J, Wei J, Sun R, Shi Y, Guo Y, Sun X, Yang Y, Yang YG, Kan Q, Tian X
Clinical and translational medicine 2025 Mar;15(3):e70270
Clinical and translational medicine 2025 Mar;15(3):e70270
Ubiquinol-mediated suppression of mitochondria-associated ferroptosis is a targetable function of lactate dehydrogenase B in cancer.
Deng H, Zhao L, Ge H, Gao Y, Fu Y, Lin Y, Masoodi M, Losmanova T, Medová M, Ott J, Su M, Wang W, Peng RW, Dorn P, Marti TM
Nature communications 2025 Mar 16;16(1):2597
Nature communications 2025 Mar 16;16(1):2597
Upregulated FSP1 by GPD1/1L mediated lipid droplet accumulation enhances ferroptosis resistance and peritoneal metastasis in gastric cancer.
Lin G, Liu Q, Xie C, Ding K, Mo G, Zeng L, Zhang F, Liu R, Lu L, Hong W, Mao Y, Su H, Li S
Cell communication and signaling : CCS 2025 Mar 12;23(1):132
Cell communication and signaling : CCS 2025 Mar 12;23(1):132
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury.
Zhuang X, Shi S, Liu S, Jiao Y, Huang B, Yang Y, Yang L, Yang X, Wang H, Liang C, Song D, Yu H, Zou D, Sun Q, Yang S, Yin C, Li J, Liu Y, Min J, Wang F, Nian Y, Du L, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(23):e2500566
Heshuxiaoji pill suppresses steatohepatitis and fibrosis by regulating the AngII-BACH1 mediated vasoconstriction.
Pu Y, Ren W, Gan Z, Wang S, Peng M, Yue R, Huang R
Journal of ethnopharmacology 2025 Jun 26;350:119989
Journal of ethnopharmacology 2025 Jun 26;350:119989
A CoQ10 analog ameliorates cognitive impairment and early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation.
Chen J, Shi Z, Chen Y, Xiong K, Wang Y, Zhang H
Redox biology 2025 Jul;84:103684
Redox biology 2025 Jul;84:103684
CD36 promotes iron accumulation and dysfunction in CD8+ T cells via the p38-CEBPB-TfR1 axis in early-stage hepatocellular carcinoma.
Qin Y, Huo F, Feng Z, Hou J, Ding Y, Wang Q, Gui Y, Yang Z, Yang J, Zhou G, Li L, Jiang J, Kong L, Wang S, Nan G, Xu D, Xie X, Wang L, He Q, Yang R, Lin P, Bian H, Chen ZN, Wu J
Clinical and molecular hepatology 2025 Jul;31(3):960-980
Clinical and molecular hepatology 2025 Jul;31(3):960-980
The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein.
Yang L, An X, Yang S, Lin X, Chen Z, Xue Q, Chen X, Wang Y, Yan D, Chen S, Fan Y, Tang D, Yu W, Liu J, Chen X
Cell death & disease 2025 Jul 26;16(1):564
Cell death & disease 2025 Jul 26;16(1):564
Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice.
Wang Y, Kuang S, Li K, Chen S, Yang M, Deng K, Li M, Xie S, Chen Q, Wen J, Zhou C, Cheng W, Huang S, Lv Z
Communications biology 2025 Jul 21;8(1):1081
Communications biology 2025 Jul 21;8(1):1081
NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis.
Ye W, Zhao Y, Zhou Y, Huang J, He X, Ma Z, Huang X, Hu C, Li F, Ling Q, Wang H, Tong H, Sun J, Jin J
Molecular cancer 2025 Jul 21;24(1):201
Molecular cancer 2025 Jul 21;24(1):201
TBBPA-BDBPE induces ferroptosis in trophoblasts through chaperone-mediated autophagy of GPX4.
Mu Y, Wang K, Kang Y, Fang Z, Yu S, Zhou J, Li S, Zhang M
Ecotoxicology and environmental safety 2025 Jul 1;299:118425
Ecotoxicology and environmental safety 2025 Jul 1;299:118425
NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation.
Lin Z, Ying C, Si X, Xue N, Liu Y, Zheng R, Chen Y, Pu J, Zhang B
Neural regeneration research 2025 Jul 1;20(7):2038-2052
Neural regeneration research 2025 Jul 1;20(7):2038-2052
Nuclear receptor subfamily 1 group D member 2 induces chemoresistance in ovarian cancer by regulating ferroptosis and immune infiltration.
Wang L, Shao N, Qu Y, Sun H, Zhao J
Discover oncology 2025 Jul 1;16(1):1215
Discover oncology 2025 Jul 1;16(1):1215
SLC10A3 regulates ferroptosis of glioblastoma through the STAT3/GPX4 pathway.
Sun Q, Lu H, Yuan F, Zhao Q, Wei Y, Wang R, Chen Q, Liu B
Scientific reports 2025 Jul 1;15(1):21259
Scientific reports 2025 Jul 1;15(1):21259
Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition.
Yan S, Xue P, Sun Y, Bai T, Shao S, Zeng X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409967
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(3):e2409967
TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis.
Qiu C, Cheng L, Di D, Xiang Z, Wang C, Li J, Xiong Y, Li M, Liu J, Zhou J, Liu T, Wang X, Luo D, Wang X, Li S, Wang H, Wang X, Zhao Y, Liu X, Wang L
Genes & diseases 2025 Jan;12(1):101251
Genes & diseases 2025 Jan;12(1):101251
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
Liu W, Lu J, Li J, Wang L, Chen Y, Wu Y, Zhang Z, Zhang J, Gao F, Jia C, Bao Y, Yang X, Song Z
International journal of molecular sciences 2025 Jan 9;26(2)
International journal of molecular sciences 2025 Jan 9;26(2)
Temsirolimus inhibits FSP1 enzyme activity to induce ferroptosis and restrain liver cancer progression.
Tian RL, Wang TX, Huang ZX, Yang Z, Guan KL, Xiong Y, Wang P, Ye D
Journal of molecular cell biology 2025 Jan 30;16(8)
Journal of molecular cell biology 2025 Jan 30;16(8)
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.
Liu M, Xie WJ, Zhang X, Wu W, Li G, Wang L
Molecular medicine (Cambridge, Mass.) 2025 Jan 29;31(1):31
Molecular medicine (Cambridge, Mass.) 2025 Jan 29;31(1):31
Comprehensive Analysis Reveals Midnolin as a Potential Prognostic, Therapeutic, and Immunological Cancer Biomarker.
Zhang XG, Li WT, Jin X, Fu C, Jiang W, Bai J, Shi ZZ
Biomedicines 2025 Jan 23;13(2)
Biomedicines 2025 Jan 23;13(2)
Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis.
