20886-1-AP

antibody from Proteintech Group

Targeting: AIFM2 AMID, FLJ14497, PRG3

Provider product page for 20886-1-AP

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Product number: 20886-1-AP - Provider product page
Provider: Proteintech Group
Product name: AIFM2/ FSP1 antibody
Antibody type: Polyclonal
Description: AIFM2/ FSP1 antibody (Cat. #20886-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AIFM2 protein structure - 20886-1-AP shown in red.

Submitted references Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis.

Liu X, Chen Z, Yan Y, Zandkarimi F, Nie L, Li Q, Horbath A, Olszewski K, Kondiparthi L, Mao C, Lee H, Zhuang L, Poyurovsky M, Stockwell BR, Chen J, Gan B
Protein & cell 2024 Sep 1;15(9):686-703

Central role of Sigma-1 receptor in ochratoxin A-induced ferroptosis.

Chen W, Han L, Yang R, Wang H, Yao S, Deng H, Liu S, Zhou Y, Shen XL
Archives of toxicology 2024 Oct;98(10):3323-3336

Comprehensive cognition of yak (Bos grunniens) AIFM2 gene and its anti-ferroptosis role in bisphenol A-induced fetal fibroblast model.

Li Y, Xu H, Ma Z, Li Q, Xiong Y, Xiong X, Li J, Lan D, Fu W
Animal biotechnology 2024 Nov;35(1):2377209

Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis.

Li H, Cao Z, Liu C, Wang Y, Wang L, Tang Y, Yao P
Journal of agricultural and food chemistry 2024 May 29;72(21):12156-12170

Pacidusin B isolated from Phyllanthus acidus triggers ferroptotic cell death in HT1080 cells.

Zhu G, Luo D, Zhao Y, Xiang Z, Chen C, Li N, Hao X, Ding X, Zhang Y, Zhao Y
Natural products and bioprospecting 2024 May 23;14(1):34

Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance.

Lin X, Zhang Q, Li Q, Deng J, Shen S, Tang M, Ye X, Ji C, Yang Y, Chen Y, Zeng L, Zhao J, Kouwenhoven MBN, Lucero-Prisno DE 3rd, Huang J, Li Y, Zhang B, Hu J
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101032

Andrographolide attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis through the Nrf2/FSP1 pathway.

Zhang Y, Zeng Y, Huang M, Cao G, Lin L, Wang X, Cheng Q
Free radical research 2024 Mar;58(3):156-169

Propionate promotes ferroptosis and apoptosis through mitophagy and ACSL4-mediated ferroptosis elicits anti-leukemia immunity.

Wei Y, Liu W, Wang R, Chen Y, Liu J, Guo X, Can C, Yang X, Wang D, Hu X, Ma D
Free radical biology & medicine 2024 Mar;213:36-51

VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.

Wang H, Yu X, Liu D, Qiao Y, Huo J, Pan S, Zhou L, Wang R, Feng Q, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563

Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry.

Lai Z, Wang C, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Wang J, Lei X, Shu K, Feng Y, Kong D, Sun W, Liu B
Journal of translational medicine 2024 Mar 7;22(1):247

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx.

Xiang Z, Zhang P, Jia C, Xu R, Cao D, Xu Z, Lu T, Liu J, Wang X, Qiu C, Fu W, Li W, Cheng L, Yang Q, Feng S, Wang L, Zhao Y, Liu X
Bone research 2024 Mar 29;12(1):20

Pitavastatin induces autophagy-dependent ferroptosis in MDA-MB-231 cells via the mevalonate pathway.

Tang WJ, Xu D, Liang MX, Wo GQ, Chen WQ, Tang JH, Zhang W
Heliyon 2024 Mar 15;10(5):e27084

Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells.

Tai F, Zhai R, Ding K, Zhang Y, Yang H, Li H, Wang Q, Cao Z, Ge C, Fu H, Xiao F, Zheng X
International journal of oncology 2024 Jun;64(6)

Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.