Huang B, Wang H, Liu S, Hao M, Luo D, Zhou Y, Huang Y, Nian Y, Zhang L, Chu B, Yin C
Nature communications 2025 Jan 20;16(1):867
Nature communications 2025 Jan 20;16(1):867
Exploring Liraglutide's mechanism in reducing renal fibrosis: the Fsp1-CoQ10-NAD(P)H pathway.
Chen Q, Song JX, Zhang Z, An JR, Gou YJ, Tan M, Zhao Y
Scientific reports 2025 Jan 12;15(1):1754
Scientific reports 2025 Jan 12;15(1):1754
AKRs confer oligodendrocytes resistance to differentiation-stimulated ferroptosis.
Saverio V, Ferrario E, Monzani R, Gagliardi M, Favero F, Corà D, Santoro C, Corazzari M
Redox biology 2025 Feb;79:103463
Redox biology 2025 Feb;79:103463
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
Wang L, Sang W, Jian Y, Han Y, Wang F, Wubulikasimu S, Yang L, Tang B, Li Y
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis.
Martin M, Kumar R, Buchkovich NJ, Norbury CC
Journal of virology 2025 Feb 25;99(2):e0185124
Journal of virology 2025 Feb 25;99(2):e0185124
Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions.
Wu Y, Zhang Z, Ren M, Chen Y, Zhang J, Li J, Gao F, Bao Y, Huang Y, Yang X, Song Z
Cells 2025 Feb 2;14(3)
Cells 2025 Feb 2;14(3)
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
Wang T, Liu B, Huang J, Zhao Q, Shen H, Bi T, Liu Z, Dai Y, Sun Q
Journal of translational medicine 2025 Feb 17;23(1):195
Journal of translational medicine 2025 Feb 17;23(1):195
Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia.
Lewczuk A, Boratyńska-Jasińska A, Charzewski Ł, Beręsewicz-Haller M, Zabłocka B
Pharmacological reports : PR 2025 Dec;77(6):1639-1656
Pharmacological reports : PR 2025 Dec;77(6):1639-1656
Development and Validation of a New Prediction Criteria for Neoadjuvant Chemotherapy Response in Locally Advanced Gastric Cancer Based on Ferroptosis-Related Biomarkers.
Shen M, Cai Q, Wang R, Zhang F, Chen H, Wang X, Xie R, Zhang J, Liu B, He Y, Hou X, Yang D
Journal of gastroenterology and hepatology 2025 Dec;40(12):2913-2924
Journal of gastroenterology and hepatology 2025 Dec;40(12):2913-2924
S100A4 regulates ferroptosis to suppress cell proliferation via the SLC7A11-GSH axis but facilitates Brucella infection in RAW264.7 macrophages.
Zhang G, Yin Y, Hu H, Tian M, Ding C, Yu S
International journal of biological macromolecules 2025 Dec;333(Pt 1):148831
International journal of biological macromolecules 2025 Dec;333(Pt 1):148831
Knockdown of TFB2M induces ferroptosis in lung adenocarcinoma via mitophagy-mediated GPX4 degradation.
Tian T, She T, Xie M, Qu X, Zhang H, Sun G
Expert review of anticancer therapy 2025 Dec;25(12):1415-1424
Expert review of anticancer therapy 2025 Dec;25(12):1415-1424
EIF4A3-induced circFAT1 promotes high glucose-induced podocyte damage via miR-30e-5p/SOX4 axis.
Huang Y, Liu Y, Yang M, Zhao L, Chen M
RNA biology 2025 Dec;22(1):1-13
RNA biology 2025 Dec;22(1):1-13
LncPEDS1-AS promotes UTUC resistance to lipid peroxidation by regulating PEDS1 expression via DDX23.
Li G, Zhang E, Wang Z, Zhang Z, Zhang Y, Di S, Lu J, Cao S, Xie G, Zhang Y, Li K
Cell death & disease 2025 Dec 8;17(1):87
Cell death & disease 2025 Dec 8;17(1):87
Targeting the MIR4435-2HG/miR-29c-3p/FSP1 axis overcomes lenvatinib resistance by inducing ferroptosis in hepatocellular carcinoma.
Zhang C, Sun M, Shi Y, Cui J, Mao Y, Lin Z, Wu X, Li S, Nan Y
Cancer cell international 2025 Dec 25;26(1):46
Cancer cell international 2025 Dec 25;26(1):46
Salidroside alleviates senile osteoporosis in SAMP8 mice by inhibiting the ferroptosis of bone marrow stromal cells via PI3K/AKT/mTOR signaling pathway.
Li Z, Yang S, Liu W, Ling L, Hu H, Cao Y, Xiang S
International immunopharmacology 2025 Dec 10;167:115703
International immunopharmacology 2025 Dec 10;167:115703
The Nrf2/GPX4 antioxidant pathway suppresses ferroptosis to protect against hearing impairment in cochlear ischemia-reperfusion injury.
Zou T, Huang S, Xie R, Liu J
International immunopharmacology 2025 Dec 10;167:115655
International immunopharmacology 2025 Dec 10;167:115655
Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.
Wang Y, Zhao Y, Zhao W, Chen H, Cao Z, Li H, Tang Y, Zhu X, Yao P
Free radical biology & medicine 2025 Dec 1;240:238-252
Free radical biology & medicine 2025 Dec 1;240:238-252
miR-134-3p Deficiency-Induced Methionine Metabolism Promotes Fibrosis via SLC25A33 in OSF.
Yao MF, Shao MY, Li QL, Yang TR, Zheng ZR, Zhang XL, Huang JJ, Sun YX, He J, Li J, Fang CY
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Aug;54(7):584-596
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Aug;54(7):584-596
Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma.
Zhu J, Xiong Y, Zhang Y, Liang H, Cheng K, Lu Y, Cai G, Wu Y, Fan Y, Chen X, Zhu H, Ding Z, Zhang W
Cancer communications (London, England) 2025 Aug;45(8):1038-1071
Cancer communications (London, England) 2025 Aug;45(8):1038-1071
Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis.
Xu H, Wu Z, Tang J, Gan Y, Li J, Yu Y, Chen Y, Sui R, Liu J, Zhang Y, Piao H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156917
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156917
FSP1 and CoQ10 have the potential to serve as biomarkers for severe preeclampsia.
Li P, Liu Y, Liao J, Rao M, Peng L, Wang Y, Shang L, Liu X, Xiao Z
BMC pregnancy and childbirth 2025 Aug 6;25(1):813
BMC pregnancy and childbirth 2025 Aug 6;25(1):813
Downregulation of Mg(2+) Efflux Protein CNNM3 Predicts Poor Prognosis but Enhances Ferroptosis Sensitivity in Kidney Renal Clear Cell Carcinoma via NCOA4-Mediated Ferritinophagy.
Hua S, Yang C, Shang P, Zhan M, Li K, Zhang T, Jia Y, Hua Z, Zhu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70948
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70948
Targeting FSP1 triggers ferroptosis in lung cancer.
Wu K, Vaughan AJ, Bossowski JP, Hao Y, Ziogou A, Kim SM, Kim TH, Nakamura MN, Pillai R, Mancini M, Rajalingam S, Han M, Nakamura T, Wang L, Chung S, Simeone D, Shackelford D, Kang YP, Conrad M, Papagiannakopoulos T
bioRxiv : the preprint server for biology 2025 Aug 23;
bioRxiv : the preprint server for biology 2025 Aug 23;
Targeting NRF2 and FSP1 to Overcome Ferroptosis Resistance in TSC2-Deficient and Cancer Cells.
Tahsin T, McPhail DK, Champion JD, Alzahrani MAM, Hilditch ML, Faris-Orr A, Calver BL, Cronin JG, Mareque-Rivas JC, Sexton DW, Hughes SF, Conlan RS, Davies DM, Tee AR
Cancers 2025 Aug 21;17(16)
Cancers 2025 Aug 21;17(16)
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Li J, Ma C, Cao P, Guo W, Wang P, Yang Y, Ding B, Yin F, Li Z, Wang Y, Li S, Huang C, Wang X, Zhou T, Chang A, Zhao L, Gao S, Zhao T, Wang H, Yu J, Xu J, Feng Y, Hao J
Cell reports. Medicine 2025 Aug 19;6(8):102292
Cell reports. Medicine 2025 Aug 19;6(8):102292
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury.
Huang L, Shen Y, Pan X, Li J, Li C, Ruan L, He S, Huang L, Liu K, Zhao X, Geng J, Guo J, Hou FF, Wang J
Nature communications 2025 Aug 19;16(1):7699
Nature communications 2025 Aug 19;16(1):7699
Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation.
Zhang E, Wang Y, Zhang H, Li X, Su Y, Cui J, Xu R, Mao X, Sang M, Lin Z, Zhou X
Free radical biology & medicine 2025 Aug 1;235:231-247
Free radical biology & medicine 2025 Aug 1;235:231-247
Stress-mediated Activation of Ferroptosis, Pyroptosis, and Apoptosis Following Mild Traumatic Brain Injury Exacerbates Neurological Dysfunctions.
Zheng L, Pang Q, Huang R, Xu H, Guo H, Gao C, Chen X, Wang Y, Cao Q, Gao Y, Gu Z, Wang Z, Luo C, Tao L, Wang T
Molecular neurobiology 2025 Apr;62(4):4055-4075
Molecular neurobiology 2025 Apr;62(4):4055-4075
Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome.
Qi Z, Huang X, Jing J, Feng W, Xu M, Yan L, Gao M, Liu S, Yu XF
Journal of environmental sciences (China) 2025 Apr;150:1-13
Journal of environmental sciences (China) 2025 Apr;150:1-13
Ferroptosis inhibitor alleviates sorafenib-induced cardiotoxicity by attenuating KLF11-mediated FSP1-dependent ferroptosis.
Li Y, Yan J, Sun H, Liang Y, Zhao Q, Yu S, Zhang Y
International journal of biological sciences 2024;20(7):2622-2639
International journal of biological sciences 2024;20(7):2622-2639
FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.
Yan Y, Ran X, Zhou Z, Gu Y, Wang R, Qiu C, Sun Y, Wang J, Xiao J, Lu Y, Wang J
Frontiers in pharmacology 2024;15:1358646
Frontiers in pharmacology 2024;15:1358646
PDK4-mediated Nrf2 inactivation contributes to oxidative stress and diabetic kidney injury.
Tian S, Yang X, Lin Y, Li X, Zhou S, Yu P, Zhao Y
Cellular signalling 2024 Sep;121:111282
Cellular signalling 2024 Sep;121:111282
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism.
Zhang X, Duan Y, Li S, Zhang Z, Peng L, Ma X, Wang T, Xiang S, Chen G, Zhou D, Lu D, Qian M, Wang Z
Cell reports 2024 Sep 24;43(9):114662
Cell reports 2024 Sep 24;43(9):114662
Cancer-associated fibroblast-derived exosome Leptin promotes malignant biological lineage in pancreatic ductal adenocarcinoma by regulating ABL2 via miR-224-3p.
Zhang L, Chen Y, Dai Y, Mou W, Deng P, Jin Y, Xu J, Jin Y
Molecular biology reports 2024 Sep 19;51(1):995
Molecular biology reports 2024 Sep 19;51(1):995
Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator.
Sone M, Mitsuhashi N, Sugiura Y, Matsuoka Y, Maeda R, Yamauchi A, Okahashi R, Yamashita J, Sone K, Enju S, Anegawa D, Yamaguchi Y
Cell death & disease 2024 Sep 19;15(9):685
Cell death & disease 2024 Sep 19;15(9):685
Engineering Biodegradable Hollow Silica/Iron Composite Nanozymes for Breast Tumor Treatment through Activation of the "Ferroptosis Storm".
Xue P, Zhuang H, Shao S, Bai T, Zeng X, Yan S
ACS nano 2024 Sep 17;18(37):25795-25812
ACS nano 2024 Sep 17;18(37):25795-25812
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis.
Liu X, Chen Z, Yan Y, Zandkarimi F, Nie L, Li Q, Horbath A, Olszewski K, Kondiparthi L, Mao C, Lee H, Zhuang L, Poyurovsky M, Stockwell BR, Chen J, Gan B
Protein & cell 2024 Sep 1;15(9):686-703
Protein & cell 2024 Sep 1;15(9):686-703
Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.
Chen W, Han L, Yang R, Wang H, Yao S, Deng H, Liu S, Zhou Y, Shen XL
Archives of toxicology 2024 Oct;98(10):3323-3336
Archives of toxicology 2024 Oct;98(10):3323-3336
FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy.
Wang X, Xu L, Meng Y, Chen F, Zhuang J, Wang M, An W, Han Y, Chu B, Chai R, Liu W, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2402671
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(40):e2402671
Tellurium-Doped Bioactive Glass Induces Ferroptosis in Osteosarcoma Cells Regardless of FSP1.
Pańczyszyn E, Lallukka M, Gagliardi M, Saverio V, Monzani R, Miola M, Verné E, Corazzari M
Antioxidants (Basel, Switzerland) 2024 Oct 30;13(11)
Antioxidants (Basel, Switzerland) 2024 Oct 30;13(11)
Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.
Yang G, Yang Y, Song Z, Chen L, Liu F, Li Y, Jiang S, Xue S, Pei J, Wu Y, He Y, Chu B, Wu H
Neuron 2024 Oct 23;112(20):3452-3469.e9
Neuron 2024 Oct 23;112(20):3452-3469.e9
Upregulation of PRRX2 by silencing Marveld3 as a protective mechanism against radiation-induced ferroptosis in skin cells.