Villareal LB, Falcon DM, Xie L, Xue X
British journal of cancer 2024 Jun;130(12):1904-1915

Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis.

Guo YY, Liang NN, Zhang XY, Ren YH, Wu WZ, Liu ZB, He YZ, Zhang YH, Huang YC, Zhang T, Xu DX, Xu S
Redox biology 2024 Jul;73:103179

Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition.

Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, Liang C, Yang Y, Fu X, Zhang Y, Liu J, Shi S, Cong J, Han Z, Xu Y, Du L, Yin C, Zhang Y, Sun J, Gu W, Chai R, Zhu S, Chu B
Nature cell biology 2024 Jan;26(1):124-137

Dissecting cell death pathways in fed-batch bioreactors.

Mentlak DA, Raven J, Moses T, Massie F, Barber N, Hoare R, Burton G, Young A, Pybus LP, Rosser S, White RJ, Ungar D, Bryant NJ
Biotechnology journal 2024 Jan;19(1):e2300257

Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction.

Bi T, Zhou Y, Mao L, Liang P, Liu J, Yang L, Ren G, Mazhar M, Shen H, Liu P, Spáčil R, Guo Q, Luo G, Yang S, Ren W
Journal of traditional and complementary medicine 2024 Jan;14(1):40-54

CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury.

Ma Y, Huang L, Zhang Z, Yang P, Chen Q, Zeng X, Tan F, Wang C, Ruan X, Liao X
Genes & diseases 2024 Jan;11(1):449-463

Inhibition of FSP1 impairs early embryo developmental competence in pigs.

Wang YQ, Qu HX, Dong YW, Qi JJ, Wei HK, Sun H, Jiang H, Zhang JB, Sun BX, Liang S
Theriogenology 2024 Jan 15;214:257-265

Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis.

Liu Y, Luo X, Chen Y, Dang J, Zeng D, Guo X, Weng W, Zhao J, Shi X, Chen J, Dong B, Zhong S, Ren J, Li Y, Wang J, Zhang J, Sun J, Xu H, Lu Y, Brand D, Zheng SG, Pan Y
Redox biology 2024 Feb;69:103008

Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.

Wang S, Xiong B, Tian Y, Hu Q, Jiang X, Zhang J, Chen L, Wang R, Li M, Zhou X, Zhang T, Ge H, Yu A
Molecular neurobiology 2024 Feb;61(2):1157-1174

FSP1 is a predictive biomarker of osteosarcoma cells' susceptibility to ferroptotic cell death and a potential therapeutic target.

Panczyszyn E, Saverio V, Monzani R, Gagliardi M, Petrovic J, Stojkovska J, Collavin L, Corazzari M
Cell death discovery 2024 Feb 17;10(1):87

Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury.

Mann J, Reznik E, Santer M, Fongheiser MA, Smith N, Hirschhorn T, Zandkarimi F, Soni RK, Dafré AL, Miranda-Vizuete A, Farina M, Stockwell BR
Cell chemical biology 2024 Feb 15;31(2):249-264.e7

Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.

Rodencal J, Kim N, He A, Li VL, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Long JZ, Sage J, Dixon SJ
Cell chemical biology 2024 Feb 15;31(2):234-248.e13

Alkaliptosis induction counteracts paclitaxel-resistant ovarian cancer cells via ATP6V0D1-mediated ABCB1 inhibition.

Chen F, Lin J, Kang R, Tang D, Liu J
Molecular carcinogenesis 2024 Aug;63(8):1515-1527

PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis.

Fujita H, Tanaka YK, Ogata S, Suzuki N, Kuno S, Barayeu U, Akaike T, Ogra Y, Iwai K
Nature structural & molecular biology 2024 Aug;31(8):1277-1285

BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers.

Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B
Cancer discovery 2024 Aug 2;14(8):1476-1495

Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.