Cao J, Wu M, Mo W, Zhao M, Gu L, Wang X, Zhang B, Cao J
Molecular medicine (Cambridge, Mass.) 2024 Oct 21;30(1):182
Molecular medicine (Cambridge, Mass.) 2024 Oct 21;30(1):182
Short-term respiratory cadmium exposure partially activates pulmonary NLRP3 inflammasome by inducing ferroptosis in mice.
Li Z, Yao YX, Lu X, Peng K, He YZ, Liu ZB, Zhao H, Wang H, Xu DX, Tan ZX
Ecotoxicology and environmental safety 2024 Oct 15;285:117106
Ecotoxicology and environmental safety 2024 Oct 15;285:117106
A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.
Wu J, Jin X, Li W, Liu E
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280
TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy.
Saha S, Skeie JM, Schmidt GA, Eggleston T, Shevalye H, Sales CS, Phruttiwanichakun P, Dusane A, Field MG, Rinkoski TA, Fautsch MP, Baratz KH, Roy M, Jun AS, Pendleton C, Salem AK, Greiner MA
Redox biology 2024 Nov;77:103348
Redox biology 2024 Nov;77:103348
New Treatment Modalities for Colorectal Cancer Through Simultaneous Suppression of FSP1 and GPX4.
Yasui C, Kono Y, Ishiguro R, Yagyu T, Kyoichi K, Yamamoto M, Matsunaga T, Takano S, Tokuyasu N, Sakamoto T, Hasegawa T, Umekita Y, Fujiwara Y
Anticancer research 2024 Nov;44(11):4905-4914
Anticancer research 2024 Nov;44(11):4905-4914
Comprehensive cognition of yak (Bos grunniens) AIFM2 gene and its anti-ferroptosis role in bisphenol A-induced fetal fibroblast model.
Li Y, Xu H, Ma Z, Li Q, Xiong Y, Xiong X, Li J, Lan D, Fu W
Animal biotechnology 2024 Nov;35(1):2377209
Animal biotechnology 2024 Nov;35(1):2377209
Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice.
Fan YG, Ge RL, Ren H, Jia RJ, Wu TY, Lei XF, Wu Z, Zhou XB, Wang ZY
Pharmacological research 2024 Nov;209:107404
Pharmacological research 2024 Nov;209:107404
Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo/YAP signaling pathway.
Zhou Y, Wang H, Bi T, Liang P, Liu X, Shen H, Sun Q, Luo G, Liu P, Yang S, Ren W
Journal of traditional and complementary medicine 2024 Nov;14(6):656-665
Journal of traditional and complementary medicine 2024 Nov;14(6):656-665
Angiotensin II depends on hippo/YAP signaling to reprogram angiogenesis and promote liver fibrosis.
Zhou Y, Liang P, Bi T, Tang B, Zhu X, Liu X, Wang H, Shen H, Sun Q, Yang S, Ren W
Cellular signalling 2024 Nov;123:111355
Cellular signalling 2024 Nov;123:111355
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury.
Lin H, Ma C, Zhuang X, Liu S, Liu D, Zhang M, Lu Y, Zhou G, Zhang C, Wang T, Zhang Z, Lv L, Zhang D, Ruan XZ, Xu Y, Chai R, Yu X, Sun JP, Chu B
Cell metabolism 2024 Nov 5;36(11):2402-2418.e10
Cell metabolism 2024 Nov 5;36(11):2402-2418.e10
MT1G promotes iron autophagy and inhibits the function of gastric cancer cell lines by intervening in GPX4/SQSTM1.
Meng K, Song J, Qi F, Li J, Fang Z, Song L
Scientific reports 2024 Nov 18;14(1):28539
Scientific reports 2024 Nov 18;14(1):28539
Brucella Manipulates Host Cell Ferroptosis to Facilitate Its Intracellular Replication and Egress in RAW264.7 Macrophages.
Zhang G, Hu H, Yin Y, Tian M, Bu Z, Ding C, Yu S
Antioxidants (Basel, Switzerland) 2024 May 8;13(5)
Antioxidants (Basel, Switzerland) 2024 May 8;13(5)
Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis.
Li H, Cao Z, Liu C, Wang Y, Wang L, Tang Y, Yao P
Journal of agricultural and food chemistry 2024 May 29;72(21):12156-12170
Journal of agricultural and food chemistry 2024 May 29;72(21):12156-12170
Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells.
Zhu G, Luo D, Zhao Y, Xiang Z, Chen C, Li N, Hao X, Ding X, Zhang Y, Zhao Y
Natural products and bioprospecting 2024 May 23;14(1):34
Natural products and bioprospecting 2024 May 23;14(1):34
Fatal COVID-19 pulmonary disease involves ferroptosis.
Qiu B, Zandkarimi F, Saqi A, Castagna C, Tan H, Sekulic M, Miorin L, Hibshoosh H, Toyokuni S, Uchida K, Stockwell BR
Nature communications 2024 May 20;15(1):3816
Nature communications 2024 May 20;15(1):3816
Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance.
Lin X, Zhang Q, Li Q, Deng J, Shen S, Tang M, Ye X, Ji C, Yang Y, Chen Y, Zeng L, Zhao J, Kouwenhoven MBN, Lucero-Prisno DE 3rd, Huang J, Li Y, Zhang B, Hu J
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101032
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101032
Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway.
Zhang Y, Zeng Y, Huang M, Cao G, Lin L, Wang X, Cheng Q
Free radical research 2024 Mar;58(3):156-169
Free radical research 2024 Mar;58(3):156-169
Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.
Wei Y, Liu W, Wang R, Chen Y, Liu J, Guo X, Can C, Yang X, Wang D, Hu X, Ma D
Free radical biology & medicine 2024 Mar;213:36-51
Free radical biology & medicine 2024 Mar;213:36-51
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Wang H, Yu X, Liu D, Qiao Y, Huo J, Pan S, Zhou L, Wang R, Feng Q, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry.
Lai Z, Wang C, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Wang J, Lei X, Shu K, Feng Y, Kong D, Sun W, Liu B
Journal of translational medicine 2024 Mar 7;22(1):247
Journal of translational medicine 2024 Mar 7;22(1):247
Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.
Xiang Z, Zhang P, Jia C, Xu R, Cao D, Xu Z, Lu T, Liu J, Wang X, Qiu C, Fu W, Li W, Cheng L, Yang Q, Feng S, Wang L, Zhao Y, Liu X
Bone research 2024 Mar 29;12(1):20
Bone research 2024 Mar 29;12(1):20
Pitavastatin induces autophagy-dependent ferroptosis in MDA-MB-231 cells via the mevalonate pathway.
Tang WJ, Xu D, Liang MX, Wo GQ, Chen WQ, Tang JH, Zhang W
Heliyon 2024 Mar 15;10(5):e27084
Heliyon 2024 Mar 15;10(5):e27084
Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.
Tai F, Zhai R, Ding K, Zhang Y, Yang H, Li H, Wang Q, Cao Z, Ge C, Fu H, Xiao F, Zheng X
International journal of oncology 2024 Jun;64(6)
International journal of oncology 2024 Jun;64(6)
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.
Villareal LB, Falcon DM, Xie L, Xue X
British journal of cancer 2024 Jun;130(12):1904-1915
British journal of cancer 2024 Jun;130(12):1904-1915
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Xian S, Li Y, Bai L, Tang S, Meng Z, Wen H, Huang F, Zeng Z
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Ciprofloxacin is a novel anti-ferroptotic antibiotic.
Chen F, Tang H, Lin J, Kang R, Tang D, Liu J
Heliyon 2024 Jun 15;10(11):e32571
Heliyon 2024 Jun 15;10(11):e32571
Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis.
Guo YY, Liang NN, Zhang XY, Ren YH, Wu WZ, Liu ZB, He YZ, Zhang YH, Huang YC, Zhang T, Xu DX, Xu S
Redox biology 2024 Jul;73:103179
Redox biology 2024 Jul;73:103179
The dual role of FSP1 in programmed cell death: resisting ferroptosis in the cell membrane and promoting necroptosis in the nucleus of THP-1 cells.
Tan X, He Y, Yu P, Deng Y, Xie Z, Guo J, Hou Q, Li P, Lin X, Ouyang S, Ma W, Xie Y, Guo Z, Chen D, Zhang Z, Zhu Y, Huang F, Zhao Z, Zhang C, Guo Z, Chen X, Peng T, Li L, Xie W
Molecular medicine (Cambridge, Mass.) 2024 Jul 15;30(1):102
Molecular medicine (Cambridge, Mass.) 2024 Jul 15;30(1):102
N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma.
Geroyska S, Mejia I, Chan AA, Navarrete M, Pandey V, Kharpatin S, Noguti J, Wang F, Srole D, Chou TF, Wohlschlegel J, Nemeth E, Damoiseaux R, Shackelford DB, Lee DJ, Díaz B
Cancer research communications 2024 Jul 1;4(7):1815-1833
Cancer research communications 2024 Jul 1;4(7):1815-1833
Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.
Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, Liang C, Yang Y, Fu X, Zhang Y, Liu J, Shi S, Cong J, Han Z, Xu Y, Du L, Yin C, Zhang Y, Sun J, Gu W, Chai R, Zhu S, Chu B
Nature cell biology 2024 Jan;26(1):124-137
Nature cell biology 2024 Jan;26(1):124-137
Dissecting cell death pathways in fed-batch bioreactors.
Mentlak DA, Raven J, Moses T, Massie F, Barber N, Hoare R, Burton G, Young A, Pybus LP, Rosser S, White RJ, Ungar D, Bryant NJ
Biotechnology journal 2024 Jan;19(1):e2300257
Biotechnology journal 2024 Jan;19(1):e2300257
Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction.
Bi T, Zhou Y, Mao L, Liang P, Liu J, Yang L, Ren G, Mazhar M, Shen H, Liu P, Spáčil R, Guo Q, Luo G, Yang S, Ren W
Journal of traditional and complementary medicine 2024 Jan;14(1):40-54
Journal of traditional and complementary medicine 2024 Jan;14(1):40-54
CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury.
Ma Y, Huang L, Zhang Z, Yang P, Chen Q, Zeng X, Tan F, Wang C, Ruan X, Liao X
Genes & diseases 2024 Jan;11(1):449-463
Genes & diseases 2024 Jan;11(1):449-463
Inhibition of FSP1 impairs early embryo developmental competence in pigs.
Wang YQ, Qu HX, Dong YW, Qi JJ, Wei HK, Sun H, Jiang H, Zhang JB, Sun BX, Liang S
Theriogenology 2024 Jan 15;214:257-265
Theriogenology 2024 Jan 15;214:257-265
Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis.
Liu Y, Luo X, Chen Y, Dang J, Zeng D, Guo X, Weng W, Zhao J, Shi X, Chen J, Dong B, Zhong S, Ren J, Li Y, Wang J, Zhang J, Sun J, Xu H, Lu Y, Brand D, Zheng SG, Pan Y
Redox biology 2024 Feb;69:103008
Redox biology 2024 Feb;69:103008
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
Wang S, Xiong B, Tian Y, Hu Q, Jiang X, Zhang J, Chen L, Wang R, Li M, Zhou X, Zhang T, Ge H, Yu A
Molecular neurobiology 2024 Feb;61(2):1157-1174
Molecular neurobiology 2024 Feb;61(2):1157-1174
FSP1 is a predictive biomarker of osteosarcoma cells' susceptibility to ferroptotic cell death and a potential therapeutic target.
Panczyszyn E, Saverio V, Monzani R, Gagliardi M, Petrovic J, Stojkovska J, Collavin L, Corazzari M
Cell death discovery 2024 Feb 17;10(1):87
Cell death discovery 2024 Feb 17;10(1):87
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury.
Mann J, Reznik E, Santer M, Fongheiser MA, Smith N, Hirschhorn T, Zandkarimi F, Soni RK, Dafré AL, Miranda-Vizuete A, Farina M, Stockwell BR
Cell chemical biology 2024 Feb 15;31(2):249-264.e7
Cell chemical biology 2024 Feb 15;31(2):249-264.e7
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.
Rodencal J, Kim N, He A, Li VL, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Long JZ, Sage J, Dixon SJ
Cell chemical biology 2024 Feb 15;31(2):234-248.e13
Cell chemical biology 2024 Feb 15;31(2):234-248.e13
CircYTHDF1/miR-19b-3p/YTHDF1 axis contributes to pregnancy-induced hypertension development by enhancing vascular endothelial cell injury.
Wang F, Yang Q, Wang X, Guo Y, Lin S
Hypertension in pregnancy 2024 Dec;43(1):2414976
Hypertension in pregnancy 2024 Dec;43(1):2414976
Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury.
Li Y, Chen Y, Yu P, Zhang D, Tang X, Zhu Z, Xiao F, Deng W, Liu Y, Tan Z, Zhang J, Yu S
Molecular medicine reports 2024 Dec;30(6)
Molecular medicine reports 2024 Dec;30(6)
MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway.
Liu X, Zhang F, Fan Y, Qiu C, Wang K
International immunopharmacology 2024 Dec 5;142(Pt A):113107
International immunopharmacology 2024 Dec 5;142(Pt A):113107
REV-ERBα inhibitor rescues MPTP/MPP(+)-induced ferroptosis of dopaminergic neuron through regulating FASN/SCD1 signaling pathway.
Wang X, Wang M, Zhi H, Li J, Guo D
Heliyon 2024 Dec 15;10(23):e40388
Heliyon 2024 Dec 15;10(23):e40388
Alkaliptosis induction counteracts paclitaxel-resistant ovarian cancer cells via ATP6V0D1-mediated ABCB1 inhibition.
Chen F, Lin J, Kang R, Tang D, Liu J
Molecular carcinogenesis 2024 Aug;63(8):1515-1527
Molecular carcinogenesis 2024 Aug;63(8):1515-1527
Ubiquitin-specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling.