Kong L, Liu Y, Li J, Wang Y, Ji P, Shi Q, Han M, Xu H, Li W, Li W
Journal of ethnopharmacology 2024 Aug 10;330:118205

Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.

Wu X, Guan Y, Wang J, Song L, Zhang Y, Wang Y, Li Y, Qin L, He Q, Zhang T, Long B, Ji L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155340

Neuron-targeted liposomal coenzyme Q10 attenuates neuronal ferroptosis after subarachnoid hemorrhage by activating the ferroptosis suppressor protein 1/coenzyme Q10 system.

Peng Z, Ding YN, Yang ZM, Li XJ, Zhuang Z, Lu Y, Tang QS, Hang CH, Li W
Acta biomaterialia 2024 Apr 15;179:325-339

Hazel Leaf Polyphenol Extract Alleviated Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis through Inhibiting Hippo Signaling.

Sun M, Chang H, Jiang F, Zhang W, Yang Q, Wang X, Lv G, Lin H, Luo H, Lin Z, Wang Y
Molecules (Basel, Switzerland) 2024 Apr 11;29(8)

Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line.

Dong S, Zheng L, Jiang T
Journal of oncology 2023;2023:2830306

Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer.

Cheu JW, Lee D, Li Q, Goh CC, Bao MH, Yuen VW, Zhang MS, Yang C, Chan CY, Tse AP, Sit GF, Liu CX, Ng IO, Wong CM, Wong CC
Cellular and molecular gastroenterology and hepatology 2023;16(1):133-159

SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy.

Yang Z, Huang R, Wang Y, Guan Q, Li D, Wu Y, Liao T, Wang Y, Xiang J
American journal of cancer research 2023;13(2):464-474

Structural insights into FSP1 catalysis and ferroptosis inhibition.

Lv Y, Liang C, Sun Q, Zhu J, Xu H, Li X, Li YY, Wang Q, Yuan H, Chu B, Zhu D
Nature communications 2023 Sep 22;14(1):5933

ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions.

Sun MH, Jiang WJ, Li XH, Lee SH, Heo G, Zhou D, Chen Z, Cui XS
Zoological research 2023 Sep 18;44(5):848-859

Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice.

Xiong L, Huang J, Wu C, Yuan Q, Wang S, Zhu L, Li Z, Sun Z, Fang Y, Li W, Hu G
Ecotoxicology and environmental safety 2023 Sep 15;263:115279

NMDA receptor activation induces damage of alveolar type II cells and lung fibrogenesis through ferroptosis.

Cheng HP, Feng DD, Li XH, Gao LH, Qiu YJ, Liang XY, Zhou Y, Huang P, Shao M, Zhang YN, Chang YF, Fu JF, Huang YH, Liu W, Tang SY, Li C, Luo ZQ
Biochimica et biophysica acta. Molecular cell research 2023 Oct;1870(7):119535

Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

Gao Y, Lu LJ, Zhang ZZ, Yang X, Du J, Wen K, Huang H, Wang XP, Sun XL
Journal of ethnopharmacology 2023 Oct 28;315:116678

Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma.

Liu MR, Shi C, Song QY, Kang MJ, Jiang X, Liu H, Pei DS
Hepatology communications 2023 Oct 1;7(10)

Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis.

Liu H, He Y, Gao X, Li T, Qiao B, Tang L, Lan J, Su Q, Ruan Z, Tang Z, Hu L
Mycotoxin research 2023 Nov;39(4):437-451

Targeting ferroptosis by poly(acrylic) acid coated Mn(3)O(4) nanoparticles alleviates acute liver injury.

Shan X, Li J, Liu J, Feng B, Zhang T, Liu Q, Ma H, Wu H, Wu H
Nature communications 2023 Nov 21;14(1):7598

Ferroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications.