Sun H, Meng Y, Yao L, Du S, Li Y, Zhou Q, Liu Y, Dian Y, Sun Y, Wang X, Liang XW, Deng G, Chen X, Zeng F
MedComm 2024 Aug;5(8):e684
MedComm 2024 Aug;5(8):e684
Levosimendan Reverses Cardiac Malfunction and Cardiomyocyte Ferroptosis During Heart Failure with Preserved Ejection Fraction via Connexin 43 Signaling Activation.
Zhang LL, Chen GH, Tang RJ, Xiong YY, Pan Q, Jiang WY, Gong ZT, Chen C, Li XS, Yang YJ
Cardiovascular drugs and therapy 2024 Aug;38(4):705-718
Cardiovascular drugs and therapy 2024 Aug;38(4):705-718
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.
Fujita H, Tanaka YK, Ogata S, Suzuki N, Kuno S, Barayeu U, Akaike T, Ogra Y, Iwai K
Nature structural & molecular biology 2024 Aug;31(8):1277-1285
Nature structural & molecular biology 2024 Aug;31(8):1277-1285
STC2 suppresses triple-negative breast cancer migration and invasion by inhibition on EMT and promotion on cell apoptosis.
Lei R, Yao C, Huang R, Wu W, Ou L, Yang C
Discover oncology 2024 Aug 9;15(1):339
Discover oncology 2024 Aug 9;15(1):339
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.
Liang FG, Zandkarimi F, Lee J, Axelrod JL, Pekson R, Yoon Y, Stockwell BR, Kitsis RN
Molecular cell 2024 Aug 22;84(16):3098-3114.e6
Molecular cell 2024 Aug 22;84(16):3098-3114.e6
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.
Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B
Cancer discovery 2024 Aug 2;14(8):1476-1495
Cancer discovery 2024 Aug 2;14(8):1476-1495
Biomineralization-Tuned Nanounits Reprogram the Signal Transducer and Activator of Transcription 3 Signaling for Ferroptosis-Immunotherapy in Cancer Stem Cells.
Zhao Y, Fei Y, Zhao Y, Li M, Hu Y, Cai K, Yu SH, Luo Z
ACS nano 2024 Aug 13;18(32):21268-21287
ACS nano 2024 Aug 13;18(32):21268-21287
MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1.
Feng B, Su W, Guo X, Ding T, Duan Y, Hu L, Yu M
Cell death discovery 2024 Aug 13;10(1):363
Cell death discovery 2024 Aug 13;10(1):363
Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.
Kong L, Liu Y, Li J, Wang Y, Ji P, Shi Q, Han M, Xu H, Li W, Li W
Journal of ethnopharmacology 2024 Aug 10;330:118205
Journal of ethnopharmacology 2024 Aug 10;330:118205
Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
Wu X, Guan Y, Wang J, Song L, Zhang Y, Wang Y, Li Y, Qin L, He Q, Zhang T, Long B, Ji L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155340
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155340
Neuron-targeted liposomal coenzyme Q10 attenuates neuronal ferroptosis after subarachnoid hemorrhage by activating the ferroptosis suppressor protein 1/coenzyme Q10 system.
Peng Z, Ding YN, Yang ZM, Li XJ, Zhuang Z, Lu Y, Tang QS, Hang CH, Li W
Acta biomaterialia 2024 Apr 15;179:325-339
Acta biomaterialia 2024 Apr 15;179:325-339
Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling.
Sun M, Chang H, Jiang F, Zhang W, Yang Q, Wang X, Lv G, Lin H, Luo H, Lin Z, Wang Y
Molecules (Basel, Switzerland) 2024 Apr 11;29(8)
Molecules (Basel, Switzerland) 2024 Apr 11;29(8)
Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line.
Dong S, Zheng L, Jiang T
Journal of oncology 2023;2023:2830306
Journal of oncology 2023;2023:2830306
Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer.
Cheu JW, Lee D, Li Q, Goh CC, Bao MH, Yuen VW, Zhang MS, Yang C, Chan CY, Tse AP, Sit GF, Liu CX, Ng IO, Wong CM, Wong CC
Cellular and molecular gastroenterology and hepatology 2023;16(1):133-159
Cellular and molecular gastroenterology and hepatology 2023;16(1):133-159
SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy.
Yang Z, Huang R, Wang Y, Guan Q, Li D, Wu Y, Liao T, Wang Y, Xiang J
American journal of cancer research 2023;13(2):464-474
American journal of cancer research 2023;13(2):464-474
Structural insights into FSP1 catalysis and ferroptosis inhibition.
Lv Y, Liang C, Sun Q, Zhu J, Xu H, Li X, Li YY, Wang Q, Yuan H, Chu B, Zhu D
Nature communications 2023 Sep 22;14(1):5933
Nature communications 2023 Sep 22;14(1):5933
ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions.
Sun MH, Jiang WJ, Li XH, Lee SH, Heo G, Zhou D, Chen Z, Cui XS
Zoological research 2023 Sep 18;44(5):848-859
Zoological research 2023 Sep 18;44(5):848-859
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.
Xiong L, Huang J, Wu C, Yuan Q, Wang S, Zhu L, Li Z, Sun Z, Fang Y, Li W, Hu G
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
Ecotoxicology and environmental safety 2023 Sep 15;263:115279
NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.
Cheng HP, Feng DD, Li XH, Gao LH, Qiu YJ, Liang XY, Zhou Y, Huang P, Shao M, Zhang YN, Chang YF, Fu JF, Huang YH, Liu W, Tang SY, Li C, Luo ZQ
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
Gao Y, Lu LJ, Zhang ZZ, Yang X, Du J, Wen K, Huang H, Wang XP, Sun XL
Journal of ethnopharmacology 2023 Oct 28;315:116678
Journal of ethnopharmacology 2023 Oct 28;315:116678
Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma.
Liu MR, Shi C, Song QY, Kang MJ, Jiang X, Liu H, Pei DS
Hepatology communications 2023 Oct 1;7(10)
Hepatology communications 2023 Oct 1;7(10)
Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis.
Liu H, He Y, Gao X, Li T, Qiao B, Tang L, Lan J, Su Q, Ruan Z, Tang Z, Hu L
Mycotoxin research 2023 Nov;39(4):437-451
Mycotoxin research 2023 Nov;39(4):437-451
The deubiquitinase ZRANB1 is an E3 ubiquitin ligase for SLC7A11 and regulates ferroptotic resistance.
Huang S, Zhang Q, Zhao M, Wang X, Zhang Y, Gan B, Zhang P
The Journal of cell biology 2023 Nov 6;222(11)
The Journal of cell biology 2023 Nov 6;222(11)
Targeting ferroptosis by poly(acrylic) acid coated Mn(3)O(4) nanoparticles alleviates acute liver injury.
Shan X, Li J, Liu J, Feng B, Zhang T, Liu Q, Ma H, Wu H, Wu H
Nature communications 2023 Nov 21;14(1):7598
Nature communications 2023 Nov 21;14(1):7598
Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications.
Sun S, Qi G, Chen H, He D, Ma D, Bie Y, Xu L, Feng B, Pang Q, Guo H, Zhang R
Cell death & disease 2023 Nov 18;14(11):754
Cell death & disease 2023 Nov 18;14(11):754
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.
Sun Q, Liu D, Cui W, Cheng H, Huang L, Zhang R, Gu J, Liu S, Zhuang X, Lu Y, Chu B, Li J
Communications biology 2023 Nov 1;6(1):1108
Communications biology 2023 Nov 1;6(1):1108
Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.
Bu C, Hu S, Yu J, Li N, Gu J, Sheng Z, Yan Z, Bu X
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 May;25(5):1378-1388
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 May;25(5):1378-1388
Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.
Xie L, Zhou C, Wu Y, Fu X, Zhang G, Han X, Xie S, Chen G, Xu H, Deng B, Liu B, Zhou Y, Li A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154748
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154748
Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells.
He J, Abikoye AM, McLaughlin BP, Middleton RS, Sheldon R, Jones RG, Schafer ZT
iScience 2023 Jun 16;26(6):106827
iScience 2023 Jun 16;26(6):106827
Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.
Ma M, Wang R, Xu M
Journal of hazardous materials 2023 Jun 15;452:131217
Journal of hazardous materials 2023 Jun 15;452:131217
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.
Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, Feng X, Fang ZM, Jiang DS, Ma MJ
Molecular medicine (Cambridge, Mass.) 2023 Jul 6;29(1):91
Molecular medicine (Cambridge, Mass.) 2023 Jul 6;29(1):91
A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2.
Rodencal J, Kim N, Li VL, He A, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Sage J, Long JZ, Dixon SJ
bioRxiv : the preprint server for biology 2023 Jul 19;
bioRxiv : the preprint server for biology 2023 Jul 19;
Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.
Du Q, Wu X, Ma K, Liu W, Liu P, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Archives of biochemistry and biophysics 2023 Jul 15;743:109644
Archives of biochemistry and biophysics 2023 Jul 15;743:109644
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.
Wang TX, Duan KL, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C, Guan KL, Yuan HX
Life science alliance 2023 Jan;6(1)
Life science alliance 2023 Jan;6(1)
Bone Marrow-Derived Mesenchymal Stem Cells Transplantation Attenuates Renal Fibrosis Following Acute Kidney Injury in Rats by Diminishing Pericyte-Myofibroblast Transition and Extracellular Matrix Augment.
Wang H, Li M, Fei L, Xie C, Ding L, Zhu C, Zeng F, Liu N
Transplantation proceedings 2023 Jan-Feb;55(1):225-234
Transplantation proceedings 2023 Jan-Feb;55(1):225-234
SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.
Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74
Cell death & disease 2023 Jan 31;14(1):74
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.
Yu R, Wu Y, He P, Bai Y, Zhang Y, Bian X, Sun G, Zhang B
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100016
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100016
Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.
Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006
Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.
Wu Y, Shi H, Zheng J, Yang Y, Lei X, Qian X, Zhu J
Heliyon 2023 Aug;9(8):e18449
Heliyon 2023 Aug;9(8):e18449
Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.
Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311
Cell research 2023 Apr;33(4):299-311
Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.
He X, Liang SM, Wang HQ, Tao L, Sun FF, Wang Y, Zhang C, Huang YC, Xu DX, Chen X
Toxicology and applied pharmacology 2023 Apr 15;465:116452
Toxicology and applied pharmacology 2023 Apr 15;465:116452
Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage.
Yuan B, Zhao XD, Shen JD, Chen SJ, Huang HY, Zhou XM, Han YL, Zhou LJ, Lu XJ, Wu Q
Oxidative medicine and cellular longevity 2022;2022:9069825
Oxidative medicine and cellular longevity 2022;2022:9069825
Dexpramipexole Attenuates White Matter Injury to Facilitate Locomotion and Motor Coordination Recovery via Reducing Ferroptosis after Intracerebral Hemorrhage.
Wang B, Zhang X, Zhong J, Wang S, Zhang C, Li M, Hu Q, Wang S, Chen L, Chen W, Ge H, Feng H
Oxidative medicine and cellular longevity 2022;2022:6160701
Oxidative medicine and cellular longevity 2022;2022:6160701
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Deng G, Zhou C, Chen Y, Huang S, Gao L, Lv Z
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro.
Zhao MY, Liu P, Sun C, Pei LJ, Huang YG
Frontiers in pharmacology 2022;13:816432
Frontiers in pharmacology 2022;13:816432
Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells.
Sun C, Liu P, Pei L, Zhao M, Huang Y
Frontiers in oncology 2022;12:837974
Frontiers in oncology 2022;12:837974
HOIP modulates the stability of GPx4 by linear ubiquitination.
Dong K, Wei R, Jin T, Zhang M, Shen J, Xiang H, Shan B, Yuan J, Li Y
Proceedings of the National Academy of Sciences of the United States of America 2022 Nov;119(44):e2214227119
Proceedings of the National Academy of Sciences of the United States of America 2022 Nov;119(44):e2214227119
SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling.
Zeng C, Lin J, Zhang K, Ou H, Shen K, Liu Q, Wei Z, Dong X, Zeng X, Zeng L, Wang W, Yao J
Cancer science 2022 Nov;113(11):3766-3775
Cancer science 2022 Nov;113(11):3766-3775
CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis.
Wu J, Chen L, Qin C, Huo F, Liang X, Yang X, Zhang K, Lin P, Liu J, Feng Z, Zhou J, Pei Z, Wang Y, Sun XX, Wang K, Geng J, Zheng Z, Fu X, Liu M, Wang Q, Zhang Z, Bian H, Zhu P, Chen ZN
Signal transduction and targeted therapy 2022 Nov 25;7(1):382
Signal transduction and targeted therapy 2022 Nov 25;7(1):382
Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.
Armenta DA, Laqtom NN, Alchemy G, Dong W, Morrow D, Poltorack CD, Nathanson DA, Abu-Remalieh M, Dixon SJ
Cell chemical biology 2022 Nov 17;29(11):1588-1600.e7
Cell chemical biology 2022 Nov 17;29(11):1588-1600.e7
Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.
Jo A, Bae JH, Yoon YJ, Chung TH, Lee EW, Kim YH, Joh HM, Chung JW
Cell death & disease 2022 Mar 7;13(3):212
Cell death & disease 2022 Mar 7;13(3):212
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents.
Fang Y, Tan Q, Zhou H, Gu Q, Xu J
European journal of medicinal chemistry 2022 Mar 5;231:114151
European journal of medicinal chemistry 2022 Mar 5;231:114151
The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.