Sun S, Qi G, Chen H, He D, Ma D, Bie Y, Xu L, Feng B, Pang Q, Guo H, Zhang R
Cell death & disease 2023 Nov 18;14(11):754

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.

Sun Q, Liu D, Cui W, Cheng H, Huang L, Zhang R, Gu J, Liu S, Zhuang X, Lu Y, Chu B, Li J
Communications biology 2023 Nov 1;6(1):1108

Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.

Bu C, Hu S, Yu J, Li N, Gu J, Sheng Z, Yan Z, Bu X
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2023 May;25(5):1378-1388

Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.

Xie L, Zhou C, Wu Y, Fu X, Zhang G, Han X, Xie S, Chen G, Xu H, Deng B, Liu B, Zhou Y, Li A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154748

Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells.

He J, Abikoye AM, McLaughlin BP, Middleton RS, Sheldon R, Jones RG, Schafer ZT
iScience 2023 Jun 16;26(6):106827

Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.

Ma M, Wang R, Xu M
Journal of hazardous materials 2023 Jun 15;452:131217

Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.

Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, Feng X, Fang ZM, Jiang DS, Ma MJ
Molecular medicine (Cambridge, Mass.) 2023 Jul 6;29(1):91

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2.

Rodencal J, Kim N, Li VL, He A, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Sage J, Long JZ, Dixon SJ
bioRxiv : the preprint server for biology 2023 Jul 19;

Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.

Du Q, Wu X, Ma K, Liu W, Liu P, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Archives of biochemistry and biophysics 2023 Jul 15;743:109644

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.

Wang TX, Duan KL, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C, Guan KL, Yuan HX
Life science alliance 2023 Jan;6(1)

Bone Marrow-Derived Mesenchymal Stem Cells Transplantation Attenuates Renal Fibrosis Following Acute Kidney Injury in Rats by Diminishing Pericyte-Myofibroblast Transition and Extracellular Matrix Augment.

Wang H, Li M, Fei L, Xie C, Ding L, Zhu C, Zeng F, Liu N
Transplantation proceedings 2023 Jan-Feb;55(1):225-234

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.

Cheng L, He Q, Liu B, Chen L, Lv F, Li X, Li Y, Liu C, Song Y, Xing Y
Cell death & disease 2023 Jan 31;14(1):74

LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.

Yu R, Wu Y, He P, Bai Y, Zhang Y, Bian X, Sun G, Zhang B
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100016

Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.

Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Feb;10(6):e2204006

Overexpression of FSP1 Ameliorates ferroptosis via PI3K/ AKT /GSK3β pathway in PC12 cells with Oxygen-Glucose Deprivation/Reoxygenation.

Wu Y, Shi H, Zheng J, Yang Y, Lei X, Qian X, Zhu J
Heliyon 2023 Aug;9(8):e18449

Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.

Qiu S, Zhong X, Meng X, Li S, Qian X, Lu H, Cai J, Zhang Y, Wang M, Ye Z, Zhang H, Gao P
Cell research 2023 Apr;33(4):299-311

Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.

He X, Liang SM, Wang HQ, Tao L, Sun FF, Wang Y, Zhang C, Huang YC, Xu DX, Chen X
Toxicology and applied pharmacology 2023 Apr 15;465:116452

Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage.

Yuan B, Zhao XD, Shen JD, Chen SJ, Huang HY, Zhou XM, Han YL, Zhou LJ, Lu XJ, Wu Q
Oxidative medicine and cellular longevity 2022;2022:9069825

Dexpramipexole Attenuates White Matter Injury to Facilitate Locomotion and Motor Coordination Recovery via Reducing Ferroptosis after Intracerebral Hemorrhage.

Wang B, Zhang X, Zhong J, Wang S, Zhang C, Li M, Hu Q, Wang S, Chen L, Chen W, Ge H, Feng H
Oxidative medicine and cellular longevity 2022;2022:6160701

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.

Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Deng G, Zhou C, Chen Y, Huang S, Gao L, Lv Z
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672

Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro.