Zhang Y, Xu Z, Wen W, Liu Z, Zhang C, Li M, Hu F, Wei S, Bae S, Zhou J, Liu R, Wang L
Oncogene 2022 Jun;41(23):3186-3196
Oncogene 2022 Jun;41(23):3186-3196
Farrerol alleviates collagenase-induced tendinopathy by inhibiting ferroptosis in rats.
Wu Y, Qian J, Li K, Li W, Yin W, Jiang H
Journal of cellular and molecular medicine 2022 Jun;26(12):3483-3494
Journal of cellular and molecular medicine 2022 Jun;26(12):3483-3494
Abrogation of ARF6 in promoting erastin-induced ferroptosis and mitigating capecitabine resistance in gastric cancer cells.
Geng D, Wu H
Journal of gastrointestinal oncology 2022 Jun;13(3):958-967
Journal of gastrointestinal oncology 2022 Jun;13(3):958-967
LncRNA LINC00961 regulates endothelial‑mesenchymal transition via the PTEN‑PI3K‑AKT pathway.
Hu JX, Zheng ZQ, Kang T, Qian W, Huang SH, Li BG
Molecular medicine reports 2022 Jul;26(1)
Molecular medicine reports 2022 Jul;26(1)
Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.
Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Zhou C, Zeng Z, Chen Y, Huang S, Gao L, Lv Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154117
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154117
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.
Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89
Nature cancer 2022 Jan;3(1):75-89
Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.
Fan XZ, Wang YY, Cui ZY, Cheng ZH, Zhang HL, Gamper N, Zhang F, Han M
Free radical biology & medicine 2022 Jan;178:111-124
Free radical biology & medicine 2022 Jan;178:111-124
Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction.
Wang Y, Kuang X, Yin Y, Han N, Chang L, Wang H, Hou Y, Li H, Li Z, Liu Y, Hao Y, Wei Y, Wang X, Jia Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112367
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112367
RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner.
Sun S, Gao T, Pang B, Su X, Guo C, Zhang R, Pang Q
Cell death & disease 2022 Jan 21;13(1):73
Cell death & disease 2022 Jan 21;13(1):73
Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
Hu Y, Wang Q, Yu J, Zhou Q, Deng Y, Liu J, Zhang L, Xu Y, Xiong W, Wang Y
Nature communications 2022 Jan 10;13(1):114
Nature communications 2022 Jan 10;13(1):114
NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Feng Z, Qin Y, Huo F, Jian Z, Li X, Geng J, Li Y, Wu J
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287
Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.
Wang S, Zheng Y, Jin S, Fu Y, Liu Y
Antioxidants (Basel, Switzerland) 2022 Dec 11;11(12)
Antioxidants (Basel, Switzerland) 2022 Dec 11;11(12)
Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.
Zhou M, Dong J, Huang J, Ye W, Zheng Z, Huang K, Pan Y, Cen J, Liang Y, Shu G, Ye S, Lu X, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Aug;9(22):e2105077
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Aug;9(22):e2105077
LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination.
Zhang B, Bao W, Zhang S, Chen B, Zhou X, Zhao J, Shi Z, Zhang T, Chen Z, Wang L, Zheng X, Chen G, Wang Y
Cell death & disease 2022 Aug 25;13(8):734
Cell death & disease 2022 Aug 25;13(8):734
A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.
Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B
Nature communications 2022 Apr 22;13(1):2206
Nature communications 2022 Apr 22;13(1):2206
Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice.
Huang S, Shao T, Liu H, Li T, Gui X, Zhao Q
Frontiers in cell and developmental biology 2021;9:812748
Frontiers in cell and developmental biology 2021;9:812748
Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.
Shao Y, Jia H, Li S, Huang L, Aikemu B, Yang G, Zhang S, Sun J, Zheng M
Oxidative medicine and cellular longevity 2021;2021:7007933
Oxidative medicine and cellular longevity 2021;2021:7007933
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.
Tan Q, Fang Y, Peng X, Zhou H, Xu J, Gu Q
Bioorganic chemistry 2021 Oct;115:105177
Bioorganic chemistry 2021 Oct;115:105177
Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.
Zeng L, Zhou J, Wang X, Zhang Y, Wang M, Su P
Free radical biology & medicine 2021 Nov 20;176:176-188
Free radical biology & medicine 2021 Nov 20;176:176-188
Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.
Li D, Liu B, Fan Y, Liu M, Han B, Meng Y, Xu X, Song Z, Liu X, Hao Q, Duan X, Nakai A, Chang Y, Cao P, Tan K
British journal of pharmacology 2021 Mar;178(5):1182-1199
British journal of pharmacology 2021 Mar;178(5):1182-1199
DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.
Du J, Wang X, Li Y, Ren X, Zhou Y, Hu W, Zhou C, Jing Q, Yang C, Wang L, Li H, Fang L, Zhou Y, Tong X, Wang Y
Cell death & disease 2021 Jul 15;12(7):705
Cell death & disease 2021 Jul 15;12(7):705
A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.
Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L
Nature communications 2021 Dec 17;12(1):7333
Nature communications 2021 Dec 17;12(1):7333
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects.
Dierge E, Debock E, Guilbaud C, Corbet C, Mignolet E, Mignard L, Bastien E, Dessy C, Larondelle Y, Feron O
Cell metabolism 2021 Aug 3;33(8):1701-1715.e5
Cell metabolism 2021 Aug 3;33(8):1701-1715.e5
Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells.
Ye Z, Hu Q, Zhuo Q, Zhu Y, Fan G, Liu M, Sun Q, Zhang Z, Liu W, Xu W, Ji S, Yu X, Xu X, Qin Y
American journal of cancer research 2020;10(4):1182-1193
American journal of cancer research 2020;10(4):1182-1193
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
Xie M, Tang Q, Yu S, Sun J, Mei F, Zhao J, Chen L
International journal of oral science 2020 Sep 30;12(1):28
International journal of oral science 2020 Sep 30;12(1):28
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Zhao Y, Li M, Yao X, Fei Y, Lin Z, Li Z, Cai K, Zhao Y, Luo Z
Cell reports 2020 Dec 8;33(10):108487
Cell reports 2020 Dec 8;33(10):108487
Impact of Wortmannilactone F and G31P on Clonorchis Sinensis-infected mice.
Qin Y, Zhang Z, Zheng L, Wu H, Dai X, Dong Y, Cui Y, Ren Y
International immunopharmacology 2020 Aug;85:106512
International immunopharmacology 2020 Aug;85:106512
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA
Nature 2019 Nov;575(7784):688-692
Nature 2019 Nov;575(7784):688-692
miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition.
Yang J, Zhou CZ, Zhu R, Fan H, Liu XX, Duan XY, Tang Q, Shou ZX, Zuo DM
Journal of gastroenterology and hepatology 2017 Dec;32(12):1966-1974
Journal of gastroenterology and hepatology 2017 Dec;32(12):1966-1974
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