Zhao MY, Liu P, Sun C, Pei LJ, Huang YG
Frontiers in pharmacology 2022;13:816432

Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells.

Sun C, Liu P, Pei L, Zhao M, Huang Y
Frontiers in oncology 2022;12:837974

HOIP modulates the stability of GPx4 by linear ubiquitination.

Dong K, Wei R, Jin T, Zhang M, Shen J, Xiang H, Shan B, Yuan J, Li Y
Proceedings of the National Academy of Sciences of the United States of America 2022 Nov;119(44):e2214227119

SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling.

Zeng C, Lin J, Zhang K, Ou H, Shen K, Liu Q, Wei Z, Dong X, Zeng X, Zeng L, Wang W, Yao J
Cancer science 2022 Nov;113(11):3766-3775

CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis.

Wu J, Chen L, Qin C, Huo F, Liang X, Yang X, Zhang K, Lin P, Liu J, Feng Z, Zhou J, Pei Z, Wang Y, Sun XX, Wang K, Geng J, Zheng Z, Fu X, Liu M, Wang Q, Zhang Z, Bian H, Zhu P, Chen ZN
Signal transduction and targeted therapy 2022 Nov 25;7(1):382

Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.

Armenta DA, Laqtom NN, Alchemy G, Dong W, Morrow D, Poltorack CD, Nathanson DA, Abu-Remalieh M, Dixon SJ
Cell chemical biology 2022 Nov 17;29(11):1588-1600.e7

Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.

Jo A, Bae JH, Yoon YJ, Chung TH, Lee EW, Kim YH, Joh HM, Chung JW
Cell death & disease 2022 Mar 7;13(3):212

Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents.

Fang Y, Tan Q, Zhou H, Gu Q, Xu J
European journal of medicinal chemistry 2022 Mar 5;231:114151

The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.

Zhang Y, Xu Z, Wen W, Liu Z, Zhang C, Li M, Hu F, Wei S, Bae S, Zhou J, Liu R, Wang L
Oncogene 2022 Jun;41(23):3186-3196

Farrerol alleviates collagenase-induced tendinopathy by inhibiting ferroptosis in rats.

Wu Y, Qian J, Li K, Li W, Yin W, Jiang H
Journal of cellular and molecular medicine 2022 Jun;26(12):3483-3494

Abrogation of ARF6 in promoting erastin-induced ferroptosis and mitigating capecitabine resistance in gastric cancer cells.

Geng D, Wu H
Journal of gastrointestinal oncology 2022 Jun;13(3):958-967

LncRNA LINC00961 regulates endothelial‑mesenchymal transition via the PTEN‑PI3K‑AKT pathway.

Hu JX, Zheng ZQ, Kang T, Qian W, Huang SH, Li BG
Molecular medicine reports 2022 Jul;26(1)

Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.

Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Zhou C, Zeng Z, Chen Y, Huang S, Gao L, Lv Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154117

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.

Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89

Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.

Fan XZ, Wang YY, Cui ZY, Cheng ZH, Zhang HL, Gamper N, Zhang F, Han M
Free radical biology & medicine 2022 Jan;178:111-124

Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction.

Wang Y, Kuang X, Yin Y, Han N, Chang L, Wang H, Hou Y, Li H, Li Z, Liu Y, Hao Y, Wei Y, Wang X, Jia Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jan;145:112367

RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner.

Sun S, Gao T, Pang B, Su X, Guo C, Zhang R, Pang Q
Cell death & disease 2022 Jan 21;13(1):73

Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.

Hu Y, Wang Q, Yu J, Zhou Q, Deng Y, Liu J, Zhang L, Xu Y, Xiong W, Wang Y
Nature communications 2022 Jan 10;13(1):114

NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.

Feng Z, Qin Y, Huo F, Jian Z, Li X, Geng J, Li Y, Wu J
Biochimica et biophysica acta. Molecular basis of disease 2022 Jan 1;1868(1):166287

Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.

Wang S, Zheng Y, Jin S, Fu Y, Liu Y
Antioxidants (Basel, Switzerland) 2022 Dec 11;11(12)

Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.

Zhou M, Dong J, Huang J, Ye W, Zheng Z, Huang K, Pan Y, Cen J, Liang Y, Shu G, Ye S, Lu X, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Aug;9(22):e2105077

LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination.

Zhang B, Bao W, Zhang S, Chen B, Zhou X, Zhao J, Shi Z, Zhang T, Chen Z, Wang L, Zheng X, Chen G, Wang Y
Cell death & disease 2022 Aug 25;13(8):734

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.

Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B
Nature communications 2022 Apr 22;13(1):2206

Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice.

Huang S, Shao T, Liu H, Li T, Gui X, Zhao Q
Frontiers in cell and developmental biology 2021;9:812748

Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.

Shao Y, Jia H, Li S, Huang L, Aikemu B, Yang G, Zhang S, Sun J, Zheng M
Oxidative medicine and cellular longevity 2021;2021:7007933

A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.

Tan Q, Fang Y, Peng X, Zhou H, Xu J, Gu Q
Bioorganic chemistry 2021 Oct;115:105177

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.

Zeng L, Zhou J, Wang X, Zhang Y, Wang M, Su P
Free radical biology & medicine 2021 Nov 20;176:176-188

Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.

Li D, Liu B, Fan Y, Liu M, Han B, Meng Y, Xu X, Song Z, Liu X, Hao Q, Duan X, Nakai A, Chang Y, Cao P, Tan K
British journal of pharmacology 2021 Mar;178(5):1182-1199

DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.

Du J, Wang X, Li Y, Ren X, Zhou Y, Hu W, Zhou C, Jing Q, Yang C, Wang L, Li H, Fang L, Zhou Y, Tong X, Wang Y
Cell death & disease 2021 Jul 15;12(7):705

A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.

Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, Martinez C, Su X, Rosato RR, Teng H, Hang Q, Yap S, Chen D, Wang Y, Chen MM, Zhang M, Liang H, Xie D, Chen X, Zhu H, Chang JC, You MJ, Sun Y, Gan B, Ma L
Nature communications 2021 Dec 17;12(1):7333

Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.

Cheng H, Feng D, Li X, Gao L, Tang S, Liu W, Wu X, Yue S, Li C, Luo Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Dec 1;1867(12):166204

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects.

Dierge E, Debock E, Guilbaud C, Corbet C, Mignolet E, Mignard L, Bastien E, Dessy C, Larondelle Y, Feron O
Cell metabolism 2021 Aug 3;33(8):1701-1715.e5

Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells.

Ye Z, Hu Q, Zhuo Q, Zhu Y, Fan G, Liu M, Sun Q, Zhang Z, Liu W, Xu W, Ji S, Yu X, Xu X, Qin Y
American journal of cancer research 2020;10(4):1182-1193

Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.

Xie M, Tang Q, Yu S, Sun J, Mei F, Zhao J, Chen L
International journal of oral science 2020 Sep 30;12(1):28

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.

Zhao Y, Li M, Yao X, Fei Y, Lin Z, Li Z, Cai K, Zhao Y, Luo Z
Cell reports 2020 Dec 8;33(10):108487

Impact of Wortmannilactone F and G31P on Clonorchis Sinensis-infected mice.

Qin Y, Zhang Z, Zheng L, Wu H, Dai X, Dong Y, Cui Y, Ren Y
International immunopharmacology 2020 Aug;85:106512

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA
Nature 2019 Nov;575(7784):688-692

miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition.

Yang J, Zhou CZ, Zhu R, Fan H, Liu XX, Duan XY, Tang Q, Shou ZX, Zuo DM
Journal of gastroenterology and hepatology 2017 Dec;32(12):1966-1974

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